# Reconstructing Heterogeneous Biomolecules via
Hierarchical Gaussian Mixtures and Part Discovery

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## Synthetic Datasets

We compare CryoSPIRE with other methods on three synthetic dataset from CryoBench, a recent standardized benchmark for heterogeneous reconstruction. Two datasets of IgG-1D and IgG-RL are based on the human immunoglobulin G (IgG) complex, simulating conformational heterogeneity of the fragment anti-body. The third dataset, Ribosembly, consists of compositional heterogeneity of Ribosome.

## IgG-1D Dataset

## IgG-RL Dataset

## Ribosembly