# 0

**SMILES:** C1=CC=C(C(=C1)C2=NC=CC(=N2)N3C=CN=C3)Cl

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: assistantHigh permeability

------
# 1

**SMILES:** CC1=NC(=NC2=CC=CC=C12)N

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high permeability to the artificial membrane.
Final answer: 

------
# 2

**SMILES:** C1=NC(=C2C(=N1)N(C=N2)[C@@H]3[C@@H]([C@@H]([C@@H](O3)CO)O)N)N

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule has a predicted permeability of high permeability.
Final answer: 

------
# 3

**SMILES:** CN1CCC2=CC(=C3C4=C2[C@H]1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)C[C@H]7C8=CC(=C(O3)C=C8CCN7)O4)OC)OC

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has a predicted low-to-moderate permeability to the artificial membrane.

------
# 4

**SMILES:** C1=CC2=C(C=C1I)C(=CC3=CC(=C(C(=C3)Br)O)Br)C(=O)N2

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 5

**SMILES:** COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CC=C3

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 6

**SMILES:** C[C@@]12C3=CC=CC=C3C[C@@H](N1)C4=CC=CC=C24

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: assistantHigh permeability.

------
# 7

**SMILES:** CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has a low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 8

**SMILES:** C1COCCN1C2=C(C=C(C=C2)C(F)(F)F)NC(=O)C3=NNC(=O)C4=CC=CC=C43

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 9

**SMILES:** CCCCCN1C(=O)C2=C(C=C(C=C2)C(=O)NCCCN3CCCCC3)NC1=O

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 10

**SMILES:** CC1=C(C(=NO1)C2=CC=CC=C2)C(=O)NC3=NN=C(S3)COC4=CC=C(C=C4)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 11

**SMILES:** C1OC2=C(O1)C=C(C=C2)C3NN4C(=NN=C4S3)C5=CC=CC=C5

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to high permeability.
Final answer: 

------
# 12

**SMILES:** COC1=CC2=C(C=C1)NC(=O)C(=C2)C3=NOC(=N3)C4=CC=CC=C4

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 13

**SMILES:** CC1=CC=CC=C1C2=NC(=C(O2)C)CN3CCC(CC3)C(=O)NCCCN4CCOCC4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 14

**SMILES:** C1=CC(=CN=C1)NC(=O)C2=CC=CS2

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability to the artificial membrane.
Final answer: assistantLow-to-moderate permeability.

------
# 15

**SMILES:** CC1=CC=CC=C1NC(=O)NC2=CC=CS2

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: assistantHigh permeability.

------
# 16

**SMILES:** C1=NC2=C(N1)C(=O)NC=N2

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polar surface area, low hydrogen bond donors/acceptors, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: High permeability

------
# 17

**SMILES:** CC1=CC=C(C=C1)N2C3=NC=NC(=C3C=N2)NC4=CC=CC(=C4)C(=O)O

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to high permeability.
Final answer: assistantThe molecule has high permeability.

------
# 18

**SMILES:** CCN(CC)CCNC(=O)C1CCN(CC1)C2=NN3C=C(N=C3S2)C4=CC=C(C=C4)F

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 19

**SMILES:** CC1=CC2=C(C=C1)C(=C(N2CC3=CC=C(C=C3)OC)C(=O)O)CNCC4=CC=CO4

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability.
Final answer: 

------
# 20

**SMILES:** CC(=O)C1=CC=C(C=C1)N2CCN(CC2)C3=C(C=C(C=C3)NC(=O)C4=CC=C(C=C4)F)C(=O)O

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 21

**SMILES:** C1CCN(CC1)C2CCN(CC2)C3=C(C=C(C=C3)NC(=O)C4=CC=C(C=C4)Br)C(=O)O

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 22

**SMILES:** CC1=C(C=C(C=C1)C2=NN3C(=NN=C3C4=CC=CC=C42)C)S(=O)(=O)NC

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to high permeability.
Final answer: assistantHigh permeability

------
# 23

**SMILES:** C1=C(OC(=C1)[N+](=O)[O-])C=NNC(=O)C(=O)N

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 24

**SMILES:** C1COCCN1C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a degree of rigidity and aromaticity, which are favorable for membrane permeation.
Final answer: assistantThe molecule is predicted to have high permeability to the artificial membrane.

------
# 25

**SMILES:** CN1C(=NN=N1)SC2=NC=NC3=C2C=CS3

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high permeability.
Final answer: 

------
# 26

**SMILES:** C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 27

**SMILES:** CN(C)C1=CC=C(C=C1)C2=C(C(=O)NC=C2)N

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 28

**SMILES:** COC1=C(C=C(C=C1)C2=CSC(=N2)N3CCC(CC3)C(=O)N)OC

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 29

**SMILES:** COC1=CC(=CC(=C1OC)OC)C2=CSC(=N2)N3CCC(CC3)C(=O)N

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 30

**SMILES:** CC(=O)NC1CCN(CC1)C2=NC(=CS2)C3=CC=C(C=C3)Br

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 31

**SMILES:** CC1=NC(=CC=C1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=NC=CN=C4C=C3

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: assistantHigh

------
# 32

**SMILES:** C1=CC(=CC(=C1)N2C=CC=C2/C=C/3\C(=O)N(C(=O)N3)C4=CC(=CC=C4)Cl)C(=O)O

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has a predicted permeability of low-to-moderate permeability.
Final answer: 

------
# 33

**SMILES:** CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)N[C@H](CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability. Additionally, the presence of aromatic rings and a relatively low hydration energy support its ability to permeate the membrane.
Final answer: The molecule has high permeability.

------
# 34

**SMILES:** CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule has high permeability to the artificial membrane.
Final answer: 

------
# 35

**SMILES:** CN(C)[C@@H]1CCN(C1)C2=CC=CC(=C2)NC3=NN4C(=O)C5=CC=CC=C5N=C4S3

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, small molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 36

**SMILES:** CCNC(=O)C1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NCC4CCCO4

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 37

**SMILES:** CC1=C(C(N=C(N1)NC2=NC3=CC=CC=C3O2)C4=NN(C=C4Cl)C)C(=O)NC5=NN=CS5

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 38

**SMILES:** CC1=C(C=CC(=C1)SCC2=C(N=C(S2)C3=CC=C(C=C3)C(F)(F)F)C)OCC(=O)O

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 39

**SMILES:** CC1=CC(=NC(=C1)NC(=S)N2CCN(CC2)C3=CC=NC=C3)C

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 40

**SMILES:** CC1=CC(=NC(=C1)NC(=S)N2CCN(CC2)C3=C(C=C(C=C3)F)F)C

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high permeability due to its lipophilic nature, small molecular size, low polarity, and neutral charge. It also has a relatively low hydration energy, which is beneficial for membrane permeation.
Final answer: assistantThe molecule has high permeability.

------
# 41

**SMILES:** CC1=CC(=NO1)NS(=O)(=O)C2=CC=C(C=C2)C(=O)NCC3=CC(=C(C=C3)Cl)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 42

**SMILES:** CC1=CC(=NC=C1)NC(=S)N2CCN(CC2)C3=C(C=C(C=C3)Cl)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 43

**SMILES:** CC1=CC(=NO1)NS(=O)(=O)C2=CC=C(C=C2)NC(=O)CC3=CC(=C(C=C3)F)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 44

**SMILES:** C1CCC2=C(C1)N=C3CCCCC3=N2

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high permeability due to its lipophilicity, small molecular size, low polarity, and neutral charge. It also has a relatively low hydration energy, which suggests that it can easily diffuse through the lipid bilayer.
Final answer: assistantHigh permeability.

------
# 45

**SMILES:** COC1C(CC2CN3CCC4=C(C3CC2C1CO)NC5=C4C=CC(=C5)OC)O

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 46

**SMILES:** CN1C2=C(C(=O)N(C1=O)C)NC(=O)N2

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to high permeability.
Final answer: assistantThe molecule has high permeability to the artificial membrane.

------
# 47

**SMILES:** C1CNCCC1NC2=CC=CC(=N2)C3=CN=C4N3C=C(C=C4)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 48

**SMILES:** CCOC1=CC=CC=C1C(=O)NC2=C(C=NC=C2)C(=O)NC3=CC(=CC=C3)S(=O)(=O)C(F)(F)F

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 49

**SMILES:** C1=CC=C(C=C1)COC2=CC(=CC=C2)SC3=CC(=C(C=C3)CCC(CO)(CO)N)Cl

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to high permeability.
Final answer: 

------
# 50

**SMILES:** C1CCC(C1)C2=C(C=CC(=C2)C3=CNC4=C3C=C(C=N4)C5=CC=CC=C5)C(=O)O

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has a predicted permeability of high permeability.
Final answer: 

------
# 51

**SMILES:** CC[C@@H](C1=NC2=C(C(=CC=C2)F)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: assistantHigh

------
# 52

**SMILES:** CC1=C(C=C(C=C1)C(=O)N)NC2=NC=CC(=N2)C3=CN(C4=C3C=CN=C4)C(C)C

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to higher permeability.
Final answer: assistantThe molecule has high permeability.

------
# 53

**SMILES:** CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N=C(C3=CC=CC=C3)C4=C(NC5=C4C=CC(=C5)C(=O)OC)O

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 54

**SMILES:** COC1=C(N=C(O1)C2=CC=CC3=CC=CC=C32)C(=O)O

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule has a predicted permeability of high permeability.
Final answer: assistantThe molecule has a predicted permeability of high permeability.

------
# 55

**SMILES:** CCNC(=O)C[C@H]1C2=NN=C(N2C3=C(C=C(C=C3)OC)C(=N1)C4=CC=C(C=C4)Cl)C

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 56

**SMILES:** C1=CC=C2C(=C1)C(=NC(=N2)N3C=CN=C3)NC4=CC(=C(C=C4)F)F

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 57

**SMILES:** C1=CC=C2C(=C1)C(=NC(=N2)NC3=CC=NC=C3)NC4=CC(=C(C=C4)F)F

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to high permeability.
Final answer: assistantThe molecule has high permeability.

------
# 58

**SMILES:** C1=CC(=C(C(=C1)[N+](=O)[O-])O)CNC2=CC=C(C=C2)S(=O)(=O)NC3=NC=CS3

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 59

**SMILES:** C1=CC(=CC=C1NCC2=C(C=C(C=C2)N)O)[S+](=O)(NC3=NC=CS3)[O-]

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a low degree of rigidity, is aromatic, and has low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: 1

------
# 60

**SMILES:** COC1=CC=CC(=C1N)CNC2=CC=C(C=C2)S(=O)(=O)NC3=NC=CS3

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 61

**SMILES:** CC1=C(NC(=C1C(=O)C)C)C(=O)NC2=CC=C(C=C2)OC

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has a predicted permeability of high permeability based on its properties. It has a low polar surface area, low hydrogen bond donors/acceptors, and a relatively small molecular size and weight. It is also neutral, aromatic, and has a low hydration energy.
Final answer: High permeability

------
# 62

**SMILES:** CC1=C(NC(=C1C(=O)C)C)C(=O)NC2=CC=C(C=C2)Cl

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has a predicted permeability of high permeability.
Final answer: 

------
# 63

**SMILES:** COC1=C(C=C(C=C1)C2CC(=O)NC3=C2SC(=N3)N)OC

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 64

**SMILES:** CCN1CCC2=C(C1)SC(=C2C(=O)N)NC(=O)NC3=CC(=C(C=C3)Cl)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 65

**SMILES:** CCOC1=CC=C(C=C1)N2CC(CC2=O)C3=NC(=NO3)C4=CC=CC=N4

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 66

**SMILES:** CC1=CC(=CC(=C1)NC2=NC(=CS2)C3=CC=C(O3)CNC(=O)C)C

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 67

**SMILES:** CC1=CSC(=N1)NS(=O)(=O)C2=CC=C(C=C2)NCC3=C(C(=CC=C3)OC)O

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 68

**SMILES:** C1=CC\2=C(C=C1Cl)NC(=O)/C2=C/C3=CC(=C(C(=C3)Cl)O)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 69

**SMILES:** C1=CC2=C(C(=C1)Cl)/C(=C\C3=CC(=C(C(=C3)Cl)O)Cl)/C(=O)N2

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 70

**SMILES:** C1=CC=C2C(=C1)C(=CC=N2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)NC4=NC=CS4

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 71

**SMILES:** C1=CC=C(C=C1)C2=NC=CC(=C2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)NC4=NC=CS4

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 72

**SMILES:** CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C=CN=C2)C(=O)NC3=CC=C(C=C3)C4=NNN=N4

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a low degree of rigidity, is aromatic, and has low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: 1

------
# 73

**SMILES:** COC1=CC=CC(=C1O)CNC2=CC=C(C=C2)S(=O)(=O)NC3=CC=C(C=C3)N4CCNCC4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 74

**SMILES:** C1CN(CCN1)C2=CC=C(C=C2)N[S+](=O)(C3=CC=C(C=C3)NCC4=C(C(=CC=C4)Cl)O)[O-]

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 75

**SMILES:** C1=CC=C2C=C(C=CC2=C1)CC(=O)NC3=CC=C(C=C3)S(=O)(=O)NC4=NC=CS4

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 76

**SMILES:** C1CNCCC1C2=CC=C(C=C2)N[S+](=O)(C3=CC=C(C=C3)NCC4=C(C=C(C=C4)Br)O)[O-]

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 77

**SMILES:** C1CNCCC1C2=CC=C(C=C2)N[S+](=O)(C3=CC=C(C=C3)NCC4=C(C=C(C=C4)Cl)O)[O-]

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 78

**SMILES:** CC1=C(C(=NO1)C)C2=C(C=C3C(=C2)N=CC4=C3N(C(=O)N4)[C@H](C)C5=CC=CC=N5)OC

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted low-to-moderate permeability to the artificial membrane due to its moderate lipophilicity, relatively small size, and low polar surface area.
Final answer: assistantThe molecule has a predicted low-to-moderate permeability to the artificial membrane due to its moderate lipophilicity, relatively small size, and low polar surface area.

------
# 79

**SMILES:** CC(C)(C)C1=CC=C(C=C1)C(=O)NC2=CN3C=C(C=CC3=N2)N4C=CN=C4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 80

**SMILES:** COC1=CC=CC(=C1O)CNC2=CC=C(C=C2)S(=O)(=O)NC3=NC=C(S3)C4=CC=CC=C4

**Label:** 1

**Predi:** None

**Correct:** 0

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to higher permeability.
Final answer: 

------
# 81

**SMILES:** COC1=CC=CC(=C1O)CNC2=CC=C(C=C2)S(=O)(=O)NC3=NC4=CC=CC=C4O3

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 82

**SMILES:** C1=CC=C(C(=C1)S(=O)(=O)NC2=C(C=CN=C2)C(=O)NC3=NC(=CS3)C4=CC=C(C=C4)F)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 83

**SMILES:** C1=CC=C2C(=C1)C(=NC(=N2)C3=CC=NC=C3)NC4=CC(=C(C=C4)C5=CC(=CC=C5)OC(F)(F)F)F

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to high permeability.
Final answer: 

------
# 84

**SMILES:** C1CCN(CC1)CCOC2=CC=CC(=C2)C3=NNC4=C3C=C(C=C4)C5=NC=NN5

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule has high permeability due to its low molecular weight, low polar surface area, low hydrogen bond donors/acceptors, and neutral charge.
Final answer: 

------
# 85

**SMILES:** CC[C@@H](C(=O)N1C[C@H](C[C@@H]1CC2=C(NC3=C2C=CC(=C3)F)C4=C(C5=C(N4)C=C(C=C5)F)C[C@@H]6C[C@@H](CN6C(=O)[C@H](CC)NC(=O)[C@H](C)NC)O)O)NC(=O)[C@H](C)NC

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule has a low polar surface area, low hydrogen bond donors/acceptors, and a relatively small molecular size and weight, which are all indicative of high permeability. Additionally, it is neutral, has a high degree of rigidity, and has aromatic rings, all of which contribute to its high permeability.
Final answer: The molecule has high permeability to the artificial membrane.

------
# 86

**SMILES:** CN(C)CCN1C(=O)C2=CC=CC3=CC(=CC(=C32)C1=O)N

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 87

**SMILES:** C1CNCCC1(C2=CC=C(C=C2)C3=CNN=C3)C4=CC=C(C=C4)Cl

**Label:** 1

**Predi:** None

**Correct:** 0

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a degree of rigidity and aromaticity, which are favorable for membrane permeation.
Final answer: 

------
# 88

**SMILES:** CN1C2=CN=C3C=CC(=CC3=C2N(C1=O)C4=CC(=C(C=C4)N5CCNCC5)C(F)(F)F)C6=CN=C(C=C6)OC

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 89

**SMILES:** C1=CC=C(C=C1)C2=NC=C(N2)C(=O)NC3=NC=C(S3)CC4=CC=C(C=C4)C(F)(F)F

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to high permeability.
Final answer: 

------
# 90

**SMILES:** CC1=C(NC(=C1C(=O)C)C)C(=O)NC2=CC(=C(C=C2)OC)[S+](=O)(NC3=CC=CC=C3C#N)[O-]

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 91

**SMILES:** C1=CC(=CC(=C1)C(=O)NCCO)C2=CC(=NC=N2)NC3=CC=C(C=C3)OC(F)(F)F

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 92

**SMILES:** CC1=C(NC(=C1C(=O)C)C)C(=O)NC2=CC(=C(C=C2)OCCCN(C)C)[S+](=O)(NC3=CC=C(C=C3)Br)[O-]

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability based on its properties.
Final answer: 

------
# 93

**SMILES:** C1CC1(C2=CC=C(C=C2)NC(=O)C3=CC(=NC=C3)C4=NC=CC(=C4)C(=O)O)N

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 94

**SMILES:** C1CC(CCC1CC(=O)O)C2=CC=C(C=C2)N3CCOC4=NC=NC(=C4C3=O)N

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 95

**SMILES:** CC[C@@H](C1=CC=CC=C1)NC(=O)C2=C(C(=NC3=CC=CC=C32)C4=CC=CC=C4)O

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability based on its properties.
Final answer: assistantLow-to-moderate permeability.

------
# 96

**SMILES:** COC(=O)CNC(=O)C1=NC(=C2N1C=CN=C2)C3=CC=C(C=C3)[S+](=O)(C)[O-]

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule is predicted to have high permeability to the artificial membrane.
Final answer: assistantThe molecule has high permeability.

------
# 97

**SMILES:** C[S+](=O)(C1=CC=C(C=C1)C2=C3C=CC=CN3C(=N2)C(=O)N4CCOCC4)[O-]

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 98

**SMILES:** CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCOP(=O)(O)O

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 99

**SMILES:** C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=C(C=C4)N

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 100

**SMILES:** COC1=CC=CC(=C1)N2C(=CC(=N2)C(=O)O)C3=CC(=C(C=C3)C4CCCCC4)Cl

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 101

**SMILES:** CCN(C1CCC(CC1)N(C)CCOC)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C#CCN4CCOCC4

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 102

**SMILES:** CN1C=NC(=C1C2=CC=C(C=C2)OC)C3=NC=CC(=C3)C(=O)O

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 103

**SMILES:** CC1=C(C=CC(=C1)Cl)COC2=CC=NN2C3=NC=CC(=C3)C(=O)O

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 104

**SMILES:** C1CC(=O)NC1CNC(=O)C2=C3C=CNC3=CC(=N2)C4=CC=CC=C4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to higher permeability.
Final answer: The molecule has high permeability.

------
# 105

**SMILES:** COCCNC(=O)C1=CC=C(C=C1)C2=NC=C3N2C=C(N=C3)C4=CC(=CC=C4)F

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 106

**SMILES:** CN1CCC(CC1)NC(=O)C2=NC3=C(N2C)C=C(C(=N3)C4=CC=CC=C4)C5=CC(=NC=C5)OC

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has a predicted permeability of low-to-moderate permeability to the artificial membrane.

------
# 107

**SMILES:** CC1=NC=CC(=C1)C2=CC3=C(N=C2C4=CC=CC=C4)N=C(N3C)C(=O)NCCN(C)C

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 108

**SMILES:** CN1CCCC1CCOC(C2=CC=CC=C2Cl)C3=CC4=NC=CC(=C4N3)C(=O)O

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 109

**SMILES:** CC1=NC2=C(N1)C=C(C=C2)C(=O)N3CCC4(CC3)CC5=C(C(=O)C4)N(N=C5)C(C)C

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 110

**SMILES:** C1C(C2=C(NC1=O)N=C(S2)N)C3=CC=CC=C3

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 111

**SMILES:** C1CN(CC2=C1N=C(N2)C3=CC=C(C=C3)C(=O)N)C(=O)CN4CCOCC4

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 112

**SMILES:** C1COCCN1CCNC(=O)C2CC(=O)N(C2)C3=NNC4=C3C=CC(=C4)Br

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 113

**SMILES:** CC1=NC=C2CNCCC2=C1CNC(=O)CN3C=NC4=CC=CC=C4C3=O

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 114

**SMILES:** C1CN(CC1NC(=O)C2=CC=CC=C2)C3=NNC(=C3)C4=CC=C(C=C4)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 115

**SMILES:** CC1=NC=C(C=C1)C(=O)N2CCC3=C(C2)N=C4C=C(NN4C3=O)C5=CC=CC=C5

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 116

**SMILES:** C1CN(CCC2=C1C(=O)NC(=N2)N3CCOCC3)CC4=C(C=CC(=C4)Cl)F

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 117

**SMILES:** C1CN(CCC2=C1C(=O)NC(=N2)N3CCOCC3)CC4=C(C=C(C=C4)Cl)F

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 118

**SMILES:** COC1=CC=C(C=C1)C(=O)N2CCCC(C2)C3=NN(C(=O)N3)C4=CC=C(C=C4)OC

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 119

**SMILES:** C1CN(CCC1C2=NN(C(=O)N2)C3=CC=C(C=C3)F)C(=O)C4=CC=CC=C4

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 120

**SMILES:** COC1=CC=C(C=C1)N2C(=O)NC(=N2)C3CCN(CC3)C(=O)C4CC4

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 121

**SMILES:** COC1=CC=C(C=C1)N2C(=O)NC(=N2)C3CCCN(C3)C(=O)C4=CC=CC=C4F

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 122

**SMILES:** CCCS(=O)(=O)C1=NC(=CC(=N1)NC2CC2)C3=CC4=C(C=C3)N(C=C4)C5CC(NC(C5)(C)C)(C)C

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 123

**SMILES:** CC1=C(C(=NO1)C)C2=CC(=C(C=C2)C3=CC(=C(S3)NC(=O)N)C(=O)N)O[C@H]4CCNC4

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantThe molecule has high permeability to the artificial membrane.

------
# 124

**SMILES:** CC(C)C1=CC(=NN1)C(=O)N2CC[C@H](C2)NC(=O)C3CC3

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 125

**SMILES:** C[C@H](C1=NN=C2N1C=C(C=C2F)C3=CN(N=C3)C)N4C=CC5=C(C4=O)C=C(C=N5)OCCOC

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has a predicted low-to-moderate permeability to the artificial membrane.

------
# 126

**SMILES:** CCN1C(=NC(=N1)C2CCN(CC2)C(=O)CCO)C3=CN=C(C(=N3)C4=NN=C(O4)C(C)(C)C)N

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 127

**SMILES:** C1CCN(C1)C(=O)[C@@H]2CCCN(C2)C3=NC4=C(C=C3)NC(=N4)C5(CC5)N6C=C(C=N6)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 128

**SMILES:** C[C@@]1(C2=C(C=C(C=C2)C3=CNN=C3)C(=O)N1)C4=NC=NC=C4F

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted low-to-moderate permeability due to its relatively high molecular weight, moderate lipophilicity, and the presence of polar functional groups.
Final answer: assistantLow-to-moderate

------
# 129

**SMILES:** CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC=CC=C5N=C4C3=C2)CCNC(C)C)O

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 130

**SMILES:** COC1=CC=C(C=C1)C2=CC=C(O2)C(=O)NC3CC(C3)C4=CC(=O)NC(=N4)N

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to higher permeability.
Final answer: assistantThe molecule has high permeability to the artificial membrane.

------
# 131

**SMILES:** C[C@]12C[C@H]([C@@H]([C@@]1(CC(=O)[C@@]3([C@H]2CC=C4[C@H]3C=C(C(=O)C4(C)C)O)C)C)[C@](C)(C(=O)/C=C\C(C)(C)O)O)O

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 132

**SMILES:** CCC[C@@H](C1=CC=CC=C1)NC(=O)C(=CC2=NC(=CC=C2)Br)C#N

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has a predicted permeability of low-to-moderate permeability to the artificial membrane.

------
# 133

**SMILES:** C1=CC=C(C=C1)C2=CN=C(N=C2NC3=CC(=C(C=C3)F)F)C4=CC=NC=C4

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: assistantHigh permeability

------
# 134

**SMILES:** CC(=O)N1CCC2=C(C1)SC3=C2C(=O)N(C(=O)N3CC4=CC(=CC=C4)C(F)(F)F)C5=CC=CC=C5

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 135

**SMILES:** C1=CC=C2C(=C1)C(=NC(=N2)C3=CC=NC=C3)NC4=CC(=C(C=C4)C5=C(C=C(C=C5)F)Cl)F

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 136

**SMILES:** C1CN(CCC1C#N)C2=NC(=CS2)C3=CC=C(C=C3)Br

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 137

**SMILES:** CC1=NOC(=C1S(=O)(=O)N2CCC(CC2)C(=O)NC3=CC=C(C=C3)C#N)/C=C/C4=CC=CC=C4F

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 138

**SMILES:** CC(C)(C#N)C1=CC=C(C=C1)C2=NC=C(C=C2)CN3CCN(CC3)C

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high permeability due to its lipophilic nature, small molecular size, low polarity, and neutral charge. It also has a relatively low hydration energy, which contributes to its ability to permeate the membrane.
Final answer: 

------
# 139

**SMILES:** C1=CC=C(C(=C1)CNC2=CC=C(C=C2)S(=O)(=O)NC3=NC=CS3)O

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 140

**SMILES:** COC1=CC2=C(C=C1)NC(=O)C(=C2)C3=NOC(=N3)C4=CC(=CC=C4)OC

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: assistantHigh

------
# 141

**SMILES:** CC1=C(C=C(C=C1)N2C3=NC=NC(=C3C=N2)NC(C)COC)C

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantThe molecule has high permeability.

------
# 142

**SMILES:** CC1=CC=C(C=C1)S(=O)(=O)N2C=C(C3=CC=CC=C32)C(=O)NC4=NC(=CS4)C5=CC=CC=C5

**Label:** 0

**Predi:** None

**Correct:** 0

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to higher permeability.
Final answer: 

------
# 143

**SMILES:** CC1=C(C=C(C=C1)N2C3=NC=NC(=C3C=N2)NCCCN4C=CN=C4)Cl

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 144

**SMILES:** CCN1CCN(CC1)C(=O)CCCN2C(=O)C3=NN(C(=C3C(=N2)C)C)C4=CC=C(C=C4)C

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 145

**SMILES:** CC1=CC=CC=C1C(=O)N2CCC3=C2C=CC(=C3)C4=C(SC(=N4)NC(=O)CC5=CC6=C(C=C5)OCCO6)C

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 146

**SMILES:** C1=CC(=CC(=C1)C2=CN3C=NC=C3C(=C2)C4=CN=CC=C4)CO

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: assistantHigh

------
# 147

**SMILES:** CC1=C(C=CC(=C1)SCC2=C(N=C(S2)C3=CC(=C(C=C3)C(F)(F)F)F)C)OCC(=O)O

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 148

**SMILES:** CC1=C(C(=CC=C1)CNC2=CC=C(C=C2)S(=O)(=O)NC3=NC=CS3)O

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a low degree of rigidity, no aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: 1

------
# 149

**SMILES:** C1=CC(=CC(=C1)OC(F)(F)F)NC(=O)C2=CC(=NN2)C3=CC=CN3

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 150

**SMILES:** C1CCC(CC1)C(=O)NCCC2=NC3=CC=CC=C3N2CCO

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has a predicted permeability of high permeability.
Final answer: 

------
# 151

**SMILES:** COC1=CC=C(C=C1)NC2=NC(=NO2)C3=CC(=CC=C3)OC

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to high permeability.
Final answer: assistantHigh permeability.

------
# 152

**SMILES:** C1CNCCC1C2=CC=C(C=C2)NS(=O)(=O)C3=CC=C(C=C3)NCC4=C(C(=CC=C4)Cl)O

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has a predicted permeability of low-to-moderate permeability.
Final answer: 

------
# 153

**SMILES:** CN1C(=NN=N1)SC2=NC=NC3=C2C(=CS3)Br

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high permeability.
Final answer: 

------
# 154

**SMILES:** CC#CC(=O)N1CCC[C@H]1C2=NC(=C3N2C=CN=C3N)C4=CC=C(C=C4)C(=O)NC5=CC=CC=N5

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 155

**SMILES:** CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=CC(=N3)OC

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 156

**SMILES:** C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)C(=O)C4CC(=O)N(C4)C5=NNC6=CC=CC=C65

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 157

**SMILES:** CC1=CC=C(C=C1)S(=O)(=O)NC2=CN=CC(=C2)C(=O)NC3=NC(=CS3)C4=CC=CC=C4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: 

------
# 158

**SMILES:** CC1=C(C=C(C=C1)NC(=O)C2=C(C(=C(N2)C)C(=O)C)C)[S+](=O)(NC3=CC=C(C=C3)Br)[O-]

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 159

**SMILES:** C1CN(CCC1C(=O)N)C2=NC(=CS2)C3=CC=C(C=C3)OC4=CC=CC=C4

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 160

**SMILES:** CC1=C(C2=C(N1C3=CC=CC=C3)C=CC(=C2)O)C(=O)C

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 161

**SMILES:** CC1=CC(=NC(=C1)NC(=S)N2CCN(CC2)C3=CC(=CC=C3)[N+](=O)[O-])C

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 162

**SMILES:** C1CC2=C(C(N=C(N2)NC3=NC4=C(O3)C=CC(=C4)F)C5=C(C=NN5)Cl)C(=O)C1

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 163

**SMILES:** C1CC(=O)NC2=CC(=C(C=C21)S(=O)(=O)NC3=CC(=C(C=C3)F)Cl)F

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 164

**SMILES:** CCCCCN1C(=O)C2=C(C=C(C=C2)C(=O)NCCCN3CCC(CC3)C)NC1=O

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 165

**SMILES:** COC1=CC=CC=C1S(=O)(=O)NC2=C(C=CN=C2)C(=O)NC3=NC(=CS3)C4=CC=CC=C4

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 166

**SMILES:** C1=CC(=C(C=C1Cl)C2=NC3=NC=CN=C3C(=N2)NC4=CC=NC=C4)F

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: assistantHigh

------
# 167

**SMILES:** CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: 

------
# 168

**SMILES:** COC1=CC=C(C=C1)N2C(=O)NC(=N2)C3CCN(CC3)[S+](=O)(C4=CC=CC(=C4)C(F)(F)F)[O-]

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 169

**SMILES:** CC1CCCCN1C2=NC=NC(=C2[N+](=O)[O-])N

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule is predicted to have low-to-moderate permeability due to its relatively high molecular weight, presence of a charged species (sulfonamide), and a polar surface area.
Final answer: assistantLow-to-moderate permeability.

------
# 170

**SMILES:** CC1=CC(=NC(=C1)NC(=S)N2CCN(CC2)C3=C(C=C(C=C3)Cl)[N+](=O)[O-])C

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 171

**SMILES:** CC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC(=C2Cl)C(=O)NC3=NC(=CS3)C4=CC=CC=C4

**Label:** 0

**Predi:** None

**Correct:** 0

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to higher permeability.
Final answer: 

------
# 172

**SMILES:** COC1=CC=CC(=C1O)CNC2=CC=C(C=C2)S(=O)(=O)NC3=CN=CC=C3

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 173

**SMILES:** CC1=C(N(C(=C1C(=O)C)C)C)C(=O)NC2=CC(=CC=C2)[S+](=O)(N(C)C)[O-]

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has a predicted permeability of high permeability based on its properties. It has a low polar surface area, low hydrogen bond donors/acceptors, and a relatively small molecular size and weight. Additionally, it is neutral, has a high degree of rigidity, and aromatic rings, which contribute to its high permeability.
Final answer: The molecule has high permeability.

------
# 174

**SMILES:** CCC1=C(C=C(C=C1)NC(=O)C2=C(C(=C(N2)C)C(=O)C)C)[S+](=O)(NC3=CC=C(C=C3)C#N)[O-]

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 175

**SMILES:** COC1=CC2=C(C=C1)OC(=N2)NC3=NC(C4=C(N3)CCCC4=O)C5=C(C=NN5)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 176

**SMILES:** CC1=C(C=C(C=C1)NC(=O)NCC2CCN(CC2)CC3=CC(=CC=C3)Cl)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 177

**SMILES:** CC1=CC(=C(N1C2=CC=NC=C2)C)C3=NN=C4N3CCCCC4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 178

**SMILES:** CC[S+](=O)(NC1=CC=CC=C1C(=O)NC2=NC(=CS2)C3=CC=CC=C3)[O-]

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 179

**SMILES:** C1=CC=C2C(=C1)/C(=C\C3=CC=C(C=C3)O)/C(=O)N2

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has a predicted permeability of high permeability.
Final answer: 

------
# 180

**SMILES:** C1CC2=C(C(N=C(N2)NC3=NC4=CC=CC=C4O3)C5=C(C=NN5)Cl)C(=O)C1

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 181

**SMILES:** CC1=C(C=C(C=C1)C(=O)NC2=CC3=C(C=C2)OC(=N3)C4=CN=CC=C4)[N+](=O)[O-]

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has aromatic rings and a low hydration energy, which are all factors that contribute to high permeability.
Final answer: assistantThe molecule has high permeability.

------
# 182

**SMILES:** CN(C1=CC=CC=C1)C(=O)CSC2=NC3=C(CCCC3)C(=O)N2

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 183

**SMILES:** CN1C2=C(C=CC(=C2)C(=O)NCC3=CC=C(C=C3)Br)[S@@](=O)C4=CC=CC=C4C1=O

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 184

**SMILES:** CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C=CC(=C2)C(=O)NC3=NC(=CS3)C4=CC=CC=C4)OC

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 185

**SMILES:** C1=CC=C2C(=C1)C(=NC(=N2)C3=CC=NC=C3)NC4=CC=NN4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: assistantHigh

------
# 186

**SMILES:** CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C=CN=C2)C(=O)NC3=NC(=CS3)C4=CC=CC=C4Cl

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: 

------
# 187

**SMILES:** C1=CC(=C(C=C1NC2=NC(=NC=C2)C3=CC=NC=C3)F)F

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: assistantHigh permeability

------
# 188

**SMILES:** C1CC(C2=C(C1)C3=C(N2)C(=CC=C3)Cl)NC(=O)C4=CC5=C(C=C4)OCO5

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 189

**SMILES:** COC1=CC(=CC(=C1OC)OC)NC(=O)C2=CC(=NO2)C3=CC=CC=C3O

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has a predicted permeability of high permeability based on its properties. It has a low polar surface area, low hydrogen bond donors/acceptors, and a relatively small molecular size and weight. Additionally, it is neutral, aromatic, and has a low hydration energy, all of which contribute to its high permeability.
Final answer: 1

------
# 190

**SMILES:** CC1=CC(=NO1)NS(=O)(=O)C2=CC=C(C=C2)NCCC3=CC(=C(C=C3)Cl)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 191

**SMILES:** CC1=CN=C(N=C1NCC2=CC=C(C=C2)C3=CN=CC=C3)C4=CC=CC=C4C5COC5

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 192

**SMILES:** CC1=C(C=C(C=C1)NC2=NC(=NC3=CC=CC=C32)C4=CC=NC=C4)F

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: assistantHigh

------
# 193

**SMILES:** CC1=CC=CC=C1C(=O)N2CCC(CC2)C(=O)N3CCC(CC3)N4CC5=CC=CC=C5C4=O

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 194

**SMILES:** COC1=CC(=CC(=C1OC)OC)C(=O)NC2CCCC3=C2NC4=CC=CC=C34

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 195

**SMILES:** COC1=CC=CC=C1NC2=NC(=NC=C2)N3CCN(CC3)C(=O)C4=CC=C(C=C4)F

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 196

**SMILES:** COC1=CC=C(C=C1)C2=NC3=C(N2)C=CC=N3

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 197

**SMILES:** CC1=CC(=NC=C1)NC(=S)N2CCCC(C2)NC3=CC=CC(=C3)C(F)(F)F

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 198

**SMILES:** COC1=CC=CC(=C1OC)CNC2=CC=C(C=C2)S(=O)(=O)NC3=NC=CS3

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 199

**SMILES:** C1=CC(=CC=C1NCC2=C(C=CC(=C2)Cl)O)S(=O)(=O)NC3=NC=CS3

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 200

**SMILES:** CN1CCN(CC1)C2=C(C=C(C=C2)NC3=NC(=NC4=CC=CC=C43)C5=CC=NC=C5)OC

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 201

**SMILES:** CC1=CC=CC=C1C(=O)N2CCC3=C2C=CC(=C3)N4C=C(C=N4)NC(=O)CC5=CC=CC=C5

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 202

**SMILES:** CC1=C(C=CC=N1)C(=O)NC2=CC(=C(C=C2)OC)[S+](=O)(NC3=CC=C(C=C3)Br)[O-]

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 203

**SMILES:** CCC(CC)C1=NC(=NC(=C1)[C@H]2CN3CC[C@H]2C[C@@H]3CNC(=O)C)C4=CC=NC=C4

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 204

**SMILES:** C1CCC(C(C1)C2C3=C(CCCC3=O)NC(=N2)NC4NC5CCCCC5S4)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 205

**SMILES:** CC1=CC=C(C=C1)S(=O)(=O)C2=CN=C(NC2=O)SC(C)C(=O)NC3=CC=CC=C3

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 206

**SMILES:** CC1=CC=CC=C1C(=O)NC2=NC3=C(S2)CC(CC3)C(C)(C)C

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 207

**SMILES:** C1=CN(C(=C1)C=C2C(=O)NC(=S)NC2=O)C3=CC=C(C=C3)O

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has a predicted permeability of high permeability.
Final answer: 

------
# 208

**SMILES:** C1COCCN1C2=NC=NC3=C2C=CC(=C3)NC(=O)C4=CC(=CC=C4)Br

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 209

**SMILES:** C1=CC=C(C(=C1)C2=NC=C(C(=N2)NCC3=CC=C(C=C3)C4=CC=NN4)F)C(F)F

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 210

**SMILES:** CC1=C(C=CN=C1)C2=NC3=CC=CC=C3C(=N2)NC4=CC(=C(C=C4)F)F

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 211

**SMILES:** CN(C)C1=CC=CC=C1C2=CSC(=N2)N3CCC(CC3)C(=O)N

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 212

**SMILES:** CC1=CC=C(C=C1)NC(=O)C2=C3NC(=C(C(N3N=C2)C4=CC=CC=C4C)C(=O)NC5=CC=C(C=C5)Cl)C

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 213

**SMILES:** CC1=C(C=CC=C1Cl)N2C(=C(C=N2)C(=O)NC3=C(C=C(C=C3)Br)F)C4CCNCC4

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 214

**SMILES:** CCOC(=O)N1CCC2=C(C1)SC(=C2C(=O)NC3=C(C=CC(=C3)Cl)OC)NCC4=C(C=CS4)C

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 215

**SMILES:** C1CCN(CC1)C(=O)C2=CC3=C(C=C2)N(C=N3)C4=CC=C(C=C4)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 216

**SMILES:** CNC1=C(N=C(O1)C2=C(C(=CC=C2)Cl)Cl)C#N

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantThe molecule has high permeability.

------
# 217

**SMILES:** CC1=C(C(=NO1)C2=CC=C(C=C2)F)COC3=NC=C(C=C3)C(=O)N4CCS(=O)(=O)CC4

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 218

**SMILES:** CN1C=NC=C1[C@@](C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted low-to-moderate permeability based on its properties. It has a moderate lipophilicity, a relatively small molecular size and weight, and a low polar surface area. Additionally, it has a low degree of rigidity and a moderate hydration energy.
Final answer: The molecule has a predicted low-to-moderate permeability.

------
# 219

**SMILES:** C1=CC(=CC(=C1)F)NC(=O)C2=CC(=NN2)C3=CC=CN3

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 220

**SMILES:** COC1=NC=C(C=C1)C2=CC(=CN3C2=CN=C3)C4=C5C=NNC5=CC=C4

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 221

**SMILES:** CC(C)OC1=CC=C(C=C1)CNC(=O)C2CCN(CC2)C(=O)N3CCOC4=C3C=C(C=C4)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 222

**SMILES:** CC1=CC(=C(C=C1)C)NC2=C(C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)C(F)(F)F

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to high permeability.
Final answer: assistantHigh permeability.

------
# 223

**SMILES:** C1CCN(C1)C(=O)C2=NC(=C3N2C=CC=C3)C4=CN=C(C=C4)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 224

**SMILES:** C1=CC=C2C(=C1)N=C3C=CC=C(C3=N2)O

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: assistantHigh permeability

------
# 225

**SMILES:** COC1=CC=CC(=C1CNC2=CC=C(C=C2)S(=O)(=O)NC3=NC=CS3)O

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 226

**SMILES:** C1CN(CCN(C1)C2=NC=C(C=C2)C(F)(F)F)CC3=CC(=O)N4C=CC=CC4=N3

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 227

**SMILES:** CC(C)(C)C1=CC=C(C=C1)C(=O)N2CC(=O)NC3=C(C2C4=CC=C(C=C4)F)C=C(C=C3)F

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 228

**SMILES:** CC1=CN=C(N=C1C2=CC(=CC=C2)N(C)C)N3CCC(CC3)C(=O)N

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 229

**SMILES:** C1=CC=NC(=C1)N[S+](=O)(C2=CC=C(C=C2)NC(=O)CC3=CC(=C(C=C3)Cl)Cl)[O-]

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 230

**SMILES:** CC(=O)NC1=CC=C(C=C1)NC(=O)C(C2=CC=CC=C2)NS(=O)(=O)C3=CC=C(S3)Br

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 231

**SMILES:** CC1=CC(=C(N1C2=CC=CC(=C2)C#N)C)C3=NN=C4N3CCCCC4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 232

**SMILES:** COC1=C(C=CC(=C1)/C=C(\C#N)/C2=NC3=CC=CC=C3N2)OCC4=CC=C(C=C4)F

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantThe molecule has high permeability to the artificial membrane.

------
# 233

**SMILES:** CCN(CC)CCN1C2=C(C=CC(=C2)OCCN(CC)CC)C(=O)C3=C1C=C(C=C3)Cl

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 234

**SMILES:** CN1C=C(C(=N1)C2C3=C(CCCC3=O)NC(=N2)NC4=NC5=CC=CC=C5O4)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 235

**SMILES:** CNC1=NC=CC(=N1)C2=CC=CC3=CC=CC=C32

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 236

**SMILES:** CC1=CC2=C(C=C1)OC3=C(C2=O)C(N(C3=O)CCCN4CCOCC4)C5=CC(=C(C=C5)OC)OC

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 237

**SMILES:** COC1=CC=C(C=C1)NC2=C(C(=O)C3=CC=CC=C32)C4=CC=C(C=C4)C(F)(F)F

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to high permeability.
Final answer: The molecule has high permeability.

------
# 238

**SMILES:** CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC(=C1)/C=C/C3=CC=CC=C3Cl)Cl

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantThe molecule has high permeability to the artificial membrane.

------
# 239

**SMILES:** CC1=C(C=CC(=C1)Br)NC(=O)C(C2=CC=CC=C2)NS(=O)(=O)C3=CC=CS3

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 240

**SMILES:** COC1=CC2=C(C=C1)C(=C(N2CC3=CC=C(C=C3)C=C)C(=O)O)CNC4CCCCC4

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability based on its properties.
Final answer: 

------
# 241

**SMILES:** CCN1C=C(C2=CC(=C(C=C2C1=O)OC)OC)C(=O)N3CCN(CC3)C4=CC(=CC=C4)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 242

**SMILES:** C1=CC=C(C=C1)C2=CSC(=N2)NC(=O)C3=C(C=NC=C3)NS(=O)(=O)C4=CC=CC=C4C#N

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 243

**SMILES:** CCN1CCC(CC1)N(CC2=CC3=C(C=C2)OCO3)C(=O)NC4=C(C=CC(=C4)Cl)C(=O)OC

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 244

**SMILES:** CCOC1=C(C=C(C=C1)CCNC(=O)C2=CC3=C(N2CC4=CC=CC(=N4)C)C=CC=N3)OCC

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has a high degree of lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantThe molecule has high permeability.

------
# 245

**SMILES:** CCOC(=O)C1=CC=C(C=C1)NC(=O)N2CC3=C(C[C@H]2C4=NC(=NO4)C(C)C)N=CN3

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 246

**SMILES:** COC1=CC=C(C=C1)C2=NOC(=N2)[C@@H]3CC4=C(CN3C(=O)NC5CCCCC5)NC=N4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to high permeability.
Final answer: 1

------
# 247

**SMILES:** C1=CC=C(C=C1)C2=CSC(=N2)NC(=O)C3=C(C=NC=C3)NS(=O)(=O)C4=C(C=C(C=C4)F)F

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 248

**SMILES:** CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 249

**SMILES:** C1=CC=C2C(=C1)C(=NC(=N2)C3=C(C=NC=C3)C#N)NC4=CC(=C(C=C4)F)F

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 250

**SMILES:** CC1=CC(=C(C=C1Cl)OC)NC(=O)CSC2=NC=C(C(=O)N2)S(=O)(=O)C3=CC=C(C=C3)C(C)(C)C

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 251

**SMILES:** CC1=C(C=C(C=C1)NC(=O)NC2=CC3=C(C=C2N4CCCCC4)N(C(=O)N3C)C)Cl

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 252

**SMILES:** CC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NC3=NC(=C(S3)C)C4=CC=CC=C4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: 

------
# 253

**SMILES:** CN(C)C(=O)C1=NC(=C2N1C=CN=C2)C3=C(C=C(C=C3)Cl)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 254

**SMILES:** CC1=CC=CC=C1C2=NC3=CC=CC=C3C(=N2)NCC4=CC=C(C=C4)C5=CN=CC=C5

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: assistantHigh permeability.

------
# 255

**SMILES:** C1CN(CCC1C(=O)N)C2=NC(=CS2)C3=CC4=C(C=C3)OC=CC4=O

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 256

**SMILES:** CCC1=C(C=C(C=C1)NC(=O)C2=C(C(=C(N2)C)C(=O)C)C)[S+](=O)(NC3=CC=CC(=C3)C#N)[O-]

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 257

**SMILES:** CCOC(=O)C1=NN=C(S1)N[S+](=O)(C2=CC=C(C=C2)NC(=O)CC3=CC(=C(C=C3)Cl)Cl)[O-]

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 258

**SMILES:** CN1C=C(C=C1C(=O)NC2=CC(=C(C=C2)Cl)C(F)(F)F)S(=O)(=O)N3CCCCCC3

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 259

**SMILES:** CC1=C(N(N=C1C(=O)NN2CCCCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 260

**SMILES:** CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C=CN=C2)C(=O)NCC3=CC=CC=C3

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 261

**SMILES:** CC1=C(N(C(=C1C(=O)C)C)C)C(=O)NC2=CC(=C(C=C2)OC)[S+](=O)(NC3=CC=C(C=C3)Br)[O-]

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has a predicted permeability of low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 262

**SMILES:** C1CCN(C1)C2=C(C=C(C=C2)NC3=NC(=NC4=CC=CC=C43)C5=CC=NC=C5)F

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 263

**SMILES:** CNC1=C(C=CC(=N1)C2=CC=CC3=CC=CC=C32)C#N

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 264

**SMILES:** CC1=CC=C(C=C1)C(=O)N2CCN(CC2)C3=NC=CC(=N3)NC4=CC=CC=C4OC

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 265

**SMILES:** C1CC2=C(C1)SC3=NC=NC(=C23)NC(=O)C4=CC=CO4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to higher permeability.
Final answer: assistantThe molecule has high permeability to the artificial membrane.

------
# 266

**SMILES:** C1CN(CCC1C(=O)N)C2=NC(=CS2)C3=CC=CC=C3C(F)(F)F

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 267

**SMILES:** CN1C=CC2=C(N=C(C=C21)C3=CC=CC=C3C#N)C(=O)NCC4=CN=CC=C4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantThe molecule has high permeability to the artificial membrane.

------
# 268

**SMILES:** CC1=C(C(=CC=C1)C)NC(=O)C2=NC(=NC=C2Cl)SC

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has a predicted permeability of high permeability based on its properties. It has a low polar surface area, low hydrogen bond donors/acceptors, and a relatively small molecular size and weight. Additionally, it is neutral, has a high degree of rigidity, and aromatic rings, which contribute to its high permeability.
Final answer: High permeability.

------
# 269

**SMILES:** CC1=CC(=C(C(=O)N1)CNC(=O)C2=C3C=CNC3=CC(=N2)C4=C(N=CC=C4)OC)C

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 270

**SMILES:** CCCCOC1=CC=C(C=C1)C(=O)N2CCC(CC2)C3=NNC(=O)N3C4=CC=C(C=C4)C

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 271

**SMILES:** CN1CCN(CC1)C2=NC=CC(=C2)C3=NC4=CC=CC=C4C(=N3)NC5=CC(=C(C=C5)F)F

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high permeability to the artificial membrane.
Final answer: 

------
# 272

**SMILES:** CN(C)C1=CC=CC(=C1)C2=CN=C(C3=C2CCO3)NC4=CN=CC=C4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantThe molecule has high permeability to the artificial membrane.

------
# 273

**SMILES:** CCOC(=O)C1=C(SC2=C1CCN(C2)C(=O)OCC)NC(=O)CN3CCCCC3

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 274

**SMILES:** CC1=C(C(=CC=C1)C)C(=O)NC2=CC(=C(C=C2)OC)[S+](=O)(NC3=CC=C(C=C3)Br)[O-]

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability based on the properties provided.
Final answer: assistantLow-to-moderate permeability.

------
# 275

**SMILES:** C[C@H]1C/C=C/C2[C@@H](C(=C)[C@H](C3[C@@]2([C@H](/C=C/[C@](C1)(C)O)OC(=O)C)C(=O)N[C@H]3CC4=CC=CC=C4)C)O

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 276

**SMILES:** C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)NCC4=CC=CC=C4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to high permeability.
Final answer: assistantHigh permeability.

------
# 277

**SMILES:** CC1=C(C(C(=C(N1)C)C(=O)OCCCN2CCC(CC2)(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 278

**SMILES:** C1=CC=C2C(=C1)/C(=C/C3=CC=CN3)/C(=O)N2

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 279

**SMILES:** CC1=NN(C2=C1C(=CC(=O)N2)C(F)(F)F)CCC3=NC(=CS3)C4=CC=C(C=C4)OC

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 280

**SMILES:** CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C=CN=C2)C(=O)NC3=NC(=CS3)C4CCC4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: 

------
# 281

**SMILES:** CC1=C(C(=CC=C1)C)N[S+](=O)(C2=CC=CC(=C2)NC(=O)C3=C(C(=C(N3)C)C(=O)C)C)[O-]

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 282

**SMILES:** CC1=C(NC(=C1C(=O)C)C)C(=O)NC2=CC(=CC=C2)S(=O)(=O)NC3=CC=CC=C3OC

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 283

**SMILES:** C1CC2=C(C(N=C(N2)NC3=NC4=C(O3)C(=CC=C4)Cl)C5=C(C=NN5)Cl)C(=O)C1

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 284

**SMILES:** COC1=CC=CC=C1C2=NC3=CC=CC=C3C(=N2)NCC4=CC=C(C=C4)C5=CN=CC=C5

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to high permeability.
Final answer: assistantHigh permeability.

------
# 285

**SMILES:** CNC1(CCCCC1=O)C2=CC=CC=C2Cl

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has a predicted permeability of high permeability.
Final answer: 

------
# 286

**SMILES:** CCC(=O)NC(C1=CC=C(C=C1)OC)C2=CC(=C3C=CC=NC3=C2O)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 287

**SMILES:** CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCSC(=N)N

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has a predicted permeability of high permeability.
Final answer: 

------
# 288

**SMILES:** CC(=O)C1=CC=C(C=C1)C2=CSC(=N2)N3CCC(CC3)C(=O)N

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 289

**SMILES:** CC1=CC=CC=C1N[S+](=O)(C2=CC=CC(=C2)NC(=O)C3=C(C(=C(N3)C)C(=O)C)C)[O-]

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 290

**SMILES:** C[C@H]1CN(C[C@@H]1C2=NC(=NO2)C3=CN=CC=C3)C(=O)C4=NN(C5=CC=CC=C54)C

**Label:** 1

**Predi:** None

**Correct:** 0

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to higher permeability.
Final answer: 

------
# 291

**SMILES:** CCCCOC1=CC=C(C=C1)CNC(=O)C2=NN3CCCN(C(=O)C3=C2)CC4=CC=C(C=C4)C

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 292

**SMILES:** COC1=CC(=CC(=C1OC)OC)C(=O)N2CCN(CC2)C3=C(C=CC(=C3)Cl)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 293

**SMILES:** COC1=CC=CC(=C1)NC2=NC(=NC3=CC=CC=C32)C4=CC=NC=C4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 294

**SMILES:** CC1=NC=C(C=C1)C2=CC=C(C=C2)CNC3=NC(=NC=C3C)C4=CC=CC=C4C(C)C

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 295

**SMILES:** CCOC(=O)C1=CC=C(C=C1)NC(=O)CSC2=NC3=C(C=C2C#N)N4CCC3CC4

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability.
Final answer: 

------
# 296

**SMILES:** CC(C1=CC=CC=C1)NC2=C(N=C(O2)C3=CC=C(O3)COC4=CC=C(C=C4)OC)C#N

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to high permeability.
Final answer: 

------
# 297

**SMILES:** CCC(C(=O)NC1=CC=C(C=C1)F)SC2=NC3=CC=CC=C3C4=NC(=NN42)CCC5=C(NN=C5C)C

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polar surface area, low hydrogen bond donors/acceptors, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: High permeability

------
# 298

**SMILES:** C1=CC=C2C(=C1)C3=C(C2=O)C(SC4=CC=CC=C4N3)C5=CC=CO5

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 299

**SMILES:** CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C=C(C=C2)C(=O)NC3=NC(=CS3)C4=CC=CC=C4)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 300

**SMILES:** CC[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)OC(=O)C)CCC4=C/C(=N/O)/CC[C@H]34

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has a high degree of lipophilicity, low molecular size and weight, low polarity, and a neutral charge. It also has a high degree of rigidity and aromaticity, which are favorable for membrane permeation. Additionally, it has a low hydration energy, which suggests that it can easily diffuse through the lipid bilayer.
Final answer: The molecule is expected to have high permeability to the artificial membrane.

------
# 301

**SMILES:** CC1=C(C=CC2=C1OC(CC2)(C)C)O

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polar surface area, low hydrogen bond donors/acceptors, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: 

------
# 302

**SMILES:** CCN(CC)S(=O)(=O)C1=CC=CC(=C1)C(=O)NC2=CC=C(C=C2)C#N

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a low degree of rigidity, aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: 

------
# 303

**SMILES:** COC(=O)CNC(=O)C1=NC(=C2N1C=CN=C2)C3=C(C=C(C=C3)Cl)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 304

**SMILES:** CC(C)(C)OC(=O)N1CCN(CC1)C2=CC=C(C=C2)NCC3=CC=C(O3)C4=CC=C(C=C4)C#N

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 305

**SMILES:** CC1=CC=C(C=C1)N(C)S(=O)(=O)C2=CC=C(C=C2)C3=CN=C(O3)C4CC4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to high permeability.
Final answer: 

------
# 306

**SMILES:** CC1=CC(=C(C=C1)C)CN2CCC(CC2)CNC(=O)NC3=C(C=C(C=C3)Br)F

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 307

**SMILES:** CCOC(=O)C1=CC(=NC2=C1C(=NN2CCC#N)C)C3=CC=CO3

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantThe molecule has high permeability to the artificial membrane.

------
# 308

**SMILES:** CNC1=NC2=C(S1)C(CC(=O)N2)C3=CC=CC=C3F

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 309

**SMILES:** C1CCN(CC1)C2=NC(=CS2)C3=CC=C(C=C3)Br

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 310

**SMILES:** C1CC2=C(C(N=C(N2)NC3=NC4=C(O3)C=CC=C4Cl)C5=C(C=NN5)Cl)C(=O)C1

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 311

**SMILES:** COC1=C(C=C(C=C1)S(=O)(=O)N2CCOCC2)NC(=O)C3=CC(=CC=C3)N4C=CC=C4

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 312

**SMILES:** CC1=CC2=C(C=C1)SC3=C(C=C(C=C3)C(=O)NC4CCCC4)N=C2C

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability.
Final answer: 

------
# 313

**SMILES:** C1CN(CCN1)C2=NC(=CS2)C3=CC=C(C=C3)Br

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 314

**SMILES:** COC1=CC=CC=C1N2C=NC3=C2C=CC(=C3)C(=O)N4CCCCC4

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 315

**SMILES:** C1=CC2=C(C=CC(=C2N=C1)O)CNC3=C(C=C(C=C3)F)F

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 316

**SMILES:** CC(=O)NC1=CC=C(C=C1)OCC2=C(C=CC(=C2)C3=NC4=CC=CC=C4C(=O)N3CC5=CC=CC=C5)OC

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: 

------
# 317

**SMILES:** CC(C)OC1=CC=CC(=C1)C2=CSC(=N2)N3CCC(CC3)C(=O)N

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 318

**SMILES:** CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 319

**SMILES:** CCCOC(=O)C1=CC=C(C=C1)OC2=C(NN=C2C3=C(C=C(C=C3)O)O)C

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 320

**SMILES:** C1CN(CCC1C(=O)N)C2=NC(=CS2)C3=CC=CC=C3F

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 321

**SMILES:** C1C(C2(CN1CC3=CC=C(C=C3)O)CN(C2)C4=CC=CC=C4)CNC5=CC=CC=C5

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 322

**SMILES:** CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C=C(C=C2)F)C(=O)NC3=NC(=CS3)C4=CC=CC=C4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: 

------
# 323

**SMILES:** C1=CSC(=C1)C2=NN=C(O2)NC(=O)C3=CC=C(C=C3)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 324

**SMILES:** CN1CCCN(CC1)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high permeability due to its lipophilic nature, small molecular size, low polarity, and neutral charge.
Final answer: 

------
# 325

**SMILES:** CN(CC1=CC=C(C=C1)/C=C/C(=O)NO)CC23CC4CC(C2)CC(C4)C3

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 326

**SMILES:** CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3COC2=O)C5=CC6=CC=CC=C6N=C5

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a low degree of rigidity, aromaticity, and low hydration energy. These properties are associated with high permeability to the artificial membrane.
Final answer: assistantHigh permeability.

------
# 327

**SMILES:** CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 328

**SMILES:** CCC1=CC=C(C=C1)NC(=O)C2=NN3C=CC=NC3=C2

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 329

**SMILES:** CC1=NN2CCCN(C2=C1C3=CC=CC=C3C4=CC=CC=C4)CC5CC5

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, a relatively small molecular size and weight, low polarity, and a neutral charge. It also has a degree of rigidity and aromaticity, which are favorable for membrane permeation. Additionally, it has a low hydration energy, which is beneficial for membrane permeation. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: 1

------
# 330

**SMILES:** CC(C)(C)C1=CC=C(C=C1)N2C=NC3=C2C=CC(=C3)C(=O)N4CCCCC4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 331

**SMILES:** C1CN(CCC1C(=O)N)C2=NC(=CS2)C3=CC4=CC=CC=C4C=C3

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 332

**SMILES:** CC1=CC=C(C=C1)N2C(=C3C(=NN(C(=O)C3=N2)CCCC(=O)NCC4=CC=CC=C4F)C)C

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: 

------
# 333

**SMILES:** C1CC(=O)NC2=C1C=CC(=C2)OCCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 334

**SMILES:** CC1CCCN(C1)C(=O)C2=CC3=C(C=C2)N(C=N3)C4=CC=CC(=C4)C

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 335

**SMILES:** CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)C[C@@H]2[C@@H]([C@H]([C@@H](O2)N3C=C(C4=C(N=CN=C43)N)Br)O)O

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantThe molecule has high permeability to the artificial membrane.

------
# 336

**SMILES:** C1=CSC(=C1)C2=CC(=NC(=N2)S(=O)(=O)CCC(=O)NC3=CC=C(C=C3)OC(F)(F)F)C(F)(F)F

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to high permeability.
Final answer: 

------
# 337

**SMILES:** C1CN(CCC1C(=O)N)C2=NC(=CS2)C3=CC=CC=C3C4=CC=CC=C4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 338

**SMILES:** C1=CC=NC(=C1)C(=O)NC2=CC=C(C=C2)[S+](=O)(NC3=NC=CS3)[O-]

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has a predicted permeability of low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 339

**SMILES:** CC1=CC=C(C=C1)C2=NC(=NC=C2)N3CCC(CC3)C(=O)N

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 340

**SMILES:** CCOC1=CC=CC=C1N2CC(CC2=O)C3=NC4=CC=CC=C4N3CCOC5=CC=C(C=C5)C(C)(C)C

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high permeability due to its lipophilic nature, small molecular size, low polarity, and neutral charge.
Final answer: 

------
# 341

**SMILES:** CCC1=CC=C(C=C1)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@@H]4CC5=CC=CC=C5CN4

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability to the artificial membrane.
Final answer: assistantLow-to-moderate

------
# 342

**SMILES:** CC1=CC(=C(C=C1)C)CN2C3=C(C=CC(=C3)C(=O)N4CCN(CC4)C5=CC=CC=C5F)S(=O)C6=CC=CC=C6C2=O

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability.
Final answer: assistantLow-to-moderate permeability.

------
# 343

**SMILES:** CCOC(=O)C1=C(C(=C(N1)C)CCC(=O)N2CCN(CC2)C3=CC=CC(=C3C)C)C

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability based on its properties.
Final answer: 

------
# 344

**SMILES:** CC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC3=C(C=C2)SC4=CC=CC=C4C(=O)N3C5CCCC5

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 345

**SMILES:** CC(=O)C1=CC=CC(=C1)C2=CSC(=N2)N3CCC(CC3)C(=O)N

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 346

**SMILES:** CC(C)C1=CC=CC=C1C2=NC=C(C(=N2)NCC3CCN(C3)C4=NC=CN=C4)F

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 347

**SMILES:** C1CCCN(CC1)C2=NC(=NC3=CC=CC=C32)C4=CC=CC=N4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: assistantHigh permeability

------
# 348

**SMILES:** COC1=CC=CC=C1N2CCN(CC2)C3=NC4=C(C=C3)C=C(C=C4)S(=O)(=O)N5CCCCC5

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to high permeability.
Final answer: 

------
# 349

**SMILES:** C1CCC(CC1)C(=O)NCCC2=NC3=CC=CC=C3N2CCOC4=CC=CC=C4N

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has a predicted permeability of high permeability.
Final answer: 

------
# 350

**SMILES:** CN1C=CC2=C1C=CC(=C2)C3=CSC(=N3)N4CCC(CC4)C(=O)N

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 351

**SMILES:** CC(C)CNC1=NC(=NC=C1)NCC2=CSC(=N2)C3=CC=CC=C3

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 352

**SMILES:** COC1=CC=CC(=C1)CNCC2=CC=CN2C3=NN=C(S3)N4CCN(CC4)C5=CC=CC=C5

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 353

**SMILES:** COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4=CC=C(C=C4)F

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 354

**SMILES:** C1CC1C2=NC3=C(CCN(CC3)CC4=CC=C(C=C4)F)C(=N2)C5=CC=C(C=C5)O

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 355

**SMILES:** C1=CC=C(C=C1)C2=CC=C(C=C2)S(=O)(=O)NC3=C(C=CN=C3)C(=O)NC4=NC(=CS4)C5=CC=CC=C5

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
# 356

**SMILES:** C1=CC=C(C=C1)CNC(=O)C2=NC(=NC=C2Cl)S(=O)(=O)CC3=CC=C(C=C3)F

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 357

**SMILES:** CCC1=CC(=CC=C1)NS(=O)(=O)C2=CC3=C(C=C2)N(C(C3)C)C(=O)C4CC4

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 358

**SMILES:** CC1=CC(=C(N1C2=CC(=CC=C2)Cl)C)C3=NN=C4N3CCCCC4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 359

**SMILES:** CC1=CC(=C(N1C2=CC=CC(=C2)C(F)(F)F)C)C3=NN=C4N3CCCCC4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 360

**SMILES:** C1CCN(C1)C2=NC=C(C=C2)CNC(=O)C3=C(C=CC(=C3)Cl)O

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 361

**SMILES:** COC1=CC=C(C=C1)CN2CCN(CC2)C(=O)C3=CC4=C(S3)CCC4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has a predicted permeability of high permeability based on its properties. It has a low polar surface area, low hydrogen bond donors/acceptors, and a relatively small molecular size and weight. Additionally, it is neutral, has a high degree of rigidity, and aromatic rings, which contribute to its high permeability.
Final answer: High permeability.

------
# 362

**SMILES:** CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C=CN=C2)C(=O)NC3=NC(=CS3)C4=CC(=CC=C4)OC

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 363

**SMILES:** CC1=C[C@H]([C@@H](C[C@H]1CC2=NC3=C(N2)C=CC(=N3)OC)C(C)C)CNCC4=CC=CC=C4O

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 364

**SMILES:** CC1=CC(=CC(=C1)NS(=O)(=O)C2=CC3=C(C=C2)NC=C(C3=O)C(=O)NCC4=CC=CO4)C

**Label:** 0

**Predi:** 0

**Correct:** 1

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 365

**SMILES:** CCCCC(C)/C=C(\C)/C=C(\C)/C(=O)NC1=CC(C2C(C1=O)O2)(/C=C/C=C/C=C/C(=O)NC3=C(CCC3=O)O)O

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polar surface area, low hydrogen bond donors/acceptors, and a neutral charge. It also has a high degree of rigidity, aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: assistantHigh permeability.

------
# 366

**SMILES:** CC(C)C1=CC=C(C=C1)OCC2=NC3=C(N2CC4=CC=CC=C4)C(=O)N(CCN3)CCOC

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to high permeability.
Final answer: 

------
# 367

**SMILES:** CC(=O)C1=C(N=C(S1)NC(=O)C2=CC=CO2)C3=CC=CC=C3

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: assistantHigh permeability

------
# 368

**SMILES:** CCOC1=C(C(=C(C=C1)CCNC(=O)C2=CC3=C(N2CC4=CC=CC=C4)C=CS3)F)OCC

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantThe molecule has high permeability.

------
# 369

**SMILES:** COC1=C(C(=C(C=C1)C2=CC3=C(C=C2)N=C(O3)C4=CC=C(C=C4)SC)OC)OC

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 370

**SMILES:** CC1=CC=C(C=C1)CCNC(=O)C2CCCN(C2)C(=O)C3=CC4=C(N3C)C=CS4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 371

**SMILES:** CCN1C2=C(C=C1C(=O)N3CCCC(C3)C(=O)NCCC4=CC=C(C=C4)C)SC=C2

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 372

**SMILES:** CCOC1=C(C=C(C=C1)CCNC(=O)C2=NC3=CC=CC=C3C=C2)OCC

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability.
Final answer: 

------
# 373

**SMILES:** CC1=CC=C(C=C1)OCCN2C3=CC=CC=C3N=C2CCNC(=O)N4CCCCC4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 374

**SMILES:** CCOC(=O)C1=CC=C(C=C1)N2C=NC3=C2C=CC(=C3)C(=O)N4CCCCC4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has a predicted permeability of high permeability.
Final answer: 

------
# 375

**SMILES:** CC1=CC(=C(N1)C(=O)NC2=CC(=CC=C2)[S+](=O)(N3CCCCCC3)[O-])C

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to higher permeability.
Final answer: The molecule has high permeability.

------
# 376

**SMILES:** CCOC1=C(C=C(C=C1)CCNC(=O)C2=CC3=CC=CC=C3N2CC4=CC(=CC(=N4)C)C)OCC

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability based on its properties.
Final answer: 

------
# 377

**SMILES:** CC(C)N(CCC(=O)C1=CC2=CC=CC=C2C=C1)CC3=CC=CC=C3

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to high permeability.
Final answer: The molecule has high permeability.

------
# 378

**SMILES:** CCOC1=CC=CC=C1CNS(=O)(=O)C2=CC=C(C=C2)C3=CN=C(O3)C4CC4

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 379

**SMILES:** CCOC1=C(C=C(C=C1)CCNC(=O)C2=CC3=C(N2C)C=CS3)OCC

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantThe molecule has high permeability to the artificial membrane.

------
# 380

**SMILES:** COC1=CC=CC(=C1O)CNC2=CC=C(C=C2)S(=O)(=O)NC3=CC=CS3

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to high permeability.
Final answer: The molecule has high permeability.

------
# 381

**SMILES:** CC1=CC(=C(C=C1Cl)OC)NS(=O)(=O)C2=C(N=C3N(C2=O)C=CS3)C

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantThe molecule has high permeability.

------
# 382

**SMILES:** C1=CC=NC(=C1)C2=NC(=CC(=O)N2)CSC3=CC=C(C=C3)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 383

**SMILES:** CCOC1=C(C=C(C=C1)CCNC(=O)C2=CC=NN2CC3=CC=CC(=C3)C)OCC

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantThe molecule has high permeability.

------
# 384

**SMILES:** C1=CC=C(C(=C1)CS(=O)(=O)C2=NC=C(C(=N2)C(=O)NC3=CC=CC=C3F)Cl)F

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 385

**SMILES:** CCCC1=NC2=C(C=CC(=C2)C(=O)NC3CCCCC3)SC4=C1C=C(C=C4)C

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability based on its properties.
Final answer: 

------
# 386

**SMILES:** CC1CCN(CC1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C=C3)CC(=O)NCC4=CC=C(C=C4)Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 387

**SMILES:** C1COC2=C(C=C(C=C2)C3=CN=C(S3)N4CCC(CC4)C(=O)NC5=CC=CC=C5)OC1

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability.
Final answer: 

------
# 388

**SMILES:** CCCC1=NC2=C(C=CC(=C2)C(=O)NC3CCCC3)SC4=C1C=C(C=C4)C

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability.
Final answer: 

------
# 389

**SMILES:** CC1=NN2CCCN(C2=C1C3=CC=CC=C3OCC4=CC=CC=C4)C(=O)CC5=CC6=C(C=C5)OCO6

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to high permeability.
Final answer: The molecule has high permeability.

------
# 390

**SMILES:** COC1=CC(=C(C=C1)OC)C2=NN=C3N2N=C(CS3)C4=C(C=CC=C4OC)OC

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 391

**SMILES:** CCN1C(=NN=N1)SC2=NC=NC3=C2C(=CS3)C4=CC=C(C=C4)C

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high permeability due to its lipophilic nature, small molecular size, low polarity, and neutral charge.
Final answer: 

------
# 392

**SMILES:** CCOC(=O)C1CCN(CC1)C(=O)C(C)(C)NC(=O)NC2=CC=C(C=C2)C3=CC=CC=C3

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 393

**SMILES:** CC1=C(N(C(=C1C(=O)C)C)C)C(=O)NC2=CC(=CC=C2)[S+](=O)(N3CCCCCC3)[O-]

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantThe molecule has high permeability.

------
# 394

**SMILES:** CCOC1=CC=CC=C1N(CC(=O)NC2=C(C=CC(=C2)OC)OC)S(=O)(=O)C3=CC=CC=C3

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 395

**SMILES:** CCCC1=C(C2=C(O1)C=CC(=C2)NS(=O)(=O)C3=CC=C(C=C3)OC)C(=O)OCC

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantThe molecule has high permeability.

------
# 396

**SMILES:** CCOC1=CC=C(C=C1)NC(=O)CC2C(=O)N(C(=O)N2CCC3=C(C=CS3)C)C4=CC=C(C=C4)F

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 397

**SMILES:** COC1=CC=CC(=C1)C2=CSC(=N2)N3CCC(CC3)C(=O)N

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: 

------
# 398

**SMILES:** CC1=CC(=C(C=C1)NC(=O)C2=C(C3=C(N2C)C=CC(=C3)C)N4CCCC4=O)C

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has a predicted permeability of high permeability.
Final answer: 

------
# 399

**SMILES:** CC1=C([C@H](C(=C(N1)C)C(=O)O[C@@H]2CCCN(C2)CC3=CC=CC=C3)C4=CC(=CC=C4)[N+](=O)[O-])C(=O)OC.Cl

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has a predicted permeability of low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has a predicted permeability of low-to-moderate permeability to the artificial membrane.

------
# 400

**SMILES:** CC1=CC(=CC=C1)N2C=NC3=C2C=CC(=C3)C(=O)N4CCCC(C4)C(F)(F)F

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: 

------
# 401

**SMILES:** CCN(CC)C(=O)C1=COC(=N1)COC2=CC3=C(CCN(C3C4=CC(=CC=C4)F)C(=O)C(C)C)C=C2

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistantThe molecule has low-to-moderate permeability to the artificial membrane.

------
# 402

**SMILES:** CCC1=CC=CC=C1N2C(=N)C3=C(NN=C3N=C2SCC(=O)NC4=CC=C(C=C4)C)C

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, which are all factors that contribute to high permeability.
Final answer: 

------
# 403

**SMILES:** C1CN(CC2=CN=C(C=C2N1)NC3=CC=CC=C3)CC4=CC(=CC=C4)F

**Label:** 0

**Predi:** 1

**Correct:** 0

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 404

**SMILES:** C1=COC(=C1)CNC(=O)COC(=O)CCC(=O)C2=CC=CS2

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and is neutral. It also has a high degree of rigidity and aromaticity, and low hydration energy. These properties suggest that the molecule has high permeability to the artificial membrane.
Final answer: 1

------
# 405

**SMILES:** CC1=CC=CC2=NC(=C(N12)NC3=CC=C(C=C3)C(C)C)C4=CN=CC=C4

**Label:** 1

**Predi:** 1

**Correct:** 1

# Response:
The molecule has high lipophilicity, low molecular size and weight, low polarity, and a neutral charge, which are all factors that contribute to high permeability.
Final answer: assistantHigh

------
# 406

**SMILES:** CN1CCC2=CC3=C(C=C2C1)OCO3

**Label:** 1

**Predi:** 0

**Correct:** 0

# Response:
The molecule has low-to-moderate permeability to the artificial membrane.
Final answer: assistant

------
