simulations characterized nonlinearity localization three dimensional effects separate interacting length scales features represent challenge computational science discuss leading software framework advanced scientific computing portable extensible toolkit scientific computation facilitate development simulations illustrate use describe simulations steady state non newtonian passive flow thermal structure mid ocean solitary waves iii formation localized bands high porosity two phase medium deformed simple shear highlight two supplementary features structured storage application parameters self documenting output especially useful simulations elsevier rights reserved
background chronic nasal associated local immunoglobulin presence ige antibodies staphylococcus aureus aspirin exacerbated respiratory disease severe form chronic nasal nearly patients express anti objectives aimed understand antibodies reactive determine whether recognize determining regions framework regions methods labeled see used isolate single specific cells nasal patients aspirin exacerbated respiratory disease using fluorescence activated cell sorting recombinant antibodies matched heavy light chains cloned igg high affinity specific assayed means elisa surface resonance ige antigen binding fragments ige activities tested assays results thirty seven specific igg iga expressing cells isolated yielded anti clones sea see competition binding assays revealed anti see antibodies recognize epitopes see unexpectedly anti see mediated see induced igg antigen binding fragments anti see enhanced anti see conclusions activate simultaneously binding antigens conventional manner framework regions anti see ige anti see ige epsilon complexes anti see igg enhance activity anti see conventional antibodies simultaneously conventional antibodies framework regions see anti see ige epsilon complexes
background government strategy indicates individuals learning disabilities access adapted psychological therapies behaviour therapy recommended treatment borderline personality disorder bpd however little published research regarding whether appropriately adapted adults learning disabilities research available primarily focuses measures behavioural psychiatric change little emphasis psychological changes occur materials methods two case studies presented using grid technique based personal construct psychology individuals completed grids prior following adapted adults learning disabilities within specialist community psychology service united kingdom results case studies show psychological changes occurred within adults learning disabilities received adapted within community psychology service changes included altered self esteem individuals conclusion contrasting case studies demonstrate complexity experiences individuals learning disabilities receive discuss information integrated clinical practice
despite number studies highlighting important impact chief executive firms several theoretical methodological questions cloud existing findings study takes alternative approach examining perceptions significance changed time using event study methodology sample sudden unexpected deaths show absolute market reactions events public firms increased markedly results indicate act ways consistent belief become increasingly influential recent decades managerial summary chief executive facing increased receiving ever increasing pay packages substantial debate exists overall contribution firm outcomes prior research sought calculate proportion firm outcomes attributable study takes alternative approach using assess think importance study finds perhaps motivated stakeholder view increasingly important drivers firm outcomes good bad versus peers decades earlier notably market reaction unexpected death increased steadily last six decades highlighting importance planning supporting least partially increased compensation given todays top copyright john wiley sons ltd
researchers software engineering attempted improve software development mining analyzing software repositories since majority software engineering data unstructured researchers applied information retrieval techniques help software development recent advances especially statistical topic models helped make sense unstructured data software repositories even however even though hundreds studies applying topic models software repositories study shows models used software engineering research community software engineering tasks supported topic models moreover since performance topic models directly related model parameters usage knowing researchers use topic models also help future studies make optimal use models thus surveyed articles software engineering literature make use topic models find studies centre around limited number software engineering tasks studies use basic topic models iii researchers usually treat topic models black boxes without fully exploring underlying assumptions parameter values paper provides starting point new researchers interested using topic models help new researchers practitioners determine best apply topic models particular software engineering task
time cost quality three important often conflicting factors optimally balanced planning management construction projects tradeoff optimization among three factors within project scope necessary maximize overall project success paper new hybrid multiple objective evolutionary algorithm based hybridization artificial colony differential evolution proposed solve time cost quality tradeoff problems proposed algorithm integrates crossover operations differential evolution original artificial colony abc order balance exploration exploitation phases optimization process numerical construction project case study demonstrates ability generated non dominated solutions assist project managers select appropriate plan optimize operation typically difficult time consuming comparisons four currently used algorithms including non dominated sorting genetic algorithm multiple objective particle swarm optimization multiple objective differential evolution mode multiple objective artificial colony verify efficiency effectiveness developed algorithm elsevier rights reserved
introduction targeted somatic genomic analysis egfr lymphoma receptor tyrosine kinase gene programmed death ligand tumor proportion score determined immunohistochemistry used selection first line therapies advanced lung cancer however frequency overlap biomarkers routine clinical practice poorly reported methods retrospectively first pairs patients lung adenocarcinoma institution analyzed using clone kit technologies evaluated occurrence genomic aberrations characteristics results surgical resection specimens small biopsy core needle samples cell blocks needle fluid tested least seen tumors tumors egfr mutations fluorescence situ hybridization positivity fluorescence situ hybridization positivity less versus one tumor least tumors least significantly associated smoking status compared tumors less associated patient sex ethnicity tumor stage biopsy site biopsy type preparation conclusions performed routine clinical lung cancer specimens least seldom presence driver approved targeted therapies three biomarker specified groups advanced lung now defined paired specific palliative first line systemic therapy proven clinical benefit egfr affected adenocarcinoma paired matched tyrosine kinase inhibitor similar cases enriched adenocarcinoma paired anti similar cases biomarker negative egfr negative adenocarcinoma paired platinum chemotherapy without similar cases international association study lung cancer published elsevier inc rights reserved
knowledge representation core artificial intelligence research knowledge representation methods include logic semantic network computer programming language database mathematical model graphics language natural language etc establish intrinsic link various knowledge representation methods unified knowledge representation model necessary according ontology system theory control theory standard model knowledge representation reflects change objective world proposed model composed input processing output knowledge representation method traditional knowledge representation method express knowledge terms multivariate multidimensional also express process knowledge time strong ability solve problems addition standard model knowledge representation provides way solve problems non precision inconsistent knowledge
purpose nocturia associated poor sleep quality however little known relationship nocturia sleep quality across different workforce relevant age groups adults implications developing new treatment strategies tolerated across populations methods conducted cross sectional study involving merged data waves national health nutrition examination survey participants responded validated questions nocturia frequency sleep functional outcomes sleep questionnaire general productivity subscale range analyses included multivariable linear regression stratification gender examine associations nocturia frequency higher worse scores lower scores indicating worse daytime function related sleep disturbance findings adults aged years completed survey complete nocturia data population age adjusted prevalence nocturia least twice among men among women nocturia increased age years greater nocturia frequency reported worse scores compared younger adults similar nocturia frequency among men women implications population based sample community dwelling men women association nocturia worsened functional outcomes sleep greater among adults older years group vulnerable drug side effects nocturia typically multifactorial additionally analyses found association nocturia functional outcomes sleep stronger increasing age among men effective treatment strategies tolerated older adults treatments simultaneously address combined effects lower urinary tract sleep dysfunction needed published elsevier journals inc
consider variable metric based proximal gradient method minimization sum smooth possibly function plus convex possibly term prove convergence iterative algorithm critical point objective function satisfies property point domain assumption limit point exists proposed method applied wide collection image processing problems numerical tests show algorithm results flexible robust competitive compared recently proposed approaches able address optimization problems arising considered applications
three dimensional printing printing additive manufacturing promising approach construction small sized complex structures systems mems paper reports design fabrication testing made titanium alloy created first time electron beam melting also known electron beam additive manufacturing titanium alloys present attractive characteristics including high biocompatibility distinct strength corrosion resistance however difficult machine titanium alloys conventional processes use additive manufacturing enabled build multidimensional amplified mechanical displacement improved bandwidth contained compact structure first characterized mechanical properties printed compared results bulk metal due porous surfaces printed acted material averaged youngs modulus considering dimensions introducing inner cad designed beam width calculated youngs modulus comparable reported literature bulk completion initial characterization fabrication undergone successfully carried mechanical printed within amplified actuation piezoelectric actuator factor six positioning platform supported network parallel supporting beams maximum displacement obtained driving voltage resonant frequencies measured axes almost identical respectively digital pid controller enabled laser based dynamic positioning stage triangular positioning error within time delays respectively elsevier rights reserved
study objectives despite several normative studies multiple surveys sleep disorders general population data collected healthy aimed survey characteristics healthy sleep methods prospectively investigated sleep history subjects representative population sample reported sleep relevant sleep disorders ruled two step screening procedure approximately four subjects contacted identifying eligible subject participated results median reported time bed total sleep duration varying age years median sleep efficiency high range fifty one subjects reported forty five subjects reported sporadic non sleep related movement disorders sleep related leg lifetime legs syndrome history sporadic non sleep conclusion population healthy common finding moreover non forms sleep related movement disorders surprisingly common findings suggest diagnostic criteria sleep disorders based presence symptoms also account minimum frequency discomfort
paper presents application fractional order controller control multi input multi output twin rotor aerodynamic system dynamics considered system highly nonlinear exists significant cross coupling horizontal vertical axes pitch paper fractional order model twin rotor aerodynamic system identified using input output data nonlinear system based upon identified fractional order model fractional order pid controller designed control angular position level bar twin rotor aerodynamic system parameters controller tuned using optimization compared particle swarm optimization techniques simulation results nonlinear model show significant improvement performance fractional order pid controller compared classical pid controller
background hereditary angioedema caused inhibitor deficiency inh hae rare autosomal dominant disorder inh hae characterized edema formation occur response stress individuals response stress stimuli partly genetically determined activation hypothalamic pituitary adrenal axis results release cortisol turn secreted affect metabolism cardiovascular immune systems hypothesized changes serum cortisol level polymorphisms glucocorticoid receptor modify individual sensitivity stressor stimuli inh hae patients results compared response stress brief stress coping inventory inh hae patients angioedema patients healthy controls inh hae patients healthy controls genotyped glucocorticoid receptor polymorphisms serum cortisol levels determined attacks symptom free periods inh hae patients relationships clinical laboratory data snps single nucleotide polymorphisms assessed using anova inh hae patients decreased coping capabilities compared healthy controls cortisol levels significantly higher attacks symptom free periods magnitude elevation cortisol levels show significant correlation clinical laboratory data among inh hae patients carriers allele significantly lower cortisol levels increased body mass index compared non carriers conclusions higher cortisol level observed attacks reflect effect stressful situation attack patients neuroendocrine system carriers lower cortisol levels reflect altered feedback hypothalamic pituitary adrenal axis due decreased sensitivity glucocorticoids
objective advanced paternal age conception linked autism schizophrenia offspring neurodevelopmental disorders affect social functioning current study explored effects paternal age social development general population method used multilevel growth modeling investigate effects development early childhood adolescence measured strengths difficulties questionnaire twins early development study sample also investigated genetic environmental underpinnings paternal age effects development using additive genetics common environment unique environment ace gene environment models results general population young advanced paternal ages associated altered trajectory social development slope behavioral domain affected either young advanced age suggesting specificity paternal age effects increased importance genetic factors social development recorded offspring older young fathers suggesting distinct underpinnings paternal age effects two conclusion findings highlight related deficits lead autism schizophrenia likely continuously distributed population
potential mechanical bridge construction application developing structural uses low grade grown investigated mechanically bridge designed half scale span bridge subjected series experimental analytical investigations flat stress deck formed post short steel bars resulting solid plate suspended two screw acts compression end bearing ends structure subjected series deck loading conditions failure loads bridge behaves beyond design load shows high level recovery capacity failure structure arises lateral instability symmetrical deck loading commercial finite element analysis programme used predict behaviour structure close agreement analytical experimental results demonstrates structural performance mechanically structures reasonably accurately predicted using linear elastic analysis study also shows relatively large span strong structures constructed using means short lengths low quality
calcium deposition disease type arthritis caused deposition calcium crystals present either acute chronic arthritis development crystal deposition disease young people associated metabolic diseases disease hypothyroidism linked therefore investigations predisposing metabolic condition advised young onset crystal deposition disease article report two young patients investigated recurrent joint pain due disease
background recent epidemiologic studies revealed significant association periodontitis oral squamous cell carcinoma furthermore periodontitis markedly associated cancer mortality whereas infection identified specific potentially independent microbial factor related increased risk cancer death authors previously reported induced precursor form matrix metalloproteinase production via activated receptor par related pathways activated enhance cellular invasion sas cells present study effects selected inhibitors cellular invasion caused sas cells examined methods cells infected strains including mutants evaluate effects inhibitors apple polyphenol polyphenol high molecular weight fractions low molecular weight fractions inhibitor inhibitor combination used mrna expressions examined using real time reverse transcription polymerase chain reaction signaling pathways evaluated western blotting analysis results significantly inhibited mrna expressions activation cellular invasion furthermore reduced activation heat shock protein nuclear translocation nuclear factor kappa whereas conclusion results suggest potent inhibitors activation cellular invasion mediated cells
report first time literature method synthesize hydrophobic concrete concrete normally hydrophilic material significantly reduces durability concrete structures synthesize water concrete hydrophobic fabricated applied cement emulsion enriched hydrogen oil hydrophobic agent silica induce alcohol fibers create hierarchical surfaces various emulsion types investigated using different mixing procedures single double layer hydrophobic coatings applied coatings characterized optical microscope scanning electron microscope sem properties including water contact angle roll angle measured theoretical model coated non coated concrete generalized types materials developed predict effect surface roughness composition optimized distance aggregates found highest value maximal measured specimen fibers treated based emulsion since water penetration main factor leading concrete deterioration hydrophobic water much longer durability regular broad range applications civil materials engineering
mammalian evolution occurred presence pathogenic micro macro organisms presence organisms mammalian evolution allowed intimate crosstalk species host immune system review introduce concept refer collection bacteria viruses fungi mammalian intestine furthermore discuss new insights host interactions context host protective immunity immune mediated diseases including inflammatory bowel disease multiple sclerosis finally provide reasons account experimental design analysis therapeutic applications authors published elsevier open access article license http creativecommonsorg licenses
widely used agriculture public health suggested interact chemicals used military result potential cause war related illness determine causal relationship human health effects basic enzymatic pathway metabolism humans understood present study report trans metabolized human liver fractions producing alcohol acid identified human alcohol enzymes involved oxidation alcohol hydrolysis product acid way cis significantly metabolized human liver fractions cytochrome isoforms involved either hydrolysis trans oxidation purified oxidized preferred substrate ethyl alcohol purified responsible oxidation similar substrate affinity previously known substrate alcohol based observations appears oxidized subsequently although accumulate incubation order analyze metabolites previous hplc methods validated modified resulting refined hplc method described detail elsevier science usa rights reserved
background within context support program smoking cessation initiated turkish ministry health present smoking cessation centres found suitable pharmacological treatment given free charge smoking cessation programme centralized selection medication made randomly provide fixed distribution rate aim study evaluate efficacy smoking cessation evaluate effect smoking cessation programme methods total individuals met study criteria included study smoking habits degree dependence determined participants test nicotine dependence therapy initiated eligible patients followed days months smoking cessation level ppm point prevalence abstinence used criteria success smoking cessation evaluation showed non smoking status previous days results mean age participants years male participants given mean package year significantly different groups rates success weeks months significantly higher group group end one year rate smoking cessation determined group difference statistically significant end year previous days smoking status evaluated point prevalence abstinence measurement success criteria success rates difference significant individuals used medications days longer successful smoking cessation common reasons given medication side effects significant difference determined groups respect side effects observed conclusions although rates smoking cessation control points higher significant difference found success rates used smoking cessation based last days end one year used medications days longer successful smoking cessation
purpose paper construct validate underlying factorial structure attitude predictors measurement scale towards skin care product analysis based sample among user collected via drop survey technique sampling approach used data collection subsequently confirmatory factor analysis executed confirm validate factorial structure results confirmed factor structure conceptualized spiritual intelligence spiritual product image product involvement published elsevier open access article license http creativecommonsorg licenses
great deal attention manufacturing engineering focused operations hard brittle materials recent years paper reports experimental work analysis surface roughness material removal using design experiment method magnetic flat surfaces change surface roughness material removal found increase increase weight percentage particles magnetic volume decrease working gap also decrease relative size particles vis vis iron particles result increase surface roughness decrease material removal observed work piece hardness considerable effect process results optimum parameter levels lead best surface finish highest material removal also derived optimum levels included weight percentage particles volume working gap relative size particles vis vis iron particles work piece hardness disk type test pieces selected two side surfaces experiments experiments made using milling machine spindle magnetic pole table work pieces
nitrogen ions five different energies implanted steel base samples high vacuum temperature degrees base implanted samples also degrees high vacuum similar bar energy dependent change structure mechanical properties implanted samples observed annealing process structural study suggested formation implantation induced surface segregation nitrogen nano hardness elastic modulus increased respectively increasing energy implantation process significantly enhanced erosion resistance base steel minimum cumulative weight loss maximum erosion resistance obtained sample implanted energy roughness values surfaces various erosion periods correlated erosion process understand erosion mechanism lowest roughness values erosion test obtained sample implanted energy
runoff water management among inherent challenges face sustainability development arid urban centers areas particularly risk flooding due rainfall concentration heavy hand susceptible drought capital stands issues hence research study aims investigating potential applying rainwater harvesting rwh city center potential urban runoff management tool rapid urbanization coupled extension surfaces intensified heat island consequently increased frequency heat waves dust dry summer flooding rainy season led environmental economical health problems study starts exposing rainfall behavior investigating rainfall variability number distribution rain season probability daily rainfall maximum daily rainfall deficit rain time daily rainfall data show strong falls occur almost every wet season decreased intra inter annual rainfall increased rainfall concentration month august taking place year rainfall variability calculated decade interval since increasing variability revealed coefficients variation annual values months july september aforementioned rainfall conditions paper explores potential rwh city center option storm water management since drainage system covers study area potential runoff center area computed using united states natural resources conservation services method weighted curve number found confirming dominant rainfall threshold runoff generation found runoff generated rainfall probability one year return period drainage system capacity extreme rainfall produces runoff equivalent drainage capacity suggested former latter volumes mentioned harvested applying rational method commercial business district area respectively based results six potential sites chosen rwh total roof catchment area potential rwh per unit area results reflect rwh potential effective urban runoff management better water resources utilization rwh provide alternative source water tackle drought phenomenon elsevier rights reserved
important advances field particularly deep brain stimulation deep brain manipulation newly introduced refinement closed loop deep brain stimulation use closed loop technology make precise procedures broaden indications utilizes feedback variety sources electrophysiological neurochemical afferent information function brain structures treated studied actions either electric classic excitatory inhibitory ones micro injection things neural proteins neural implants pluripotent stem cells mesenchymal stem cells variants gene therapy pathologies treated beside parkinsons disease movement disorders include repair neural tissues neurodegenerative pathologies psychiatric behavioral dysfunctions schizophrenia various bipolar disorders obesity anorexia drug addiction possibility using new modalities treat number cognitive dysfunctions also consideration technology brings cross fertilization scientific investigation surgical practice also contribute enhanced understanding brain function published elsevier inc
active electronically scanned array method provides enhanced selectivity interference rejection number antennas compared conventional delay sum proposed conventional transfer function modified introducing complex pole based recently proposed infinite impulse response beam filters guaranteed stability continuous time domain signal flow graph proposed based first order pass filters eliminate need transmission line based delays used conventional improved interference rejection verified using closed form signal processing models array antennas desired signal direction arrival interference array proposed scheme shows improvement signal interference ratio around number antennas compared improvement interference rejection observed uniform non uniform aperture weights terms side lobe performance feasibility study presented potential cmos circuit implementation proposed linear array eight antennas maximum operational frequency ghz
paper addresses problem joint inference optimization wireless networks optimization framework based information geometric network inference developed implemented using real radio testbed scalable solutions infer end end rate distributions stochastic network flows link rate measurements proposed low complexity solutions apply underlying network inference network tomography problem decomposed smaller size solved independently partially inferring flow rates interest solutions extended infer flow rates jointly link loss rates considered unreliable wireless links using inferred distributions flow rates inference mechanism presented optimize network performance first distributions flow rates inferred average rate measurements selected links distributions links rates computed inferred distributions flow rates finally inference results used network optimization weighted sum link probabilities minimized adapting power control routing decisions mobile wireless access approach network inference optimization providing link end end throughput gains compared static approaches fixed network inference optimization parameters joint network inference optimization framework implemented real configurable performance verified hardware loop test results obtained actual radio transmissions channels
electric machines concentrated winding single tooth design provide cost effective way use flat wires high filling factors achieved due geometric constraints influence current displacements remains space inside slot space used water cooling channels result small thermal resistance winding cooling fluid leads outstanding cooling performance compared round wires efficiency improved wide parts operating area absence cooling leads comparable production costs even compact machine design technological aspects discussed particular high power density interior permanent magnet synchronous machine water cooling round wires compared flat wire wound slot cooled motor use fem cfd simulations measurements single tooth specimen
men women traditional expectations regard professional status perceived negatively others face negative outcomes workplace examine whether negative perceptions extend observers evaluations status intimate relationships employed scenario depicting heterosexual married couple manipulating professional status character holding information constant participants projected lower relationship satisfaction onto lower professional status condition participants condition also less perceived power relationship finally effects mediated ratings characters perceived normative masculinity findings contribute existing research male female gender role face suggesting additional consequences perceptions intimate relationships
background treatment prevalent issue internet interventions guidance health care professionals found increase treatment adherence rates internet interventions range physical mental disorders evaluating different guidance formats varying intensity important particularly respect improvement effectiveness cost effectiveness identifying predictors allows opportunity better adapt internet interventions needs participants especially risk treatment objective goal study investigate influence different guidance formats content focused guidance adherence focused guidance administrative guidance adherence identify predictors internet based mobile supported stress management intervention get stress employees methods data groups received intervention pooled three randomized controlled trials rcts evaluated efficacy internet based mobile supported stress management intervention rcts differed terms guidance format content focused guidance control adherence focused guidance control administrative guidance control adherence defined number completed treatment modules anova performed compare adherence rates different guidance formats multiple hierarchical linear regression analysis conducted evaluate predictors included gender age education symptom related factors hope improvement results content focused guidance sample adherence focused guidance sample participants administrative guidance sample completed treatment modules guidance significant effect treatment adherence omega participants content focused guidance mean adherence focused guidance samples mean completed significantly modules participants administrative guidance sample mean content focused guidance significantly associated higher adherence compared adherence focused guidance effect size pass equivalence margin upper bound lay predefined margin indicating equivalence adherence focused guidance content focused guidance beyond influence guidance none predictors significantly predicted conclusions guidance shown influential factor promoting adherence internet based mobile supported stress management intervention adherence focused guidance included feedback demand equivalent content focused guidance regular feedback requiring approximately quarter coaching resources promising discovery terms cost effectiveness however even considering guidance sociodemographic symptom related characteristics differences remain unexplained
electromagnetic methods commonly employed detect wire however determining residual strength wire based quantitative recognition remains problematic designed prototype device based residual magnetic field ferromagnetic materials overcomes disadvantages associated service large volume operation low precision poor portability providing relatively small lightweight device improved detection precision novel filtering system consisting hilbert transform compressed sensing wavelet filtering presented digital image processing applied achieve localization segmentation defect images statistical texture invariant moment characteristics defect images extracted input radial basis function neural network experimental results show device detect defects various types wire prolong service life test equipment reducing friction detection device wire high lift distance
purpose immigration enforcement ice takes place community near school property maintaining school environment conducive learning difficult article examines school leader personnel perceived impact ice activity community students families whether school personnel incorporated community concerns response exhibited community research methods approach data come embedded case study educators school experienced ice activity close school grounds findings principal school personnel tried minimize impact uncertainty presence neighborhood school environment took steps limit short term long term effects community personnel demonstrated relationships dialogue collaboration community members central decision making process implications research practice school leaders practitioners know legal ethical responsibilities toward students anticipate contexts related legal status students family members article highlights need schools school districts create policies resources protect students educational rights ensure personnel receive training policies research expand understanding personnel respond sensitive personal legal contexts involving families
one biggest challenges health data sharing regulations transmission distribution personal health information phi even among organizations research reduces utility datasets address issue phi maintaining analytical utility data much research focused data static independent complete unfortunately typical health data instead static independent tables health data relational databases multiple high dimensional tables constantly changing data recipients usually receive multiple versions database time study reviews literature methodologies large fast changing high dimensional datasets especially health data relevant papers analyzed categorized compared terms scope contributions finally used extracted details analysis outline possible research direction developing realistic framework health data sharing authors published elsevier
people often discuss events seen discussions influence later investigated effects emotional free discussion memory individuals witnessed event participants shown video made initial individual recall participated one three conditions emotional versus versus free control condition recalled event individually participants free conditions reported items previously recalled participants control condition emotional condition show advantage participants three conditions failed report previously recalled items compared control condition finally memory effect observed three conditions findings suggest discussions influence accuracy subsequent memory reports especially discussions focused emotional details thoughts
high dimensional data space generated hyperspectral sensors introduces challenges conventional data analysis techniques popular dimensionality reduction techniques usually assume gaussian distribution accordance real life metric learning methods explore global data structure labeled training samples proved efficient hyperspectral fields however utilizing locally adaptive decision constraints labeled training samples per class obtain even better performance paper present locally adaptive dimensionality reduction metric learning method hyperspectral image classification aims presented method first utilize limited training samples reduce dimensionality data without certain distribution hypothesis second better handle data complex distributions use locally adaptive decision constraints assess similarity pair samples based distance changes metric learning experimental results obtained number challenging hyperspectral image datasets demonstrate proposed algorithm outperforms state art dimensionality reduction metric learning methods
health risk concerns associated household use harvested rainwater constitute one main exploit benefits rainwater harvesting united states however benchmark based epa acceptable annual infection risk level case per persons per year developed aid drinking water regulations stringent sustainable water practice study challenge current risk benchmark quantifying potential microbial risk associated consumption irrigated home produce comparing current risk benchmark microbial pathogen data exposure rates reported literature applied assess potential microbial risk posed household consumers produce quantitative microbial risk assessment model based worst case scenario overhead irrigation pathogen inactivation applied three crops popular among home commonly consumed raw infection risks household consumers attributed consumption home produce vary type produce presents highest risk followed tomato respectively results show percentile values infection risk per intake event home produce one three orders magnitude lower epa risk benchmark however annual infection risks scenario multiple intake events year likely exceed risk benchmark one order magnitude cases estimated percentile values annual risk range still lower risk range water irrigated produce estimated comparable studies discuss home produce based relative risk wastewater irrigation food crops appropriateness risk benchmark assessing safety level irrigated fresh produce questioned considering assumptions made model consequently need updated approach assess appropriateness sustainable water practice making guidelines policies proposed elsevier ltd rights reserved
production derivatives amino analogue base base employing standard procedures coupling described versatile molecules possess shaped core groups carry two modifiable extremities enable synthesis molecular assembly synthesis straightforward requires inexpensive starting materials facilitates application different fields research light driven molecular machine design
objective present study aimed detect levels serum synovial fluid synovial membrane patients knee osteoarthritis investigate association severity articular cartilage damage methods according american college rheumatology criteria osteoarthritis diagnosis cases diagnosed knee group selected patients underwent surgery hospital june june additional cases knee joint diseases non group included controls levels synovial fluid serum assayed elisa synovial membrane assayed immunohistochemistry severity knee articular cartilage damage related pathological changes evaluated using scores respectively results levels synovial fluid synovial membranes group significantly higher non group levels synovial fluid synovial membranes positively correlated serum level high sensitivity reactive protein crp score score group conclusion levels synovial fluid synovial membrane increased patients positively correlated severity
development organic fluorescent materials great interest fundamental research practical applications fluorescent material smart material fluorescent properties changed response external pressure stimuli however materials depended change physical molecular modes remaining extremely rare work new compound synthesized chemical structures derivative determined nmr elemental analyses properties investigated tga dsc methods results show compound possess properties aggregation induced emission enhancement effect intensity quantum yield high water fraction times higher pure respectively nature generated phase transformation crystalline state amorphous state external stimuli organic light emitting diode device fabricated compound non doped exhibited good performances maximum maximum current efficiency maximum power efficiency indicated compound multi functional
worldwide increase resistance significant challenges treatment pseudomonas aeruginosa infections study investigation production resistant aeruginosa isolates recovered clinical specimens tertiary hospital aimed total resistant aeruginosa isolates examined inactivation method used phenotypic detection production existence genes investigated polymerase chain reaction pcr subtypes detected genes identified sequence analysis arbitrarily primed pcr pcr performed evaluate clonal relationship among isolates presence high risk clones producers investigated matrix assisted laser desorption flight mass spectrometry maldi tof three isolates identified producers tests pcr tests demonstrated three isolates carrying genes gene found two isolates gene found one isolate sequence analysis demonstrated pcr yielded high clonal diversity among isolates according maldi tof analysis none producing strains belonged high risk clones conclusion presence type aeruginosa isolates demonstrated first time hospital reported second time turkey results lead strategies controlling spread contribute epidemiological data turkey
paper discusses opportunities constraints evidence based policy evidence based practice education expectations held different public policy makers teachers parents discussed constraint underlying educational research furthermore expectations constrain communication researchers public case science communication relationships educational research evidence based policy communication research public exemplified case studies three topics impact violent computer games relationship class size students learning outcomes issue streaming public schools
thermal analysis high speed machine necessary made check temperatures electric machine individual parts influence aspects electric machine design paper deals modeling thermal phenomena high seed asynchronous machine main requirement model easy integration electromagnetic model computational fluid dynamics cfd analysis used determine boundary condition thermal model commonly known high speed machine
background anaphylaxis acute potentially lethal syndrome resulting sudden release mast cell derived mediators circulation objectives methods report plasma protease cascade factor driven contact system critically contributes pathogenesis anaphylaxis murine models human subjects results deficiency pharmacologic inhibition factor plasma high molecular weight bradykinin receptor receptor largely attenuated allergen ige mediated mast cell mice factor null mice human factor restored susceptibility allergen ige mediated activated mast cells systemically released heparin provided negatively charged surface factor activated factor generates plasma leading bradykinin evaluated contact system patients anaphylaxis plasma samples immunoblotting revealed activation factor plasma acute phase anaphylaxis basal conditions healthy control subjects severity anaphylaxis associated mast cell increased plasma heparin levels intensity contact system activation bradykinin formation conclusions summary data collectively show role contact system patients anaphylaxis support hypothesis targeting bradykinin generation signaling provides novel alternative treatment strategy attacks
migraine characterized severe headaches preceded aura likely caused cortical spreading depression shows clinical promise migraine therapy although efficacy mechanism action unclear detected diffusion weighted mri mri mice acute systemic administration increased threshold initiation vivo familial migraine type mutant mice expressing human mutations type calcium channel subunit speed propagation vivo acute systemic administration vivo also selectively prevented migration subcortical striatal hippocampal regions strain exhibits phenotype gain channel function cellular level inhibited glutamatergic synaptic transmission differentially mice study describes mri analysis method tracking progression provides support mechanism action possible effective therapy treatment migraine
background fungal infection nail plate area study examined efficacy laser treatment using self controlled study programs involving long pulsed laser combined oral medication methods self controlled strategies followed study patients received treatment oral conjunction long pulsed laser treatment unilateral limb week total four times total affected divided group mild moderate group severe according disease severity affected scoring clinical index scores selected compare therapeutic effects pure medication treatment group combination treatment group week follow period results group weeks follow pure medication treatment group respectively combination treatment group respectively differences groups significant week chi week chi week chi group weeks follow pure medication treatment group respectively combination treatment group respectively differences groups weeks follow statistically significant week chi week chi conclusions patients mild moderate recommended pure medication treatment combination treatment medication laser patients severe recommended combination medication laser therapy
background transcription factor highly expressed lymphocytes loss leads premature cell differentiation antibody cells secretion autoantibodies development autoimmune disease despite importance cell biology target genes known cells results obtain complete picture function regulating cell differentiation performed chip seq primary mouse cells identify binding sites many localized near genes play important roles cell activation differentiation although bound many sites genome required regulation less evidenced gene expression changes cells lacking cohort genes whose expression altered included numerous genes associated autoimmune disease susceptibility focused attention four target genes assess contribute function limiting formation found dysregulation particular targets explain altered differentiation absence conclusion identified genome wide binding targets cells determined relatively small number putative target genes require normal expression interestingly cohort genes associated autoimmune disease susceptibility among regulated identification target genes cells help provide picture regulates cell responses loss promotes secretion
background cold increase mortality however little known effect cold cardiovascular morbidity study aims assess effect cold cardiovascular diseases mediterranean region southern europe methods conducted population based retrospective study data obtained system development research primary care meteorological service outcome first emergency hospitalizations due coronary heart disease stroke heart failure exposures cold cold subsequent days incidence rate ratios confidence intervals calculated using self controlled case series method accounted age time trends air pollutants results shown age groups gender cardiovascular event type results cardiovascular hospitalizations winter summer overall incidence cardiovascular hospitalizations significantly increased cold effect even stronger days subsequent cold conversely cardiovascular hospitalizations increase neither overall stratified analysis conclusions cold increased incidence emergency cardiovascular hospitalizations effect cold greater including subsequent days knowledge useful develop strategies reduce impact extreme temperature episodes human health
paper present educational video game developing teach fundamentals computer programming similar educational tools scratch project spark code provides users intuitive graphical interface writing programs however video game uses problem based learning approach players learn programming concepts solving individual environment moreover intended autonomous learning game played without teacher support thereby potentially reaching students economic ethnic gender groups using iterative development process evidence centered design work proposes develop evaluate improve performance acquiring programming skills
explore effects inhibiting proliferation regulating methylation tumor gene possible mechanisms human erythroid cells cells treated various concentrations observe cellular morphology proliferation assay cell cycle mrna protein expression levels detected reverse transcription polymerase chain reaction pcr western blot dna methylation protein expression levels dna methyltransferase analyzed methylation specific pcr western blot respectively effective inhibit proliferation cells dose dependent manner suppression rates half maximal inhibit concentration mol typical apoptosis morphology observed treated cells proliferation index cell cycle decreased expression levels mrna protein reduced gradually increasing doses meanwhile methylation status gene changed partially totally methylated expression levels protein gradually increased treatment dose dependent manner significantly inhibit proliferation cells arrest cell cycle phase also induce cellular apoptosis regulate expression level results provide evidence anti leukemia mechanism involve increasing methylation status related regulation proteins erythroid cells
background genetic influences self medication counter drugs merit investigation example patients frequently use anti inflammatory drugs nsaids treat inflammation inflammatory response also affected endogenous cytokines whose production varies across polymorphisms encoding genes case interleukin literature suggests single nucleotide polymorphism snp promoter region cytokines gene influences production higher levels associated variant alleles objective demonstrate feasibility role genetics self medication using existing national survey data evaluate possible association use genotype snp gene methods statistical analyses performed using data participants third national health nutrition examination survey iii results use aspirin previous month significantly common among persons genotypes snp odds use consistently increased relative number alleles trend remained statistically significant odds ratio per additional allele confidence interval adjustment confounding conclusions analysis population based genetic data suggests association common self medication behavior specific genetic polymorphism findings broadly demonstrate data provide opportunities investigate associations specifically imply potential among use genotype cytokine levels deserve study
study describes engagement veterans dementia evidence based care coordination intervention called partners dementia care uses person centered approach encourages participation individuals dementia despite cognitive impairment also targets primary family caregivers often main user program total passed mental status screening considered engagement potential study actual engagement based data records combined data structured research interviews approximately engagement potential minimum level actual engagement smaller subsample actively engaged indicated assigned accomplished action steps younger self reporting memory difficulties higher levels engagement results describe one example extent limits engagement psychosocial interventions
integrated global positioning system gps satellite digital audio radio antenna proposed automotive use gps antenna formed modifying ring antenna operating mode antenna placed ring center using slot loaded mode square patch gps antenna operates mhz right hand circular polarization antenna operates mhz left hand circular polarization antenna also placed automotive model simulations vehicle performed simulations measurements antenna exhibit good performance automotive use
study specimens patients myeloproliferative diseases carried course chemotherapy combinations initial manifest myelofibrosis loose network fibers extensive network collagen fibers respectively chronic myeloid leukemia chronic lymphoid leukemia multiple manifest myelofibrosis detected patients chronic myeloid leukemia without hematological response failure normalization hematological values patients progressing relapsing multiple combinations foci initial manifest myelofibrosis incident patients progressing relapsing chronic lymphoid leukemia incidence myelofibrosis higher patients multiple chronic lymphoid leukemia progression relapses patients chronic myeloid leukemia without hematological response disease case response chemotherapy response chemotherapy patients chronic myeloid leukemia chronic lymphoid leukemia associated decrease incidence myelofibrosis patients multiple responding chemotherapy incidence myelofibrosis change comparison disease
microscope eukaryotic animal cells adopt variety different shapes sizes cells also move physical mechanisms driving movements shape changes important fundamental cell biology tissue mechanics disease biology article reviews basic mechanical concepts cells emphasizing continuum mechanics description cytoskeletal networks hydrodynamic flows across cell membrane discuss cells generate movement shape changes controlling mass fluxes cell boundary mass fluxes come polymerization actin cytoskeleton osmotic hydraulic pressure driven flow water across cell membrane combining hydraulic pressure control force balance conditions cell surface discuss quantitative mechanism cell shape volume control broad consequences model cell tissue mechanics outlined
paper reviews sixty nine field failures involving geotextile filters performed categorized herein failures grouped four categories inadequate design atypical soils unusual installation first category poor fabric selection poor fabric design drainage pipe reversing flow conditions second category fine grained soils gap graded soils dispersive third category water alkaline water agricultural waste liquids fourth category lack intimate contact completely adhesive surfaces topic paper noted conditions known sand filters geotextile filters elsevier ltd rights reserved
family planning methods act administered substantial benefits used longer sex current emergency contraceptives potentially woman use relatively rare occasions menstrual period delayed although methods abortion likely many women research develop post fertility control agents pursued
information active area research secret information embedded looking carriers images videos existence maintaining visual quality researchers presented various image techniques since last decade focusing payload image quality however trade two metrics keeping better balance still challenging issue addition existing methods fail achieve better security due direct embedding secret data inside images without encryption consideration making data extraction relatively easy therefore work propose secure image framework based key directed adaptive least significant bit substitution method multi level cryptography proposed scheme key encrypted using two level encryption algorithm secret data encrypted using multi level encryption algorithm encrypted information embedded host image using adaptive substitution method depending secret key red channel sensitive contents quantitative qualitative experimental results indicate proposed framework maintains better balance image quality security achieving reasonable payload relatively less computational complexity confirms effectiveness compared state art techniques
background idiopathic intracranial hypertension syndrome defined elevated intracranial hypertension without radiographic evidence mass lesion brain venous sinus stenosis increasingly recognized cause venous sinus increasingly performed methods year single center retrospective analysis consecutive patients undergoing medically refractory results patients mean imaging follow months mean clinical follow period months performed first procedure medically refractory patients whereas patients included previously surgical procedure shunt optic nerve headache present patients improved remained stable respectively visual changes visual field changes present patients respectively visual field improved remained unchanged worsened rate stenosis rate procedures performed technical success rate zero major minor complications conclusion based single center retrospective analysis performed high technical success low complication rates majority patients presented primarily headache patients excellent symptom relief alone patients presenting visual symptoms lower success rates population carefully followed progression symptoms
background borderline personality disorder bpd complex clinical state highly polymorphic symptoms signs studies demonstrated people bpd diagnosis likely numerous occurring psychiatric disorders physical comorbidities aim study obtain insight associations among comorbidities bpd demonstrate practicality using association rule mining arm technique clinical databases methods retrospective case control study conducted information patients bpd patients control patients selected taiwan national health insurance research database information physical psychiatric comorbidities diagnosed within years enrollment collected logistic regression model used calculate odds ratios comorbidities patients without bpd arm technique used study associations bpd two psychiatric comorbidities results classified physical comorbidities categories according international classification diseases ninth revision clinical modification system results indicated categories common bpd patients control patients except congenital anomalies however psychiatric comorbidities including depressive disorder bipolar disorder anxiety disorder sleep disorder substance use disorder mental retardation common bpd patients control patients furthermore associations bpd two comorbidities evaluated conclusion physical psychiatric disorders common bpd patients control patients failure bpd associated suffering chronic physical conditions psychiatric comorbidities lead delays diagnosis bpd clinicians caring people bpd aware possible comorbidities
nowadays important study provide confidentiality digital image encryption proposals committed visual secret sharing techniques traditional scheme mainly focused binary images later investigations extended color images visual cryptography encodes secret information shares distribute among group participants qualified participants reconstruct original image collected share images previous schemes still weakness construction secret shares reconstruction secret image paper present reversible visual cryptography technique color images using field theory secret image split two sub images shared cover image construct images additionally field theory applied construct images effective transmission individual images reveal field inverse operation exponential employed reveal secret image pair pixels images reveals cover images
aim development new multi level model fuzzy semi structured information data storage distinction proposed model known use extended sets description fuzzy data representation fuzzy attributes three typing levels main result formal description fuzzy semi structured data storage verify result example application developed model data storage intellectual diagnostic decision making system railway transport showed
wireless networks gained immense popularity recent years though wireless networks advantages conventional networks nature wireless networks makes prone various activities context network security one crucial vulnerabilities caused serious global concern mac address mac address facilitates attacks denial service man middle flooding etc paper propose methodology detection attacks ieee networks involve performance cluster analysis patterns detect presence attack also determine number attackers propose discriminant adaptive neural network based localization system
paper describes experiments relating response control section long span suspension bridge deck mounted part wind tunnel experiment bridge section subject grid generated flow turbulence two grids used one standard grid second new design provides larger turbulence length scales response results compared calculated using unsteady three dimensional lifting surface theory extends standard two dimensional theory bridge deck pitch responses predicted comparisons made wind tunnel measurements order suppress increase critical flutter speed deck model fitted controllable leading edge two sets passive controllers use angles control inputs demonstrated evaluated capability suppress response deck increase critical flutter speed first set controllers sense position pitch angle pitch angle alone whilst second set mechanical controllers sense vertical velocity points control system design problem solved mixed infinity optimisation problem wind tunnel experiments show control systems reduce considerably response whilst simultaneously increasing critical flutter speed elsevier ltd rights reserved
relationship among beta risk developing invasive fungal infections observed adult icu children hematological malignancies scant data evaluated value assays diagnosis patients diseases pediatric intensive care unit study assessed diagnostic value markers records patients retrospectively evaluated patients proven probable cases without evidence performed assays results showed many factors associated false positive test results patients aged years higher levels younger infants levels higher subjects dairy human blood products antibiotics corticosteroids therapy cases without treatments unlike assay assay less susceptible mentioned factors expect blood products levels cases dramatically higher controls diagnostic performance assays showed assay better results compared assay whole negative predictive value assays dramatically higher diagnostic parameters conclusion assay highly susceptible many factors assay useful diagnosis high sensitivity benefit assay limited inadequate specificity comparative advantage assays excluding non hematological patients
increasing number wind turbines offshore need cost effective predictive proactive maintenance large fraction wind turbine due bearing failures particularly generator one way assessing problems install vibration sensors key positions equipment costly requires sophisticated software analysis data alternative approach require extra sensors investigated paper involves monitoring power output variable speed wind turbine generator processing data using wavelet order extract strength particular frequency components characteristic faults done doubly fed induction generators commonly used modern variable speed wind turbines technique first validated test rig controlled fault conditions applied two operational wind turbine generator shaft detected one turbines technique detected problem months bearing failure recorded
transcription factor related factor key regulator cellular defense mechanisms oxidative stress multiple sclerosis chronic inflammatory disease central nervous system characterized progressive demyelination neurodegeneration induced inflammation oxidative stress induction signaling shown inhibit disease development progression experimental autoimmune encephalomyelitis model mice present study performed high throughput screening assay using chimeric construct terminal portion fused using approach identified novel inducer using human primary cell profiling systems found inhibited cell proliferation exerted immuno modulatory effects inhibiting production also inhibited secretion human peripheral blood mononuclear cells stimulated anti anti mice treated expression target gene increased brain spleen disease severity ameliorated plasma levels decreased furthermore inhibited luciferase activity transgenic mice expressing human interleukin luciferase reporter therefore findings indicate potent inducer inhibits inflammatory cytokine production disease progression mice promising therapeutic agent
major corresponding rigorous thermal thermo mechanical analyses applied chapter transient temperature fields replaced fixed temperature profiles computationally efficient methods introduce transverse longitudinal thermal strains derived approximations embodied thermal strain transverse contraction strain algorithms analytical approach strains applied linear elastic small strain models using conventional strength materials techniques computational approach strains applied linear elastic large strain finite element models various hybrid stepwise methods also shown measure sequential description included together use plastic finite element computation
skin setup hydrophilic enzymatic non enzymatic antioxidant systems sodium phosphate reported hydrophilic antioxidants respectively used skin care present study aimed assess combined oil phase aqueous phase via multiple emulsion controlling healthy human females ftir analysis performed identification multiple control prepared analyzed physical stability antioxidant activities combination compounds determined method female volunteers included single blinded placebo controlled split face comparative study volunteers instructed apply left control without right period days non invasive device used measurement sides face subsequent time intervals good antioxidant activity observed treatments reduced significant facial compared control placebo treatments concluded combined skin proved promising choice controlling facial evaluated undesired skin reductions facial appearance
using recycled concrete rubber aggregates produce green concrete promising technology toward sustainability construction industry study compressive flexural behaviours new type concrete material rubber steel fibre reinforced recycled aggregate concrete investigated application new type green building material experimental study conducted investigate effect rubber content compressive flexural behaviours total tested axial compressive loading tested subjected three point bending rubber content varied investigation levels volume substitution sand recycled concrete aggregate introduced concrete mixture volume substitution natural coarse aggregate volumetric quantity steel fibre added concrete mixture effect rubber content compressive flexural strength failure mode modulus elasticity toughness analysed results indicate optimal rubber content displays good compressive behaviour compared normal concrete also environmentally friendly alternative normal rubber concrete use flexural members concrete structures elsevier ltd rights reserved
background common benign bone tumour rarely found difficult detect early imaging atypical symptoms presence concurrent trauma sports injuries lead delayed treatment herein analyse case discuss improve early diagnosis rare lesion thereby rapid treatment case presentation year old man history left ankle sprains chronic pain diagnosed another ankle managed based normal ray findings year pain diagnosed ankle traumatic arthritis underwent surgery preoperative ankle ray findings still normal magnetic resonance imaging time demonstrated bone marrow left symptoms shortly surgery progressively worsened magnetic resonance imaging performed months surgery demonstrated widespread bone marrow patient presented hospital pain assessment diagnosed years symptoms began preoperative computed tomography demonstrated typical second surgery patients symptoms completely resolved pathologic examination confirmed lesion patient recovered months later able walk normally conclusions ankle joint exhibits progressive course difficult diagnose early stage patients often atypical imaging findings signs ankle instability anterior ligament valuable diagnosing although multiple scans required detect proper imaging helps doctors achieve correct diagnosis early disease course significantly shortening treatment cycle improving patients quality life
cardiomyopathy heart failure syndrome occurring late pregnancy early post period pathophysiology cardiomyopathy fully understood various mechanisms postulated including underlying inflammatory process report four cases presenting acute left ventricular systolic dysfunction three four patients presented left ventricular ejection fraction one left ventricular ejection fraction made full clinical recovery following treatment high dose intravenous steroids case series adds growing body evidence role management cardiomyopathy
infection serious complication implantation total knee however fungal infection rarely found joints reports infecting organism candida species case report infection left knee total arthroplasty caused species patient still undergoing antifungal therapy still followed authors knowledge present case first report species patient total knee arthroplasty
present study results measurement campaign aiming assess cancer risk among two special groups population laboratory exposed toxic substances formaldehyde presented exposure compared general population risk results show working outdoor traffic regulation foot vehicles etc exposed significantly higher concentration times general population exposure general lower laboratory appear highly exposed formaldehyde significant variation exposure comparison general population recorded assessment revealed laboratory run higher cancer risk respectively compared general population indoor working place air quality significant assessing cancer risk two categories professionals due higher inhalation unit risk formaldehyde compared since origin danger laboratory clear use chemicals necessary experiments presence indoor air concentrations due smoking used materials constitute danger equal exposure traffic originated air pollutants
aiming evaluating see performance complex electronic system multi signal flow graph method adopted based theory see soft error propagation model proposed analysis methodology stated complex electronic system consists devices based fpga model established simulated teams software fault diagnosis average first failure time estimated report indicates percentage fault detection average first failure time system varies hours days
background one disadvantages implants lack elasticity increased use ceramic consequences result lack elasticity led search new materials improved mechanical properties case presentation patient year old woman non medical record interest longitudinal fracture root molar tooth absence tooth selected order receive implant based restoration composite coating following case report describes analyses treatment implants following surgical technique implants alternative titanium implants patients allergies sensitive metal alloys however one disadvantages lack elasticity increases use ceramic consequences arise lack elasticity led search new materials better mechanical properties loads based restoration implant compensate forces facilitating conclusion procedure provides excellent elasticity resembles natural tooth structure clinical case suggests used implants
background assessed week efficacy safety adalimumab children moderate severe crohns disease long term efficacy safety adalimumab patients entered extension reported methods patients completed endpoints assessed weeks pediatric crohns disease activity index remission pediatric crohns disease activity index baseline using observed analysis hybrid discontinued patients failures unless commercial adalimumab study site closure adult care last observation carried forward corticosteroid free remission patients receiving corticosteroids baseline discontinuation patients receiving baseline linear growth improvement reported observed adverse events assessed patients receiving adalimumab dose january results patients enrolled achieved remission response week remission rates maintained patients entered remission week patients receiving corticosteroids baseline achieved corticosteroid free remission patients receiving baseline discontinued adalimumab treatment led growth velocity normalization new safety signals identified conclusions efficacy safety profiles prolonged adalimumab treatment children crohns disease consistent adult crohns disease adalimumab trials
kinase plays important role normal hematopoietic growth factor signaling detection mutation crucial diagnosis myeloproliferative neoplasm mpn become essential criteria diagnosis mpn high resolution melt curve analysis based closed tube method pcr amplification subsequent analysis sequentially performed making convenient scanning methodologies methodswe evaluated mutation twenty nine patients diagnosed mpn examined studied analytical sensitivity analysis using real time polymerase chain reaction pcr identifying mutation additionally sensitivity analysis allele specific pcr pcr assay compared resultsthe mutation successfully discriminated abundance analysis analysis pcr showed accuracy detection limits respectively analysis fast simple reliable method detection mutation however validation detection limits analysis performed analytic sensitivity method
notch important geometry widespread applications engineering structural components finding universal equation predict effect notch strength materials much significance structural design materials selection present work tried find universal equation experimental results metallic materials theoretical based universal fracture criterion sci experimental results showed notch effect studied affected notch geometry characterized stress concentration factor becomes smaller notch strength ratio ratio nominal ultimate tensile strength sample sample increases comparing materials like brittle ceramics crystalline metals find larger metals smaller brittle ceramics theoretically derived universal equation notch effect strength materials constant related materials universal equation found consistent experimental results
research participants sexual orientation consistently taken account experimental psychological research argue research related participant target gender argument example study presented gender bias face recognition finding women correctly recognize female male faces contrast findings male participants inconclusive online experiment carried purpose sampling lesbian gay participants findings demonstrate pro female gender bias face recognition modified male participants sexual orientation heterosexual women heterosexual men showed pro female gender bias face recognition whereas gay men showed pro male gender bias consistent explanation differences face expertise develop congruent interests results contribute growing evidence participant sexual orientation used distinguish alternative theoretical explanations given gender correlated patterns findings
mechanical systems rotary machines rotating elements experience torsional vibration lead extreme damage wear conventionally isolate undesirable structural vibrations passive torsional used however passive vibration adaptive varying oscillation frequencies real time due need real time adaptability controllable stiffness research development smart material called magnetorheological interest paper presents mathematical modelling development implication torsional vibration control based model experimental studies properties stiffness factor regard varying magnetic fields investigated change magnetic field achieved changing amount applied current found stiffness increases increasing magnetic field consequently modifies systems natural frequency allows shift curve achieve minimum factor applications involving varying frequency
paper presents design simulation fabrication frequency selective surface based unit cell structure flexible film effective electromagnetic absorption proposed structure designed using rings unit cell dimensions selected effective absorption band simulated results show absorption ghz film thickness proposed absorber film effectively used radar cross section reduction object proposed structure fabricated tested electromagnetic absorption reduction close match simulated experimental results observed proposed structure flexible flame makes good potential candidate stealth technology
background addition known concerns regarding antibiotic overuse recent research indicates excessive antibiotic use associated poorer long term health given leading condition accounting antibiotic prescriptions ambulatory setting aimed evaluate characteristics associated greater antibiotic use chronic methods adult patients enrolled prospective multi institutional observational cohort study evaluating treatment outcomes included analysis study participants asked report number days previous days systemic antibiotics taken sinus disease patient demographics disease characteristics measures disease severity evaluated results total patients institutions included analysis mean antibiotic use prior days differences antibiotic use groups found objective measures disease severity computed tomography endoscopy brief identification test scores however increased patient reported symptom burden item nasal outcome test disability index associated antibiotic use patients reporting antibiotic use older ethnic gender differences seen comorbid diagnoses allergy asthma diabetes depression associated increased antibiotic use accordance literature recommendations nasal patients less likely used antibiotics endoscopic sinus surgery significantly decreased antibiotic use conclusion variability antibiotic use appears driven symptom burden independent objective measures disease severity patient demographics presence comorbid disease clear guidelines essential define appropriate antibiotic use llc
working status huge rotating mechanical equipment judged method detection processing analyzed variation sound reflected variation material percentage equipment sound caused different material percentage collected analyzed time frequency domain paper practical material percentage detection algorithm proposed frequency spectrum quantitative analysis material percentage determined procedure algorithm design includes calibration quantitative detection field detection results show effectiveness
spectrum disease extends beyond rigid ankylosing spondylitis axial spondyloarthritis encompasses non radiographic individuals without established radiographic changes clinical imaging features definite joint changes pelvic rays broad consensus management emerging among clinicians evidence base remains open question explore whether treated similarly examined literature prevalence natural history disease burden treatment strong evidence expressions disease approximately patients develop radiographic disease years years figure exceed patients lower crp less spinal inflammation mri patients similar disease activity pain quality life impairment patients manage conservative treatment minority severe disabling symptoms anti tnf therapy demonstrated similar efficacy safety current evidence clearly indicate anti tnf treatment inhibit limit bony progression basis conservative anti tnf treatment control symptoms function patients need powerful treatments great thus treatment consistent across spectrum anti tnf agents available irrespective radiographic change according criteria applied
objective understand effective ways providers interact family members field intervention involving recent hospital pediatric death methods eight focus groups providers conducted urban rural settings november march sixty eight providers also completed short questionnaire specific event including demographics seventy eight percent providers males either african american hispanic average number years years asked team members managed family response child helpful families whose child unexpectedly dead setting follow efforts family effective results professional response team critical family coping getting necessary support several critical competencies identified help family cope including provide excellent care seamless coordination allowing family including attempts save childs life providing ongoing communication whether child removed scene keeping family critical exclusion families process cases suspected child abuse warranted giving tangible forms support calling friends family along allowing family time child death giving emotional support follow gestures help families cope conclusion study revealed effective ways providers interact family members pediatric death
recent years development cfd simulations increased knowledge fluid structure interaction problems trend particularly important floating offshore wind turbines however especially sectors two different fluids involved reliability cfd prediction tools requires experimental end complementary approach respect ocean wave basins need wind tunnel elastic dynamic tests paper presents degrees freedom dof motion simulator device hardware loop wind tunnel tests floating scale models step machine design loop motivated described synthesis obtained multi objective optimization using genetic algorithm inverse dynamic properties mapped finally drive system mechanically sized using called alpha beta theory emphasis placed design methodology different mechanisms requirements considered elsevier ltd rights reserved
diet induced obesity lead detrimental chronic disorders severity global epidemic encouraged ongoing research characterize mechanisms underlying obesity comorbidities recent evidence suggests saturated fatty acids sea high fat diets rapidly generate inflammation nucleus hypothalamus arc centrally regulates whole body energy homeostasis herein review roles hypothalamic neurons resident microglia initiation induced hypothalamic inflammation particularly focus neuronal microglial free fatty acid sensing capacity produce inflammatory signaling also outline potential role derived monocytes inflammation finally explore synaptic plasticity mechanism hypothalamic inflammation modulate arc circuitry thus disrupt energy homeostasis elsevier ireland ltd rights reserved
article uses analytical tool called space examine structural role distortion hard rock heavy metal space facilitates comparing changes compositions distortion structure demonstrate distortions capacity generate formal structures application generalization contour theory space couples sequential time sequentially ordered dimension discrete distortion regions whose foundation distortion function spectral analysis process comparing distortion sounds partially subjective distortion function underlying spaces sequentially ordered dimension distortion regions provides objective foundation measuring identifying comparing distortion sounds subjective judgments leading greater agreement although primary analytical focus space tool distortion wider range applications example provide analytical insights distortion sounds recording engineers produce tape machines digital analog signal processing become integral process producing tracks fact study demonstrates distortion heard recordings often product amplification recording techniques
ras radar absorbing structure effective load bearing electromagnetic wave absorbing capability stealth technology although ras usually designed absorb waves broadband range wave frequencies effective absorb waves certain frequency range narrow band stop filter specific applications work non reflective conditions ras analytically investigated determine medium thickness wave transmission destructive interference sandwich type ras composed carbon nano composite face foam core carbon epoxy composite fabricated wave absorbing characteristics ras measured free space measurement method develop high wave absorption characteristics flexural stiffness strengths ras measured three point bending method respect thickness carbon epoxy composite elsevier ltd rights reserved
background aortic stenosis common heart valve disease elderly representing important economic social burden developed countries currently way predict either onset progression emphasizing need identify useful biomarkers condition methods performed multi proteomic analysis different kinds samples patients healthy donors tissue plasma results validated independent cohort subjects immunohistochemistry western blotting selected reaction monitoring results alpha abundance altered samples confirmed validation phase significant changes observed amounts protein strongly suggest involved molecular mechanisms underlying addition results suggest enhanced release extracellular fluids disease conclusions significant increase patients suggests important role disease results permit propose serve potential marker diagnosis considerable clinical value
year old man week history headache acute chronic presented imaging findings suggestive spontaneous intracranial negative leak blood patches result symptom relief cerebrospinal fluid leak study using demonstrated focal area asymmetric activity left nerve root left root tie targeted blood patch resulted resolution patient symptomatology highlighting importance fused images detection cerebral spinal fluid leak
introduction crohns disease chronic immune mediated condition potentially disabling destructive course despite growing data use therapeutic top strategy clinical management complex disorder still challenging currently discussion top strategy mostly includes biological therapy alone covered article based review existing literature regarding use biological therapy top approach treatment crohns disease authors reviewed major databases including medline abstracts opinion top therapeutic approach crohns disease strongly supported existing data patients several risk factors severe course disease moreover increasing amount published data therapeutic strategy identify candidates top treatment based enhanced diagnostics using biomarkers emerging therapeutic approaches besides existing therapy concepts using possibly top therapeutic strategy crohns disease future
purpose study reveal gender differentiation food preparation consumption behaviors iran end observations made capital city iran period one month apart observations order able determine gender gender roles regard food preparation consumption interviews also held ten people different jobs genders ages using semi structured interview form result observations interviews stated taken place especially regard eating however found traditional gender patterns gender roles continue regard food preparation consumption home short food seen womans
hereditary angioedema hae esterase inhibitor deficiency autosomal dominant potentially life threatening disease characterized recurrent self limiting edema involving mainly extremities face intestine airways prevalence hae range general population hae frequently delays years onset initial symptoms diagnosis fully human monoclonal antibody plasma showing potent selective inhibition range subcutaneous route proof concept clinical trial showed long lasting efficacy tolerability prophylactic treatment hae two phase iii studies assess efficacy safety prevent angioedema attacks hae patients ongoing received drug european medicines agency food drug administration fda fda fast track breakthrough therapy prevention attacks hae
patients alzheimers disease triple transgenic mouse model low glucose metabolism brain loss memory cognitive decline metabolism brain passes glycolysis therefore correct several deficiencies associated glucose dietary supplement composed ester beta referred ester incorporated rodent diet fed mice months months age animals brains analyses carried hippocampus frontal cortex acid cycle intermediates amino acids oxidized lipids proteins enzymes higher concentrations beta hippocampus fed mice also higher concentrations cycle intermediates energy linked biomarker acetyl aspartate compared controls control fed animals free mitochondrial nad ratio highly oxidized whereas fed animals mitochondria reduced also levels oxidized protein lipids lower energy atp hydrolysis greater compared controls mice maintained supplemented diet higher concentrations cycle metabolites reduced mitochondrial redox potential lower amounts oxidized lipids proteins compared controls offers potential therapy counter fundamental metabolic deficits common patients transgenic models
flexible alternate current transmission systems facts controllers improve quality supply power enhance power system performance also provide optimal utilization existing resources especially controlled series compensator static var compensator proposed enhance power transfer capability improve quality voltage adjusting line paper present study west network furthermore try ask problems encountered practice find solutions moving towards facts devices particular controller application technical advantage software used analyse behaviour west electrical network without facts devices elsevier ltd open access article license http creativecommonsorg licenses selection peer review responsibility mediterranean institute sustainable development
introduction maintenance replacement therapies opioid dependence also used pain management lesser extent seen sharp increases mortality associated use distinct routes metabolism mostly cytochrome dependent distinct pharmacologic activity metabolites metabolism play role differences toxicity areas covered article reviews peer reviewed literature obtained pubmed searches literature referenced within review considers first overview drug use mortality past decade provides extensive detail vitro vivo human metabolism using human experimental animal studies presents pharmacodynamic activity parent drug metabolites opioid receptor glycoprotein substrates plasma brain concentration ratios activity channel lessons learned drug interaction studies humans examined attempt bring together combined information expert opinion use misuse drugs contributes epidemic opioid associated better understanding metabolism transport medication induced changes contribute safer use
introduction immunotherapy targeting programmed death programmed death ligand checkpoint shown promising efficacy patients nsclc lymphocyte activating gene lag another important checkpoint role nsclc still clear study investigated lymphocyte lag protein expression correlation tumor infiltrating lymphocytes association survival nsclc methods expression lag protein assessed nsclc cell lines immunohistochemistry lag cell protein expression evaluated immunohistochemistry abundance scored surgically specimens patients nsclc also verified results samples patients untreated nsclc detected correlation lag expression egfr mutation microtubule associated protein like gene lymphoma receptor tyrosine kinase gene rearrangement results lag expressed nsclc cell lines however lag expressed patients nsclc sixty patient samples positive positive tumor cells neither lag expressed tumor cells lag overexpressed compared adenocarcinoma lag expression significantly correlated tumor cells percentage logistic regression model ors lag confidence interval compared adenocarcinoma negative compared positive recurrence free survival significantly different patients whose lag negative opposed lag positive years versus years likewise lag status negative versus positive significantly affect overall survival years versus years using kaplan meier analysis found patients negative tumor cells lag negative longer recurrence free survival patients either lag positive lag positive years versus years versus years verification stage high expression lag also significantly correlated higher expression tumor cells correlation lag expression egfr mutation fusion conclusions lag expressed tumor tissues patients nsclc expression higher correlated expression lag positivity lag positivity correlated early postoperative recurrence lag related poor prognosis international association study lung cancer published elsevier inc rights reserved
aim study evaluate association crack cocaine addiction dental health men forty crack cocaine patients patients years underwent full mouth dental examinations missing filled teeth identified using criteria recommended world health organization crack cocaine addiction determined based medical records interviews patient drug patients used crack cocaine chi square test logistic regression analysis used assess association crack cocaine addiction teeth showed positive association crack cocaine addiction odds ratio confidence interval whereas filled missing teeth showed negative association filled teeth missing teeth associated age present population crack cocaine addiction associated greater teeth index lower filled missing teeth index programs aimed encourage self esteem encourage individuals seek dental care required population studies using larger sample size studies women required confirm results
iii iii utilized absorption spectroscopic probes investigate interaction biomolecules like vitro abundant metal ion human body system spectroscopic techniques involving comparative absorption absorption difference quantitative intensity analysis using transitions utilized changes inner sphere coordination pattern iii iii solution solid state present study deals important human metabolism absorption spectral parameters oscillator strength lambda intensity parameters inter electronic parameters calculated using chi square methods obtained results used determine probable geometry complex solution nature bond iii iii inner sphere coordination environment transitions results obtained various experimental conditions utilized investigate coordination changes iii iii complexes caused different coordinating sites normalized solvent nature coordination number nature bond parameters mimic interaction ion
despite nutritional value population level consumption remains low studies suggest individuals eat doctors advice making health professionals potentially important promoting consumption cross sectional study aimed examine perceptions knowledge predictors promotion among health professionals new zealand general practitioners gps practice nurses identified roll invited complete questionnaire respondents respectively one fifth gps practice nurses believed eating increase blood cholesterol concentrations cause weight gain common perceptions overall healthy high protein fat consumption recommended reasons relating perceptions selenium content conversely reasons suggesting consumption fewer included high fat cause weight gain concerns regarding allergies cost groups health professionals likely promote consumption perceived reduce risk diabetes education improve health professionals knowledge regarding effects consumption blood cholesterol body weight alongside health benefits improve advice given patients thereby increase consumption
germany high prevalence rates problematic alcohol use problematic internet use adolescents reported objective present study identify psychopathological factors associated two behavior patterns knowledge first investigation assessing psychopathological factors problematic alcohol problematic internet use sample adolescents surveyed sample adolescents germany regarding problematic alcohol use problematic internet use psychopathology psychological conducted binary logistic regression analyses sample showed problematic alcohol use problematic internet use problematic alcohol problematic internet use problematic alcohol use higher adolescents problematic internet use compared without problematic internet use conduct problems depressive symptoms statistically significant associated problematic alcohol problematic internet use prosocial behavior related problematic internet use male gender less peer problems associated problematic alcohol use first time associations adolescent problematic alcohol problematic internet use due common psychopathological factors identified however addition shared factors found also specific psychopathological correlates associated two behavior patterns elsevier ireland ltd rights reserved
background affects majority elderly adults associated higher health costs utilization specific patterns morbidity influence resource use less understood objective objective identify specific combinations chronic conditions functional limitations geriatric syndromes associated direct medical costs inpatient utilization design retrospective cohort study using health study linked medicare claims analysis used machine learning techniques classification regression trees random forest subjects population based sample medicare enrolled adults aged older united states measures main covariates self reported chronic conditions measured none mild severe geriatric syndromes functional limitations secondary covariates demographic social economic behavioral health status measures outcomes medicare expenditures top quartile inpatient utilization results median annual expenditures hospitalized within years tree model shows notable combinations self rated poor health plus activities daily living instrumental activities daily living disabilities expenditures top quartile inpatient utilization highest aged mild severe heart disease plus mild severe diabetes functional limitations important many chronic diseases explaining resource use conclusions population heterogeneous considerable variation specific combinations morbidity influence resource use modeling effects chronic conditions functional limitations geriatric syndromes advance understanding groups greatest risk inform targeted tailored interventions aimed cost
cultural heritage documentation tasks usually involve professionals different knowledge areas implies huge amount information requirements also heterogeneous set sources data structures content formats geographic information systems gis used extensively cultural heritage specialists just working around real problem specialized software professionals document work paper present software named allows specialists interact real time high resolution models different information directly onto useful current future research moreover annotations exported standard format allows researchers disciplines interested dataset access information easily system able manage buildings sites also directly dataset physical element elsevier masson sas rights reserved
neurons highly differentiated cells responsible conduction transmission information nervous system proper function neuron relies intracellular domains differentiated neuroblastoma cells extensively used study understand physiology cell biology neuronal cells show differentiation neuroblastoma cells pronounced upon exposure chemical analog cyclic amp camp camp next analysed expression key microtubule regulating proteins differentiated cells expression activation key camp players microtubule promoting factors regulated differentiation cells microtubule proteins regulated observed increase post translational modifications related microtubule stability expected camp increased dependent signalling consistently pharmacological modulation activity instructed cell differentiation number length cells moreover disruption interaction reduced morphometric parameters interestingly act synergistically induce neuronal differentiation altogether results show changes observed differentiation cells proceed regulating several microtubule stabilizing factors acquisition neuronal phenotype process involving although independent functions
investigate cervical compensation pattern clarify relationships cervical compensation quality life qol ankylosing spondylitis patients cross sectional study consecutive patients performed forty four patients cervical spine assigned group sixteen cervical spine group sagittal parameters measured compared including slope cervical cervical sagittal vertical axis global global independent factors cervical compensation identified exclude confounding variables comparing qol patients cervical spine patients selected group similar patients group distribution matching variables age gender course disease global radiographic progression assessment qol assessed neck disability index indices mean significantly lower group group whereas mean slope global significantly larger group slope independent factor slope correlated global group group showed lower score independently affects notable cervical compensation exists patients cervical compensation responsive global imbalance mediated slope patients cervical spine present better qol patients cervical spine
hepatitis great burden health systems countries accounts million infected people worldwide approximately people worldwide died due hepatitis countries africa asia hepatitis accounts approximately population hepatitis accompanied cases neuropsychological diseases mainly depression depression seen hcv patients ifn treatment also developed treatment patients screen depression pre treatment treatment support family relatives also important helps patients better cope disease increase successful treatment chances treatment also greatly reduced patients assisted therapist treatment full support family relatives large spectrum causes depression causes influenced gender social stigma education local culture etc rare occasions depression lead suicidal ideation attempts suicide attempts per represent high percentage hepatitis infected patients mortality due hepatitis virus per year death hepatocellular carcinoma accounting almost half total deaths number morbidity cases hcv virus together hiv mainly hepatitis responsible total deaths considered high number establishes hepatitis important priority
background aim study compare multidisciplinary approach menstrual related migraine combining neurological consultation mono disciplinary approach involving neurological treatment clear relationship cycle occurrence migraine menstrual migraine nowadays treatment menstrual related migraine performed treatment attention hormonal treatment seems convenient methods retrospective study performed cohort using data women menstrual related migraine visited menstrual migraine clinic intervention group results compared historical control group consisted women menstrual related migraine treated received mono disciplinary approach results intervention group headache impact hit score significantly improved points mean headache days per month declined significantly days women needed less use pain medication control group decline hit score less striking points mean headache days per month increased days appeared patients control group required consultation course time conclusion treatment women menstrual related migraine gives better results compared mono disciplinary approach results interpreted caution performed retrospective study relative small control group
prior epidemiological study identified reduction opioid deaths states medical cannabis one theory explain phenomenon potential substitution effect opioids study evaluated whether substitution effect opioids also applies medications new england members completed online survey medical history experiences among respondents regularly used opioids three indicated reduced use since started significantly greater patients reduced use antidepressants alcohol approximately two thirds patients decreased use anti anxiety migraine sleep medications following significantly exceeded reduction antidepressants alcohol use patients family friends likely know use primary care provider conclusion majority patients reported using less opioids fewer medications treat anxiety sleep initiating smaller portion used less antidepressants alcohol additional research needed corroborate self reported retrospective cross sectional findings using data sources
background cerebrospinal fluid csf opening pressure now considered diagnostic criterion syndrome children however proposed diagnosis probable made seven children mri findings supportive seen eight patients conclusions diagnosis probable subgroup made children results opening pressure measurement always need interpreted within whole clinical context treatment decisions patients probable follow stage based principles proven european paediatric neurology society published elsevier ltd rights reserved
objectives womens physical mental health shows marked increase menopause usually occurs years age mental illness somatic symptoms common causes long term sick leave women suffer lack knowledge menopause transition associated symptoms aim study investigate whether group education women primary health care menopause transition improve physical mental health study design randomized controlled study conducted aimed evaluate group education programme women aged years around menopause transition total women randomized group education intervention group intervention included two education sessions topics related menopause answered two questionnaires baseline four month follow menopause rating scale depression rating scale main outcome measure change scores four months results intervention group experienced slight reduction symptoms control group mostly experienced opposite conclusion study showed feasible implement group education menopause women aged years clinical trial registration number elsevier rights reserved
detection distributed denial service traffic great importance availability protection services information communication resources research presented paper shows application artificial neural networks development detection classification model three types attacks legitimate network traffic simulation results developed model showed accuracy classification pre defined classes traffic
purpose objective study analyze effect size intervention studies posttraumatic growth patients cancer methods total studies published identified searching medline cinahl pubmed scopus cochrane library studies selected inclusion meta analysis data analyzed using comprehensive meta analysis program effect sizes shown using score results intervention studies included studies cognitive behavioral stress management studies mindfulness based stress reduction studies couple based intervention study health coaching building resilience intervention overall controlled effect size using fixed effects model effective intervention couple based intervention followed conclusion cancer one significant traumatic events affect patients lives cancer patients known posttraumatic growth therefore necessary consider nursing interventions increase posttraumatic growth cancer patients couple based intervention
glass systems composition mol mol mol mol mol prepared using normal melt technique effect used intensively help investigate structure bonding oxide spectra indicate presence iron iron iii coordination dependence electrical data analyzed frame work impedance plot frequency range mhz room temperature constant phase elements used equivalent electrical circuits fitting experimental impedance data frequency dependence electric conductivity found follow simple power law behavior accordance relation sigma sigma smaller thermal activation energies electronic conduction estimated basis plots published elsevier
cyber physical systems result integration information communication technologies physical systems particular case cyber physical power systems use communication technologies perform real time monitoring operations impacting systems characteristics reliability addition known failures communication network just relevant electrical network failures terms cyber physical power distribution systems reliability however operators performances response time decision quality investigated yet study authors introduce model operator response time present sequential monte carlo simulation methodology incorporates response time reliability indices estimation evaluate impact response time reliability indices method tested using different values operators average response time results show operators response time affects reliability indices related failures duration indicating fast decision directly contributes system performance authors conclude improvement reliability dependent electric communication components also dependent operators performance
background angioedema potentially life threatening condition hereditary hae acquired causes careful allows identification etiology attacks appropriate management cohort study based clinical practice setting aimed investigating clinical laboratory findings concerning different features patients recurrent referred single tertiary level center hae methods clinical laboratory data patients fulfilling criteria inhibitor deficient hae inh hae angiotensin converting enzyme inhibitor related idiopathic evaluated descriptive statistics analyzed means mann whitney test fisher exact test used group comparisons results patients diagnosed type hae type hae inh included patients concomitant autoimmune diseases group age disease onset diagnosis younger type hae groups diagnostic delay longer type hae levels lower inh type hae hae inh showed lower inh antigen function compared groups peripheral attacks frequent type hae airway abdominal oral attacks prevalent inh conclusion investigating clinical laboratory features recurrent without represents major topic facilitating early diagnosis improving treatment strategies heterogeneous condition karger basel
study examines whether firms business strategy influences reporting rely organizational literature develop prediction firms utilizing innovative strategy likely firms utilizing cost leadership strategy receive going concern material weakness opinions empirical evidence supports prediction specifically find among sample firms significantly likely receive going concern opinion analyze sample clients subsequently find less likely issue going concern opinions clients indicates type errors clients also find significantly likely receive material weakness opinion taken together evidence suggests business strategy significant determinant going concern material weakness reporting
timely accurate estimation winter wheat yield regional scale crucial national food policy security assessments near infrared reflectance sensitive leaf area index biomass winter wheat medium high canopy cover vegetation indices displayed saturation phenomenon however biomass medium high efficiently estimated using imaging data radar stronger penetration study following three objectives combine vegetation indices based previous studies estimating biomass winter wheat using imaging data combine imaging data model using particle swarm optimization pso algorithm estimate winter wheat yield iii compare results assimilation imaging data imaging data imaging data model using pso algorithm remote sensing data concurrent biomass yield sample fields acquired district china winter wheat growing season pso optimization algorithm used integrate model remote sensing data yield estimation modified triangular vegetation index radar vegetation index enhanced vegetation index good relationships biomass respectively results indicated predicted measured yield rmse agreement estimated data used dynamic input variable model estimated biomass data used dynamic input variable model predicted yield showed agreement measured yield rmse results show using biomass dynamic input variable provides better yield estimation using dynamic variable predicted biomass yield accurately estimated combining data model combining data model using pso algorithm results indicated pso based assimilation method used estimate winter wheat yield spot regional scale international society photogrammetry remote sensing inc published elsevier rights reserved
aiming problems low precision using traditional response surface method structural reliability analysis high nonlinear implicit performance function gaussian process regression model response surface checking design point method solving reliability iterative algorithm presented reduce errors response surface self adaptively thus new method namely gaussian process based response surface reliability analysis suspension bridge proposed research results show proposed method feasible proposed method advantages high efficiency excellent adaptability reliability analysis complex structural suspension bridge
shear mode piezoelectric materials widely used shunt damping vibrations utilizing surface interface shear stresses thick shear mode elastic constant mechanical loss factor change correspondingly piezoelectric materials different electrical circuits phenomenon makes possible control performance shear mode piezoelectric damping system designing shunt circuit however due difficulties directly measuring elastic constant mechanical loss factor piezoelectric materials relationships parameters shunt circuits rarely investigated paper coupling electro mechanical resonant system proposed indirectly measure variations elastic constant mechanical loss factor piezoelectric materials main idea transform variations elastic constant mechanical loss factor changes easily observed resonant frequency electrical quality factor coupling electro mechanical resonator based model relationships set theoretically equivalent circuit method validated finite element analyses finally prototype coupling electro mechanical resonator fabricated two shear mode plates investigate elastic constants mechanical loss factors different circuit cases piezoelectric plate resonant frequency shifts bandwidth changes observed experiments good theoretical analyses shunt conditions proposed coupling resonator obtained relationships validated limited
non point source water pollution mainly comes chemical become obstacle agricultural sustainability ecological health public policy tool assessing global ecological crisis environmental pollution ecological compensation important regional agricultural sustainability ecological compensation farmers receive governments based reduction fertilizer application optimal ecological economic levels study estimated ecological compensation standards nitrogen non point pollution city contingent method cost benefit method results showed range theoretical values ecological compensation nitrogen city depended upon optimal ecological economic nitrogen application levels willingness farmers accept compensation positively correlated farming experience education half farmers willing accept compensation based present study found ecological compensation standard controlling nitrogen non point pollution current economic development level
design analog filter using active building block gained significant attention become interesting research topic five inputs single output voltage mode universal filter using active building block namely voltage differencing differential difference amplifier presented paper proposed filter consists two two grounded capacitors presented circuit high impedance input voltage nodes low impedance output voltage node ideal cascade voltage mode circuit without use buffer circuits provide five output voltage functions band pass low pass band reject high pass pass responses high pass band pass functions inverting non inverting response achieved matching condition inverting double gain amplifier required easy select output response digital method natural frequency quality factor electronically tuned attractive microcontroller controllability verify validity proposed filter pspice simulation experimental results using constructed commercially available included measured results agree theoretical expect elsevier gmbh rights reserved
alcohol exposure result array morphological behavioral neurobiological deficits range severity despite extensive research field significant progress made especially understanding range possible malformations abnormalities molecular mechanisms alcohol responses development still understood multiple transcriptomic studies looking changes gene expression animal models however limited apparent consensus among reported findings effort address issue performed comprehensive analysis meta analysis suitable available expression data sets methodswe assembled microarray data sets gene expression mouse rat models consisting samples total ethanol exposed control animals analyzed data set differential expression used results perform meta analyses considering data sets together grouping time duration exposure pre postnatal acute chronic respectively performed network gene ontology enrichment analysis characterize identified signatures identified signatures differential expressed genes show support multiple studies overall changes gene expression extensive acute treatment prenatal development models considering analysis data together identified robust core signature genes regulated regulated genes functional analysis reveals representation genes involved protein synthesis mrna splicing chromatin organization meta analysis shows existing studies despite superficial findings share features allow identify common core signature set transcriptome changes important step identifying biological processes underlie etiology fetal alcohol spectrum disorders
parent origin dependent genetic factors important determinants prenatal development program adult phenotype however data magnitude specificity maternal paternal genome effects fetal bone lacking used bovine model dissect quantify effects parental genomes fetal sex maternal effects fetal skeleton analyzed phenotypic molecular relationships fetal muscle bone analysis bone morphometric weight parameters fetuses recovered day gestation term identified six principal components explained variation skeletal parameters parental genomes accounted variation bone wet weight limb ossification flat bone size axial skeletal growth limb length showed lesser effects parental genomes significant maternal effect gestational weight gain fetal sex affected bone wet weight limb length partitioning variation explained parental genomes revealed strong maternal genome effects bone wet weight axial skeletal growth whereas paternal genome controlled limb ossification data revealed strong maternal genome effects growth plate height trabecular thickness distal femur parental genome effects fetal bone maternal genome effects fetal serum paternal genome effects alkaline phosphatase correlations controlled bone wet weight controlled limb ossification respectively bone wet weight flat bone size correlated positively muscle weight negatively muscle expression expressed regulates growth factors mirna interference suggests muscle bone interaction via epigenetic factors american society bone mineral research
clinical practice guide examine diagnostic therapeutic management adult patients constipation abdominal discomfort spectrum irritable bowel syndrome functional constipation fall within framework functional intestinal disorders major personal health social impact altering quality life patients affected former subtype irritable bowel syndrome constipation altered bowel habit often along abdominal pain abdominal constipation characterised infrequent hard pass bowel movements often accompanied sensation incomplete underlying organic cause majority cases considered functional bowel disorder many clinical pathophysiological similarities two conditions constipation responds similar way commonly used drugs fundamental difference presence absence pain way severity disorders depends intensity intestinal symptoms also factors association gastrointestinal symptoms degree involvement forms perception behaviour functional bowel disorders diagnosed using rome criteria clinical practice guide rome criteria published end first part examined conceptual pathophysiological aspects alarm criteria diagnostic test referral criteria primary care second part reviews available treatment alternatives exercise fluid ingestion diet soluble fibre rich foods fibre supplements dietary components osmotic stimulating probiotics antibiotics essence ant psychological treatment sacral root surgery practical recommendations made elsevier espana slu
background attrition pediatric weight management negatively impacts treatment outcomes potentially modifiable contributor attrition unmet family expectations study aimed evaluate association adolescent parent treatment expectations attrition patients methods prospective uncontrolled single arm pilot trial conducted among pediatric weight management programs childrens hospital associations focus future collaborative parents adolescents completed expectations goals survey initial visit categories including healthier food physical activity exercise family support behavior weight management goals attrition assessed months results january august parents recruited reported children adolescents children years adolescents also self reported attrition rate months adolescents greater interest family support behavior skills associated decreased odds attrition months odds ratio confidence interval discordant parent adolescent responses category higher odds attrition months weight loss important weight management goal adolescents parents adolescents goal median weight loss goal attrition associated adolescent weight loss goals desired median median median conclusions assessing initial expectations help tailor treatment meet families needs especially focus family based change realistic goal setting
paper aims present methodology control position actuator objective improve position reference tracking order get better performances accuracy slip control originality work use model takes account nonlinear characteristic stiffness instead robustness approach nonlinearity managed using quasi representation additionally nonlinearity switching developed control law consequently nonlinear switching one moreover order use values controller current electric motor switching observer designed simulation results highlight efficiency proposed approach ifac international federation automatic control hosting elsevier ltd rights reserved
designed delivery system obtain efficient optimal nose brain transport sirna potentially useful treatment alzheimers disease selected cell penetrating peptide short peptide derived virus glycoprotein known increase pathway neuronal cells optimal molar ratio sirna elucidated complex two encapsulated propose chitosan coated solid lipid nanoparticles nasal delivery system capable exploiting olfactory trigeminal nerve pathways coating process effect zeta potential obtaining positively charged nanoparticles sirna protection positive charge coating formulation ensured particles also prolonged residence time nasal cavity studied cellular transport sirna released using model epithelial like phenotypes found sirna monolayer greater extent released studied formulations bare sirna primarily chitosan coated elsevier rights reserved
social bonds critical survival adaptation periods bond formation involve neurobiological systems mediated social behavior theoretical accounts animal studies suggest similarity parent infant pair bonding hypothesis yet directly tested humans study recruited three groups human adults parents child last months new began romantic relationship within past months non attached measured plasma oxytocin beta beta end biomarkers affiliation reward stress response systems micro coded gaze affect parents infants among new social interaction significantly increased periods parental romantic bonding highest new contrast beta end highest new parents lowest biomarkers became tightly coupled periods bond formation inter correlation among hormones highest romantic bonding structural equation modeling indicated effects beta end behavioral mediated impact highlighting integrative role system supporting human social affiliation findings suggest periods bond formation accompanied increased activity cross talk among systems underpinning affiliation reward stress management research multidimensional process bonding light effects attachment health elsevier inc rights reserved
paper first introduce generalized system definition set generalized system given called generalized set achieve control generalized sets applying classic control methods gradient control optimal control addition synchronization two different generalized sets implemented using gradient control optimal control simulations illustrate effectiveness correctness two control methods results displayed computer graphics
development level economy society improves technology changes quickly human society degree also continuously distinguishing feature information age gradual promotion internet computer meanwhile internet technology computer technology also prevent development trend present internet computer successfully entered field production life peoples work learning living modes change greatly although internet technology computer technology establish close relationship field social life people ignore potential safety hazard internet computer caused peoples production life basis paper aims briefly introduce computer network security analyze reasons computer network security discuss feasible measures improve computer network security propose suggestions improving level computer network security
carried animal toxicity tests chemicals chemical safety program implemented ministry economy trade industry japan tested combined repeat dose developmental reproductive toxicity test test chemical administered daily gavage week old rats doses males treated beginning mating females treated mating day lactation decreased spontaneous locomotion decreased respiratory rate incomplete opening observed sexes resolved within min administration suggesting central nervous system depression notable changes observed body weight food consumption functional battery tests blood test increased liver weight diffuse hepatocyte hypertrophy observed sexes biochemical histopathological changes related increased kidney weight increased droplets observed males immunohistochemical staining indicated alpha globulin nephropathy male rat specific toxicity although kidney weight also increased females considered adverse effect histopathological changes weights postnatal day decreased still decreased postnatal day data indicated observed adverse effect level repeated dose reproductive developmental toxicity
paper discusses critically give form participatory design processes age ubiquitous participation often superficial application various societal domains processes instruments participation often cut loose political context stories happened process clear develops via different design moves towards defined plot leaving alternative narratives inspired history reject perspective explore way give renewed attention political context giving form design process process focuses future creates alternatives past speculate future evaluate thinking participatory architecture urban planning process
autism spectrum disorder asd characterized impairment social communication restricted repetitive interests included diagnostic characterization aspects face processing learning shown disruptions stages development asd although exact nature extent impairment vary age level functioning asd sample task demands review examine nature face attention perception learning individuals asd focusing three broad age ranges early development middle childhood adolescence adulthood propose early delays basic face processing contribute atypical trajectory social communicative skills individuals asd contribute poor social learning throughout development face learning life long necessity social world individual age thus addressing source impairment asd trajectory ability throughout lifespan targeted treatments serve positively impact lives individuals struggle social information understanding
traditional chinese herbal drugs used thousands years chinese known name traditionally used chinese japanese medicines treatment anxiety asthma depression gastrointestinal disorders headache moreover extract major constituent currently dietary supplements cosmetic products much pharmacological activity reported major compounds notably antioxidant anti inflammatory antibiotic effects however mechanisms underlying elucidated clinical trials published vitro vivo toxicity studies also published indicate intriguing features present review aims summarize literature composition utilisation pharmacology safety
aim study describe detail characteristics compliance laboratories united states applying commission transcranial doppler methodsthis retrospective study laboratories used database extract laboratory characteristics guideline compliance metrics laboratories demonstrated hospital based located south corresponding location stroke belt states cases interpreting physicians evaluated process established practice common training pathway majority obtained additional vascular interpretation case studies frequent indications hemorrhage stroke carotid stenosis although laboratories previously delayed due incomplete studies findings report diagnostic criteria findings report waveforms images conclusionsthe results suggest significant differences laboratories laboratories represented centers medicaid medicare services cms claims data addition accurate study reporting physician training ongoing quality improvement activities optimized laboratories applying information learned study educational strategies professional organizations including tailored help improve practice
paper analyses influence different solar screens pss annual daylight conditions expressed using climate based daylight metrics pss design require parametric studies often complex time consuming due large number simulations hence new methodology proposed optimize pss design applying design experiments using orthogonal arrays case study perspective conducted involves office space spain goal assess effect following pss design variables performance percentage matrix shape orientation results reveal optimized pss increase area reduce area compared reference models pss method reduces number simulations required save time initial stages building design
one health emerging concept stresses linkages human animal environmental health need interdisciplinary communication collaboration address health issues including emerging diseases climate change impacts human animal bond promotes complex problem solving using systems framework considers interactions humans animals shared environment many medical educators yet familiar concept one health approach endorsed number major medical public health organizations beginning implemented number medical schools research setting one health opens new avenues understand detect prevent emerging infectious diseases also conduct translational studies across species clinical setting one health provides practical ways incorporate environmental animal contact considerations patient care paper reviews clinical research aspects one health approach illustrative case updating model proposes basic set one health competencies training education human health care providers
platelets actively participate inflammatory processes drive diseases atherosclerosis rheumatoid arthritis cancer metastasis however platelets also anti inflammatory anti properties received less consideration past review highlight recent findings role platelets host defense describe regulatory pathways modulating immune responses furthermore discuss role platelets resolution inflammation tissue repair conceptual changes contribute understanding platelet biology disease
letter propose novel method unsupervised change detection landsat images using multiobjective evolutionary algorithm proposed method minimizes two different objective functions using provide tradeoff objective functions used evaluating changed unchanged regions difference image separately difference image obtained using structural similarity index measure method provides combination comparisons contrast structure two images evolving population solutions set pareto optimal solution estimated single run find best solution markov random field fusion approach used experiments real world data sets show efficiency effectiveness proposed method
longitudinal cross sectional profiles channels altered presence however available literature suggests considered analyses bank profiles threshold channels experimental study reported downward applied parabolic channels based force theory order determine effect longitudinal cross sectional profiles observed sediment transport threshold channels increased downward applied parabolic shape hold channels formed new cross sectional shape flat bed two curved banks achieved stability reason increased sediment transport threshold channel application downward sought analysing time averaged velocities empirically derived exponential expression developed bank profiles threshold channels affected relationship among hydraulic parameters stable channel downward also suggested basis experimental observations
compensation hysteresis nonlinearities smart material based actuators presents challenging task applications many approaches proposed literature including inverse scheme advantage scheme avoid direct model however approach mainly developed model focusing model utilized describe actuators paper inverse compensation approach model using inverse structure developed since input signal implicitly involved model imposes great challenge construct inverse function model obtain explicit expression input signal implicit form inverse technique applied model decomposed non memory part memory part using separation requires solve inverse non memory part obtain explicit expression input signal thus avoiding constructing inverse entire complex dual integral formulation model experimental results actuator demonstrate effectiveness proposed approach
article describes examination sociodemographic characteristics adult children particularly baby caregivers provide financial care older parents dementia sample including children dementia caregivers aged years selected nationally representative sample health study exact logistic regression revealed race provision financial assistance caregiver children number children significantly associated financial caregiving parents non white caregivers likely provide financial care parents parents law dementia children provide financial assistance children less likely provide financial care parents dementia current findings present valuable new information sociodemographic characteristics adult children provide financial assistance parents dementia inform research programs services dementia caregiving
smart grids often analyzed using top approach starting communication control technologies evolution focus effects active passive users terms new services higher efficiency quality supply however bottom approach virtual power plants promising instruments promoting effective integration distributed generation energy storage devices valid means enabling consumers respond load management signals operated supervision scheduling aggregation factors distributed energy resources economy energy network paper presents new algorithm optimize day ahead thermal electrical scheduling large scale contains many small scale producers consumers distributed large territory energy storage processes algorithm also takes account actual location der public network specific capability thermal electrical generator models load storage devices detailed flexible rates incentives framework several respect previous literature proposed case study results also described discussed
new quantum dialogue protocol designed using continuous variable two mode vacuum states due property two communication parties encode secret information optical modes translation operations communication party secret information counterparts help secret information bell basis measurement results security proposed quantum dialogue protocol guaranteed correlation two mode vacuum states states performed translation operations randomly selected time compared discrete variable quantum dialogue protocols proposed continuous variable quantum dialogue protocol easy realize perfect utilization quantum bits
introduction objectives two objectives study examine effects introduction post event information correct incorrect memory central peripheral aspects given situation determine effects additional information level confidence claimed participants regarding reported memories method one hour half watching film participants presented three types information means open questions leading misleading neutral one week later carried recognition task assess extent answers results memory event accurate concerning central aspects event peripheral elements misinformation effect appeared central condition addition following presentation incorrect information participants certain answers related central aspects conclusion results highlight importance taking account centrality factor studies misinformation phenomenon elsevier masson sas rights reserved
background effect hepatitis virus hcv cell recovery treated hiv infected children poorly understood objective compare cell recovery hiv hcv children recovery hiv children method studied hiv hiv hcv children receiving antiretroviral therapy art median follow period years interquartile range years dataset came pediatric hiv cohort hiv hcv study within european pregnancy paediatric hiv cohort collaboration fitted asymptotic nonlinear mixed effects model cell age standardized counts children investigated factors predicting speed extent recovery results found significant impact hcv either long term age adjusted counts scores however rate increase score slower hiv hcv children compared counterparts children starting art younger ages higher long term scores started older conclusions hiv hcv children receiving art slower cell recovery hiv children hiv hcv impact pre art long term scores early treatment hiv hcv children art encouraged
paper multi mode parallel hybrid power train called smart transmission proposed assessed terms fuel economy use single motor generator gear enables provide remarkable flexibility four operational modes including parallel hybrid mode based novel configuration fuel consumption model newly developed simulated analyze fuel economy performance compared power split hybrid system conventional manual transmission city highway cycles shows best efficiency highway driving reducing unnecessary energy loss electric motor moreover thanks brake regeneration efficient engine operation specific operational modes fuel economy city cycle comparable power split hybrid system even though uses just single electric motor
growing evidence members cytochrome enzymes contribute regulation normal prenatal development cyp convert acid four acids biologically active molecules involved cell signaling almost known localization expression tissues human prenatal development spatio temporal expression pattern human embryonic fetal liver kidney investigated immunohistochemical method cyp expressed already early stages development embryonic fetal tissues early week iud week iud liver week iud kidney kidney cyp expressed tubular system diverse cyp distribution along axis suggest role cell differentiation moreover detected higher level organs adult tissue samples
determined whether approved myelofibrosis drug ruxolitinib inhibitor janus kinases anti cancer agent solid tumors ruxolitinib synergistically interacted dual inhibitors breast lung ovarian brain cancer cells knock target drug effects combination ruxolitinib inhibitor rapidly akt activated alpha parallel drug combination reduced expression bcl increased expression activated forms akt mtor prevented drug induced decline bcl levels expression maintained akt mtor activity presence drugs protected tumor cells drug combination expression dominant negative alpha prevented increase expression protected tumor cells drug combination loss mtor activity associated increased phosphorylation formation initially localized mitochondria subsequently knock suppressed drug induced activation toxic domain proteins bax tumor cell killing knock apoptosis inducing factor protected tumor cells drug combination whereas blockade caspase signaling drug combination released increased nuclear localization day transient exposure tumors ruxolitinib profoundly reduced tumor growth following days grown tumors exhibited high levels bad phosphorylation activation kappa data demonstrate essential component ruxolitinib inhibitor drug combination explored phase trial solid tumor patients
natural repair mechanism demyelinating disorders central nervous system cns multiple sclerosis several animal models used study demyelination among toxic animal models oral administration toxin leads white gray matter demyelination contrast focal demyelination models include application toxin bromide injection procedure generates local disruption blood brain barrier thus trigger local inflammatory reaction consequently influence demyelination order study consequences applied injections model demyelination mediated independent procedure immunohistochemistry performed detect presence lymphocytes activated glial cells injection area blood protein used assess integrity myelin staining evaluate demyelination processes injection led local disruption shown local blood proteins along injection lymphocytes detected tendency higher however changes influence demyelination processes site injection corpus cerebral cortex results suggest local injection major impact cns demyelination
insufficient excessive thyroid hormone levels fetal development cause long term neurological cognitive problems studies animal models perinatal hypo hyperthyroidism suggest problems consequence formation maladaptive circuitry cerebral cortex persist adulthood used mouse models maternal hypo hyperthyroidism investigate long term effects altering thyroxine levels pregnancy corresponding embryonic days dynamics adult offspring perinatal hypothyroidism linked visual processing deficits humans performed chronic two photon imaging primary visual cortex found decrease increase maternal serum levels associated atypical steady state dynamics adult offspring hypothyroid offspring exhibited axonal branch dynamics indicative abnormal increase connectivity whereas changes offspring indicative abnormal decrease connectivity collectively data suggest alterations prenatal levels cause long term synaptic instability circuits impair early stages visual processing
fractional order controllers among emerging solutions increasing closed loop performance robustness however applied mostly stable processes applied unstable systems tuning technique uses known frequency domain procedures complex genetic algorithms brief proposes special type controller novel tuning procedure simple involve optimization routines controller parameters determined directly using overshoot requirements study stability systems tuning procedure given general case class unstable systems pole advantage proposed controller consists simplicity tuning approach case study considered brief consists magnetic system experimental results provided show designed controller indeed stabilize magnetic system provide robustness modeling uncertainties supplementary loading conditions comparison purposes simple pid controller also designed point advantages using proposed controller
introduction aim interest gut brain axis emerging evidence intestinal microbiota influence central nervous system function led hypothesis probiotic supplementation positive effect mood psychological symptoms depression anxiety although several human clinical trials investigated results inconsistent therefore systematic review meta analytic approach chosen examine probiotic consumption effect psychological symptoms methods online databases pubmed scopus cochrane library searched relevant studies july randomized placebo controlled measured preclinical psychological symptoms depression anxiety perceived stress healthy volunteers pre post supplementation probiotic included control differences scales measurement data converted percentage change standardized mean difference probiotic control groups investigated using software random effects model used analysis heterogeneity assessed using statistic quality assessment undertaken using scale results seven studies met inclusion criteria provided data nine comparisons studies passed quality analysis meta analysis showed supplementation probiotics resulted statistically significant improvement psychological symptoms standardized mean difference confidence interval compared placebo conclusion results show probiotic consumption positive effect psychological symptoms depression anxiety perceived stress healthy human volunteers
virus disease caused virus transmitted primarily people virus disease symptoms including mild fever skin rash muscle joint pain headache symptoms normally last days scientific consensus virus cause syndrome association neurological complications also investigated aim present review summarize discuss evidence base data regarding virus related complications copyright wolters kluwer health inc rights reserved
gram positive aerobic pathogen usually affects immunocompromised patients report case pulmonary infection caused rare species year old woman received treatment multiple sclerosis invasive pulmonary infection successfully treated
investigated interaction approach behaviours measured performance resource gathering task self reported global life stress predict substance use hypothesis high levels approach behaviour combination high life stress predict elevated substance use guided reinforcement sensitivity theory gray ninety three young adult students women men completed computerized resource gathering task questionnaires assessing global life stress substance use consistent hypothesis approach behaviour positively related substance use individuals high life stress findings suggest person environment interactions useful understanding substance use discuss approach motivated individuals different substance use outcomes function stressful contexts copyright john wiley sons ltd
design designers explore design space gain insight feasible solutions learn alternatives optimization selection design space consists multidimensional sets data order select best design among numerous alternatives designers use several different graphs study test find appropriate graph indicate best solution corresponding set objectives represented design scenario constraint done shortest possible time three graph types tested three different design scenarios one car chosen total response quality index proposed computes quality designers choice given scenario total tests participants performed parallel coordinates plot proved best graph selection design
one main objectives spanish sleep society promote healthy sleep general population health professionals document aims conduct review current scientific literature sleep habits serve basis establish set general recommendations regarding healthy sleep use general population spain identify main challenges faced research sleep habits document developed multidisciplinary team made members spanish sleep society experts paediatric sleep medicine clinical neurology physiology psychology existing scientific literature dealing sleep habits general population reviewed following aspects addressed current state sleep habits spanish population generic review optimum number hours sleep impact environmental setting noise temperature illumination etc hours sleep diet sport together several specific sections children teenagers shift workers drivers different vehicles conclusions aspects addressed document resulted set final general recommendations serve guide general population health professionals likewise principal environmental challenges future lines research also discussed
cellular automata artificial neural networks used researchers last three decades simulate land use change conventional ann models assign cell one land use class reality cell belong several land use classes simultaneously recently developed multi label concept overcomes limitation land change science although concept new paradigm classes shown considerable merit several applications studies land change science applied addition determining transition rules conventional difficult number drivers large since shown potential model consider neighborhood effects ann shown effective determining transition rules integrated ann model overcome limitations tool study specifically extended ann based land transformation model based model concept create integrated modeling framework also compared using standard evaluation measures differences proposed integrated model conventional based model called parameterization made using learning testing procedure common machine learning results showed modified model produced consistently better fit calibration values compared outcome modified model used managers decision makers improved urban planning
background diet affect kidney health effects inflammation objective tested whether adapted dietary inflammatory index associated kidney function whether effects diet chronic low grade inflammation explain association methods observational analysis elderly community dwelling participants aged independent cohorts longitudinal study adult men men prospective investigation vasculature men women calculated food records combining proinflammatory anti inflammatory effects nutrients vitamins trace elements validated serum reactive protein crp concentrations estimated glomerular filtration rate egfr assessed serum creatinine associations egfr investigated crp considered mediator results adjusted analysis higher associated higher crp beta lower egfr chronic kidney disease epidemiology collaboration ckd ckd crp also inversely associated egfr mediation analyses showed total effect kidney function ckd ckd equations respectively explained mediated serum crp findings similar cohort analyzed separately conclusions proinflammatory diet associated systemic inflammation reduced kidney function combined analysis community based cohorts elderly individuals results also suggest systemic inflammation one potential pathway dietary pattern linked kidney function
human brain complex yet origin simple tubular structure development fetal period characterized series accurately organized events underlie mechanisms dramatic structural changes fetal development revealing detailed anatomy different stages human fetal brain development provides insight understanding highly ordered process also neurobiological foundations cognitive brain disorders mental retardation autism schizophrenia bipolar language impairment diffusion tensor imaging dti histology complementary tools capable fetal brain structures macroscopic microscopic levels review structural development fetal brains characterized dti histology major components fetal brain including cortical plate fetal white matter cerebral wall layer ventricle delineated dti histology anisotropic metrics derived dti used quantify microstructural changes dynamic process human fetal cortical development prenatal development animal models fetal white matter pathways dti based reveal growth patterns individual white matter tracts connectivity detailed anatomical accounts structural changes fetal period provide clues detecting developmental cognitive brain disorders early stages anatomical information dti histology also provide reference standards diagnostic radiology premature newborns published elsevier ltd rights reserved
background bladder disorders associated interstitial frequently characterized increased pain purposes study examine effects blocking mammalian target rapamycin mtor bladder activity pain evoked underlying mechanisms responsible role mtor regulating cystic sensory activity results expression mtor mtor mediated phosphorylation ribosomal protein kinase binding protein kinase pathway amplified rats compared control rats blocking mtor infusion rapamycin attenuated bladder hyperactivity pain addition blocking signal pathway attenuated activities mtor accompanied decreasing bladder hyperactivity pain inhibition either mtor blunted enhanced spinal substance gene related peptide rats conclusions data first time revealed specific signaling pathways leading induced bladder hyperactivity pain including activation mtor inhibition pathways cystic pain targeting one signaling molecules present new opportunities treatment management overactive bladder pain often observed
contact sports athletes often suffer various skin disorders inflammatory diseases bacterial fungal origin atopic dermatitis psoriasis etc resulting long breaks training athletic performance implies intense skin skin contact creates perfect conditions transmission infectious agents following standard rules hygiene directly competition training exclude possibility get infection partner characterize skin microbial composition current manifestation skin disorders analysis performed absolute predominance bacillus genus profiles skin observed contrast existing literature data classic microbiological approaches allowed detect forms microorganisms skin appeared whereas non athletes bacteria skin shifts microbial community cause emergence skin diseases revealed properties help design highly effective contact sports hygiene
justice therapeutic measures recently introduced youth justice systems measures childrens court play crucial role success however little research undertaken views measures article addresses gap presenting results interviews undertaken childrens court new south australia research suggests philosophy therapeutic measures consider poorly understood poorly implemented implications findings discussed
one important parts developing kind software check sustainability software done software testing software engineers varied number test cases taken account test done using unified modelling language using combination hybrid revised genetic algorithm along colony optimization test come favour finding maximum minimum coverage novel approach tested application smart card users security user order increase security smart card security novel approach smart card security proposed decision making structure self systems based software engineering details obtained total number smart card users approach total flaws present system easily detected along maximum possible paths novel technique software testing guarantees minimum time considered maximum coverage elsevier ltd rights reserved
background postural instability one disabling motor symptoms parkinsons disease indices multi muscle new measurements postural stability objectives explored effects dopamine replacement drugs multi muscle stabilizing center pressure coordinate adjustments prior self triggered perturbation patients parkinsons disease hypothesized synergy indices synergy adjustments improved dopaminergic drugs methods patients stages iii performed whole body tasks drugs standing muscle modes identified factors muscle activation space synergy indices stabilizing center pressure anterior posterior direction quantified muscle mode space load release task results dopamine replacement drugs led consistent organization muscles stable groups muscle modes drugs patients showed larger indices synergy adjustments contrast medication effects seen postural adjustments performance indices conclusions dopamine replacement drugs lead significant changes characteristics multi muscle parkinsons disease studies provide biomarker sensitive problems postural stability efficacy dopamine replacement therapy elsevier ltd rights reserved
article aims analyze whether change characteristics cooperation company using object analysis projects established university external partners last five years managed institutional support scientific technological development foundation among results emphasized cooperation projects environment characterized cases low long intervals regarding type private companies main activities developed university study activities research development projects another important factor partnerships private companies occurred center exact sciences technology departments civil engineering materials engineering number projects volume resources furthermore possible note growth potential cooperative activity company
term refers manifestation multiple somatic complaints explained organic changes according literature percent medical visits related medical training put enough emphasis evaluation possible psychological background certain somatic symptoms physicians feel make diagnostic therapeutic efforts patients also feel anxiety intensity complaints increase stress important factor process stress reduction improvement coping key elements treatment guidelines chronic diseases evidence based interventions range short counselling medication cognitive behavioral psychotherapy short minutes structured intervention implemented primary secondary care certain cases result significant decrease somatic symptoms anxiety
evaluate whether reactive protein crp including variation within normal range predictive long term disease outcome juvenile idiopathic arthritis consecutive patients newly diagnosed included prospectively defined geographic areas countries inclusion criteria availability baseline serum sample within months disease onset year clinical assessment data systemic onset included crp measured high sensitive elisa detection limit one hundred thirty participants median follow time months range included follow patients remission medication absence remission associated elevated level crp baseline odds ratio confidence interval applying cutoff normal upper limit risk achieving remission increased variations crp within normal range predictive impact disease activity follow baseline levels esr available patients elevated esr associated absence remission multivariable logistic regression analysis results study indicate baseline crp concentrations predictive poor outcome year follow demonstrate predictive value crp variations within normal range
present novel image analysis based method automatically distinguishing low intermediate high grades breast cancer histopathology multiple level feature set including pixel object semantic level features derived convolutional neural networks cnn extracted hematoxylin eosin stained breast biopsy tissue studies women patients multilevel features allow characterization cancer morphology also extraction structural information within histopathological images study improved hybrid active contour model based segmentation method used segment nuclei images semantic level features extracted cnn approach described proportions nuclei belonging different grades conjunction pixel level texture object level architecture features create integrated set image attributes potentially outperform either subtype features individually utilized cascaded approach train multiple support vector machine svm classifiers using combinations feature subtypes enable possibility maximizing performance leveraging different feature sets extracted multiple levels final class cancer grade combining scores produced individual svm classifiers employing light three layer cnn model parallel computing presented approach computationally efficient applicable large scale datasets method achieved accuracy low versus high low versus intermediate intermediate versus high overall accuracy discriminating low intermediate high grades histopathological breast cancer images suggested grading method useful developing computational diagnostic tool differentiating breast cancer grades enable objective reproducible alternative diagnosis elsevier rights reserved
order improve efficiency quality tests optimize process quality control paper deeply investigates main aspects quality tests floor application hierarchical model quality tests firstly set paper layout hardware network analyzed integration software floor application introduced advanced technology guide post time advanced technology applied quality tests discussed paper including apparatus instrument technology data acquisition communication link technology computer programming technology
three studies conducted establish extent life drawing effective promoting positive body image study women showed life drawing positive impact state body image observed human model non human objects study women men showed life drawing positive impact state body image women men irrespective whether observed sex congruent incongruent model study showed participating weekly life drawing sessions week period resulted significantly elevated trait positive body image body appreciation body reduced social anxiety however intervention significant impact negative body image drive results highlight potential life drawing promoting positive body experiences elsevier ltd rights reserved
although geotextile considerable potential soil conservation field studies impacts soil particle size distribution nutrient conservation scant hence field experiments conducted east degrees degrees study impacts palm geotextiles particle size distribution changes selected nutrients total geotextile constructed palm west africa palm south america leaves termed respectively ten runoff plots degrees slope established duplicate treatments treatments bare soil permanent grass iii bare soil buffer zones area coverage similar lower end plots bare soil buffer zones area coverage similar lower end plots completely covered initial final samples collected analysed sand fine medium coarse fine medium coarse clay selected nutrients results revealed soil clay contents significantly decreased completely covered plots concomitant increase proportion sand content similar years buffer strip plots also lower soil clay contents indicating palm geotextile cover significantly affected particle size distribution even years cover within buffer strip plots resulted notably higher decrease mean clay content concomitant increase mean sand contents compared mean clay sand contents bare soils within plots data indicate total total contents completely covered plots significantly increased total content decreased similar years however except plots plots significant increases total concentrations buffer strip plots also significant decreases total contents initial contents increases total contents within complete cover plots significantly higher buffer strip plots buffer strip plots significantly effects changes selected nutrients total concentrations summary evident despite significant decreases soil clay total contents use buffer strips successful improving selected soil properties elsevier rights reserved
many aspects human adaptation changing environment remain unanswered even substantial progress made towards better understanding populations evolution recent years paper proposes explanatory model evolutionary adaptation seems account fairly certain qualitative dynamic patterns pointed model characterised presence feedback loops addition feedforward channels certainly present although importance feedback evolution process widely accepted today explicit representation phenomenon presented yet task undertaken control engineering perspective note claim scientifically accurate simply stimulate discussion among experts delicate manifold field specifically proposed model consists four nested loops characterised different time scales different spheres basis simple model considerations system stability transient asymptotic behaviour made
background discrepancy subjective objective severity depressive syndromes proposed predictor treatment outcome suicidal risk depression associated depressive cognitive distortions recent study reported evening type depressed patients showed higher depressive cognitions morning type patients therefore hypothesized genetic factors affecting evening preference carrying clock allele influence discrepancy method tested hypothesis patients affected major depressive episode course bipolar disorder severity depression evaluated using self rated beck depression inventory bdi observer rated hamilton depression rating scale measures bdi discrepancy score calculated effects polymorphism score depressive cognitive distortions measured cognitions questionnaire examined results carriers showed higher bdi discrepancy scores mediation analysis using procedures revealed dimension depressive cognition fully mediates association polymorphism bdi discrepancy limitations many gene polymorphisms clock also influence bdi discrepancy depressive cognitive distortions conclusion current results suggest factors affecting biological clock influence non clock psychopathological features mood disorders
limited information exists application evidence based treatments eating disorders among diverse populations increasing number international immigrant clients provides pressing need culturally responsive treatments case study highlights eating disorder treatment incorporates behavior therapy cultural adaptation guidelines study culturally adapted behavior therapy treatment year old female chinese international student suffering eating disorder depression cultural adjustment issues particular case addresses chinese cultural values including interdependence values clients presenting issues treatment cultural modifications made case conceptualization behavior therapy discussed client reported significant decrease distress increase quality social relationships increase satisfaction social roles results provide support effectiveness importance integrating cultural adaptation evidence based treatment clinical implications recommendations clinicians students provided
media violence poses threat public health leads increase real world violence aggression research shows television film violence contribute short term long term increase aggression violence young viewers television news violence also contributes increased violence principally form acts aggression video games clearly capable producing increase aggression violence short term although long term longitudinal studies capable demonstrating long term effects conducted relationship media violence real world violence aggression moderated nature media content characteristics social influences individual exposed content still average overall size effect large enough place category known threats public health
chondrocytes enables long term vitro culture however capacity transformed cells varies thus highlighting need develop proliferative cell line hypertrophic differentiation controlled study large antigen human reverse transcriptase employed pooled chondrocytes vector mediated transduction either combination transformed chondrocytes stably multiple resulted significantly lower expression specific collagen mrna regulation hypertrophic marker collagen three dimensional cultures promoter driven gfp reporter constructed real time monitoring differentiation significant increase promoter activation observed cultures treated growth factor tgf native articular phenotype large antigen chondrocytes vectors allowing either constitutive inducible expression cultures expressing chondrocytes secreted significantly higher levels extracellular matrix regulating collagen mrna expression systems similar patterns observed staining high levels collagen mrna protein maintained constitutive reflecting differentiation significantly lower expression achieved inducible conclusion chondrocytes results stable proliferation reduction potential whilst modulation expression enabled control hypertrophic characteristics cell wiley periodicals inc
background seasonal affective disorder sad characterized recurrent episodes major depression seasonal pattern therapy choice light therapy suggested administered relative patient optimal timing earlier morning evening types study aims retrospectively investigate relation effect fixed time morning population sad patients methods data four different studies conducted university center psychiatry netherlands used data patients used women depression score determined structured interview sad prior prior preference patient determined questionnaire patients received clinic independent results patients average score significant relationship score therapy success measured sad patients divided ranging definite morning moderate evening significant relation score therapy success found limitations retrospective design conclusions lack significant relationship measured therapy success fixed indicate anti depressive effect morning light sad patients explained phase shift biological clock elsevier rights reserved
grow divide creating variability growth pole age growth properties antibiotic investigate importance growth pole age growth properties determining spectrum responses mycobacterium challenge used combination live cell microscopy modeling prospectively identify subpopulations altered susceptibility found two subpopulations increased susceptibility initiation treatment susceptible cells either small early stages cell cycle large later stages cell cycle contrast temporal window susceptibility tolerance associated factors inherited division long birth length mature growth poles thus response complex due combination differences established asymmetric division timing treatment relative cell birth
increasing need understand patient outcomes osteoporosis article discusses fracture osteoporosis lead cycle impairment driven complex psychosocial factors profound impact physical function activity time information required treatments impact physical function increasing need understand patient centred outcomes osteoporosis clinical research management multi method paper provides insight effect patients physical function everyday activity data collected three sources targeted literature review physical function conducted medline embase psycinfo secondary thematic analysis transcripts patient interviews conducted develop patient reported outcome instrument transcripts coded focus impact daily activities physical function without fracture history discussions literature review secondary qualitative analysis results three clinical experts review interpret importance implications findings results suggest particularly fracture profound impacts physical function activity impacts accumulate time cycle impairment fracture leads longer term physical function including loss muscle activity avoidance reduced physical capacity turn leads greater risk fracture potential physical restrictions cycle impairment complex physical psychosocial treatment related factors comorbidities beliefs physical activity fracture risk influence physical function everyday activity information treatments impact physical function benefit healthcare professionals persons making treatment decisions improving treatment compliance persistence impacts salient patients fracture incidence
visual tracking learning robust efficient appearance model challenging task model learning determines strategy frequency model updating contains many details affect tracking results self learning recently attracting considerable interest fields machine learning computer vision inspired learning principle underlying cognitive process humans whose learning process generally easier samples complex aspects task propose tracking method integrates learning paradigm visual tracking reliable samples automatically selected model learning contrast many existing model learning strategies visual tracking discover missing link sample selection model learning combined single objective function approach sample weights model parameters learned minimizing single objective function additionally solve real valued learning weight samples error tolerant self function considers characteristics visual tracking proposed demonstrate robustness efficiency tracker recent tracking benchmark data set video sequences spie
background studies published association mental disorders violence based general population studies focus different types violence adjusting violent victimization taking account limitations previous population studies method data used first two waves netherlands mental health survey incidence study nationally representative face face survey general population aged years violence differentiated physical psychological violence intimate partner children person general dsm diagnoses assessed composite international diagnostic interview version results psychological violence occurs considerably frequently physical violence showed almost identical associations mental disorders adjustment sociodemographic characteristics main categories common mental disorders associated violence strongest associations found externalizing disorders substance use impulse control antisocial personality disorder additional adjustment violent victimization negative life events social support diagnostic correlates lost significance whereas substance use particular alcohol disorders still associated types violence conclusions increased risk violent offending among people common mental disorders substance use disorders attributed factors mental illness
software defined networking relies open network devices achieved defining new communication interfaces network operating systems changing traditional decision making logic regular tcp networks network functions virtualization turn permits network functions traditionally performed physical intrusion detection prevention although improve flexibility management computer networks remains vulnerable major network security problems distributed denial service attacks attacks typically result disruption network services resources paper introduce answer architecture combines features create sophisticated network resilience strategies answer relies feedback control loop explores features monitor analyze behavior network infrastructure indicating whether parts existing resilience strategy achieve satisfactory results entire resilience strategy needs added replaced experiments demonstrate answer rapidly identify handle distinct anomalies different scenarios indicating reconfiguration deployment resilience strategies performed real time
depressive disorders among common mental illnesses around world children children adolescents affected markedly impair psychosocial development associated higher rate morbidity mortality throughout life many physicians treatment approaches effective treatment planned systematic literature search carried electronic databases study registries manual search studies mostly randomized controlled trials rcts identified summarized evidence tables recommendations agreed upon consensus conference review summarizes evidence complementary treatment methods evidence complementary treatment methods art music therapy sleep deprivation exercise therapy transcranial magnetic stimulation relaxation computer based therapy light therapy omega treatment low evidence due missing studies studies poor quality methods light therapy relaxation stress reduction sleep deprivation limited indication effectiveness without sufficient evidence practical guidance urgent need adequately informative comparative studies treatment depression children adolescents considering also complementary methods
objectives evidence supports girls less boys performing ball skills study examined immediate long term effects ball skill intervention preschool age girls ball skill performance design randomized controlled trial methods girls age months randomly assigned high autonomy based week motor skill intervention childrens health activity motor program min control group free play ball skill assessed pretest posttest retention test weeks using object control subscale test gross motor development edition treatment efficacy examined using linear mixed models two models fit one short term changes pretest posttest one long term changes pretest retention results linear mixed models revealed significantly time treatment interaction models post hoc analysis confirmed girls experienced significant gains ball skills pretest posttest pretest retention significantly higher ball skills scores posttest retention conclusions study demonstrates positive effects ball skill intervention improving girls ball skills short long term findings suggest early childhood interventions focus development ball skills young girls avenue improve girls ball skill performance sports medicine australia published elsevier ltd rights reserved
background objective study assess anxiety depression disorders among patients diagnosed copd investigate correlation disease severity quality life tobacco use methods observational study performed january september among patients diagnosed copd copd staging according gold criteria anxiety depression assessed using hospital anxiety depression scale attacks evaluated based icd criteria results almost sample smokers medium years medium score overall mean modified medical research council scale mean copd assessment test cat score study participants copd exacerbations year mean distribution anxiety depression symptoms scores among copd subjects respectively smokers smokers similar scores regard anxiety depression presence attacks results bivariate correlations indicated associations anxiety depression attacks disease severity poor quality life patients copd regardless current tobacco use status conclusions conclusion results study indicate anxiety depression attacks constant characteristics among copd patients regardless current tobacco use
cell lymphoma follicular helper derived neoplasm displaying peculiar appearance biological complexity new mutations described contribute elucidating underlying pathogenetic events disease behaves typically affects elderly patients outcomes reported containing regimens poor therefore autologous transplantation first remission offered whenever possible newer approaches urgently needed relapsed refractory patients newly approved agents show activity pretreated patients response durations short innovative induction strategies biologic agent designed enhance response quality facilitate transplantation prolong survival
sufficient first aid equipment essential treat injuries football fields deficits first aid field still present youth football injury pattern youth football one season first aid equipment youth football analyzed retrospectively price abc procedure served basic principles emergency management assess need first aid equipment field considering financial limits adapted youth football injuries sufficient first aid equipment youth football configured participating youth football teams first aid kit majority equipped team youth teams responsible using first aid equipment injury evaluation presented injuries youth players one season frequently presented types injury sprains lower extremity based analyzed injury data youth football first aid equipment sign sufficient occurred youth football injuries current first aid equipment youth football insufficient scientific based first aid equipment sign adequate serve injuries football need education first aid management
background gastric bypass one widely performed bariatric surgeries world performing surgical system new advancement aim study describe single docking single technique short term results materials methods january december robotic performed performed single docking single approach data analysed retrospectively intra post operative details every patient documented follow done per protocol months years total patients completed follow protocol per database results mean age patients years ratio males females equal mean operative time min early mortality seen days post surgery two late complications documented late mortality average length stay days average blood loss hospital admission surgery conclusion single docking single technique simple effective time saving without complicated port position multiple docking minimal complications
psychosocial conditions depression intimate partner violence ipv history childhood sexual abuse csa associated poor hiv related outcomes india third largest hiv epidemic world little understood impact psychosocial conditions people living hiv aimed understand prevalence correlates psychosocial conditions among entering hiv care centre aids research education india thirteen questions added standard voluntary counseling testing questionnaire including patient health questionnaire depression scale questions assessing csa ipv fitted logistic regression models stratified gender psychosocial condition outcome interest substance use variables socio demographic variables correlates interest three hundred eighty three persons enrolled study tested positive hiv including men women included models one quarter men women reported least one psychosocial condition probable depression csa ipv adjusted analysis current alcohol use associated greater two times higher odds psychosocial condition adjusted odds ratio among men conclusion estimated prevalence probable depression csa ipv among presenting hiv care southern india found among male alcohol use associated markedly higher odds reporting psychosocial condition study needed characterize alcohol use among male possible deleterious impact psychosocial conditions alcohol use hiv related outcomes india
aiming improving poor real time performance existing nonlinear filtering algorithms applied autonomous navigation based global positioning system gps measurements simplifying algorithm design navigation algorithms autonomous navigation algorithm based linear differential inclusion proposed paper firstly demonstrated nonlinear estimation error system autonomous navigation modelled linear differential inclusion system model according idea global linearization thus filtering nonlinear system simplified filtering linear system coefficients secondly tensor product model transformation applied determine linear differential inclusion system model model error introduced global linearization reduced compromise computational complexity modelling accuracy finally autonomous navigation algorithm based linear differential inclusion designed combining multi model kalman filtering data fusion compared extended kalman filter proposed algorithm simpler easier implement since need update matrices online simulation results demonstrate estimation accuracy proposed algorithm
assess quality evidence determine effect patient related economic outcomes self management support interventions chronically patients low socio economic status evidence self management support interventions chronically people low socio economic status lacking literature review data database trials pubmed cinahl web science psycinfo institute library searched randomized controlled trials addressing self management support interventions patients cardiovascular disease stroke cancer diabetes chronic respiratory disease included review extraction quality assessment performed independent researchers using data extraction form focused mainly diabetes fourteen studies cited underlying theoretical basis frequently used self management support components lifestyle advice information provision symptom management problem solving goal setting strategies frequently integrated eleven studies adapted interventions needs patients low socio economic status differences found interventions developed based health behaviour theoretical models evidence found self management support interventions chronically patients low socio economic status essential characteristics component effective self management support interventions patients detected rigorous reporting development underlying theories intervention recommended
purpose fatigue common end stage renal disease patients receiving reduces significantly quality life associated cause cardiac related mortality unfortunately little known course fatigue patients chronic methods vitality subscale short form health survey administered patients january june november results score differ significantly among similarly year course vitality subscale score differ significantly among stratification patients sex age bmi patients changed fatigue status patients became patients became patients changed fatigue status patients became patients became patients changed fatigue status patients became became conclusion present study first identify variations fatigue status among patients chronic year course findings suggest frequently assess presence severity fatigue patients chronic
decades known diagnostic statistical manual mental disorders dsm diagnosis antisocial personality disorder aspd psychopathy dsm alternative model personality disorders provides opportunity long held concerns current study compared section iii alternative models trait based conception aspd categorical model main diagnostic codes section dsm terms associations differing models psychopathy also evaluated validity trait based conception broadly relation measures antisocial tendencies psychopathy participants male administered battery self report interview based researcher rating measures relevant constructs analyses showed section iii aspd outperformed section aspd predicting scores psychopathy checklist revised pcl additionally aggregate scores section iii aspd performed capturing variance differing aspd psychopathy measures finally found section iii aspd impairment criteria added section iii aspd traits predicting pcl psychopathy scid aspd
purpose case probable interaction levothyroxine presented along review relevant literature recommendations clinical management summary year old woman human immunodeficiency virus infection recently undergone benign presented clinic hypothyroidism also found pregnant treatment levothyroxine daily initiated receiving antiretroviral therapy pregnancy patient elevated serum thyroid stimulating hormone tsh concentrations despite gradual escalation levothyroxine dosage daily interaction levothyroxine suspected substituted within months tsh concentration normalized daily levothyroxine dose month period stabilized tsh concentrations remained within normal range month follow period scoring case using drug interaction probability scale yielded score indicating probable interaction levothyroxine literature search identified reported cases interactions involving levothyroxine conclusion potentially serious drug interaction levothyroxine observed pregnant woman related hypothyroidism case review cases reported literature indicate higher usual doses levothyroxine required patients taking concurrently
introduction diffuse intrinsic constitute brain tumors pediatric population currently prognosis remains poor overall survival months recently indication biopsy enlarged due development molecular biology various ongoing clinical therapeutic trials classically biopsy performed using frame assisted procedure workflow sometimes heavy complex especially children study authors present experience robotic guided biopsy pediatric population patients methods retrospective study series five consecutive pediatric patients harboring treated year period patients underwent robotic guided biopsy via approach results among patients studied male female median age years range years clinical presentation included cranial nerve palsy patients mri imaging lesion showed typical features located hypo intensity hyper intensity signal sequences diffuse enhancement mean procedure time minutes range minutes new postoperative neurological deficits recorded histological diagnosis achieved cases follows two grade iii two one diffuse grade iii conclusion robotic assisted biopsy pediatric population easier effective safe highly accurate method achieve diagnosis elsevier masson sas rights reserved
previous animal studies indicated associations circadian clock genes cognitive impairment study assessed whether circadian clock genes associated cognitive aging independently complex interactions old taiwanese population also analyzed interactions environmental factors genes influencing cognitive aging total taiwanese subjects aged years taiwan analyzed mini mental state examinations mmse administered subjects mmse scores used evaluate cognitive function data showed associations cognitive aging single nucleotide polymorphisms snps key circadian clock genes clock also found interactions clock affected cognitive aging finally investigated influence interactions clock environmental factors alcohol consumption smoking status physical activity social support cognitive aging similar study indicates circadian clock genes clock genes contribute risk cognitive aging independently gene gene gene environment interactions
candida albicans major fungus medical implants causing device associated infections high mortality bacterial products interesting biological properties recently considered biofilm prevention study investigated activity produced bacillus adhesion biofilm formation albicans medical grade chemical analysis stability surface activities crude extract physicochemical characterisation coated disk surfaces also carried showed good reduction water surface tension low critical concentration good activity thermal resistance stability incubation significantly reduced adhesion biofilm formation three albicans strains range respectively pre coated fungal adhesion biofilm formation reduced respectively additionally inhibit viability albicans strains form chemical analysis crude extract revealed presence two families principally lower percentage evaluation surface indicated coating surface successful although uneven significantly initial deposition albicans biofilm growth suggesting potential role coatings preventing fungal infection associated medical devices
present theoretical study electronic thermal transport combining graphene hexagonal grains varying size distribution increasing grain density percent system evolves good conductor mobility orders magnitude sheet resistance reaching omega regime coefficient suppressed mixing thermal conductivity found order results available experimental data provide guidelines tuning properties context two dimensional materials engineering particular proved electrical thermal properties largely affected morphological features grain size composition find cases nanometer sized good thermoelectric materials
background multi centre randomized controlled trial rct compared modified based treatment specialist supportive clinical management patients eating disorders eds borderline personality disorder symptoms bpd group patients presents complex challenges clinical services treatment addresses multiple problems potential improve outcome shown effective improving outcome patients bpd use reported methods sixty eight eligible participants randomised primary outcome measure global score eating disorder examination secondary outcomes included measures bpd symptoms rating scale borderline personality disorder general psychiatric state quality life service utilisation participants assessed baseline months analysis performed using linear mixed models results participants completed month follow early drop occurred significantly group drop vary treatment model later therapy sometimes attributed participants moving away higher drop amongst smokers higher neuroticism scores participants arm arm attended least therapy sessions offered amongst remaining trial months associated greater reduction shape concern weight concern eating disorder examination compared months decline bpd symptoms groups combined ten participants reported adverse events trial mostly self harm one death attributed unexplained conclusions high drop rate made interpretation results difficult greater involvement research staff clinical management improved compliance therapy research assessment impact core body image psychopathology
creating new model train high quality primary care workforce great interest american health care stakeholders consensus effective educational approaches need combined work environment emphasize good work life balance focus achieving meaningful outcomes center patients public still significant barriers limit numbers clinicians interested careers primary care including low potential heavy medical school lack respect physician colleagues enormous burdens record keeping pool primary care look especially changes focus institutions practice environment students residents need training environments primary care clinicians interdisciplinary teams play important role patient care variety reasons many academic medical centers easily meet standards authors propose major part primary care education training located settings high performing health systems built comprehensive integrated care models primary care clinicians play principle role leadership care delivery
background study investigates relationship insomnia cognitive dysfunctions including subjective memory impairment mild cognitive impairment mci dementia considering depression community sample elderly individuals methods data elderly individuals aged years obtained nationwide dementia epidemiological study conducted south korea cognitive functional status assessed mini mental state examination consortium establish registry alzheimers disease assessment packet clinical assessment battery insomnia defined presence least one four sleep complaints difficulty initiating sleep difficulty maintaining sleep early morning sleep accompanied moderate severe daytime consequences depression evaluated using geriatric depression scale results prevalence insomnia patients mci dementia found respectively patients mci dementia significantly likely insomnia four sleep complaints normal comparison patients adjusting sociodemographic factors significant relationships cognitive dysfunctional status insomnia remained however adjusting sociodemographic factors depression significant relationships sleep complaints insomnia remained conclusion insomnia common complaint elderly mci dementia depression play important factor relationship insomnia cognitive dysfunctional status elderly
fully electric vehicles multiple allow significant variation steady state transient responses individual control electric motor drives consequence alternative driving modes created provide driver option select preferred dynamic vehicle behavior article presents torque control structure based combination feedforward feedback contributions continuous control vehicle rate controller specifically developed easily real world vehicles novel model based procedure definition control objectives described detail together automated tuning process algorithm implemented control functions demonstrated experimental vehicle tests results show possibilities torque control designing vehicle characteristic authors published elsevier ltd
multi view facial expression recognition challenging active research area computer vision paper propose simple yet effective method called locality constrained linear coding based layer model learn discriminative representation multi view facial expression recognition address issue large pose variations locality constrained linear coding adopted construct overall bag features model used extract overall features estimate poses first layer second layer establish one specific view dependent model view respectively pose information facial image known use corresponding view dependent model second layer extract features combining features two layers obtain unified representation image evaluate proposed approach conduct extensive experiments multi databases experimental results show approach outperforms state art methods elsevier rights reserved
complex traffic networks include number controlled commonly multiple districts result overall traffic control problem extremely complex computationally moreover given different distinct non aligned interests traffic light controller design inherently decentralized consideration almost entirely absent related literature complexity great bearing quality traffic network overall security consider issues dynamic traffic network first propose effective local search algorithm efficiently design system wide control logic collection second propose game theoretic game model traffic network security attacker deploy denial service attacks sensors develop resilient control algorithm mitigate threats finally propose game theoretic model investigate model context baseline traffic network design resilient design accounting attacks methods implemented evaluated using simple traffic network scenario
headache frequent neurological symptom children adolescents recurrent headaches significant disabling effect consequences including school decreased participation activities poor academic performance risk factor chronic headaches pain syndromes merit increased attention common types primary headache children adolescents migraine tension type headache recent survey south korean school students reported recurrent headaches frequent recurrent migraine headaches frequency migraine increased age prevalence rate urban areas higher rural areas trend found severe disabilities occur older children headache children adolescents migraine severe headache related disabilities predictors headache related disability found migraine severe intensity headache frequent headache longer duration symptoms presentation children adolescents recurrent significant headaches diagnosed treated reduce headache related disability improve quality life
task interdependence received great deal attention critical driver project dynamics study focuses one key dynamics helping among information technology implementation project team members uniquely distinguish perceptions receiving help one provides team members positive giving one receives negative argue using equity theory frame members tendency resolve perceived adjusting subsequent levels helping extent adjustment moderated task interdependence results empirical evaluation members implementation teams examined several points throughout project cycles provide insight relationships extending equity theory find lower interdependence effect positive subsequent helping leaves effect negative unaffected find support inverted shaped relationship level subsequent helping team final cost implementation holds critical implications project team design dynamics
objective different biomaterials used scaffolds bone tissue engineering purpose study analyze effect bovine bone collagen porosity water retention degradation rate biomechanical characteristics composite scaffolds methods bovine bone collagen solution mixed cellulose solution mixture added certain quality divided mixture two groups according different bovine bone collagen solution mass fraction bovine bone collagen bovine bone collagen surface structure pore size observed scanning electron microscopic calculated porosity degradation rate water content biomechanical properties results two groups scaffold materials showed multi pore structure average pore size porosity statistical analysis showed two groups material porosity difference statistically significant degradation rates two groups scaffold materials six weeks statistical analysis showed degradation rate material differences two groups statistically significant water content two groups scaffold materials perpendicular perpendicular statistical analysis showed water content material differences two groups statistically significant biomechanical properties second group increased significantly conclusion seen experimental data bovine bone collagen increase pore size improved stability degradation biomechanical strength materials therefore studied several characteristics considered ideal use scaffold
paper proposes innovative method power consumption measurement microcontroller based systems provides high accuracy wide dynamic range current values makes particularly suitable applications characterized alternating low high power modes fast current variations demonstrate using amp based voltage feedback configuration possible use shunt resistor values higher usual obtain increased voltage drops without affecting power supply voltage consequently possible directly use data acquisition board acquire shunt voltage eliminating common errors like offset gain due use additional intermediate amplification stage proposed scheme successfully used accurately characterize power consumption single sensor node wireless sensor network
oscillators essential fuel autonomous behaviours molecular systems artificial oscillators built programmable biological molecules dna rna generally easy build tune serve biological computation regulation describe new artificial nucleic acid biochemical reaction network demonstrate capacity exhibit oscillatory solutions network built vitro using nucleic acids three enzymes potential implemented cells numerical simulations suggest oscillations occur realistic range reaction rates concentrations
knowledge material properties important machine design composite materials information found related literature standard therefore necessary determine measurements basic experiments mechanics materials paper presents new finite element model cell modeling material properties numerical modeling method one determine macroscopic material properties model cell models numerically consists thousands fibers embedded matrix material material numerical results material properties applied definition macroscopic material properties fiber reinforced composite
past decade rates depression suicide adolescents increasing journal child psychology psychiatry australian new zealand journal psychiatry time evidence rates diagnosis least referral depression adolescents declining general psychiatry john psychological medicine statistics highlight importance accurate information risks benefits treatments adolescent depression order combat therapeutic extant controversy best ways treat adolescent depression particular regards use antidepressants contributed trends specifically believe recent high profile publications interpreted benefit risk ratio use antidepressants adolescent depression review clinical trial epidemiological data supports retention use antidepressants management depressed adolescents
virus infection results severe disease cases lethal hemorrhagic fever infection directed seven viral genes encode nine viral proteins definition viruses intracellular parasites require aspects host cell biology order replicate genetic material assemble new virus particles host cell antiviral responses currently licensed targeted viral proteins inhibit function however experience treating hiv influenza virus demonstrates resistant viruses soon selected emerging area transiently target host cell proteins play critical roles virus biology especially acute infections advantage protein targeted evolutionary removed genome virus proteomics aid discovery biology identify cellular proteins utilized virus facilitate infection work focused defining identified cellular including associate protein promote stability utilization mini genome replication system based recent isolate demonstrated disrupting stability adverse effect viral rna synthesis
effective education reform depends successful realization school leadership carrying reform school middle leaders century examine traditional role understand complexities characterizing various responsibilities within context school reform critical change agents system players formal leaders interpret reform demands translate school practices process sense making though sense making ongoing process school leaders undergo collectively policy reforms little attention paid role middle leaders perform sense makers literature review article explores sense making school leadership holistic approach demonstrates sense making framed theoretical empirical studies suggests implications avenues future research
article represents possibility using modified algorithm automatic controllers higher order derivatives control complex plants significant delay mathematical models control systems developed comparative analysis quality indexes derived transient responses carried
objective systematically review literature determine whether sedentary time associated cardiometabolic diseases risk factors among south asian adults six electronic databases searched identify studies examined association sedentary time cardiometabolic diseases diabetes cardiovascular disease risk factors body mass index bmi waist circumference lipids blood pressure glucose among south asian adults two independent reviewers performed abstract full text screening data abstraction quality assessments searching identified potential articles used analysis greater sedentary time associated increased likelihood diabetes higher bmi glucose thirteen studies higher quality results identified trend whereby greater sedentary time associated increased risk diabetes several cardiometabolic risk factors among south asian adults high quality studies needed identify whether risk factors independent physical activity levels inform culturally specific interventions south asians
engineered cells currently clinical trials treat patients cancer solid organ autoimmune diseases however field still infancy design manufacturing cell therapies standardized performed mostly academic settings competing groups reliable methods define dose pharmacokinetics cell therapies need developed mid food drug administration fda approved cell therapeutics market fda regulations slowly adapting new technologies development engineered cell therapies requires advances immunology synthetic biology manufacturing processes government regulation review outline challenges discuss contributions make emerging field
aims hypothesis investigated effects triglyceride metabolism type diabetes methods double blind placebo controlled cross study diet treated type diabetic subjects measured differences tissue blood flow muscle subcutaneous abdominal adipose tissue used stable isotope techniques analysed gene expression responses mixed meal containing assessed results induced insulin without altering fasting concentrations concentrations lowered compared placebo adipose tissue release decreased fasting state treatment associated increased fasting hormone sensitive lipase rate action triglyceride concentrations decreased treatment despite unchanged fasting concentrations change concentrations triglyceride rich lipoprotein adipose tissue blood flow increased triglyceride acid concentrations unchanged whilst acid concentrations decreased muscle mrna expression increased whilst expression genes involved insulin signalling unchanged adipose tissue expression fat increased conclusions interpretation decreases triglyceride concentrations represent decreased adipose tissue decreased delivery liver lead lowered triglyceride concentrations upregulation expression muscle contribute insulin
typical based quantum key distribution protocols maximally states used standard way generate use parametric conversion low intensity laser beams way probability produce two pairs negligible however one obtains cost large likelihood producing particles work ask question approach optimal one point view key generation rate case study take protocol find optimal intensity beam show optimal intensities much higher ones typically used results generalized protocols based states
previously described ethyl interesting multifunctional neuroprotective compound potential treatment neurodegenerative diseases describe new derivatives different synthetic routes solid phase synthesis aiming improve previously described route solution lipase studied using candida cases alpha compound obtained main product pointing independent nature lipase efficient solid phase route used produce new based derivatives resulting good yield concentrations new compounds inhibited human protected neurons toxic related alzheimers disease cerebral ischemia cns permeable compounds ethyl blocked voltage dependent calcium channels protected rat hippocampal slices oxygen glucose deprivation becoming promising anti stroke lead compounds elsevier masson sas rights reserved
study examines statistical process control chart used detect parameter shift poisson integer valued models zero poisson models models conditional mean structure similar models known appropriate analyzing count data feature special attention paid study conditional general likelihood ratio based charts score function based chart performance proposed methods evaluated simulation study calculating average run length findings show proposed methods perform adequately chart outperforms chart increased shift parameters moreover use chart particular found lead lower false alarm rate use chart
paper presents three phase back back inverter online power supply applications inverter consists three phase three wire input rectifier stage three phase four wire output inverter stage ground wires tied together two stages sinusoidal pulse width modulation based division summation sigma digital control input stage controls power flow utility grid link regulates link voltage power factor correction output stage tracks three phase reference voltages proposed control laws derived based sigma digital approach take account effects link voltage fluctuation grid voltage distortion inductance variation due different current levels thus distortion input current output voltage filter inductor core size reduced significantly moreover circulating current common ground suppressed effectively simulated experimental results three phase back back inverter confirmed analysis discussion proposed control approach
avian analogue human executive dysfunction used study long term effects repeated low dose known selectively excitatory methyl aspartate receptors nmda indirectly impair inhibitory related processes gaba first eight divided two groups receiving either saline hour prior session thirty min sessions differential reinforcement low rate response schedule run months overall number responses efficiency unaffected treatment establishing sub threshold dose another eight treated given visual discrimination task results demonstrated impairment striatal function excitatory inhibitory processes group entire months session treatment cross showed saline group unaffected whereas saline group exhibited rapid recovery inhibitory control however excitatory control fully recover together results suggested nmda system involved acquisition excitatory learning expression inhibitory learning findings discussed terms value avian models translational research furthermore results examined within context research domain criteria initiative rule nmda disruption underlie executive dysfunction various neuropsychiatric disorders finally findings suggested potential long term effects clinical recreational use nmda require study elsevier inc rights reserved
recent years interest green building materials products multiple industries increasing industry allows various compounds added mixing procedure much research conducted highlight impact fired clay paper examines significance adding organic matter coming agricultural solid waste olive stone wheat residues improve thermal performance maintaining load bearing capacity results show decreasing bulk density mixtures containing ranging compared clay alone mixtures bulk density reduction total porosity increases implying lower thermal conductivity relative clay alone compared incorporated compressive strength respectively significant positive correlation increasing amount organic matter porosity striking result emerge data creates higher total pore volume owing difference grain size distribution consequently pore size distribution new materials containing structured leads better compressive strength elsevier ltd rights reserved
many regions russia centralized electricity supply geographical location taking account variable electricity generation available energy storage systems requirements imposed consumers power quality electricity supply reliability say operating conditions systems control including emergency control represent difficult problem needs studied generation wind power plants however example stochastic operation generators research aimed developing algorithms construction automated systems control active components electrical network method applied research describe object control based universal approach mathematical modelling nonlinear dynamic system black box type represented polynomials degree makes possible input output characteristics object obtain adequate fast mathematical description results computational experiment demonstrate applicability mathematical tool control active components intelligent power system
naturalistic study examined differences students motivations elective versus required service learning classes students two successive academic years cohorts surveyed center large university analyses compared classes differing requirements community based service students required participate community service part class within program required admission university less likely want involved future community work another class recommend class compared groups students including others classes required part program students enrolled findings suggest students motivations participate community engaged activities shaped simply whether community engagement required classes also factors including engagement opportunity
three different geosynthetic clay different manufacturers tested cell new testing procedure quantify flow rate interface coating attached film presenting hole upper geotextile testing device previously used studies aiming evaluate interface damaged regular different results obtained regarding evolution time flow rate ranging steady state average range flow rate results obtained composite liner additional tests performed adding top give lower values flow rates shows importance film coating rigidity decreasing flow rate better quality contact interface
bladder symptom screening tool used identify multiple sclerosis patients possible need evaluation urinary symptoms primary objective study identify barriers experienced patients seeking evaluation urinary symptoms also assessed utility tool identifying patients follow evaluation methodsthis prospective observational study patients enrolled center patients completed demographic information questions assess barriers care short form incontinence questionnaires score met criteria referral evaluation one year enrollment follow calls assessed whether patients seen urinary specialist resultsthe common barriers seeking care included doctor never referred doctor never asked thirty eight percent men stated doctor never referred compared women twenty seven patients score interested seeing specialist compared scoring patients reached follow total patients followed evaluation screened positive conclusionsthe valuable tool identify patients urinary symptoms likely follow evaluation however barriers beyond awareness exist prevent patients evaluated
rationale environmental challenges adolescence drug exposure cause enduring behavioral molecular changes contribute life long maladaptive behaviors including addiction selectively low rats represent unique model assessing long adolescent environmental manipulations inherently differ number addiction related traits rats prone whereas rats least baseline conditions moreover relative rats likely attribute incentive motivational value reward cues track objectives utilized rats determine whether adolescent cocaine exposure alter behavioral neurobiological profiles specific focus conditioned approach behavior sign goal tracking hippocampal methods rats administered cocaine saline days adolescence postnatal day subsequently tested conditioned approach behavior adulthood wherein conditioned stimulus followed response independent delivery food stimulus behaviors directed toward food recorded sign goal tracking respectively hippocampal cell genesis evaluated immunohistochemistry results adolescent cocaine exposure impaired hippocampal cell genesis proliferation survival enhanced inherent propensity goal track adult rats conclusions adolescent cocaine exposure long lasting changes stimulus reward learning enduring deficits hippocampal selectively adult rats conclusions adolescent cocaine exposure long lasting changes stimulus reward learning enduring deficits hippocampal selectively adult rats
work capacitance multiplier designed using negative current feedback operational amplifier proposed circuit low sensitivity temperature variations simulation results obtained pspice simulations verify theoretical analysis
paper describes development new approach speed small hydropower plants employing servo pneumatic positioning system system aiming cost reduction easy maintenance obtaining environmentally friendly product pneumatic system designed control gates turbines replace conventional approach using hydraulic system positioning system development based non linear modeling pneumatic valve cylinder includes pid controller dead zone compensation using test bench corresponding power plant model validated performance requirements according international standards fully satisfied results presented speed prototype installed site turbine load rejection step response tests carried theoretical experimental results show servo pneumatic speed used successfully restricted turbines considering pneumatic component costs
past research provided abundant evidence playing violent video games increases aggressive tendencies contrast evidence possible positive effects video game exposure prosocial tendencies relatively sparse present research tested found support hypothesis exposure prosocial video games increases accessibility prosocial thoughts results provide support predictive validity general learning model effects exposure prosocial media social tendencies thus depending content video game playing video games harm also benefit social relations
confocal raman spectroscopy implemented new label free technique quantify molecular diffusion coefficients within leading anti hiv drug analyzed clinical gel gel tested vaginal fluid capture range conditions likely occurring vivo concentration distributions gel time space measured input mathematical diffusion model diffusion coefficients gel increased depending extent dilution results interpreted respect traditional release rate measurements devices cells comparison highlighted advantage assay characterizes barrier within gel material contrast release rate traditional assay affected external conditions drug partitioning gel liquid sink interface new assay relevant diffusion polymeric relevant length scales example characteristic topical drug delivery resulting transport parameters salient measures drug delivery potential serve inputs computational models drug delivery performance american pharmacists association published elsevier inc rights reserved
scientific advances allowed development multiplex gene panels assess many genes simultaneously women tested negative examined correlates interest testing genes confer modest moderate breast cancer risk risk communication preferences women negative families female first degree relatives breast cancer patients tested negative mutations completed survey assessing multiplex genetic testing interest risk communication preferences interest testing high even higher results guide risk reducing behavior changes taking medications participants preferred receive genomic risk communications variety sources including primary care physicians genetic printed materials web factors independently associated testing interest perceived lifetime risk developing cancer odds ratio confidence interval high cancer worry findings suggest women negative families unique population primed behavior change findings also provide guidance clinicians help develop genomic risk communications promote informed decision making behavioral interventions
contains natural used fabricate biodegradable low cost sizes potential replacing non biodegradable alcohol sizes large quantity industrial applications sizes isolates reported potential substitute sizes contribute high chemical oxygen demand textile effluents cause serious water pollution however sizes high cost need additional overcome films research developed low cost sizes contain majority oil minorities comparing films sizes size higher film flexibility adhesion resistance respectively oil formed size extraction plant based additives capability improving adhesion protein sizing cotton increasing elongation protein based size films successful utilization textile sizing lead large quantity application resulting high value addition agricultural profound impact soybean industry textile industry elsevier rights reserved
battery electric vehicles slow diffuse international swedish market previous studies indicated situational factors economic factors size performance major importance vehicle choice vehicle paper authors explore consumer centric total cost ownership model investigate possible discrepancy purchase price internal combustion engine vehicles hybrid electric vehicles creation testing model reveals computation challenging task consumers due bounded access relevant data prediction future conditions application model vehicle sample found cheaper compared findings paper prove importance policy marketing alike designing appropriate business models information campaigns based consumer conditions order promoting diffusion society authors published elsevier ltd
experiments performed three spring supported separated box girder section models closed wind tunnel investigate vortex induced vibration characteristics particle image velocimetry instrument employed obtain flow field around models four sensitive velocity intervals observed test model vertical torsional oscillations repeatedly induced comparisons control groups show vortex shedding gap crucial factor induces wake induced vibration observed occur gap accompanied dramatic amplitude becomes weaker wind velocity increases wake vortex shedding mode changes classic mode mode vortex shedding frequency shows special lock mode phase found taking model vortex shedding two coupled oscillators
background previous studies showed associated variety cognitive deficits executive dysfunctions persist even states however role cognitive impairments psychopathology treatment fully understood article aims discuss executive functions central components working memory attention mediate psychopathology considering role dorsolateral prefrontal cortex present findings brain stimulation experiment support notion methods effect transcranial direct current stimulation enhancing cognitive control functions investigated twenty four patients experimental group control group received sessions min consecutive days experimental group received active stimulation control group received sham stimulation participants performance cognitive functions depression scores assessed results results showed brain stimulation improved executive dysfunction patients significant improvement depression scores also observed suggesting cognitive control dysfunction mediator emotional dysregulation psychopathology limitations follow investigation done study allow infer long term effect low stimulated adjacent areas conclusion cognitive components namely cognitive control dysfunction play role psychopathology involved emotion dysregulation amount contribution cognitive components psychopathology however open question used intervention improve cognitive dysfunction
background classic genetic disorder described already causes urine turn black upon exposure air also leads early osteoarthritis main body abstract objective implementation precision medicine approach present novel database facilitating collection integration analysis patient data order create dedicated ecosystem genetic biochemical clinical resources shared among registered researchers order exploit database developed analytic method based pearsons correlation coefficient value generates correlation matrix complete statistical analysis obtained every pair parameters examine dependence multiple variables time short conclusions employing analytic approach showed clinically used biomarkers suitable prognostic biomarkers reliable patients clinical monitoring believe database good starting point creation new clinical management tool lead development deeper knowledge network disease advance treatment moreover approach serve model paradigm errors metabolism rare diseases general
functional food ingredients offer potential benefits digestive particularly circumstances gut compromised antibiotic use exposure pathogens growing body evidence also points towards wider health effects including infant health enhanced mineral absorption weight management act stimulating growth activity selected species bacteria large intestine including lactobacillus much research performed offer effective route influencing health across lifecycle
context software engineering experienced increased calls attention theory including process theory general theory however process theories potential general theories proposed little empirical evaluation attempted objective purpose paper empirically evaluate two previously software development process theories implementation theory sci function behavior structure framework method survey software developers combined four longitudinal case studies achieve simultaneously broad deep empirical evaluation instrument development statistical analysis questionnaire data case data analysis using closed ended priori coding scheme data described results case data analysis strongly supports sci analysis questionnaire response distributions chi square fit test furthermore case questionnaire found evidence support sci varied participants gender education experience size nature projects conclusions sci supported evidence found suggests instead weakly coupled phases analysis design coding testing accurate useful development hoc oscillation making sense project context simultaneously improving mental representations context design space constructing deploying software artifacts implementation elsevier rights reserved
background childhood maltreatment important risk factor mental physical health problems adolescents living residential youth care experienced high rate childhood maltreatment high risk group psychiatric disorders quality life qol subjective multidimensional concept goes beyond medical diagnoses lack research regarding associations childhood maltreatment qol present study compare self reported qol adolescents norway without maltreatment histories adolescents general population also study impact number types qol methods adolescents aged years living norway invited participate study participated yielding response rate maltreatment histories assessed interviews trained research completed adolescents previous exposure maltreatment reported adolescents questionnaire measuring health related quality life children adolescents used peers sample adolescents general population used comparison general linear model analyses conducted five life domains dependent variables linear regression used study effect number types results exposed adolescents reported poorer qol peers control groups compared peers confidence intervals mean score differences scale physical emotional self esteem friends compared general population sample confidence intervals mean score differences physical emotional self esteem friends number types associated poorer qol score physical emotional self esteem friends school conclusions childhood maltreatment associated poorer qol score suggest use qol maltreatment measures children adolescents
paper conduct theoretical analysis novel computer assisted film television animation design pattern based computer graphics theory three dimensional modeling structure optimization computer graphics rely visualization technology data graphics effectively combined graphic display major direction development computer graphics follow trend analyze issues different perspectives computer graphics applied computer animation success development flight simulator prompted application computer graphics television film industry
following collaborative remembering people adopt partners contributions memory two studies asked people study partially overlapping lists words collaborative remembering dyads either worked include words matter studied limited recall words studied members differential focus source information collaborative recall impacted performance later source memory test nonetheless found frequent source monitoring errors displayed bias people likely claim partners contributions memories attribute memories partners collaborative remembering people work construct agreed upon version past quickly becomes individuals memory society applied research memory cognition published elsevier inc rights reserved
rare case death young man due airway obstruction course angioedema edema type hereditary angioedema due esterase inhibitor deficiency diagnosed man information concerning health state given public decision ordering legal autopsy extremely helpful recognizing cause death elsevier ireland ltd rights reserved
multi channel mixed signal full customized cmos integrated sensor chip microcontroller based electronic system developed vitro extracellular recording neural signals multi site planar array sensors simultaneous neural signal recording designed chip fully integrated analog signal processing circuitry control system biosensor system built hierarchical modules incorporate electrophysiological sensors analog signal configured two stage amplifier gain providing amplifiers based operational transconductance amplifier ota capacitive feedback digital logic interface units including clock generation time division control circuitry prototype fabricated using ami double poly triple metal layer cmos technology gold process used replace aluminum material obtained standard cmos process metal gold planar array sensors prevent cell poisoning undesirable electrochemical corrosion post cmos processing packaging techniques applied biosensor chip promotes biocompatibility stability aqueous cell culture environment microcontroller based electronic system biosensor client post processing action potential signals sensed sensor chip also developed biosensor tested electrically presence electrolyte environment shown provide satisfactory signal noise ratio neural signals amplitudes range frequencies range khz biological example vitro recordings conducted neurons shown research work proves full functionality neural recording biosensor chip incorporated electronic system based bit processor chip amplification time division techniques multi channel biosensor chip allow large scale simultaneous recording biological activities neurons
paper describes development two self balancing robot kinematic analysis system architecture consists two axial rectangular structure powered pair motors two separate motor drivers controlled pulse width modulated voltage signals received arduino microcontroller board attitude determination robotic platform accomplished sensor combination accelerometer rate mechanical system design velocity decomposition two wheels robot body analyzed establish kinematic model model local position robot mapped according global coordinates finally kinematic constraints established fixed standard wheels two robot
given initial assignment processes machines machine problem find assignment improves machine usage subject several resource allocation constraints considering costs propose heuristic based simulated annealing solving problem uses two neighborhoods one moves process one machine another second one two processes different machines present data structures permit validate execute move time number resources number dependencies service process belongs heuristic runs two different sets parameters parallel convergence criterion satisfied machine problem subject challenge proposed algorithm ranked fourth final round senior category competition
wavelet analysis applied detect greatest deviation perfect circle shaft like components virtual manufacturing engineering based concepts least square method adopted determination reference least square circle deviation calculated order obtain errors wavelet transform carried binary wavelet time domain frequency domain virtual probe used signals measured point using function accuracy measurement depends large extent length individual step along axis density measured points sections experiments shown measuring processing time saving results wavelet analysis much reliable
technical note first present adaptive distributed observer discrete time leader system adaptive distributed observer provide follower estimation leaders signal also estimation leaders system matrix based estimation matrix devise discrete adaptive algorithm calculate solution regulator equations associated follower obtain estimated feedforward control gain finally solve cooperative output regulation problem discrete time linear multi agent systems state feedback output feedback adaptive distributed control laws utilizing adaptive distributed observer
purpose review microbiome continues demonstrate important role immune metabolic programming review focus mechanistic implications recent findings diabetes pathogenesis treatment recent findings multiple techniques developing specify microbiome time new insights emerged local interactions microbial products human development new findings demonstrate key bacteria products result programming diabetes modulating regulatory lymphocytes within outside intestine role bacterial programming human metabolism also revealed new insights turn findings suggest framework microbiome modified change course diabetes summary microbiome key regulator metabolism immunity specific bacteria secreted products now known program regulatory cell development change course diabetes bacterial genomics demonstrating important modifiable roles bacterial gene products metabolism understanding symbiotic relationship provide new avenues intervention diabetes
developed experiment help students understand basic regulation glucose metabolism availability energy sources physical activity fed state within practical session teams two three students subject investigators performed one three different trials inactive subjects ingested glucose solution water position end trial prior activity subject performed min walking glucose ingestion subsequent resting phase subject ingested glucose solution min afterwards glucose levels drawn trials fasting value immediately glucose ingestion min min thereafter students analyzed glucose values worked tasks students evaluated usefulness experiment students found experiment useful enable gain understanding learning objectives clarify items indicated experiment necessary enable understand learning objectives experiment necessary helpful check learned found experiment necessary present article shows great value experiments within practical courses help students gain knowledge energy metabolism using active learning strategy students complex physiological tasks improved beneficial communication interaction students different skill sets problem solving strategies
purpose study aims classify schools based traffic pollutants complex sources assess environment determine state allergic diseases among students using international study asthma allergies children questionnaire assess connection air pollutants materials methods total seven schools divided three categories according characteristics surrounding environments three schools traffic related zones two schools complex source zones urban two schools complex source zones industrial complex questionnaires administered completed questionnaires analyzed results frequency asthma treatment past months showed significant increase exposure confidence intervals cis complex source zones frequency allergic rhinitis treatment past months increased significantly exposure black carbon cis cis cis subjects conclusion terms supporting childrens health care prevention related major spaces children school zones spaces used coming leaving school classrooms essential ensuring safety children traffic accidents also protection local traffic pollutants various hazardous environmental factors
disease bone chronic metabolic bone disorder characterized increased bone resorption new bone formation aim study defining role inhibitors canonical wnt catenin signaling pathway patients disease bone scarce contrasting results reported literature studied patients females males radiological evidence disease bone healthy subjects matched age sex type collagen terminal type collagen related protein evaluated blood samples laboratory expected mean serum levels bone turnover markers type collagen terminal type collagen significantly higher disease bone group compared control group difference observed groups never correlated bone turnover markers positively correlated age conclusion results suggest regulators wnt beta catenin pathway altered patients disease bone positive correlation found age disease bone patients indicates comparative studies serum levels adjusted age
micrornas mirnas small non coding rnas involved fine tuning gene regulation antisense promising tools anti mirna anti mir agents toward therapeutic applications uncover mirna function anti mir include methyl cationic peptide nucleic acids like locked nucleic acid based anti dna northern blotting widely used robust technique detect mirnas however mirna quantification presence anti mir proved challenging due detection artifacts led poor understanding mirna fate upon anti mir binding show anti mir bound mir prevent mirna properly purified rna fraction using standard rna extraction protocol tri reagent yielding rna extract reflect real cellular levels mirna increase numbers equivalents precipitation step leads full recovery targeted mirna back purified rna extract following improved protocol demonstrate northern blotting conjunction strategy use high page high affinity anti dna mir without causing mirna degradation mir targeting lower affinity anti mir seems promote degradation mirna technical issues explored work relevance hybridization based techniques mirna quantification presence anti mir
synthesized particles prepare porous exhibited phase transition behavior temperature similar lower critical solution temperature incorporation cotton done pad dry cure method aqueous dispersion contained acid agent vitro drug release experiments performed two different temperatures degrees study drug release behavior response temperature due shrinkage drug release profiles obtained found enhanced release temperature release conditions loaded fabrics proved vivo skin irritation studies displayed obviously high water vapor permeability degrees mtt assay showed obvious cytotoxicity loaded cotton mouse fibroblast cells within days results obtained demonstrated potential use responsive loaded cotton fabrics textile based drug delivery system treating skin care elsevier rights reserved
social dominance orientation stable early emerging trait influencing outgroup evaluations view supported evidence cross sectional two wave longitudinal research yet limitations identifying causal paths cross sectional two wave designs increasingly acknowledged article presents first use multi wave data test time relationship outgroup affect among young people use cross lagged latent growth modeling three wave data set employing norwegian adolescents years five wave data set american university students years overall exhibits high temporal rank order stability predicts changes outgroup affect research represents strongest test date role stable trait influences development prejudice highlighting valuable tool social political psychology
apache hadoop widely used distributed computing framework file system hadoop distributed file system assumes system homogeneous nature cloud system scales likely become heterogeneous thus extensive research placed improving performance heterogeneous hadoop systems little attention placed security improvements motivates investigate data allocation scheme called secure integrating secret sharing technique improve storage security heterogeneous hadoop system hadoop system classified variety different types groups based vulnerability characteristics addresses increased risk issue caused data replication fragments file many different types possible multiple fragment type storage assurance model developed evaluate quality security offered analysis assurance model performance evaluation experiments show impact performance hadoop system much comparison default significantly improving data assurance heterogeneous environment
context hiv considerable debate role schools teachers potential sources care support vulnerable children qualitative research examines care experienced practiced pupils teachers rural western kenya primary secondary schools interviews conducted teachers vulnerable pupils alongside drawing thematic analysis care theoretical perspective informal caring practices teachers within resource constrained settings research provides schools spaces care participation support vulnerable pupils providing institutional support development care schools help tackle considerable educational barriers facing girls boys vulnerable move care closer towards centre educational policy practice global south
accessible mind maps tools due visual nature hardly available available focus rendering structure considering nonverbal communication elements ongoing discussions paper describe need type communication mind map tool capable processing respective information coming tracking system attached interactive surface
stochastic model creep long term strength metallic materials proposed experimental data creep alloy temperatures equal degrees analyzed experimental data used hypotheses applied constructing model stochastic model checked adequacy experimental data creep alloy stationary loading conditions shown calculated experimental data satisfactory agreement
system design development fundamental capabilities engineer department control engineering national institute technology college offering course called practical system design unique opportunity students experience entire process developing autonomous mobile robot fourth year students years however recent years robot design construction become huge challenge students address problem worked improving engineering program first introduced problem based learning education program experimental engineering classes years also require students written report class session report intended help improve students schedule management role sharing work tracking skills reports reviewed relevant course teachers assessed logic quantitative representation paper discuss approach achievements future subjects taken multi stage experience educational program especially effect report writing
development new sensor systems able detect identify find position targets equipped stealth technology began early sensor systems acoustic magnetic seismic physical effects target activity reason motivating development new sensor systems based radar optical principal operation detecting targets systems usually electromagnetic energy operation thanks passive principle provide users advantages hidden positioning difficult discovery tools therefore new systems also allow detecting low targets jet aircraft etc detection range several information flight direction usually estimated deduced spatiotemporal sequence multiple systems submitted paper analyses low target position finding principle time direction arrival basis presents qualities found arrangement topologies characteristics position determination low targets also contains mathematical description signal digital processing intended find low targets position processed results presented table diagram forms created matlab mathematical environment presented detection identification results obtained real recorded signals
composite materials fine structure development high cost complex moreover developing traditional method time consuming costly difficult obtain accurate systematic scientific conclusions application finite element analysis software ansys optimized composite design performance analysis strength materials bearing damage computer simulation process range experiment information substantial cost savings shorten development cycle paper properties sic reinforced polymer composites researched aspect ratio volume ratio interfacial bonding status meaning finite element software results show aspect ratio interface volume ratio increased load transfer distance increased time bear axial stress matrix aspect ratio increased stress interface reduced however interface volume ratio increased stress interface increased impact interfacial bonding status bear axial stress much larger one resin matrix
table essential experimental facility many industrial applications real time simulate actual vibration situations including structural vibration earthquake however still challenging area acceleration waveform replication acceleration output responses table intended magnitude phase acceleration closed loop system due inherent hydraulic nonlinear dynamics servo systems thus accurately control parallel hydraulic actuators table critical issue many control techniques developed address issue currently used key techniques field reviewed article objectives academic investigations industrial applications article reviews new control algorithms table obtain high fidelity acceleration waveform replication accuracy
male infertility multifactorial disorder genetic basis besides sperm abnormalities cause numerous cases male infertility study evaluated genetic variants exons intron exon boundaries gene men short tail sperm defects define association variants human male infertility purpose dna extracted peripheral blood pcr reaction sequencing results sequenced segments analyzed present study men defect men recruited men iranian origin took years collect patients samples defect result variant identified five patients defect one patient defect form variant identified controls allelic frequency variant significantly statistically higher men bioinformatics studies suggested allele modify splicing pre mrna addition identified new genetic variant gene according present study allele gene risk factor iranian men defect genetic studies required understand accurate role variant pathogenesis human male infertility
century evolution research relating public health general occupational risks particular largely dominated industrial needs strategies play role studies carried also design thus feeding uncertainty exist one main issues underlying uncertainty relates work related diseases particular occupational cancers based multidisciplinary surveys social sciences life sciences challenge dominant model understanding links cancer risk factors first part article demonstrates interpretation cause cancer uncertainty paradigm knowledge recognition occupational cancers two case studies french mining sector illustrate danger clearly identified always called question rights recognition occupational diseases workers suffer maintaining hence paradigm public health allows state actors today rely uncertainty means looking mining sites areas without taking account health issues cancer epidemic continues grow reaching estimated incidence new cases per year france compared uncertainty health effects industrial risks proven still currently continuation conditions cause future cancers particularly among exposed namely workers
avoidance allergens treatment asthma hitherto achieved significant benefit despite strong evidence allergy increases severity contributes exacerbations asthma house dust mite cat dog allergens common allergic triggers avoidance strategies focused reducing exposures cochrane reviews suggested neither significantly reduce allergen levels improve asthma lack efficacy assumed consequence exposures occurring outside prolonged sleep associated increased susceptibility airway inflammation thus efficient reductions allergen exposure achieved sleep expected result significant improvements control asthma temperature controlled laminar airflow system employed beds domestic environment results massive reductions particulate exposure subjects including highly allergens trials demonstrated highly significant improvements asthma quality life reductions airway inflammation monitored exhaled nitric oxide levels furthermore patients worst disease severe exacerbation frequency significantly reduced based health service costs use falls national institute health care excellence threshold incremental cost effectiveness ratio per quality adjusted life year indeed frequent exacerbations cost saving prescribed allergic asthmatic patients
time dependent bridge flood waves analysed experiments conducted novel installation able produce complex high precision experimental data used test formulas including new mathematical model results confirm reliability superior performance proposed dimensionless effective flow work based model steady unsteady hydraulic conditions analyses highlight impact different demonstrating strong control shape temporal evolution depth rate although final flood depends total effective flow work exerted sediment bed hysteresis flow discharge rate reported explained flow acceleration shown play minor role proposed model promising alternative computation local highly unsteady hydraulic conditions
novel graphene quantum dot based reported targeted drug delivery sensing dual modal imaging therapy terminated firstly conjugated functionalized cancer targeting molecule acid drug molecules loaded surface via resulted conjugates based mechanism donor molecules acceptor molecules meanwhile successfully performed vitro mri fluorescence imaging living hela cells monitored intracellular drug release process using cell viability study demonstrated low cytotoxicity enhanced therapeutic efficacy cancer cells potential platform cancer accurate diagnosis therapy
microrna mirna highly conserved class small noncoding rna nucleotides length function specific manner post regulate gene expression organisms tissue mirna expression studies discovered myriad functions mirnas various aspects role mirnas chicken ovarian tissue days age hitherto reported study performed first mirna analysis ovarian tissues low high rates egg production using high throughput sequencing comparing low rate egg production high rate egg production significantly differentially expressed mirnas found including known six novel mirnas found known mirnas involved mainly pathways reproduction regulation steroid hormone biosynthesis dopaminergic synapse additionally expression profiling six randomly selected differentially regulated mirnas validated quantitative real time polymerase chain reaction qpcr mirnas mir mir mir reported regulate processes proliferation cell cycle apoptosis metastasis expressed differentially ovaries high rates egg production suggesting mirnas important role ovary development reproductive management chicken furthermore uncovered significantly regulated mirna mir ubiquitous related pathways mirna play special central role reproductive management chicken needs studied confirmation
even though one studied pharmaceutical aquatic environment still lack information fate generation different transformation products along wastewater treatment plants products generated human metabolism microorganisms present natural waters soils sediments increase probability find environment work presence main metabolites carboxylic acid monitored quantitatively along processes occurring different batch activated sludge experiments different working conditions total removal achieved almost experiments related part formation metabolites mentioned another metabolite detected experiments first time metabolites remained solution end experiments whereas disappeared faster metabolites addition also evaluated batch experiments removal occurred highest rate followed exhibited lowest removal rate finally metabolites monitored sewage natural water samples found higher levels expected maximum concentration wastewater samples respectively whereas maximum levels effluent wastewater samples respectively high levels compounds also found river samples particular detected elsevier rights reserved
advances membrane cell biology hampered relatively high proportion proteins known function proteins largely entirely devoid structurally significant domain annotations structural developed profile profile tools online version called detect remote missed tools used databases applied study single structural fold single model organism proof principle entire protein domains sharing homology domain fold yeast systematic application accurately identified known like domains also predicted new domains yeast proteins many implicated intracellular traffic one confirmed functional importance predicted like domain even though predictions require considerable work corroborated useful first steps applied widely particularly across entire model organisms significantly improve database annotations
background mental illness disease affects millions people every year causes stress mentally patients also family members provide care family caregivers therefore need form coping strategies dealing mentally family qualitative study aims identifying analysing coping strategies adopted family caregivers dealing mentally family total family caregivers state malaysia participated face face semi structured study findings identified array coping strategies used family caregivers including religious coping emotional coping acceptance becoming engaged leisure activities use traditional healing help cope mentally conclusions study suggests family caregivers engage social support groups learn obtain positive coping strategies used caregivers similar experiences caring mentally study also suggests get appropriate training mental health professionals order enhance caregivers coping skills
distributed generators distribution networks brought much influence fault current traditional fault section locating algorithm distribution networks work paper new switching function built used distribution network single power supply multi power supplies regional processing method used paper distribution network several independent regions fault locating algorithm used independent regions regions without connection eliminated fault current detected complexity computation fault section location reduced ant colony algorithm good optimization algorithm swarm intelligence positive feedback fault tolerance distributed computing features good application effect locating faulty section distribution network attained order overcome disadvantages large amounts calculation long searching time local optimal ant colony algorithm improved adaptive dynamic modifying ant system strategy also used paper improved algorithm used distribution network multi distributed generators results example analysis show effective good fault tolerance algorithm
background peanut allergic reactions heterogeneous ranging mild symptoms anaphylaxis objective identify peanut allergic sensitized phenotypes patient management methods combined factor cluster analysis used study phenotypes patients diagnosed peanut sensitization enrolled survey method first applied patients oral food challenge applied patients without confirm findings independent population results three independent clusters emerged subgroup cluster severe peanut allergy little allergic multi morbidity subjects highest proportion patients positive medium level peanut protein inducing positive lower percentage allergic multi morbidity asthma plus atopic dermatitis cases multiple food allergies cluster severe peanut allergy frequent allergic multi morbidity subjects high proportion patients positive lowest level peanut protein inducing positive allergic subjects allergic multi morbidity cluster mild peanut allergic sensitized phenotype subjects lowest mean age lowest proportion patients positive high level peanut protein inducing positive low percentage allergic multi morbidity two severe phenotypes frequent girls clusters found subgroup patients without conclusion clinical relevance besides classic markers associated lower threshold doses allergic multi morbidity female gender also taken account better adapt progressive dosage tests
high rise building construction highly complex involves many different disciplines projects accomplished efficiently appropriate quality means overall optimized construction process however understanding term quality among involved participants always equivalent providing required shaft walls constantly throughout concrete works often challenging task execution situ concrete works paper based scientific research project efficiency optimization quality control engineering processes civil engineering aimed developing method instant quality assurance construction based techniques time optimizing efficiency process respect time paper shows hierarchical modular modeling construction processes using high level nets delivers base real time quality evaluation planning construction site example modeling approach simulated construction concrete core characteristic high rise structure concrete works considered carried using form work three different scenarios shown paper first scenario simulated deterministic durations developed net second scenario uses stochastic process durations show robustness construction process finally disturbances delays integrated automated based prioritized alternative paths used elsevier rights reserved
like true memories false memories capable priming answers insight based problems recent research attempted extend paradigm advanced problem solving tasks including involving verbal reasoning however experiments constrained problem solutions generated via spreading activation mechanisms much like false memories rather using complex reasoning processes three experiments examined false memory priming complex reasoning tasks absence simple semantic associations experiment demonstrated robustness false memory priming reasoning backward associative strength among problem terms eliminated experiments extended findings demonstrating priming newly created solved inhibiting semantic associations within analogy overall findings present experiments provide evidence efficacy false memory priming extends complex reasoning problems
work proposes algorithm called morphological sets based morphological reconstruction heuristics faster cpu parallel means worst case scenarios produces enhanced visualizations dataset distinct also faster similar methods sensitive density shapes addition deterministic intrinsic sense maximal clusters created given input sample input parameters differing means algorithms words given constant structuring element dataset produces less clusters without using random pseudo random functions finally proposed algorithm also provides straightforward means removing noise images datasets general
one widely used techniques improve quality existing software systems process improving design existing code changing internal structure without altering external behavior important suggest improve quality structure system many criteria also important consider reducing number code changes preserving semantics software design behavior maintaining consistency previously applied article propose multi objective search based approach recommendation process aims finding optimal sequence improves quality minimizing number design defects minimizes code changes required fix defects iii preserves design semantics maximizes consistency previously code changes evaluated efficiency approach using benchmark six open source systems different types move method move field pull method pull field push method push field class move class extract class extract method extract interface six commonly occurring design defect types code functional decomposition data class surgery feature empirical study conducted experts addition performed industrial validation technique software engineers large project provided industrial partner found proposed succeed preserving design coherence code acceptable level code change score knowledge recorded applied past similar contexts
sustained prenatal hypoxia decreases growth metabolic rate embryo causes blunted hypoxic response newborn likely interpretation sustained hypoxic stimulation interfere normal prenatal development however wanted consider possibility prolonged hypoxic contributing factor chicken embryos incubated degrees cold group known lower embryonic oxygen consumption dot similar throughout incubation degrees controls cold incubation delayed similar days day old normal pulmonary ventilation dot measured technique oxygen consumption dot simultaneously measured open flow methodology acute hypoxia similar similar increase dot dot almost identical two groups conclude sustained decrease metabolic rate embryonic period carry obvious consequences newborns resting dot elsevier rights reserved
gain insight comparative function stress response insects three cloned fat body encoding protein amino acids respectively northern blotting revealed three mrnas expressed fat body mid gut mrnas expressed fat body whole body different levels different developmental stages three transcripts highly expressed fat body first day fifth larvae fourth days stage whole body initial stages larvae heat cold shock conditions mainly heat shock cooling also function recovery stage important functions short term heat shock recovery long term cooling results revealed long term affect expression long term cooling influence expression recovery stage published elsevier inc
objectives assess association obesity control inflammatory activity increased adverse effects psoriatic arthritis psa disease modifying anti inflammatory drugs methods systematic literature review performed using medline embase databases following guidelines meta analysis observational studies epidemiology consensus statement studies selected included patients psa obesity studied predictive factor outcome adverse effects including efficacy failure quality assessed using hoc risk bias tool qualitative analysis carried type study study population quality specific results results found articles basis title abstract ten articles studied detail finally excluded three majority concluded statistically significant results patients psa treated tnf alpha inhibitors tnf alpha obesity associated poorer chances achieving maintaining minimal disease activity higher treatment discontinuation rates lower skin response regarding conventional synthetic trend toward moderate increase methotrexate observed obese patients psa conclusions obesity negative predictor clinical response patients psa treated alpha except adverse effects either alpha drugs found relation obesity psa elsevier slu rights reserved
purpose subgroup individuals anorexia nervosa displays social difficulties however clear individuals comorbid autism spectrum disorders account difficulties methods compared social function using autism diagnostic observation schedule young females first episode comorbid autism spectrum disorder individuals recovered adolescent onset healthy comparison individuals age range years measured adaptive behavior parent questionnaire aspects social cognition psychological tests reading mind eyes test profile nonverbal sensitivity short version awareness social inference test affective task results participants first episode recovered displayed difficulties social function associated body mass index state factors disorder first episode mood problems anxiety associated difficulties parents rated participants first episode lower recovered control participants socialization domain finally participants recovered demonstrated deficits specific domains social cognition perceiving nonverbal bodily gesture vocal conclusions young females first episode recovered displayed impairments social function represent stable traits disorder participants recovered demonstrated deficits social cognition society adolescent health medicine rights reserved
self locomotion central animal behaviour survival generally analysed focusing preferred speeds particular biological physical constraints present paper focus instead maximum speed study order magnitude scaling body size bacteria largest terrestrial aquatic organisms using data species various taxonomic groups find maximum relative speed order magnitude ten body lengths per second fold mass range running swimming animals result implies locomotor time scale order one second virtually independent body size anatomy locomotion style whose requires explanation building basic properties organisms first principle estimates relate generic time scale basic biological properties using particular recent muscle specific tension molecular motors finally step relating time scale still basic quantities environmental conditions earth addition fundamental physical chemical constants
accepted people coast protection damage reduction china information status benefits prospects documented fragmented incomplete study creates database includes episodes occurred along chinese coast total episodes occurred locations china past two decades locations order reduce avoid additional dry decrease place semi submerged geotextile trap sediment prevent filled material sandy coast popular type china rise coastal tourism real developing furthermore conception coastal sediment cell understood accepted sediment management china larger volume sand placed entire environment maintain favorable sediment status elsevier ltd rights reserved
human target characteristic parameter extraction important approach behavior monitoring extraction characteristic applied various backgrounds hospital therefore technology widely studied towards extracting physiological characteristic parameters motion characteristic features human target novel human parameter extraction algorithm proposed paper high detection accuracy high accuracy detection achieved combining time frequency analysis image processing algorithm besides utilization short wavelength evident micro motion features inherent radar also contributes improvement detection accuracy simulations test effectiveness proposed algorithm illustrate performance high extraction precision noise comparison simulations also performed band radar via thorough simulations clearly find advantage proposed algorithm human target characteristic parameter extraction elsevier rights reserved
children syndrome experience difficulties recognizing facial emotions particularly fear clear skills best facilitated using photo matching task emotion recognition tested children syndrome children nonspecific intellectual disability cognitively matched typically developing children groups four conditions emotions emotion labelling generic task instructions groups emotions facilitated recognition accuracy speed emotion labelling facilitating recognition accuracy overall accuracy speed differ children syndrome although recognition fear poorer typically developing children unrelated emotion label use implications interventions considered
titanium based alloy applications implantable material chemically different methods order improve adhesion thin film aim study increase biocompatibility metallic material deposition ceramic material surface metallic material known titanium grade investigated scanning electron microscopy sem detector images energy dispersive ray chemical attack deposition deposited using electrophoretic equipment time using experimental conditions comparison made deposition material mechanical properties investigated experimental results present homogeneous layer formed good adhesion reduced particles metallic material used dental implant presents better corrosion resistance simulated body fluid electrolyte eis electrochemical impedance spectroscopy tests emphasize formation two layers compact one titanium oxide porous one top surface
aim study follow sample physicians began core medical training paper examines long term validity selection methods predicting performance membership royal college physicians examinations performed longitudinal study examining extent selection methods predict performance examinations total completed selection methods included study looking part part written scores selection methods show evidence predictive validity outcome variables hierarchical regressions show methods add significant value selection process selection methods predict performance important outcomes good evidence validity methods additional role alongside selection methods
background health system responsiveness measures non health aspect care relating environment way healthcare provided clients study measured performance correlates hiv aids treatment care services zone ethiopia methods cross sectional survey across seven responsiveness domains attention autonomy care choice communication confidentiality respect conducted people using pre art art care likert scale categories allocated percentages analysis classified fail acceptable good good performance results participants health centers hospital respectively art pre art care respectively range response classifications reported domain fail performance higher choice attention autonomy domains communication attention confidentiality domains higher scores good performance category hand respect domain higher score good performance category attention choice domains low scores respect confidentiality communication showed low proportion fail performance responsiveness percent score fail good categories respectively rest good performance category multivariate analysis unit increase perceived quality care satisfaction services financial fairness scores respectively resulted increase contrary visiting traditional medicine practitioner formal hiv care associated decrease conclusion health facilities performed low autonomy choice attention domains overall weaknesses strengths showed overall good performance domain specific responsiveness scores better ways measuring responsiveness improving quality care client satisfaction financial fairness important interventions improve responsiveness performance
study deals evaluation compliance map variability flexible structure using active material namely shape memory alloy sma compliance stiffness maps important indicator performances robotic structures mechanisms instance assess positioning error production task paper carefully examines impact combination compliant structure closed loop flexible structure sma spring various static compliance maps simulated analyzed respect state sma several aspects discussed concept pseudo deriving deformation structure anisotropy non linearity compliance change relevance large displacement framework strength materials sense correct calculation compliance maps results enable validate capability combination compliant structure sma component achieve variable compliance maps used robotic tasks
objectives group based cognitive behavioral therapy children aggressive behavior resulted significant reductions behavior problems small medium effect sizes report efficacy individualized treatment program children aggressive behavior method within subject design two phases waiting treatment chosen sixty boys aged years peer related aggressive behavior included course outcome measures growth rates week waiting phase compared subsequent treatment phase weekly child sessions together average parent contacts multilevel modeling primary outcome peer related aggressive behavior rated parents outcome measures included parent ratings patient self reports aggressive prosocial behavior results treatment growth rates parent rated outcome measures significant comparison waiting phase indicated stronger decrease aggressive behavior stronger increase prosocial behavior self rated outcome measures growth rates treatment significant comparison waiting phase indicated stronger decrease disturbance social interaction conclusions treatment program effective intervention children peer related aggressive behavior
due unpredictable varied often physical nature law enforcement police high risk work related physical injury aim critical narrative review identify synthesize key findings studies investigated musculoskeletal injuries sustained law enforcement occupational tasks systematic search four databases using key search terms conducted identify potentially relevant studies assessed key inclusion exclusion criteria determine studies included review included studies critically level evidence determined relevant data extracted synthesized identified studies ranged percentage quality scores mean score high agreement scores reflected cohens kappa coefficient common body site injury upper extremity common injury types soft tissue sprains strains common cause injury non compliant often involving assault however limited peer reviewed research area published research narrow focus low fair methodological quality
purpose rehabilitation nurses essential responsibility detailed functional independence measure documentation accurate scoring goal performance improvement project improve individual accuracy establish maintain accuracy standard design case study methods performance improvement project implemented bed acute care hospital inpatient rehabilitation unit findings improved individual overall scoring accuracy increased length stay case mix index conclusions concurrent scoring documentation review holds staff allows timely following discrepancy identification leadership supports concurrent utilization available technology transparent reporting results individual accountability lead sustained improvement scoring accuracy clinical relevance accurate documentation scoring drive appropriate length stay case mix group assignment assessment competence enhances nursing engagement confidence process accountability
peptide modular enzymes catalyze synthesis important peptide products variety standard non amino acid substrates within single module multiple catalytic domains responsible incorporation single residue amino acid activated covalently attached integrated carrier protein domain substrates intermediates delivered neighboring catalytic domains peptide bond formation modules chemical modification final module peptide delivered terminal domain catalyzes release peptide product multi domain modular architecture raises questions structural features enable assembly line synthesis efficient manner structures core component domains determined demonstrate insights catalytic activity recently multi domain structures determined providing clues features enzyme systems govern functional interaction multiple domains chapter describes structures proteins strategies used assist structural studies dynamic proteins including careful consideration domain boundaries generation truncated proteins use mechanism based inhibitors trap interactions catalytic carrier protein domains
pre ejection period reactivity reward specific index behavioral approach incentive motivation suggesting uniquely associated affective motivational deficits study evaluated reactivity reward task predictor depressive symptoms among adolescents examining global depressive symptoms specific symptoms clusters participants included adolescents ages years female study found marginal support association reactivity reward concurrent symptoms association global scale findings discussed terms potential associations peripheral measures dopaminergic functioning also utility measure future research
background sexual reproductive rights include access accurate appropriate information order make informed decisions current age media internet adolescents exposed information sexual health sexuality myriad sources objective study explore sources information adolescent learning sexual health sexuality methods data collection included four focus group discussions total adolescents years old semi structured interviews adolescents years old seven interviews key informants working adolescents audio recordings transcribed analysed using content analysis results primary sources sexual health sexuality information parents teachers friends whilst secondary sources included health professionals females internet males information provided trusted sources parents teachers health professionals tended focus biological aspects sexuality particularly pregnancy sexually transmitted infections limited emphasis placed topics love attraction relationships abstinence sexual violence information focused primarily heterosexual relations reproduction adolescents relationships sexual acts friends partners many males findings indicate lack available information partner communication setting personal limits contraception including neutral medically correct information emergency contraception conclusions study highlights numerous gaps adolescent information needs information provided parents teachers health professionals priority trusted sources place providing biological information learning emotional relational aspects sexuality biological adolescent sexual behaviour way gender inequality peer pressure media religion influence adolescent sexual decision making information sexual orientations diverse spectrum human sexual behaviours finally limited provision practical information hinders development skills necessary ensuring safe sexual relations trusted adults encouraged engage adolescents critical reflection broad range sexuality topics building knowledge skills necessary make informed decisions
study aimed investigate formation three inclusion complexes acid main component dye named beta beta methyl beta beta beta beta exploring particularly effects solubility binding ability final inclusion dye natural widely used food textile industry low water solubility application dye restricted study employed beta derivatives hydrophobic part resolve aforementioned limitation binding constants solubility determined three beta using phase solubility method followed rank order beta beta beta inclusion interactions beta detected using fourier transform infrared spectroscopy nuclear magnetic resonance moreover scanning electron microscope transmission electron microscope applied characterize appearance inclusion complexes study provide useful approach obtaining novel based products high water solubility low toxicity elsevier ltd rights reserved
objective report discusses role congenital acquired risk factors pathogenesis portal vein thrombosis study design describe clinical management treatment preterm newborn homozygous mutation reductase activator inhibitor genes sepsis candida results although literature data suggest minor role genetic factors case one mutation hypothesize combined genetic defects cumulative effect significantly increase thrombotic risk conclusion appropriate include detailed analyses factors diagnostic neonatal thrombosis also investigation genetic polymorphisms anticoagulant therapy removal concurrent risk factors remain basic steps adequate management prevention complications
objectives brief version world health organizations quality life instrument widely used evaluating personal subjective quality life qol patients particular populations however absence sufficient studies among general population normative data remain scarce fill gap present study explored sociodemographic health related factors affecting qol study design total participants aged years rural areas province screened stratified cluster multistage sampling scheme anthropometric measurements laboratory examinations self reported information disease history collected trained personnel depression symptoms assessed using patient health questionnaire methods stepwise multiple linear regression used explore association multiple factors qol results females single subjects lower qol scores males married subjects respectively total qol scores scores domain decreased age increased positive correlation found age environmental domain score participants higher annual education levels activity levels higher qol scores regression model coefficient stroke confidence interval total qol score one level increase depression level total qol score decreased physical domain score decreased psychological domain score decreased conclusions socio economic status including marital status highly related qol regarding chronic diseases stroke important factor qol depressive symptoms strong negative relationship qol royal society public health published elsevier ltd rights reserved
disease bone predispose development malignant bone tumors giant cell tumor consequence disease rare bone characterized rapid growth destruction bone extension surrounding soft tissue abnormal bone turnover caused abnormality receptor activator nuclear factor kappa rank rank ligand rankl pathway rank rankl inhibitor used treat osteoporosis bone current study year old male presented severe pain located right knee patient bear weight affected leg patient suffered disease years complications disease included degenerative hip disease patient underwent right total hip replacement right lesion identified confirmed disease induced needle biopsy positron emission tomography pet scan revealed significant tumor metabolic activity subsequent obtaining informed consent patient started treatment total months starting pet scan showed residual pathological uptake site previously identified large pet tumor year patient exhibited satisfactory clinical improvement conclusion treatment markedly reduced size pelvic led complete metabolic response
background irritable bowel syndrome ibs inflammatory bowel disease ibd patients report similar gastrointestinal symptoms yet comparisons symptom severity groups general population lacking methods compared patient reported outcomes measurement information system symptom scales measuring esophageal reflux disrupted diarrhea bowel incontinence nausea vomiting constipation pain gas usa sample ibs patients iii ibd patients tertiary care community populations symptom severity scores based score metric mean standard deviation relative key results patients enrolled ibs patients mean age ibd patients mean age subjects mean age ibs patients reported greater severity disrupted nausea vomiting pain gas constipation symptoms ibd counterparts compared ibd patients worse pain gas diarrhea bowel incontinence less severe disrupted ibs patients severe nausea vomiting pain gas constipation women severe pain gas men whereas men severe bowel incontinence conclusion inferences ibs ibd associated severe symptoms compared excluding esophageal symptoms unlike ibd ibs characterized observable inflammation patients report severe upper lower symptoms
step length estimation important issue areas gait analysis sport training localization article estimate step length walking using waist wearable computer named motion sensors within device used record body movement trunk instead extremities two signal processing techniques applied algorithm design direction cosine matrix transforms vertical acceleration device coordinates coordinates empirical mode decomposition used remove zero first order effects resulting integration process experimental results show algorithm performs step length estimation effectiveness direction cosine matrix algorithm improved walking speed increased
purpose exhibits significant heterogeneity occurrence severity lifespan goal discuss recent evidence regarding determinants natural history asthma childhood review rationale behind status major efforts alter microbial exposures associated risk allergic disease use bacterial promising preventive strategy exposure air pollution appears particularly damaging prenatal early life interventions reduce pollution feasible result clinical benefit cigarette use role harm reduction conventional cigarette smokers asthma undefined short term long term effects clarified vitamin insufficiency first several years life associated risk asthma vitamin supplementation reduces risk severe identification risk factors asthma occurrence persistence severity continue guide efforts alter natural history disease reviewed several promising strategies currently investigation vitamin supplementation air pollution reduction shown effective strategies warrant increased investigation implementation
linear stability analysis performed base state solution describing transported system inclined angle theta one two modes found dominant depending angle low shear mode whose remains nearly symmetric degrees marked significant asymmetry throughout domain high level shear inside thin regions adjacent walls critical angle theta increases amount momentum energy lost particle wall friction collisions respectively time evolution latter mode onto base state solution reveals alternating train dense regions near top domain qualitatively development propagation inclined systems observed experiment analytic solution corresponding vertical system uniform base state also derived identify instability mechanisms responsible class non oscillatory transverse waves exist vertical particle systems american institute chemical engineers
bleeding pattern second consecutive levonorgestrel releasing intrauterine system lng use consecutive use lng associated predictable bleeding pattern characterized absence initial period irregular bleeding seen interval insertion lng non bleeding pattern vast majority women increased popularity lng long term birth control treatment heavy menstrual bleeding consecutive use system becoming frequent one previous study showed rate consecutive users however sample size small prospective multicenter study four european countries recruited women continue lng use immediately first year period total women followed end first year second thereafter women continued extension phase study full years use second women continued end study total women mean age years using first lng years months years months either contraception treatment planned replace device new lng recruited followed years second use total centers four european countries involved study bleeding patterns analyzed using daily bleeding diaries using day reference periods first year second use last year years use approximately women free bleeding years slight increase number bleeding days similar days first immediately placement second number bleeding days returned level preceding second insertion absence bleeding associated high overall satisfaction continuation rates serious adverse events assessed related lng use occurred year period cumulative rate year study period sample size large enough study bleeding patterns subjects likely represent typical consecutive users therefore role chance small women represent selected group already successfully used first almost years willing continue use however currently common clinical situation results therefore extrapolated first time users lng data importance counseling women making decisions concerning long term contraception
frequent become serious problem urban areas necessary improve rainwater retention infiltration urban watershed purpose study report private rainwater retention harvesting facilities spread gradually steadily city initiated activities rainwater harvesting tanks installed intensively rainwater harvesting house constructed city japan city experienced flood disaster former enhanced users daily emergency latter inspired construction rainwater harvesting housing complex public elementary school use april inspired facilities school located land old irrigation pond thus school needs adapted condition rainwater retained within amounts retention discharge monitored data utilized science education big cities people tend depend much top system surfaces urban areas bottom individual collaborative approaches adopted order achieve multiple purposes preventing mitigating disasters preserving ecosystems communities city elsevier ltd rights reserved
objectiveto identify risk factors suicide attempts individuals treatment manic mixed episode total manic mixed cases bipolar disorder type recruited european countries included prospective year observational study poisson regression models used identify individual treatment factors associated new events two multivariate models built stratified presence absence prior resultsa total recorded prospectively peak incidence weeks treatment cases prior history risk repetition associated younger age first manic episode rapid cycling history alcohol substance use disorder number psychotropic drugs prescribed initiation study entry cases previous first event associated rapid cycling lifetime history alcohol use disorder initiation study entry conclusionthe introduction recent onset manic mixed episode associated increased risk studies determine whether link causal
epstein barr virus ebv large dna virus establishes life long infected host associated number human tumors ebv genome encodes proteins essential persistence proteins render vulnerable hosts immune system therefore ebv gene transcription tightly regulated one critically important regulatory mechanism utilized ebv dna methylation methylation within cpg promoter regions important gene silencing genome integrity although parasitic elements methylated mammalian cells never ebv evolved utilize dna methylation maximize persistence immune detection reliance dna methylation also provides unique therapeutic strategy treatment ebv associated tumors dna agents capable transcription highly immunogenic viral proteins rendering tumor cells susceptible killing host immune system inducing viral cycle cell elsevier inc rights reserved
aims objectivesto investigate relationship quality life social support female nurses play important role providing care managing patients health hospitals however limited studies shown association quality life social support female nurses china survey investigate full time female nurses different departments four comprehensive hospitals cross sectional correlational design using questionnaires demographic data questionnaire menopause specific quality life questionnaire social support scale used resultsthe scores physical psychological subscales higher sexual subscales quality life average score objective support higher subjective support utilisation social support significant association quality life social support found support influenced quality life social support buffer pressure influence individual stress perception help individuals cope pressure reduce negative impact stress mental physical health thus improving different aspects health relevance clinical social support active environment allow female nurses better quality life clinical practice
article focuses exploring students understanding concept function concerning three main aspects secondary students ability define concept function present examples functions solve tasks asked recognize interpret concept function presented different forms representation solve function problems confirmatory factor analysis verified dimensions comprising conceptual understanding functions definition recognition interpretation problem solving furthermore important role ability define concept rest abilities revealed leading important didactic implications
since frequent communication applications takes place high speed networks deep packet inspection plays important role network application awareness signature based network intrusion detection system contains technique examines incoming packet employing pattern matching algorithm overall inspection performance existing studies focused implementing efficient pattern matching algorithms parallel programming software platforms advantages lower cost higher scalability either central processing unit cpu graphic processing unit gpu involved studies focused designing pattern matching algorithm based cooperation cpu gpu paper present enhanced design previous work length bounded hybrid cpu gpu pattern matching algorithm preliminary experiment performance comparison previous work displayed experimental results show achieve effective cpu gpu cooperation also higher throughput previous method
present study investigated correlation significance transcript antisense rna epithelial mesenchymal transition emt related factors occurrence metastasis esophageal squamous cell cancer progression mrna protein expression levels emt related factors detected para carcinoma tissues using reverse transcription quantitative polymerase chain reaction western blot analysis expression levels factors correlation factors clinicopathological characteristics subsequently analyzed mrna expression levels significantly higher compared para carcinoma tissues mrna expression levels significantly higher groups lymph node involvement organ metastasis compared group without furthermore expression levels demonstrated significant increasing trend differentiated cancer poorly differentiated cancer mrna protein expression levels zinc finger protein beta catenin significantly higher compared para carcinoma tissues whereas cadherin mrna protein expression levels lower tissues compared para carcinoma tissues mrna protein expression levels also significantly higher groups lymph node involvement organ metastasis compared without beta catenin protein expression levels significantly higher groups lymph node involvement organ metastasis compared group without tissues mrna expression levels positively correlated mrna protein expression levels negatively correlated cadherin expression levels mrna expression levels also positively correlated beta catenin mrna expression levels conclusion involved carcinogenesis metastasis induce expression emt related factors detection factors assist early diagnosis prognostic prediction
high work stress consistently associated disturbed autonomic balance specifically lowered cardiac control increased sympathetic activity lead increased cardiovascular risk stress management procedures proposed reduce autonomic dysfunctions related work stress different categories workers exposed heightened work demands limited number studies addressed issue managers present study aimed evaluating effectiveness respiratory sinus arrhythmia intervention psychological physiological outcomes managers high level work responsibilities thirty one managers leading outstanding private public companies randomly assigned either training control group training consisted five weekly min sessions designed increase whereas controls provide daily stress diary week training managers groups reported reduced heart rate rest lower anxiety levels improvement health related quality life importantly managers group showed increased control indexed increased decreased sympathetic arousal indexed reduced skin conductance systolic blood pressure lower emotional compared managers control group results study showed training effective improving cardiac autonomic balance rest moreover findings study underline effectiveness reducing negative outcomes associated stress managers
radio devices complexes strategic application highly complicated technical systems working difficult conditions including conditions intentional interference radio systems developed various times various technical parameters operation requirements makes common use even difficult due mutual influence article examines semi markov model maintaining electromagnetic stability system control radio complexes suggest analytical tools solving problem maintaining electromagnetic compatibility total radio complexes basis analysis state model conditions interference use state space representation theory thus suggested tools allow calculate efficiency radio systems operation probability task performance period exceeding predetermined one work offers methods studying dependence efficiency parameter following parameters system functioning expected value time radio system operation task performance expected value start interference expected value restoring operation capacity probability conditions overlapping frequencies interference power exceeding limit value signal power resulting mathematical tools allow calculate average time effective radio system functioning conditions intentional interference calculate probability effective simultaneous work two radio systems mutual interference also help determine optimum plan frequency resource interference reduction developed methods determining optimum working plan number heterogeneous radio complexes thus aiming build single effective system control changing dynamically parameters radio emissions
dna based vaccination appears promise chronic hepatitis immunotherapy although urgent need increase efficacy preclinical study evaluated therapeutic benefit cytokine ifn genes delivery dna vaccine targeting proteins chronic hepatitis virus infection model investigated persistence replication competent virus livers apparently resolved animals carriers received four injections plasmids encoding envelope core alone delivered ifn plasmids long term follow viral covalently closed circular dna analysed liver samples liver also tested vivo neonatal delivery resulted significantly lower mean starting week viral undetectable conventional methods livers animals respectively interestingly inoculation liver apparently resolved animals exhibiting undetectable southern blotting expression undetectable restricted hepatocytes revealed three liver transmitted high naive animals conclusion results indicate ifn gene delivery considerably enhances efficacy dna vaccine targeting proteins importantly also showed livers exhibiting minute amounts induce extremely high infection highlighting caution taken hepatitis patients prevent hbv transmission liver transplantation context
goal paper describe added value complexities nonlinear system identification applied large scale industrial test setup additional important insights provided frequency domain nonlinear approach significant systems nonlinear system identification important example estimate noise non levels indicate mechanical configuration issues goal provide final full scale model explore applicability nonlinear system identification theories complex multi physical non academic test case elsevier ltd rights reserved
paper series offshore wind farm modular multilevel converter presented consideration different cable models normally cable represented either small capacitance sections implies frequency dependent effects cable neglected one careful using cable models high frequency simulations especially series offshore wind farm whose topology forms resonance circuit consequently accurate model cable adopted represent transient characteristic transmission system proper way paper shows two common lumped parameter types cable model small capacitance section model unable provide equivalent damping effect wideband cable model universal line model wideband model suitable transients emt analysis distributed parameters make impossible transferred state space representation paper first introduces topology series offshore wind farm resonance characteristic wind farm topology analysed based different cable models finally offshore wind farm simulated three types cable models controlled modular multilevel converter
background animal human studies indicate encoding receptor subunit encoding neuronal gamma acid gaba transporter play role addiction modulating synaptic gaba therefore variants genes predict risk resilience methods study included populations differed ethnicity phenotype african american men treatment seeking inpatients single comorbid diagnoses alcohol drug dependence controls finnish caucasian men half comorbid antisocial personality disorder controls community sample indian men women controls seven tag single nucleotide polymorphisms genotyped finnish samples genotyped replication also uniquely african functional insertion promoter polymorphism genotyped results found significant congruent association populations major genotype major allele significantly common moreover abundant controls major genotype predicted analysis combined genotypes showed irrespective status increased risk whereas carriers allele either resilient conclusions results show minor genotypes alleles protective risk finally predict treatment response adverse effects receptor agonist
real world many phenomena time related last three decades database community devoted much work dealing time facts databases many approaches incorporating time relational model already devised assume exact time facts known however assumption hold many practical domains temporal facts occurs treatment valid time requires depth extensions current relational approaches paper propose theoretically grounded approach cope issue overcoming limitations related approaches literature particular present temporal relational model propose new temporal relational algebra query also formally study properties new data model algebra thus approach pre existent temporal non temporal relational approaches top finally consider computational complexity showing limited overhead added moving time
computer graphics combination mobile devices finds many applications fields entertainment education displaying data amount information shown user real time depends mostly speed process thus optimization graphic chain application development development optimized solution developers need familiar possibilities differences developing platform appropriate way implementation graphics engine sample scenes show basic indicators quality level current smart devices paper focuses problem selecting proper graphics engine selected visualization task optimization several used techniques different types effects quality implementation finally evaluated developed testing engine provides relevant data sense frame per second based speed second aspect quality evaluated visual correctness four selected scenes water level volumetric light scattering simulation forest
introduction comprehensively described expression profiles mitochondrial dna nuclear dna genes encode subunits respiratory oxidative phosphorylation complexes hippocampus young controls age matched mild cognitively impaired mci alzheimers disease subjects methods hippocampal tissues non controls mci cases analyzed plus arrays results microarray data revealed significant regulation genes particularly encoded nucleus contrast regulation gene mci subjects compared cases significant differences observed mtdna genes identified array mci subjects except one discussion findings suggest restoration expression nuclear encoded genes aging viable strategy progression published elsevier inc behalf alzheimers association
current mechanical methods oil extraction based electric motor drive systems existing schemes power supply electrical system operating modes development implementation energy conservation measures high potential lying raising energy efficiency equipment current state power supply network new oil wells increasing power consumption associated growth crude oil production require new technical organizational measures ensuring reliability power supply reduction energy losses maintenance desired voltage level operating equipment paper presents example technical solution justification implementation aimed reducing energy losses electrical power network reactive power compensation devices filter compensating devices gradually put operation within existing power schemes enabled increase flow capacity power transmission line order commission new oil authors analyzed operating modes electrical system used two oil fields showed potential introducing effective energy conservation measures
reviewed cases patients diagnosed tertiary university affiliated medical center mean overall hospitalization duration days patients showed specific seasonal incidence mean duration symptoms prior hospitalization weeks duration correlated outcome patients presented cranial however presentation correlated adverse outcome pseudomonas aeruginosa main causative organism multidrug resistance rate high rate fungal pathogens noted seventeen patients eventually operated however patients needed extensive surgery general anesthesia computed tomography evidence adjacent structures involvement correlated adverse outcome eighty percent patients improved clinically overall death rate disease related mortality rate findings state importance limited surgical intervention cultures disease treatment particularly important patients cranial finding adjacent structural involvement correlate adverse prognosis rising antibiotic resistance fungal infections challenge antibiotic treatment future elsevier inc rights reserved
background limited data regarding associated factors return sports activities years anterior cruciate ligament acl reconstruction purpose test patient characteristics concomitant articular lesions graft maintenance sports activities years acl reconstruction hypothesized years operation young adult men maintenance greater activity level better knee function associated greater activity level younger age reconstruction absence concomitant articular lesions minimal graft follow study design case series level evidence methods one hundred six men autologous acl reconstruction ages years reviewed years surgery excluded patients contralateral acl tear revision reconstruction another injury function fifty five patients eligible available follow independent variables included score time interval injury surgery smoking status age articular lesions side side difference shift grade main outcome measures activity level international knee documentation committee subjective score knee injury osteoarthritis outcome scale score years surgery results greater activity level follow associated regression model greater activity level correlation coefficient lower difference correlation coefficient negative shift correlation coefficient younger age operation predicted return greater activity level univariate analysis correlation coefficient regression model significant lesions surgery predicted lower subjective scores scores affect maintenance sports activities conclusion years autologous acl reconstruction young men predictors greater sports activity level primarily high activity level knee younger age operation moderate lesions lower impact respect
background antibody responses seasonal influenza vaccine patients atopic dermatitis carefully characterized objective primary objective study compare antibody responses vaccination participants moderate severe participants secondary objectives evaluate effect route administration staphylococcus aureus skin colonization disease severity vaccine response methods open label study conducted influenza season clinical sites total participants moderate severe subjects assessed eligibility received vaccination per label followed days vaccination primary outcome difference proportion participants achieving inhibition antibody day vaccination results rates influenza different participants participants receiving vaccination participants receiving vaccination vaccination participants aureus colonization experienced lower rates lower inhibition antibody geometric mean fold increase influenza lower rates influenza participants conclusion participants aureus exhibited reduced immune response influenza vaccination compared participants vaccination patients aureus influenza vaccination given preference patients
dha diet endogenous synthesis proposed affect infant development however results inconclusive study aim verify previously observed fatty acid gene cluster snp specific associations erythrocyte dha status month old children sex specific association developmental outcomes study performed children boys obese mothers erythrocyte fatty acid composition analysed blood samples obtained months age developmental outcomes assessed ages stages questionnaire years erythrocyte dha level ranged fatty acids show association snp potential determinants regression analysis showed associations erythrocyte dha scores personal social skills problem solving tendency observed association opposite direction minor alleles variant personal social skills respectively became significant snp combined based previously observed effect erythrocyte dha months age sex snp interaction indicated genotype fine motor scores due higher scores among minor allele carrying girls whereas effect seen among boys conclusion dha increasing snp erythrocyte dha status consistently associated improved personal social skills small cohort children obese mothers irrespective sex sample small verify potential sex specific effects
schizophrenia without comorbidity confers modest statistically significant elevation risk violence risk considerably increased comorbid antisocial personality disorder psychopathy comorbid substance use disorders comorbidities frequent conduct disorder conduct disorder symptoms risk aggressive behavior patients schizophrenia violence among adults schizophrenia follow least two distinct pathways one associated conditions including antisocial conduct another associated acute psychopathology schizophrenia aggressive behavior bipolar disorder occurs mainly manic episodes remains elevated patients comparison controls risk violent behavior increased comorbidity borderline personality disorder antisocial personality disorder substance use disorders comorbidities frequent borderline personality disorder bipolar disorder related response medication two disorders share tendency impulsive behavior including impulsive aggression particularly expressed occur
several cancer types outcomes improved significantly patient stratification treatment based molecular characteristics histologically identical tumors potential genomics improve management distinct tumor entities exemplified egfr mutant lung cancer mutant melanoma targeted small molecule kinase inhibitors recent discovery genetic determinants clinical benefit immune checkpoint blockade likely possible extend entities protein families classes drugs advances high throughput dna rna sequencing provide accurate information somatic alterations cancer genomes decreasing costs however remains challenge integrate analyses clinical setting within master program standardized workflow including multidisciplinary molecular tumor board allows tumor genome sequencing within clinical context efforts way molecularly stratified treatment trials optimize clinical implementation biology guided therapeutic interventions systematic evaluation patient outcomes
growing trend universities switch conventional teaching methods focus knowledge transfer methods based concept active learning many methods devised tested show validity concept study project designed implemented simple principles students construct fly remote controlled model goals motivate students study foster teamwork communication paper explains project effectiveness demonstrated three trials three groups students
article discusses practices parental support healthcare provided welfare state drawing ethnographic material clinics finland discuss healthcare practices processes specific contexts welfare state analysis shows nurses work experience based knowledge knowledge parental competence achieved largely natural process experiencing pregnant life care practices seen enabling respect process clinics encourage parents self reflect self emphasis self reflection self reliance previously interpreted state adoption therapy culture response market demands welfare state offer require citizens autonomy choice argue however parental subject emerging practices welfare service reduced individual individual project individual shortcomings equally mere product conform parent figure derived collective ideas good
paper describes wearable encounter type device suitable combined usage visual display features device lie driving mechanism enables encounter type display compact implementation entire device including driving mechanism driving mechanism displays natural sense based smooth transition follow constraint finger movements important contributes preserving quality visual information used together visual display test basic performance device response driving mechanism evaluated display function evaluated simulation device used touch object computer graphics space
paper focuses real time estimation ion state charge soc first principles model validated experimental data literature chosen mimic real ion cell impedance responses different studied simulated electrochemical impedance spectroscopy eis equivalent circuit model developed estimator design parameters including lumped series resistances lumped interfacial resistances time constant tau derived system identification compared eis results estimator designed using extended kalman filtering implemented first principles model demonstrated computer simulation soc charge discharge cycles estimated relative error accuracy soc tracking improved jointly estimated along either given model parameters vary soc revealed eis elsevier ltd rights reserved
significant perform damage identification wind turbine using running condition data guaranteeing safe operation acquired condition data usually mixed heavy background noise feature enhancement noise elimination method necessary task means algorithm increase signal noise ratio without original frequency spectrum structure reserve useful information meanwhile eliminate noise seems possible powerful tool along technique constant speed condition order tracking analysis method variable speed condition damage identification however actual application cases show obtain entirely satisfying results face strong background noise situation specialization improved means method developed damage identification generator bearing based analyzing essence characteristic mechanical vibration signal reasonable ideas algorithm design neighborhood selection variation weighting function means task proposed effectiveness specialization improved means method verified fault identification cases study including variable speed condition elsevier ltd rights reserved
perceptual systems rapidly generate accurate representations world sensory inputs internal external noise typically obtain representations integrating information multiple channels integration lead biases inputs fact source although considerable amount known different sources information combined influence perceive known whether temporal features combined vital address question given divergent predictions made different models cue combination time perception concerning cross modal temporal integration implications integration research programs action control social cognition present four experiments investigating influence movement duration perceived duration auditory tone participants either explicitly experiments implicitly experiments produced hand movements shorter longer durations judging duration concurrently presented tone duration across experiments judgments tone duration attracted toward duration executed movements perceived longer executing movement longer duration results demonstrate temporal information associated movement biases perceived auditory duration placing important constraints theories modeling cue integration state estimation models time perception action control social cognition
family policies france various european countries like schemes involve mechanisms compensate inequality women men associated organization family compensation sometimes tied directly marriage broadly couple sometimes parental investment time devoted maintenance welfare family members article examine principles compensation applied legislation five european countries characterized different social protection systems use concept characterize underlying womens social rights different systems understand processes connecting developments family social policies dual process parental activities specialization gender roles
background unintended pregnancy continues major public health concern particularly among women years age emergency contraception became available purchase without prescription united states however use among women risk unintended pregnancy adequately explored therefore purpose project gain insight perceptions experiences college women regarding counter emergency contraception since change status methods study used descriptive exploratory qualitative design small group interviews conducted early obtain data women ages currently attending college data analyzed using content analysis findings participants aware emergency contraception availability counter although certain gaps knowledge exist decision making related use driven recognition pregnancy risk strong desire prevent unintended pregnancy confidentiality major concern lack access women age participants noted limitations health services provision education conclusions although women awareness availability comprehensive knowledge needed barriers use exist particularly confidentiality age related restrictions increasing awareness personal risk unintended pregnancy particularly among college women important elsevier rights reserved
aims objectives recent studies show carcinoma situ invasive carcinoma share similar genetic molecular biology increasing concerns regarding biological significance aim study investigate whether presence coexisting affects tumor biology behavior correlate methods study cases included parameters immunohistochemical estrogen receptor progesterone receptor cadherin human epidermal growth factor receptor cases retrieved patient coexisting compared pure cases respect different cases cases pure cases coexisting seventy six cases showed lymph node metastases lymph node metastasis absent cases present cases stage cases respectively nodal involvement distant recurrence less frequent compared without value respectively presence coexisting predicted higher disease free survival compared pure log rank test divided different positive cases associated cases showed better positive pure cases log rank test similarly cases patient less years showed better patient less years pure log rank test conclusions conclusion coexisting carcinoma situ characterized less nodal involvement lower distant recurrence better pure divided different positive less year groups show even significant better pure findings suggest biological significance coexisting effect tumor aggressiveness certain
paper modular platform provides student services smart educational environment described platform represents point mutual integration various services hosting platform students projects platform integrating service students web applications internet things platform enables acquiring data sensors distributed within university building controlling various actuators platform deployed part smart learning environment integrated single sign service uses rest api also provided framework relational non relational databases used deploying platform platform evaluated tested
aim assess accuracy magnetic resonance predicting extension location characteristics small bowel segments affected crohns disease method prospective study including consecutive series patients crohns disease small bowel underwent surgery specialized colorectal unit tertiary hospital preoperative magnetic resonance performed patients following homogeneous protocol within months prior surgery thorough exploration small bowel performed surgical procedure calibration spheres used according surgeon accuracy magnetic resonance detecting areas affected crohns disease small bowel assessed findings magnetic resonance compared surgical pathological findings results thirty eight patients lesions included study surgery lesions described magnetic resonance found seven detected exclusively use calibration spheres passing surgical exploration magnetic resonance accuracy detecting location stenosis sensitivity specificity magnetic resonance precisely diagnose presence inflammatory accuracy accurate detecting accuracy respectively conclusion magnetic resonance useful tool preoperative assessment patients crohns disease however thorough intraoperative exploration entire small bowel still necessary
past decade research carbon nanotubes revealed potential advances thermal engineering applications present study investigates radiative absorption reflection vertically aligned carbon nanotubes broad spectrum near infrared far infrared regions optical constants modeled based dielectric function graphite effective medium approach film medium calculated radiative properties show characteristics near unity index matching high around wavelength density degree alignment shown affect predicted radiative properties angle penetration depth examined infrared spectrum radiative properties thin films also evaluated showing reduction near infrared due transmission film thicknesses less study provides better understanding infrared behavior guide design applications energy harvesting space borne detectors stealth technology
purpose study face opportunities children older adults routinely interact one another sometimes result adolescent age gated communities families geographical mobility many communities introduced intergenerational programs within school curriculum decade one community maintained intergenerational program brings fourth grade students together older adults question students involvement intergenerational program beliefs years later design methods quasi experimental research design examined images aging held students grew neighboring attend regional high school participants completed brief questionnaire results separate regression analyses positive negative images aging controlling students frequency self reported quality interaction older adults ethnicity age gender reveal town difference students positive negative images aging implications certain high school students one community ongoing intergenerational programming hold positive image older adults research needed exactly short long term legacy effects arise young students opportunity interact closely older adults neighbors
recent years electricity crisis still becomes noticeable countries due gap demand supply consequently future demand plays significant role efficient management utilization electricity pertaining efficient supply handling increase power system reliability electricity demand forecasting one crucial tools forecasting technique used decision makers world predict future demand key information proper policy research hybrid model consists maximal overlap discrete wavelet transform support vector machine svm differential evolution optimization emphasizing simplifying complex structure data pre processing proposed forecast thirty two annual electricity compared traditional forecasting models hybrid model svm combined model svm optimization based mean absolute error mean absolute percentage error symmetric mean absolute percentage error measures test post hoc test empirical results indicate proposed model outperforms forecasting models provides accurate forecasts candidate models significance levels nearly highest precision consequently proposed model able reduce limitations individual models regarding annual electricity used promising tool order forecast annual electricity elsevier rights reserved
standards reflect consensus semantics terms used communicate whether people software systems standards ensure communication correct different standards different semantics terms express common concepts using different terms different ways communication software systems based different standards sometimes difficult achieve standards integration concerns explicit representation overlapping sets concepts standards differences semantics ensure standards used consistently together turn enables software based integrated standards reducing cost software integration standards determines whether interpretation standardized terms used software applications consistent semantics given standards paper proposes general architecture design ontologies standards integration manufacturing engineering ontology architecture divided four levels standards domain core manufacturing turning tools used case study illustrate approach finally paper offers short examples first order logic
borderline personality disorder bpd characterized severe persistent impairments interpersonal functioning given complexity social interactions studying interactive behavior bpd patients challenging one way implement tight experimental control realistic externally valid settings use game theoretical experiments review discusses findings economic exchange studies bpd background game theoretical literature bpd patients seem derive utility mutual cooperation others appear partners strategy negative bpd patients seem act mostly self interest trigger strategy resembles theoretical ideal rational self interested agent finally summarize research findings economics clinical psychiatry mutually propose new research ideas fascinating field elsevier ltd rights reserved
micrornas mirnas extensive class small rnas nucleotides important roles regulation gene expression although large number mirnas identified variety eukaryotic systems function vast majority molecules remains unknown study functions mirnas crucial determine spatial temporal expression patterns although existing methods analyze expression mirnas easy task routine gene expression studies study established simple method detect expression mature mirnas total rna poly polymerase cdna synthesized specific reverse transcriptase primer reverse transcriptase using poly total rna templates expression several mature mirnas assayed method expression profile two mirnas determined polymerase chain reaction pcr assay identical determined northern blotting data show poly pcr convenient method detect expression mirnas
singular value decomposition based ultrasound blood flow filters recently demonstrated substantial improvement rejection plane wave imaging become commonly used filtering method many novel imaging applications functional ultrasound super resolution imaging present however computational burden remains major practical implementation clinical translation method address challenge study present two blood flow filtering methods based randomized randomized spatial accelerate filtering minimal compromise filter performance computation largest singular values random full original large data matrix small matrices processed parallel vitro blood flow phantom study presence heavy tissue showed significantly improved computational performance using proposed methods minimal deterioration filter performance less reduction blood ratio less increase flow mean squared error less increase standard deviation vessel blood flow signal less increase tissue velocity full factor less maximum acceleration randomized spatial approximately another vivo rabbit kidney perfusion study showed provided comparable performance full rejection vivo maximum difference blood ratio less random provided artifact free perfusion imaging results combined full blood ratio still factor also demonstrated imaging feasibility similar processing time combining random findings methods presented paper greatly facilitate new area imaging research
past research shown exposure aggression associated negative responses toward others also toward self present research argue aggressive priming influences content thoughts primary cognition also influence people think thoughts secondary meta cognition circumstances two experiments showed effect direction thoughts positive negative self evaluation greater receiving aggressive control priming induction among participants negative self attributes aggressive control prime condition reported negative self attitudes however among participants positive traits aggressive neutral led favorable self attitudes reversing traditional effects aggression self evaluation
paper describes design two stage operational amplifier using three structures calculation various parameters three basic designs include cmos hybrid cmos full operate power supply technology paper simulation curves computed different characteristics gain simulation carried pspice tool three design application specific basic cmos based stage amp provides high open loop voltage gain rail rail output swing first proposed design hybrid cmos provides additional gain increased higher phase margin second proposed design full based stage amp used low power applications best alternative implementation low power circuits
short wavelength blue light caffeine studied mood enhancing effects humans ability blue light increase mood cognitive function via non image forming suggested non pharmacological depression across range occupational settings experimental study compared blue light caffeine aimed test effects blue light placebo white light caffeine blue light caffeine white light placebo mood randomised controlled crossover design study used convenience population healthy volunteers participants rated mood swedish core affect scales prior experimental condition assess dimensions valence activation significant main effect light combination blue light caffeine clear positive effects core effects ranging global mood benefits combination blue light caffeine investigated across range applications due observed effects dimensions arousal valence activation
use computer vision techniques post harvest processing agricultural products increased considerably recent years due non destructive rapid monitoring abilities image processing combined pattern recognition applied fruit sorting classification study bag feature model used classification sweet varieties laplace laplace maximally stable regions detectors along scale invariant feature transform descriptor used model means clustering method applied building descriptors performance classifiers nearest linear chi square support vector machine svm chi svm respectively compared using classification results model observed chi svm classifier outperformed svm classifiers using model possible detect classify sweet varieties high overall accuracy published elsevier ltd rights reserved
paper focuses identification nonlinear vibration system power transformers model used identify system electrical inputs vibration transformer tank output nonlinear property system modelled using fourier neural network consisting nonlinear element linear dynamic block order weights network determined based criterion back propagation algorithm system identification method tested several power transformers promising results predicting transformer vibration extracting system parameters presented discussed
irritable bowel syndrome diarrhea ibs common chronic functional gastrointestinal disorder symptoms patients often result substantially impaired quality life review focuses providing clinicians information practical evidence based treatment ibs current therapies commonly used treatment ibs including pharmacologic interventions briefly reviewed followed discussion emergent pharmacologic treatments medical foods given lack standard treatment algorithm ibs emergence new pharmacologic therapies treatment needs tailored individual patient take account severity disease context latter part manuscript examines treatments ibs used clinical practice presenting three patient case scenarios varying degrees ibs severity case patients medical history clinical presentation related rome foundation multidimensional clinical profile potential treatment options current emergent therapies reviewed interplay gastrointestinal symptoms psychosocial impact importance patient centered approach therapy discussed consideration given potential need combination therapies emergent treatments fit treatment pathway mild moderate severe cases ibs clinical practice
article reviews recent advances study european court justice political impact european member state levels new quantitative qualitative analyses show great empirical precision member state preferences guide court article findings argues greater attention needs given law order fully capture political impact even european less often assumed individual decisions face member state opposition case law evolves highly fashion caution regarding expectations quasi deterministic law making found impacts heavily european member state policy making
based electromagnetic wave provide perfect absorption significant range electromagnetic spectrum perfect broadband absorption play important role stealth technology paper design simulation measurements novel band ghz broadband absorber presented absorber operating middle microwave band obtained selecting differently sized unit cells placing resonant frequencies close paper presents two consist different number unit cells first absorber unit cells unit cells observed simulation results good agreement measurements measurement bandwidth absorption level ghz ghz highest absorption levels planar band absorption mechanism broadband absorber also investigated using electric magnetic field distribution results study promising stealth applications absorbing elements band elsevier gmbh rights reserved
mobile cloud computing uses features deliver data remotely available mobile devices however flexible nature mobile device critical challenge mobile cloud computing environment mobile phone significantly data transfer performance initiating process thus energy efficient process improve quality service qos introduce secure energy efficient quality service architecture process mobile cloud computing environment proposed architecture involves four layers application internet protocol multimedia subsystem communication media connectivity layers four layers collectively handle energy efficiency security qos parameters existing service oriented architectures designed mobile cloud computing based symmetric encryption cryptography support different media services however approach easily allows adversary expose symmetric key gain access private data thus proposed architecture uses secure strong authentication process layer protecting media services users central layer entry point adversary furthermore extend mobile lifetime process energy detection model deployed communication layer detect energy level mobile device prior initialization process media connectivity layer supports secure process using priority enforcement module allows legitimate users complete registration process initiating finally architecture tested using simulation environment validated comparison known service oriented architectures
study sending receiving secret messages called cryptography generally receivers unaware process encryption decryption hence encryption plays important role data communication data security meaning encryption keep data unwanted access also ensuring data integrity available way capacity breaking security increasing rapidly process information one concerned topics advanced encryption standard popular widely used efficient encryption algorithm used since paper focuses aes key generation process substitution box modifies conventional key generation technique builds dynamic dimensional box advance encryption standard proposed approach suggests key generation matrix box per shown novel technique increases amount time needs encryption decryption experimental result shows also enhances strength aes algorithm proposed approach illustrates theoretical analysis corresponding results
todays highly demanding customers aggressive product development getting complex needs continuously hand common direction towards cost savings shortening design cycle forces make product design process highly efficient high level performance accordingly paper provides new creative design tool support robust product development taking advantage creativity based design process achieve goals innovative product design describes pilot prototype software system used computer aided product development developed based characteristics product design process integrating creative thinking methods information technologies computer application technologies cad system labview game technology etc new design environment leads flexible working flow designing product hand hand searching product library arranged geometric properties allows designers engineers professionals collaborate platform product development process
aim augmentation late sodium current causes intracellular accumulation results intracellular overload via reverse mode exchange current reverse also induces early lead arrhythmia cardiac dysfunction thus inhibition considered potential way therapeutic intervention ischemia heart failure study investigated effects competitive receptor antagonist normal augmented reverse isolated rabbit ventricular contribute activity methods rabbit ventricular prepared reverse recorded voltage clamp mode whereas action potentials induced early recorded current clamp mode drugs applied via results nmol concentration dependently inhibited normal augmented values nmol nmol respectively mol affect inhibitory effects nmol augmented contrast much high concentrations needed inhibit transient sodium current value mol addition nmol significantly shifted inactivation curve toward membrane potential without affecting activation characteristics moreover nmol significantly decreased augmented reverse nmol increased action potential duration basal conditions mol considerably extended evoked cells presence nmol markedly decreased eliminated cells conclusion inhibits normal augmented decreases augmented reverse addition prolongation eliminates induced thus prevents induced arrhythmia
affective subclinical manifestations phenotypes mood states represent one healthy end mood disorder spectrum however scarcity studies investigating neurobiological basis affective one fundamental aspect temperament behavioral reactivity environmental stimuli effectively evaluated use cognitive event related potentials reflecting diversity information processing aim present study explore associations affective traits healthy individuals recorded erp waves using auditory paradigm medical student volunteers females males participants affective evaluated using temperament evaluation paris san auto questionnaire version bivariate analyses depressive temperament score significantly correlated latency multiple linear regression analysis latency showed significant positive correlation scores depressive temperament significant negative one scores temperament affective temperament scores associated amplitude reaction times results indicate affective related information processing brain depressive temperament characterized decreased physiological arousal slower information processing opposite observed temperament
bim technology kind brand new concept involves series innovation change planning design theory construction maintenance technology development trend information construction bim technology research important application value broad application prospects building life cycle management extremely vital significance improve level construction design construction operation scientific technological level promote construction industry level
environmental exposures pregnancy increase breast cancer risk mothers female offspring tumor tissue assays provide insight regarding mechanisms study assessed feasibility obtaining tumor samples pathology reports mothers enrolled child health development studies pregnancy developed breast cancer years follow breast cancer cases identified linkage california cancer registry self report written consent obtained breast cancer survivors access pathology reports tumor blocks contacted respond obtained tissue samples pathology reports diagnosis made years obtained tissue samples pathology reports respectively obtaining pathology reports tumor tissues two generations feasible support investigation relationship early life exposures molecular tumor markers however found recent diagnosis increased accessibility tumor tissue recommend cohorts request consent obtaining future tumor tissues study enrollment implement real time tissue collection enhance success collecting tumor samples data
controlling geometric parameters pool main method getting better welding quality industrial robotic welding paper presents technology real time welding process sensor necessary improve welding quality using intelligent robot gas metal arc welding process set vision systems consists active vision sensor passive vision sensor designed clear steady images pool obtained passive vision part images laser projected obtained active vision part time features acquired images analyzed geometric parameters cross section pool successfully extracted images detection precision system also analyzed
paper presents new approach infer worldwide infected machines solely analyzing generated probing activities contrary adopted methods proposed approach rely symptoms infection detect compromised machines allows inference infection early stages contamination approach aims detecting whether machines infected exact type family latter insights allow network security operators diverse organizations internet service providers backbone networks detect clients compromised machines addition effectively providing tailored anti patch solutions achieve intended goals proposed approach exploits internet space initially filters traffic targeting space using probabilistic model subsequently approach employs statistical methods infer large scale probing activities perceived dark space consequently activities correlated samples leveraging fuzzy entropy based techniques proposed approach empirically evaluated using recent real traffic thousand real samples results rationale exploiting probing activities worldwide early infection detection indeed promising results validated using available data resources demonstrate extracted inferences exhibit noteworthy accuracy generate significant cyber security insights used effective mitigation elsevier rights reserved
home programs designed provide comprehensive services promote parents abilities create stable care environments children order program goals met parents participate actively engaged programs mission however promoting engagement participation complex processes understudied research home current qualitative study examined national funded home program early head start engaged retained families potentially helpful preventative interventions delivered study also identified barriers active engagement semistructured interviews conducted parents children enrolled findings suggest engagement increased reduced social isolation forming connections among parents program focused involving parents fostering childrens meeting important developmental barriers engagement identified included organizational challenges parental biases differences values attitudes practice policy recommendations improving programs serve similar populations increase engagement discussed
known studies fatal child abuse attention parental scripts regarding children relationships ways sometimes fatal children article reports new system assessing meaning child parent called meaning child interview parents interviewed using established parent development interview equivalent transcript interview analysed according parental sensitivity likely risk child constructs developed used observed parent child interaction specifically care index form discourse analysis used dynamic model adult attachment interview allowing systemic inter subjective understanding parenting representations often put forward article discusses theoretical background gives brief review similar measures introduces coding system patterns caregiving validity addressed elsewhere
aquaculture gaining importance affordable source animal protein among production total production followed farmers however facing challenges regards financial viability poor water quality fish farms also contributing towards water pollution environmental impacts order improve situation launched project train farmers best management practices distribute generation strain present study aimed evaluating relative environmental gains offers compared conventional farming using life cycle assessment lca inventory data representing farmers four groups control evaluated life cycle impact assessment results including quantitative uncertainties calculated statistically tested using monte carlo analysis wilcoxon paired significance test five impact categories explored global warming freshwater consumption land use offered greatest improvements across evaluated impact categories significantly reducing environmental impacts offered significant improvements compared control regards freshwater consumption land use meanwhile performed except significantly larger environmental footprint efficient feed utilization higher productivity main reasons environmental improvements additional improvements explored include improved made raw materials better pond water management including probiotics wheels statement relevance improved help reduce environmental impacts elsevier rights reserved
aimed implement extension community healthcare outcomes echo model hepatitis evaluate outcomes health providers following echo model hepatitis clinic established hospital clinic provides support training physicians treat patients hepatitis order evaluate clinic outcomes physicians completed survey focused skills competence hepatitis months participating project survey consisted questions participants rated ability highest ability analyze difference participation project wilcoxon signed rank test used first months implementation model total physicians sites agreed participate survey median age participants years participants primary infectious diseases general practice significant improvement observed evaluated fields month participation clinic namely fibrosis staging determining appropriate candidates treatment selecting appropriate hcv treatment addition general interest hepatitis increased successfully replicated implemented first clinic physicians improved ability provide best practice care patients hepatitis wiley periodicals inc
complex construction program usually consists group interrelated projects different levels importance degrees certainty currently time management construction program uses techniques single project commonly used technique critical path method however method lacks flexibility handling uncertainties options desirable feature managing complex programs paper proposes new scheduling method drawn authors experiences managing large scale construction program shanghai facility construction new method developed basis traditional method able incorporate options importance levels program schedule theoretical basis calculation method new scheduling technique discussed context managing shanghai facility construction program paper contributes body knowledge construction management developing new scheduling technique proven applications american society civil engineers
chronic food restriction behavioral cellular responses drugs abuse dopamine receptor agonists administered systemically locally nucleus however alterations synaptic transmission underlying effects incompletely understood receptor trafficking major mechanism regulating synaptic strength previous studies shown sucrose rapidly alter abundance receptor subunits density manner differs food restricted fed rats study examined whether food restriction absence reward stimulus challenge alters subunit abundance food restriction found increase surface expression specifically abundance suggesting synaptic incorporation lacking permeable antagonist decreased amplitude evoked blocked enhanced locomotor response local receptor agonist food restricted fed subjects although receptor agonist also induced greater locomotor activation food restricted fed rats effect decreased taken together present findings consistent synaptic incorporation receptor expressing medium neurons mechanistic underpinning enhanced responsiveness food restricted rats natural rewards drugs abuse
semantic web uses descriptions particularly web ontology language universal medium formally describe exchange knowledge various domains currently many ontologies different domains come successively therefore store ontologies becomes one ordinary needs semantic web based efficient storage mechanism object oriented databases used store ontologies realizing management large amounts knowledge semantic web end main objective paper investigate store ontologies object oriented databases propose formal approach develop prototype tool storing ontologies object oriented databases firstly giving complete formal definition ontologies propose overall architecture storing ontologies object oriented databases based architecture give storage rules explain store ontologies object oriented databases running example detail correctness quality storage approach proved analyzed finally implement prototype tool store ontologies widely used open source object database also query interface developed prototype tool querying stored ontologies storage query examples provided show approach feasible tool efficient elsevier rights reserved
novel type hydraulic structure proposed rainwater harvesting arid area project develop irrigation scheme near dead sea low annual precipitation high salinity major concerns scheme consists irrigated farm reservoir intake structure flood flows reservoir harvested water expected fresh comparison groundwater vulnerable freshwater lens research hydraulic design actual construction processes structure structure consists cutting across wide valley bottom channel long guide water reservoir channel equipped part result level surveys hydrological considerations revealed structure width supercritical flows dominant details structure dimensions designed numerical model experiments finite volume scheme two dimensional shallow water equations used numerically reproduce whole flow field rainwater harvesting event maximum design discharge numerical scheme employs special data reconstruction techniques realize stable computation shallow flows distorted hydraulic model horizontal scale roughness scale constructed experimental station japan order test hydraulic phenomena numerical method represent structure actually constructed site channel made reinforced concrete side walls concrete blocks whose sizes chosen according design however minor changes made construction processes due constraints numerical experiments conducted confirm actual structure showing desired performance
purpose major problem producing artificial livers primary hepatocytes cultured many days recently dimensional printing technology draws attention technology regarded useful tool current cell biology using bio printing problems resolved methods generate bio printed structures cells constructs fabricated bio printing system mouse primary hepatocytes isolated livers weeks old mice step method samples hepatocytes viability printed solution cultured defined culture medium primary hepatocytes confirm functional ability hepatocytes cultured scaffold conducted quantitative real time polymerase chain reaction immunofluorescence hepatic marker genes results isolated primary hepatocytes printed printed hepatocytes remained days gene expression levels albumin alpha gradually increased structures immunofluorescence analysis showed primary hepatocytes produced hepatic specific proteins period time conclusion research indicates bio printing technique used long term culture primary hepatocytes therefore used drug screening potential method producing artificial livers
surface development origins making computer graphics without consideration thickness involving nonlinear optimization constraints moreover research surface development mainly focuses planar development paper development non sheet planar curved doubly curved surface patterns investigated optimal developing algorithm formulated minimize strain energy required deformation sheet orthogonal coordinate system used three target patterns simplify constraints developing process resulting quadratic optimization element solid element utilized finite element analysis similar developed results obtained planar spherical patterns using two types elements cylindrical pattern solid element model gives accurate result due contribution element translation rotational freedom elsevier ltd rights reserved
acute mechanical damage resulting joint contact abnormalities central initiation progression posttraumatic osteoarthritis study typically performed vivo replicate animals using artificially induced injury features goal work measure changes joint contact stress knee large creation clinically realistic overload injury focal cartilage defect whole joint overload achieved anterior medial focal cartilage defects created using custom pneumatic impact specifically developed mechanically characterized work evaluate effect injuries joint contact mechanics inc south measurements obtained pre group loaded sheep peak contact stress medial compartment increased contact area decreased center pressure shifted toward cruciate medial lateral compartments creation cartilage defect significantly change aspect contact mechanics measured knee work characterizes mechanical environment present animal knee joint two methods induce joint injury features lead
work based gate around arch shaped tunneling field effect transistor designed analyzed using technology computer aided design simulations progress characteristics arch shaped highly attractive iii compound material adopted channel material owing arch shaped structure tunneling region gate area extended state current subthreshold swing improved however performance limitations related height source region source grown thickness channel thus performed design optimization based arch shaped variables source optimization process characteristics gate capacitance transconductance cutoff frequency maximum oscillation frequency max extracted analyzed small signal modeling finally designed based arch shaped demonstrated max
background objective oral epithelial cells help prevent bacterial infection oral cavity producing antimicrobial peptides broad spectrum amp complex proteins expressed oral epithelial cells regulated interleukin alpha alpha traditional japanese herbal medicine immunomodulatory effects reported enhance levels alpha epithelial cells purpose study investigate effect expression regulation alpha oral epithelial cells material methods human oral epithelial cells cultured concentrations ranging presence absence anti alpha receptor antagonist expression specific mrnas examined northern blotting expression alpha secretion investigated staining elisa expression alpha analyzed pcr quantitative real time pcr results significantly increased expression specific mrnas protein increased expression effect expression expression alpha specific mrna protein slightly increased neutralizing antibody alpha receptor antagonist inhibited regulated mrna expression conclusion results suggest increases expression oral epithelial cells response regulation partially induced via alpha
continuity interpolation crucial topics computer graphics since every time want values across area need take set samples region however samples allowing results closely match underlying functions task functions sample smooth worst case even impossible continuous situations bringing required continuity easy task much work done solve problem paper focus state art continuity interpolation three stages real time rendering pipeline study problems current solutions texture space object space screen space review literature areas hope bring new light foster research fundamental yet completely solved problems computer graphics
primary progressive heterogeneous neurodegenerative condition prominent clinical feature language difficulties cognitive domains described remain unaffected early stages disease therefore excluded diagnostic criteria however show article executive function disorders present variants semantic also illustrate changes language means year behavioral neuroimaging longitudinal study patient suffering semantic variant review provides update current knowledge suggesting symptoms encountered variants early phases advanced stages atrophy extends adjacent brain areas
syndrome inappropriate hormone reported common cause retrospective cross sectional study evaluated diagnosis patients australian tertiary hospital reference recently published clinical guidelines investigation incomplete cases adrenal insufficiency hypothyroidism excluded significant number cases
form business promotion widely different applications lighting one key entire outdoor facilities order improve effectiveness facilities security especially outdoor lighting applications remote areas occasionally occur damaged novel lighting anti security system based digital control technologies designed implementation paper designed system achieve real time online status monitoring lighting abnormal situation system issued site sound light alarms remote line etc greatly improving anti security performance outdoor lighting
unsteady state gas dynamics intake engine analysed objective tune intake line low operating speeds exhaust gases lack enthalpy needed operate rated speeds provide boost pressure needed proposed methodology lack boost pressure existing wave action intake zero dimensional acoustic modelling first used investigate geometrical parameters low end acoustic tuning impedance bench electrically driven engine tests complete study compare different intake configurations two geometries charge air air air charge air water cooled charge air optimal intake configurations found low end torque considerations high speed operation reduction pressure losses important findings validated established engine test bench torque gain different rotational speeds engine study led proposal active charge air duct enables solution found low end torque acoustic tuning high speed operation boost pressure readily available acoustic response part compared reference solution conclusions possible topics future work obtained analysis
reported digital emission current controllers use floating voltage sources produce noise current consequently decrease quality electron beam implementation digital control electron source system without floating sources gives average value electron emission current standard deviation described controller developed order investigate properties new hot
impaired dual namely inability concurrently perform cognitive motor task walking largely unexplained frequent symptom parkinsons disease consider two circuit level accounts striatal dopamine depletion lead impaired dual patients parkinsons disease first loss segregation striatal induced dopamine depletion lead dysfunctional motor cognitive processes usually implemented parallel striatal circuits second known posterior anterior gradient dopamine depletion patients parkinsons disease cause motor cognitive processes relatively anterior putamen causing neural bottleneck using functional magnetic resonance imaging measured brain activity patients parkinsons disease control subjects performance motor task auditory ankle movements cognitive task implementing switch stay rule tasks simultaneously dual task distribution task related activity known segregation motor cognitive putamen groups motor related responses posterior putamen task switch related responses anterior putamen dual task performance patients made motor cognitive errors control subjects recruited striatal territory posterior putamen engaged either cognitive motor task used controls relatively higher posterior putamen activity controls associated worse dual task performance observations suggest dual task impairments parkinsons disease related reduced spatial focusing striatal activity pattern striatal activity explained loss functional segregation striatal occurs specifically dual task context
resistance distance two vertices connected graph defined effective resistance electrical network constructed graph replacing edge unit resistor index graph defined sum resistance distances pair vertices graph let generalised join graph determined paper first give formulae resistance distances index terms parameters show computing resistance distances index decomposed simpler ones finally obtain explicit formulae resistance distances index take special graphs complete graph path cycle
industry around world grow automated intelligent smart camera plays important role smart camera equipped processor memory communication interface operating system process large amounts data advance assist follow automatic inspection judgment additionally since smart camera independent system affect original system immense advantage besides thanks technology recent years using graphics processing unit gpu implementing parallel computing helps significantly boost overall efficiency therefore rising number consider improving production capacity production lines use gpu assist improvement important issue based scenario paper used platform gpu cuda cores core arm cortex processor industrial camera simulate smart industrial camera gpu perform myriad complex computations paper designed recognize count objects real time manner industrial inspection environment large volumes data verify concept smart camera gpu cores proposed experimental results proved ideas software design architecture provided paper simple efficient design future application internet things internet structure valuable reference
introduction influence personality traits suicidal behaviour risk documented personality traits suicidal behaviour partially genetically determined personality described suicidal behaviour aim study investigate possible association personality traits suicidal behaviour selected serotonergic gene polymorphisms methods study included patients meeting dsm criteria bipolar disorder healthy controls personality dimensions assessed using temperament character inventory genotyped two selected polymorphisms tryptophan hydroxylase gene polymorphism promoter region serotonin transporter gene related neurotransmission multiple poisson regression logistic regression tests applied results found numerous differences patients control group terms dimensions significant differences found patients without suicidal attempts harm avoidance also found interactions interaction spiritual acceptance integrated significantly contributing suicidal behaviour risk found association studied genetic polymorphisms several dimensions conclusion results confirm personality traits partially determined genes personality traits interactions temperament character traits helpful predicting suicidal behaviour
availability important issue software defined networking paper experiments based testbed showed resource utilization data plane control plane changed drastically attacks happened mainly attacks send large number flows network short time based observation analysis defense mechanism based legitimate source destination address database proposed paper firstly flow abstracted source destination address pair legitimate source destination address pair database established historical normal traffic trace proportion new source destination address pair traffic per unit time non parametric cumulative sum algorithm detect attacks quickly accurately based alarm non parametric attack flows filtered middle box network deep analysis via south bound api line updating policy adopted keep timely accurate mechanism mainly implemented controller simulation results show mechanism achieve good performance protecting attacks
introduction assess ability low dose hybrid iterative reconstruction pure model based images maintain accurate unit determined tissue characterization methods standard protocol low dose modified protocol acquired crohns disease patients referred image reconstruction via manufacturers recommendations filtered back projection adaptive statistical iterative reconstruction data sets underwent four reconstructions three observers measured tissue volumes using thresholds fat soft tissue bone contrast data set analysis via spss results inter observer agreement strong tissue volume measurement superior reconstructions closely correlated reference images tissue types superiority marked fat volume calculation close plot correlation seen lowest average difference compared reconstructions conclusions unit determined tissue volume calculations images resulted values comparable calculations values superior images accuracy estimation volume tissues fat using segmentation software low dose images appears optimal reconstructed pure
global optimization algorithm genetic algorithm advantageous tool due global convergence great robustness suitable parallel computing selection optimal parameters maximum generations population size genetic operators crossover fraction mutation fraction extremely crucial particle size characterization ultrasound attenuation spectroscopy genetic algorithm series particle system different distribution functions numerically investigated work revealed simulated results consistent given particle size distribution maximum generations population size crossover fraction mutation fraction appropriate chosen furthermore anti noise performance genetic algorithm three improved forms applied particle system distribution also studied two groups samples sized glass beads glycerol suspension aqueous suspension investigated experimentally ultrasound attenuation spectroscopy showed good agreement improved genetic algorithm microscope image analysis elsevier rights reserved
objective estimate effect participating cognitive cooperation groups mediated computers internet mini mental state examination mmse percent variation outpatients memory complaints attending two memory clinics methods prospective controlled intervention study carried intervention group attended cognitive cooperation group sessions hours control group received routine medical care outcome percent variation mmse control variables included gender age marital status hypertension diabetes hypothyroidism depression vascular diseases use exposure tobacco sedentary lifestyle obesity functional capacity final model obtained multivariate linear regression results intervention group obtained independent positive variation mmse compared control group conclusion results suggested cognitive cooperation groups mediated computers internet associated cognitive status improvement older adults memory clinics
lung transplantation using rna hepatitis hcv donors recipients currently performed due high risk transmission previous reports shown poor survival practice applied emergence new direct acting antiviral drugs suggests high chance sustained response patients report successful transplantation lungs hcv donor hcv recipient recipient hcv patient chronic lung allograft dysfunction viral transmission occurred early excellent clinical outcomes observed including elimination hcv weeks treatment using
teacher centered traditionally playing role basic teaching method long time way students perceive learn subjects content class seems remember content taking exam hand time comes solve real problems usually find difficulty accomplish due lacking practical experience basic programming skills factor students information technology field content knowledge adequate learning programming subjects students practice actual work comprehensive understanding study represents teaching processes applied problem based learning technique learning directions communications student computer programming subject school university target group empirical study
three novel small noncoding rnas identified conserved regions using comparative genomics method molecular biology approach one novel way displays structural features typical box family possesses long rrna antisense element guiding methylation rrna two mirnas whose predicted precursors adopt stem loop structure characteristic known mirna two mirnas genes appear ubiquitous expression profiles similar rna transcripts detected northern blotting study revealed multi species conserved sequences nested length addition small rna coding function cis acting elements involved gene transcription post transcriptional processing
tested across three studies effect cultural life memory phenomenological properties focused particular effects schema consistency frequency life addition testing recognition study recall studies also collected remember know remembered events studies memory emotional valence study primary finding across three studies higher frequency events lower frequency events measured either recognition recall also attained three additional complementary effects first schema inconsistent events received remember ratings often schema consistent events study trend effect study second events emotional valence inconsistent life memory valence reconstructed fit study third recall disproportionately life events study although case recognition study conclude life serves cognitive schema shapes memory phenomenological properties
background date association obesity lower urinary tract symptoms luts controversial objective overcome current inconsistent results regarding association obesity luts investigate association obesity luts using propensity score matching analysis setting bariatric center excellence health promotion center university hospital methods august december total obese patients men women visited bariatric center undergo bariatric surgery patients international prostate symptom score overactive bladder symptom score compared healthy controls visited health center period control effects age propensity score matching used results matching propensity score male patients female patients included study men items except frequency significantly different obese patients controls median scores higher obese group women items except feeling incomplete significantly different groups voiding storage also marked differences genders total quality life total overactive bladder symptom score significantly different genders conclusion marked differences luts obese patients including voiding storage symptoms considering relatively young age groups case control study supports hypothesis relationship obesity bladder pathophysiology published elsevier inc behalf american society metabolic bariatric surgery
paper presents study political debates based integrated model simultaneously examines verbal nonverbal communication integrative approach yields better explanatory power separate analysis modalities model used analyze debates israeli campaigns identify consistent discrepancy patterns behavior model also sheds light gender differences similarities novel perspective communication styles set kinds behaviors beneficial detrimental debate provided
river virus transmitted prevalent australia believed cause poor performance muscle stiffness australian however disease progression management poorly documented better understanding disease presentation acute therapy long term management required aim study describe clinical presentation diagnosis acute treatment long term management infection study series retrospective case reports clinical diagnostic data obtained veterinary records owner interviews five performance presented acute poor performance coupled evidence exposure clinical owner reports evaluated time presentation appeared asymptomatic returned normal performance river virus suspected cause generalized muscle stiffness poor performance five performance located southeast clinical symptoms included exercise intolerance generalized muscle stiffness synovial edema lower limbs investigations elisa virus assay detected antibody responses treated drugs disease modifying osteoarthritis drugs returned previous athletic capabilities months onset symptoms study preclinical submitted paired blood samples meaning assumption acute infection made based clinical signs coupled positive river virus significant poorly understood cause poor performance australian report one document longitudinal management performance affected infection much research needed gain better understanding infection elsevier inc rights reserved
ultrasonic ranging technology used widely many industries around world paper aims design manufacture ultrasonic distance measuring system lower price higher accuracy based deep study principle ultrasonic ranging designed general plan detailed electrical circuits ultrasonic distance measuring system based single chip including transmitter module ultrasonic wave receiving module ultrasonic wave display module etc compiled relative driven programs modules combined system hardware software system last experimental results show cost prototypes measuring similar accuracy means ranging system meets design requirements lower price higher accuracy
fundamental optimization problem vehicle routing problem wide application backgrounds paid lots past decades paper study applications data gathering wireless energy charging wireless sensor networks improved approximation algorithms variants key ingredients algorithm design include exploiting combinatorial properties problems making use tree decomposition minimum weighted maximum matching techniques specifically given metric complete graph integer consider rooted rooted min max cycle cover problems aim find rooted edge cycles covering vertices maximum cycle weight among cycles minimized mentioned problems develop improved approximate solution min max cycle cover problem develop epsilon approximation algorithm rooted min max cycle cover problem devise epsilon approximation algorithm rooted min max cycle cover problem propose epsilon approximation algorithm algorithms improve best existing approximation ratios corresponding problems epsilon epsilon epsilon respectively epsilon constant finally evaluate performance proposed algorithms experimental simulations experimental results show actual approximation ratios delivered proposed algorithms always much better analytical counterparts
fluid mechanics problem relevant foam processes analysed specifically fluid flow field surfactant foam plateau fed surfactant rich material towards comparatively surfactant lean foam films considered extent surfactant mass transfer limited surface viscous effects studied previous work made assumptions likely flow field along plateau border surface assumptions suggested high surface viscosity measured suitable dimensionless parameter led strong suppression rate surfactant mass transfer plateau border film whereas low surface viscosity suppress mass transfer rate significant way detailed fluid mechanical calculations carried corroborate aforementioned assumptions high surface viscosity regime however calculations suggest low surface viscosity regime contrast findings previous assumptions moderate reductions rate surfactant mass transfer also possible moderate reductions mass transfer rate potentially negative impact processes aforementioned strong suppression tend arise conditions efficiency system particularly sensitive reduction surfactant mass transfer rate elsevier ltd rights reserved
decentralized monitoring systems attractive alternative centralized architectures distributed sensor nodes smart grids distribution network closer observed event global remote observer controller improves visibility response time system moreover distributed system local problems also handled locally without communication network paper studies distributed computing perspective two fundamentally different scenarios duty duty model system sensor network consisting set distributed nodes performing local measurements sense events order avoid false alarms sensor nodes event raise alarm number sensor nodes sensing event exceeds certain threshold duty scenario nodes affected event actively help communication process duty scenario non event nodes inactive present analyze algorithms minimize reaction time monitoring system avoiding unnecessary message transmissions investigate time message complexity different settings also light optimality algorithms deriving cost lower bounds distributed systems
background recommended screening animal cases involves testing fresh brain tissue preservation fresh tissue however difficult field conditions fixation provides simple alternative allow confirmatory diagnosis occurrence location histopathological changes immunohistochemical labelling fixed paraffin embedded canine brain described samples cases presence bodies immunohistochemical detection virus antigen evaluated cortex hippocampus cerebellum brainstem effect degeneration tissue also assessed results confirmed cases labelling statistically abundant brainstem bodies observed positive cases although tissue degradation effect diagnosis associated inability detect bodies cases confirmatory polymerase chain reaction pcr testing virus rna undertaken extracting rna fresh frozen tissue also attempted using samples pcr detection using fresh frozen samples agreement results pcr method tissues suitable control material unsuccessful field cases conclusions histopathological examination brain essential define differential diagnoses behaviour modifying conditions virus negative cases unreliable sole method diagnosis particularly change occurred fixation paraffin embedding prevent detection virus via labelling even degeneration occurred represent pragmatic secondary assay diagnosis field fixation prevent sample degeneration brain stem shown site viral immunoreactivity supporting recommended sampling protocols favour improved safety field pcr testing fixed tissue successful certain circumstances alternative test
useful modification known signal flow graph technique circuit synthesis described paper order obtain filters working current mode maximally variable parameters namely characteristic frequency quality factor bandwidth basic gain procedure based reciprocal conversion branch variables adjustable conversion constants obtained structures discussed detail described example current mode multifunctional active filter today popular analogue application theoretic assumptions supported experimental results using modern functional blocks
purpose diabetic leading cause vision loss previous studies shown signaling pathways mediated signal transducer activator transcription play primary role diabetic progression study tested small molecule inhibitor dose dependent therapeutic effects vision loss rat model diabetic methods brown norway rats administered streptozotocin induce diabetes administered daily oral gavage weeks concentrations respectively beginning days post streptozotocin administration systemic ocular drug concentration quantified mass spectrometry visual function monitored week intervals weeks using tracking measure visual contrast sensitivity presence severity visually monitored correlated visual transcription translation multiple angiogenic factors inflammatory cytokines measured real time polymerase chain reaction multiplex immunoassay results streptozotocin diabetic rats sustain progressive vision loss weeks loss visual function rescued dose dependent manner positive therapeutic effect correlates positive effects vascular leakage presence inflammatory cytokines retina conclusions present study indicates inhibition strong therapeutic potential treatment vision loss diabetic
background human metabolism essential biological process involves consumption different substrates ensure nutritional energetic needs cells disruption highly regulated system constitutes onset several disorders dysfunctions diabetes mellitus cardiovascular diseases hypertension objective review propose discuss promising natural products act modulators cell metabolism point towards possible targets take account development new therapies metabolic diseases methods defined main focus undertook intensive search databases select peer reviewed papers fits within review thematic information screened papers described organized manner review different types studies included results two hundred seventy papers included review one reliable website world health organization several articles described pharmacological agents commonly used counteract metabolic disorders however many cases products insufficient represent high costs health care systems associated several undesirable effects highlighting need search new therapies notably many papers reported promising results natural products treatment several metabolic disorders possible alternative complementary strategy pharmacological agents conclusion findings review confirm currently available treatments metabolic disorders associated complications remain far expected results
paper new approach proposed design arbitrary plane filters including band pass band stop filters desired frequency response proposed method based replacing conventional new form resonator made plane plane metal plane thickness parts removed introduced plane supported thin low permittivity dielectric located longitudinally middle rectangular parallel plane design proposed filters scattering parameters structure calculated purpose coupled set electric field integral equations derived solved method moments suitable cost function defined optimized using genetic algorithm matlab tool used optimize cost function proposed method facilitates optimization process comparison full wave simulator software examples band pass band stop plane filters designed results show proposed filter comparison conventional filters advantages frequency band selectivity ability adjustment desired frequency response results designed structures validated simulator software
market led strategies growth development resulted negative various stages production consumption cycle leading destruction environment negative consequences sustainable development prior emergence sustainable development economic development towards economic growth paid less attention since competitive private sector approaches creation jobs employment coupled factors country middle income status focus competitive private sector without practices sustainability led exploitation use natural resources caused land degradation air water pollution soil erosion destruction bio diversity effects estimated cost annually green vital addressing challenges eradication poverty using study approach paper assesses harness innovative potentials green foster attainment sustainable development
background angioedema condition cause cutaneous mucosal edema practically part body isolated edema rather rare manifestation cause important morbidity hereditary angioedema certain medications give rise intestinal angioedema seen rise frequency intestinal angioedema since advent angiotensin converting enzyme inhibitors ultrasound abdomen inexpensive safe easy tool help differential diagnosis case report describe case year old woman presented acute abdominal pain diagnosed intestinal angioedema due hereditary angioedema type emergency physician aware lead administering wrong treatment even unnecessary surgical interventions intestinal angioedema best treated purified inhibitor fresh frozen plasma avoided carries risk worsening symptoms elsevier inc
familial man rare autosomal dominant disorder characterized development numerous throughout colon associated increased risk colorectal cancer time accompanied certain manifestations congenital hypertrophy retinal epithelium dental disorders tumors caused mutations coli gene present study reported chinese family polymerase chain reaction direct sequencing full coding sequence gene performed identify mutation family mutation gene identified heterozygous substitution position exon gene formed premature stop codon amino acid residue resulting truncated protein lacked amino acids present study expanded database gene mutations enriched spectrum known germline mutations gene prophylactic considered possible treatment carriers mutation
study evaluated alveolar bone response testosterone impact testosterone induced osteoblast function vivo characterization male adult rats used treatments established sub physiologic normal physiologic concentrations testosterone forty rats subjected rats received testosterone injections rats received testicular sham operation four weeks surgeries rats group received around lower first induce experimental periodontal inflammation bone loss parallel osteoblasts differentiated neonatal mice treated various doses testosterone cell conditioned media used determination alkaline phosphatase osteocalcin rankl micro computed tomography linear analysis demonstrated bone loss significantly increased groups compared animals normal levels testosterone expression increased group ten testosterone significantly decreased osteocalcin rankl levels osteoblasts significantly increased rankl ratio partially reversed impact testosterone osteocalcin rankl findings suggest testosterone levels increase inflammatory bone loss male rats low testosterone predominantly increases inflammatory response high testosterone promotes higher osteoblast derived rankl ratio mediator testosterone derived downregulation osteocalcin rankl primary murine osteoblasts suggesting direct role inflammation osteoblast function
let set points integer grid maximal layer set points dominated point considering axes parallel query design adaptive space efficient data structure using layers iterative maximal layers reporting points boolean data structure needs linear space time log epsilon log epsilon number layers points query size output epsilon small arbitrary constant range also worst case query time data structure model computation word ram size word log epsilon elsevier rights reserved
introduction myelofibrosis complex heterogeneous disease continues challenge treating clinician ruxolitinib first jak inhibitor approved delivers reduction splenomegaly disease related symptoms likely survival jak inhibitors combination appear alleviate thrombocytopenia response however number patients gain benefit lose response able tolerate ruxolitinib areas covered remains need alternative agents myelofibrosis patients jak inhibitors failed discuss different therapeutic options currently available explore therapeutic option patients without splenomegaly expert opinion responses documented clinical trials suggest efficacy variable limited benefit improving constitutional symptom burden reversing disease process however number phase trials demonstrated safe efficacious option managing splenomegaly reducing transfusion requirements minority improving platelet number discuss currently approved use multiple potential alternative challenging myelofibrosis patient thrombocytopenia exist
diaries found assist weight regulation long term intervention current study attempted expand previous findings testing consideration priming questions within diary instead filling answers investigated levels state mindfulness state self compassion state anxiety observational trial pre forty five participants completed state mindfulness state self compassion state anxiety scales meal asked read consider concrete diary questions results illustrate state mindfulness state self compassion state anxiety levels significantly improved increased mindfulness self compassion decreased anxiety participation findings provide evidence diaries work supporting weight regulation suggest another method making eating current findings limitations recommendations future research discussed
fast global adoption materials genome initiative scientists engineers faced need conduct sophisticated data analytics large datasets extract knowledge used modeling behavior materials raises new problem materials scientists create foster interoperability share developed software tools generated datasets microstructure informed cloud based platform developed addresses need enabling users easily access insert microstructure informatics computational tools predict performance engineering products accounting microstructural dependencies manufacturing platform extracts information microstructure data employing algorithms including signal processing machine learning pattern recognition computer vision predictive analytics uncertainty quantification data visualization interoperability capabilities various web based applications demonstrated case study analyzing microstructure data via automatic identification various features interest quantifying characteristics used extracting correlations associated mechanical behavior yield strength cold etc data recorded two methods electron imaging extracting spatial morphological information alpha beta phases electron diffraction extracting spatial morphological information regions alpha phase extracting reliable knowledge generated information requires data analytics large amount multiscale microstructure data necessitates development efficient algorithms associated software tools data recording analysis visualization interoperability tools superior effectiveness cloud computing approach validated featuring several examples use alpha beta titanium alloys based reflecting anticipated computational cost time savings via use web based applications implementations microstructure informed integrated computational materials engineering
gut microbiota largest organ human body although growth bacteria colony forming unit cfu per culture upper gut used diagnosis small intestinal bacterial growth cfu considered suggest particularly colonic type bacteria present upper gut although neither sensitive specific hydrogen breath tests widely used diagnose best treatment due broad spectrum lack systemic absorption safety profile
represent pediatric brain tumors recent classification pathology enriched localization molecular biology age total removal one several looks required remains major prognostic factor children focal radiation remains standard role chemotherapy matter randomized studies infants front line chemotherapy standard inclusion protocol encouraged case relapse surgery radiation advised inclusion innovative trials including irradiation phase encouraged better understanding underlying mechanisms cell provide close future key use targeted therapies time relapse soon first line therapy subgroups patients
calculation energy protein doses critically patients still matter controversy years nutrition support total amount nutrients delivered patients calculated based expert recommendations calculation based administration one attempt ameliorate response avoid weight loss new evidence suggests protein delivery important intervention improve clinical metabolic outcomes article describes metabolic rationale new evidence supporting change approach metabolic support critically proposing physiological based intervention supported recognition ancillary characteristics metabolic response trauma injury moderate dose around delivery protein appears new recommendation many patients first week following injury
background clinically diagnosed eating disorders adverse cardiometabolic consequences including overweight obesity high blood pressure however link problematic eating attitudes early adolescence lead disordered eating behaviors future cardiometabolic health knowledge unknown objective assessed whether variations eating attitudes influence future development overweight obesity high blood pressure design children participated promotion breastfeeding intervention trial included participants response rate completed childrens eating attitudes test age measured adiposity blood pressure ages assessed whether percentile indicative problematic eating attitudes compared scores percentile age associated new onset overweight obesity high systolic blood pressure high diastolic blood pressure early adolescence results controlling baseline sociodemographic confounders observed positive associations problematic eating attitudes age new onset obesity new onset high systolic blood pressure new onset high diastolic blood pressure age controlling body mass index age problematic eating attitudes remained positively associated new onset obesity however associations new onset high blood pressure attenuated new onset systolic diastolic blood pressure respectively conclusions problematic eating attitudes seem related development obesity adolescence relatively novel observation potentially important public health implications obesity control
use narrative structures learning environments teaching computer programming importance classroom automatic generation narratives one research themes paper presents adaptive specification mechanism generates narratives considering characters emotional facet writing process specification included emotional state machine adaptive methods methods help organize behavioral specification state machine end result takes form prototype demonstrates operation narratives generation mechanism
multi functional materials actuator applications developed toward sensitivity various fields work magneto electro responsive materials consisting matrix composites embedded nanoparticles dispersed phase fabricated tailor electromechanical properties bending performance electric magnetic electromagnetic fields due superior characteristics magnetic materials composites fabricated electronic polarization highly responsive electric field highest storage modulus sensitivity belonged composite possessed value electric field moreover composites material stress depended electric field demonstrated composites also possessed good fast response large bending angle relative applied electric field interestingly steady state storage modulus response attained within first electrical actuation cycle composite fully reversible material addition shown common characteristic fabricated composites magnetic field composite provided largest bending distance magnetic field electromagnetic field respectively summary composite material potential candidate used smart material influences electric magnetic fields existing dielectric materials elsevier rights reserved
adenine nad dependent host cells observed mitochondria cytoplasm nucleus various functional roles also described cellular metabolism energy production detoxification oxidative stress apoptosis reported results seemingly inconsistent even contradictory one another using molecular biology gene transfection flow cytometry investigated expression subcellular distribution possible functional roles regulating apoptosis oxidative stress cultured neuroblastoma cells endogenous transfected exogenous observed mitochondria host cells overexpression markedly protected cells apoptosis induced incubation balanced salt solution also lowered level oxidative stress toxicity hydrogen peroxide cells suggested anti apoptotic role mediated least part anti oxidative effect neuroblastoma cells although involved molecular mechanisms remain elucidated details
recent studies psychiatry reveal acceptance trauma media traditionally restricted immediate experience post traumatic stress disorder ptsd now expanding include mediated experience development come mediated trauma manifest consequences essay addresses questions three cases trauma film paradigm early research program employed films simulate traumatic effects psychiatric study clinical effects watching catastrophic events television september attacks reports operators exhibit ptsd symptoms combat away war zone recognition mediated trauma marks qualitative change understanding media effects rendering impact consequences clinical recent possibility trauma media conceptual link visual media contemporary conceptions trauma
background several ingredients personal care products classified endocrine eds concern raised whether use affect human health aimed characterize norwegian female users skin care products compare life style characteristics heavy users non users methods cross sectional study consisted women age years participating norwegian women cancer study large population based prospective cohort study based self reported questionnaire data classified study subjects five groups according calculated percentage skin area per day life style characteristics compared heavy users using body twice day non users change use assessed repeated measurements results heavy users skin care products significantly lower bmi higher level physical activity higher income higher alcohol consumption fewer children shorter total time breastfeeding non users significantly fewer current smokers former smokers among heavy users among non users current earlier use oral contraceptives hormone replacement therapy hormonal intra uterine device significantly common among heavy users among non users use skin care products moderate extent weighted kappa consistent time many women classified user group category conclusions heavy users skin care products differ significantly non users bmi degree daily physical activity income number children use hormonal pharmaceuticals smoking alcohol consumption use skin care products common among women aged years norway use consistent time
study technology solve energy demand problem global warming replacing gasoline vehicles electric vehicles interesting solution electric vehicle uses electric motor drive powertrain research study evaluation centers main factors influence energy consumption non fixed route diesel fuel bus electric using artificial neuro fuzzy inference systems method comparing energy consumption saving fuel bus model model indicate significance factors affected energy consumption based collected questionnaires surveyed non fixed route around simulation fuel electric bus created artificial neuro fuzzy inference systems method output method relates significance factors energy consumption units result study shows electric bus save around energy consumption compared fuel bus scenarios included study non fixed route years old changed electric defined percent replacement including percent results showed replacement save energy rate year however traffic conditions still affect energy consumption air conditioning electric bus consumes around total usage
two dimensional localized correlated spectroscopy offers greater spectral dispersion conventional one dimensional techniques yet long acquisition times limited post processing support clinical adoption improving acquisition efficiency developing versatile post processing techniques clinical viability purpose study implement non uniformly weighted sampling scheme faster acquisition sequence developed whole body mri phantom containing metabolites commonly observed brain physiological concentrations scanned ten times scheme duration constant eight average sequence using channel head coil spectra also acquired occipital lobe four healthy volunteers using proposed conventional uniformly averaged sequence sequence facilitated shorter acquisition time maintaining comparable snr humans phantom studies compared uniform averaging schemes successfully demonstrated improved efficiency facilitating reduction scan time without affecting signal quality elsevier inc rights reserved
burden chronic kidney disease ckd growing rapidly around world however limited information overall regional prevalence ckd prognostic implications treatment patterns asian region established asian renal collaboration arc goal region wide data regarding ckd methodsthis collaborative project synthesize data perform meta analyses observational studies conducted asia studies identified systematic literature search including abstracts meetings electronic databases medline embase personal among experts region identify additional studies data sources registries cross sectional longitudinal studies describe prevalence ckd complications included longitudinal studies describe important clinical outcomes people ckd individual participant data sought possible studies included collaboration baseline parameters subsequent outcomes order maximize flexibility consistency data analyses study initiative offering unique opportunity obtain information prevalence manifestations ckd asia risk factors arc also provide insights important outcomes including progression ckd ckd complications cardiovascular disease death findings improve understanding kidney disease asia thus help inform service provision preventive care research across region
optimal technique coronary artery still debated additional advances computational simulations soon used compare designs strategies based verified structural results order identify optimal solution individuals anatomy study patient specific simulations deployment performed cases replicate complete procedure conducted interventional subsequent computational fluid dynamics cfd analyses conducted quantify hemodynamic quantities linked patient specific pre operative models coronary reconstructed angiography optical coherence tomography oct plaque location composition estimated oct assigned models structural simulations performed artery geometries virtual expansion prime created compared post operative geometry oct extracted used cfd simulations inflow boundary conditions based body surface area downstream vascular resistances applied branches mimic physiology artery geometries obtained virtual expansion good agreement reconstructed patient images quantitative comparison distance reconstructed post geometries revealed maximum difference area adverse indices wall shear stress pronounced patients findings verify structural analyses expansion introduce workflow combine software packages solid fluid mechanics analysis underscore important design features prior studies proposed approach ultimately useful determining optimal choice position patient elsevier ltd rights reserved
purpose review findings first signs neonatal viral infection review provides update diagnostic features therapies selected viral illnesses simplex virus virus virus present cutaneous manifestations recent findings dna polymerase chain reaction plasma cerebrospinal fluid routinely used diagnosis neonatal expanded utility assessing prognosis therapeutic efficacy maternal antiviral suppressive therapy alter clinical appearance congenital resulting delayed diagnosis treatment immune globulin food drug administration approved form prophylaxis centers disease control prevention expanded period eligibility preterm infants group particularly susceptible severe infection severe neonatal sepsis results randomized double blind placebo controlled trial viral inhibitor suggest compound effective therapy human type strain within newly formed viral genus similar potentially underestimated clinical presentation sepsis however distinctive rash specific human type infection perinatal virus infection present nonspecific rash rash specific obtaining maternal travel history appropriate additional diagnostic testing critical early diagnosis summary neonatal transient whereas others reflect presence severe systemic illness recognizing key cutaneous features viral associated aid prompt accurate diagnosis treatment neonatal viral illnesses
article provides ecological framework understanding adolescent initiated parent abuse review research adolescent initiated parent abuse identifying sociodemographic characteristics perpetrators victims gender age race ethnicity socioeconomic status ses ecological systems theory applied examines risk protective factors adolescent initiated parent abuse within micro maltreatment domestic violence parenting behavior disciplinary strategies peer influence media influence macro gender role socialization change family structure levels findings review suggest older white children significantly likely abuse parents females selective target aggression males target family members general mothers significantly likely abused fathers however researchers also report variations association ses parent abuse domestic violence child maltreatment risk factors findings parenting behavior disciplinary strategies mixed peer influence exposure media violence gender role socialization change family structure potentially increase risk parent abuse practice research implications also discussed ecological systems framework allows examination various contexts interact influence parent abuse behavior provide needed directions research
work presents design fabrication characterization passive printed identification tag ultra high frequency band multiple optical sensing capabilities tag includes five cover wide spectral range near infrared visible ultraviolet spectral regions tag antenna circuit connections screen printed flexible polymeric substrate ultra low power microcontroller based switch included measure five magnitudes optical sensors providing spectral incident electromagnetic radiation ultraviolet infrared without requiring energy battery normalization procedure designed applying entire system tested measuring colour chart sensing fruit
human immunodeficiency virus hiv begins replicate within hosts immune responses elicited escape mutations viral epitopes immunogenic peptide parts presented surface infected cells allow hiv partially responses thus rapidly fixation faster fixation higher escape rate larger selective pressure exerted immune system assumed relation rationale using assess strength immune responses however escape rate estimates often obtained employing aggregation procedure several mutations affect epitope aggregated single composite epitope mutation aggregation procedure thus upon assumption within epitope mutations indistinguishable effects immune recognition study investigate violation assumption affects escape rate estimates end extend previously developed simulation model hiv accounts mutation selection recombination include different distributions fitness effects inter mutational genomic distances use discrete time fisher based model simulate early within host evolution hiv apply standard estimation methods infer escape rates compare true estimated escape rate values also compare escape rate values obtained applying aggregation procedure values estimated without use procedure find across analyzed aggregation procedure alters escape mutations large effect mutations small effect mutations effect aggregation procedure similar extracting largest effect mutation appearing within epitope furthermore pronounced exponential decay severely true escape rates underestimated conclude aggregation procedure two main consequences one hand leads fixed mutations hand within epitope interactions generate mutation frequency trajectories thus left unexplained
introduction neurodegenerative syndromes significant clinical pathological overlap making early diagnosis difficult cerebrospinal fluid csf biomarkers aid differentiation disorders synuclein light chain protein limited diagnostic power specific protein biomarkers remain elusive objectives study disease mechanisms identify possible csf diagnostic biomarkers discovery proteomics discriminate syndromes healthy controls methods csf collected consecutively participants parkinsons disease atypical syndromes including progressive palsy multiple system atrophy syndrome elderly healthy controls participants divided discovery validation set analysis samples subjected digestion followed liquid chromatography mass spectrometry analysis identification relative quantification labelling candidate protein biomarkers identified based relative identified peptides predictive performance evaluated analysis validation set results peptides derived proteins found differ significantly atypical patients controls included acute phase inflammatory markers neuronal synaptic markers respectively increased decreased atypical levels subjects intermediate controls atypical conclusion using unbiased proteomic approach proteins identified able differentiate atypical syndrome patients healthy controls study indicates markers reflect neuronal function plasticity amyloid precursor protein inflammatory markers hold future promise candidate biomarkers published elsevier ltd
novel integrated fuel rankine cycles capturing introduced analyzed carbon dioxide used working fluid extracted process high pressure liquid state process benefits high temperature solar cycle heat source lng cold energy heat sink solar energy used fuel cycle heat source context required heat duty lng desired operating condition provided solar energy employing cold energy lng increases net electrical power parametric analysis conducted turbine inlet temperature lng flow rate solar cycle operating parameters energy exergy analysis done find better performance process obtained results indicate lng flow rate positive effects exergy efficiency net electrical power generation also applying degrees concentrated parabolic collector area equal lng absorbed high temperature solar energy net electrical power generated energy exergy efficiencies overall process respectively elsevier ltd rights reserved
background recently pruritus recognised important association spectrum disorders objective determine clinical radiological characteristics patients pruritus methods results among consecutive patients women reported pruritus antibodies mean age age onset duration illness pruritus preceded neurological disturbances patients predominant patients experienced pruritus cervical followed region trigeminal nerve lumbar region lesions extending junction thoracic segment common site followed junction cervical cord cervical cord thoracic segment conclusion report one largest series reporting close association pruritus onset neurological symptoms highlights importance rare symptom help making correct diagnosis patient suspected demyelinating disorder patient early treatment pruritus prevent minimise occurrence neurological dysfunction
due thermal nature multi effect med integration suitable power cycle highly desirable waste heat recovery one proper power cycle proposed integration internal combustion engine ice exhaust gas heat ice used produce steam required heat first effect med system also water heat utilized heat exchanger seawater paper studies thermodynamic model tri generation system composed ice integrated med ice thermodynamic model used place different empirical efficiency relations estimate performance load curves reasonably entire system performance coded matlab results proposed thermodynamic model engine verified manufacturer increasing engine load water production med unit increase cubic meters per day cubic meters per day tri generation efficiency economic analyses med unit integrated ice performed based cost system method integration makes system economical determined higher market prices fresh water per cubic meter increase effects number significant period return elsevier ltd rights reserved
last decade several candidate genes extensively studied potential moderators detrimental effects postnatal family adversity child externalizing behaviors aggression conduct disorder many studies candidate gene environment interactions published first part paper offers systematic review integration findings overview shows set heterogeneous findings however large differences studies terms sample composition power difficult determine different findings indeed illustrate inconsistent findings findings simply second part paper therefore argue one way help resolve problem development theory driven priori hypotheses mechanisms underlie theoretically based approach help specify research strategies create comparable findings help interpret different findings studies accordance describe three possible explanatory mechanisms based extant literature concepts emotional reactivity reward sensitivity punishment sensitivity mechanism discuss link putative mechanism externalizing behaviors genetic polymorphism family adversity possible research strategies test mechanisms implications interventions discussed
social cognitive skills indispensable successful communication others substantial research determined deficits abilities patients mental disorders neurobiological development continuing adulthood cross cultural differences social cognition demonstrated moreover symptomatic patterns mental disorders vary according cultural background individual cross cultural studies thus help understanding underlying biological mechanisms factors influence behavior health disease addition studies apply novel paradigms assessing impact culture cognition benefit advance neuroscience research review authors give overview cross cultural research field social cognition health mental disorders provide outlook future research directions taking neuroscience perspective
transfer antigen specific cells adapted investigators treatment cancer technology becoming popular aspects cell vitro preparation cell proliferation addition also enhancing immunity effect reducing cytotoxicity major advantage cell therapy act ability efficiently patients cells reactivity tumor antigens stable regulated introduction genes encode high affinity tumor targeting cell receptors synthetic chimeric antigen receptors cars overcome issues immune tolerance limit endogenous adaptive immune response tumor associated antigens robust systems genetic modification characterization cells express chimeric antigen receptors cars specificity produced cases indicated car cells excellent cancer treatment however still many limitations treatment solid malignancies addition toxicity cars cells also serious problem car therapy present car therapy developed four generations review thus focuses opportunities challenges facing car cells
based large displacement non linear elastic generalized variational principle coupling effect axial flexural action strain energy torsional strain energy girder considered large displacement incomplete generalized potential energy functional space coupling free vibration three span self anchored cable stayed suspension bridge presented constraint variation fundamental differential equations vertical flexural vibration lateral flexural vibration longitudinal vibration vibration formulated also presented equations main tower respect longitudinal lateral vibration linear free vibration differential equation obtained nonlinear items approach provides theoretical basis analysis natural vibration character self anchored cable stayed suspension bridges
paper presents synthesis procedure using signal flow graph sfg technique realize general order voltage transfer function employing voltage differencing buffered amplifiers grounded capacitors proposed methodology general contains grounded capacitors without needing external passive resistors also show design procedure given simple structure convenient suitable integration furthermore circuit low sensitivity also provides high input low output suitable voltage mode operation pspice simulation results agree theoretical analysis also included
introduction dedicated progestin emergency contraceptive pills available prescription brazil since however utilization emergency contraception limited conducted client study retail three regions assess current availability methods using predetermined client profile approached random sample chain independent urban areas southeastern northeastern central west regions documented product availability price client pharmacy representative interaction site analyzed data descriptive statistics content themes results visited early three stock time interaction offered client medication without prescription general pharmacy representatives ask questions provide client information emergency contraception prompted one third pharmacy representatives reported levonorgestrel used immediately within time intercourse conclusion despite current regulatory status findings suggest progestin widely available without prescription additional efforts ensure women date medically accurate information progestin appear warranted findings suggest work needs done align national regulatory policies international standards evidence based practices implications virus epidemic importance providing timely access emergency contraception latin america public health emergency offers window opportunity advance national policies practices ensure brazilian women access full range reproductive health services elsevier inc rights reserved
study sets extend current knowledge parenting stress fear parents children type diabetes mellitus examined relationship parental childrens metabolic control reflected mediated parenting stress total parents children recruited routine physicians parents completed questionnaires parenting stress children eight years older also completed questionnaire values obtained children mediation analysis revealed indirect association parental values parenting stress indirect association childrens concluded parental indirect association childs metabolic control mediated parenting stress simply fear predicts parent stress turn predicts metabolic control
growing recognition involving patients development new patient reported outcome measures helps ensure outcomes matter people living health conditions captured describe discuss different experiences integrating patients full patient research partners outcomes research multiple perspectives researcher patient drawing three real world examples diverse experiences highlight strengths challenges impact patients design conduct research findings basis experiences suggest basic guidelines outcomes researchers establishing research partnerships patients including establishing supportive organizational institutional policies supportive attitudes researchers recognition partnerships evolve time grounded strong communication shared goals principles respect trust learning addressing training needs team members ensure communications familiar language process research identifying resources advanced planning required successful patient engagement recognizing value partnerships across stages research three experiences presented explore different approaches demonstrate fundamentally change way research work conceptualized conducted disseminated serve forms patient centered outcomes research work needed identify skills qualities approaches best support effective patient researcher partnerships
paper presents low power rail rail amplifier folded structure input stage feed forward class output switch bias circuit switching driving capability input single low amplifier works switching state save using process cooled cadence supply voltage amplifier performs almost gain reaches lowest static power consumption just amplifier used precision sigma delta adc buffer meet input range gain
objective examine effects feeding bacillus target inclusion rates colony forming units cfu per cfu per million cfu per intestinal health pigs challenge porcine epidemic diarrhea virus materials methods two three factorial design conducted composed three experimental diets sham challenge sixty day old pigs negative quantitative real time reverse transcription polymerase chain reaction pcr negative pcr porcine reproductive respiratory syndrome virus randomly allocated six treatment groups pigs per group pigs housed groups five solid floor treatment diets fed total days including days days challenge sham challenge oral gavage results pathological changes associated significantly less severe challenged treatment groups received group received treatment significant differences small intestinal length ratio small intestinal weight body weight colon dry matter content average daily gain fecal scoring six treatment groups
emergence small rnas key potent regulators gene expression prompted need robust detection assay protocols developed investigating generation tissue distribution physicochemical nature rnas allows traditional assay methods employed however due relatively small size key changes protocols required present method detection mouse tissue method comprises steps rna extraction page low northern blotting using labelled rna probes moreover includes strategy design generate cheap hybridization probes greatly increased sensitivity methods used simple robust protocol detection small rnas combined strategies potentially enhance signal intensity
indoor air pollution closely related childrens health plus transmitted indoor dust along carbonyl compounds black carbon analysed five hong kong results showed median levels indoor outdoor five higher guidelines set world health organization indoor mass concentrations correlated outdoor four dust dust detected dust samples fire levels air correlated levels dust study median concentrations varied fold cooking events caused concentrations rise total concentrations ranged whilst formaldehyde abundant air carbonyl indoor carbonyl concentrations correlated outdoor three health risk assessment showed hazard indexes non cancer risks lower whilst non cancer carbonyl compounds ranged human intake inhalation accounted total intake cancer hazard formaldehyde ranged general indoor air pollution five hong kong present adverse effects children although different schools showed distinct pollution levels indoor air quality improved artificial measures data useful developing feasible management protocol indoor environments elsevier ltd rights reserved
energy storage key challenge sustainable energy supply design new storage systems accurate representative thermal property measurements essential history method quick however numerous adaptations proposed years study methods classified critically assessed based mathematical formulation experimental configuration broadly categorized according one three assumptions regarding heat transfer coefficient natural convection constant either function time temperature negligible work proves addition heat transfer coefficient natural convection varies function time temperature demonstrated experimentally rigorous simulation proposed configurations thus history methods show promise precise measurements eliminate convection making conduction dominant thermal resistance system techniques tailored different materials require simultaneous reference due use rigorous fundamental model compared lumped parameter approximation addition heat flux sensors quantify actual heat losses recommended absolute measurement certainty elsevier rights reserved
background article aims survey describe injuries illnesses german team games methods electronic documentation system injuries illnesses requiring treatment recorded evaluated injury illness defined physical symptom required medical attention impaired participation training competition classification distinguished type injury acute overload region type illness infections skin allergy etc results total treatments performed german team musculoskeletal related treatments performed lower limb treatments addressed back problems treatments performed due upper respiratory tract infections extrapolated athletes treatments required due illness treatments addressed musculoskeletal problems number treatments injuries illness almost identical addition less severe problems following serious injuries occurred lethal traumatic brain injury acute compartment syndrome acl tear medial lesion lateral instability isolated acl tear stress fracture base third bone acute lateral ankle instability joint dislocation infected conclusions documentation system reliable injury illness surveillance multi sport events treatment numbers consistent summer games london reliable strategy assumed addition illnesses predominantly affecting upper respiratory tract system also recorded serious musculoskeletal injuries need interdisciplinary setup medical team methods used data collection currently allow
increased popularity building information modeling bim application construction eco friendly green buildings given rise techniques evaluating green buildings constructed using bim features existing bim based green building evaluation techniques mostly rely externally provided evaluation tools pose problems associated interoperability including lack data compatibility amount time required format conversion overcome problems study sets develop template green template evaluating embodied environmental impact using bim design tool part bim based building life cycle assessment lca technology development firstly bim level detail determined evaluate embodied environmental impact constructed database impact factors embodied environmental impact major building materials thereby adopting lca based approach libraries major building elements developed using established databases compiled evaluation table embodied environmental impact building materials finally green template developed embodied environmental impact evaluation tool case study performed test applicability results green template based embodied environmental impact evaluation test building validated actual quantity reliability confirmed effective error rate study aims develop system assessing impact substances discharged concrete production process six environmental impact categories global warming abiotic depletion adp depletion oxidant creation using life cycle assessment lca method achieve proposed lca method specifically applicable concrete tailored korean concrete industry adapting iso standards suit korean situations
many studies deal impact prevention campaigns method used people take campaign consideration soon exposed cognitive theory principle selective exposure people tend expose consistent information strengthen attitude behavior avoid inconsistent one avoiding inconsistent information prevents threatening position modify attitude goal research consists verifying selective exposure effect concerning smoking prevention using measure implicit attitude research conducted professional training institute participants recruited consultation part training design either employees institute forty four smokers non smokers took part experiment precise prevention thematic among six interest order construct new training formation program dealing addiction harmful effects tobacco alcohol drugs etc people asked kind topic interest attitudes behavior toward smoking evaluated evaluate smoking attitudes used explicit attitude toward smoking scale implicit measure single category implicit association test personalized smoking habits also recorded results revealed smokers implicit attitude less negative non smokers implicit attitude smokers also predicts selective exposure attitude positive less people like expose smoking prevention information last smokers already considered quitting inclined expose information smokers results support hypothesis effect attitudes explicit implicit expression needs context smoking prevention training design published elsevier masson sas rights reserved
immunotherapy treatment allergic respiratory diseases demonstrated efficacy safety several formulations now available worldwide treatment allergic rhinitis grass tablets containing group major allergen reduced combined symptoms medication use treatment years follow years pollen tablets liquid extracts reduced combined symptoms medication use respectively house dust mite tablets containing index reactivity reduced symptoms treatment year follow year respectively different house dust mite tablet standardized quality house dust mite able reduce risk asthma exacerbation compared placebo hazard ratio adverse events local mild moderate severity products reviewed herein effective doses range major allergen however allergen content uniformly standardized expressed arbitrary units depending manufacturer assays determination allergen content highly variable thus results one study given product extrapolated products despite limitations clinical management review aims provide practitioners relevant information dosing selected formulations treatment allergic respiratory disease american academy allergy asthma immunology allergy
background replication factor contains four active atpase sites results mutation one atp binding site affects clamp activities conclusion although atp sites fill sequentially atp binding four sites needed activity significance provides insight atp dependent conformational changes drive clamp loading reaction clamp belong family proteins known associated various cellular activities proteins utilize energy atp binding hydrolysis perform cellular functions clamp required load clamp onto dna use dna increase atp binding hydrolysis coordinated several key residues including conserved located within motif loop residue required subunit bind atp specific function atp molecule bound saccharomyces cerevisiae clamp unknown series point mutants lacking single residue generated study effects atp binding individual clamp subunits variety biochemical assays used analyze function atp binding discrete steps clamp loading reaction mutants reduced clamp binding opening different degrees decreased clamp binding activity generally correlated decreases population open suggesting differences binding affinities mutants stem differences stabilization proliferating cell nuclear antigen open conformation mutations smaller effect dna binding clamp binding opening data support model atp site functions independently regulate different step clamp loading cycle coordinate steps instead atp sites work promote conformational changes clamp drive clamp loading
access recovery substance abuse mental health services administration funded initiative offers mix clinical supportive services substance abuse clients choose services help overcome barriers road recovery recovery provides helps link client community resources one goals provide services involved criminal justice system addressing substance abuse issues reduce subsequent criminal behaviors study examines goal looking among sample clients one states program returned community results suggest differential effects service subsequent however significant differences rates among agencies provided services agencies resources focus better outcomes focus substance abuse services
financial prosocial biases favor attractive adults documented labor market social transactions everyday life studies involving experimental economic games according taste based discrimination model developed attractiveness related financial prosocial biases result preferences similar displayed toward members particular sex racial ethnic religious group explanations proposed social psychologists maintain attractiveness marker personality intelligence trustworthiness professional competence productivity evolutionary psychologists argued attractive adults favored preferred sexual partners evidence stereotypes attractive people related financial prosocial biases toward weak consistent evolutionary explanations biases favor attractive women appear consistent stronger favor attractive men biases consistently reported interactions opposite sex sex individuals evolutionary explanations also account increased prosocial behavior situations attractive individuals simply finally evolutionary explanations consistent psychological physiological behavioral changes occur individuals exposed potential facilitate expression behavior increase probability occurrence mating therefore multiple lines evidence suggest mating motives play important role driving financial prosocial biases toward attractive adults previously recognized
study model magnetic system ground state coupled two temperature varying temperatures generate non thermal electronic distributions create additional density matrix system thus thermally induced magnetic response goes beyond simple picture majority minority population dynamics furthermore discuss influence temperature induced relaxation effects dynamics induced optical perturbation quantum system elsevier rights reserved
aim program access review information evaluate correlation symptoms patients heart failure partners trial elaborated model prediction acute advanced heart failure patients based office data cardiac devices study evaluated ability partners criteria detect initial population moderate heart failure patients remote monitoring methods retrospectively applied partners criteria transmissions patients median follow months range months enrolled programme cardiac therapy tested ability score based criteria predict acute clinical occurring days following transmission results cases acute heart failure diagnosed index transmission area curve auc score diagnosis acute confidence interval best score cut consistent results partners score sensitivity specificity odds ratio events conclusions retrospectively applied remote monitoring transmissions arranged score partners criteria identify patients subsequently developed acute results warrant prospective studies applying partners criteria remote monitoring
objectives determine immediate pain relief effect low level laser therapy sports injuries athletes degree pain relief therapy design double blind randomized comparative clinical study methods participants college athletes motion pain defined site participants randomized two groups tested placebo laser therapy administered determine pain intensity painful action laser irradiation using modified numerical rating scale post therapeutic modified numerical rating scale score pre therapeutic modified numerical rating scale score determine pain intensity difference rate pain intensity difference pre therapeutic modified numerical rating scale calculated pain relief rate results low level laser therapy effective laser group whereas effective placebo group indicating significant difference favor laser group pain relief rate significantly higher laser group placebo group respectively difference pain relief rate conclusions low level laser therapy provided immediate pain relief effect reducing pain effective pain relief participants sports medicine australia published elsevier ltd rights reserved
study develops integrated multi scale model pilot concentrated high intensity electric field chief system using finite element method fem chief system novel non thermal technology uses medium low voltage frequency power supply offers satisfactory results liquid food milk model study provides accurate predictions fluid behavior electric field distribution temperature profile validated using experimental results results model shows chief system provide electric field power supply enabling log reduction bacteria furthermore recommendations optimizations made based modeling results benefit process scale design published elsevier ltd
model based fault diagnosis attracted considerable attention researchers developers flight control systems thanks hardware simplicity cost effectiveness however model adopted commonly fault diagnosis exists theoretically linearized approximation reason uncertainties system non linearity degrade fault diagnosis results paper propose novel actuator fault diagnosis scheme flight control systems based model identification techniques scheme system identification achieved linear model uses closed loop subspace model identification algorithm non linear model uses extended state observer neural networks basis current actuator fault estimated using adaptive two stage kalman filter finally non linear six degree freedom model simulated matlab simulink environment effectiveness proposed scheme verified fault diagnosis tests
population growing faster pace growth rate urbanization rapid alongside economic growth expected robust future altogether pose serious challenges energy system africa condition makes development res necessity though res least developed deployed partly due limited research development sector particularly implications res thoroughly studied leaves big literature gap motivates current study investigate implications res using case study country res one integrated res overall energy policy specifically study examined implications res concentration electricity price uncertainty investigated persistent profile effect system wide individual equilibrium relations finally decomposed variance electricity price permanent components explained drives trends elsevier ltd rights reserved
hiv aids epidemic continues persist particular among race sexual orientation gender minority populations pre exposure prophylaxis using antiretroviral medications hiv prevention effective option uptake slow sociocultural barriers using largely yet potential uptake therefore warrant understanding order assess relationships potential barriers stigma beliefs interest black men transgender women sex men white surveyed gay event large southeastern city bivariate multivariate logistic regression analyses completed examine factors associated interest among full sample moderate levels awareness low levels use observed people stigma belief strongly associated lack interest using individuals endorsed belief likely report sexual risk taking behavior beliefs related reported among large minority sample frequently reported among given strong emphasis use biomedical strategies hiv prevention addressing sociocultural barriers access urgently needed failure potential benefits biomedical prevention
forest harvesting operations significant impact soil physical properties reducing porosity organic functions soil variations particular bulk density total porosity caused external perturbations soil becomes due machinery passes lead changes cycles consequences soil ecosystems study investigated impact forest operations time harvest influence physical chemical characteristics soil nitrogen microbial communities study area located inside regional park san italy study area soil classified recent sandy texture slightly soil taxonomy classification soil samples collected cut areas strip cut stand harvested two steps half area rest soil samples collected also control area harvested similar stand soil characteristics statistical analysis preceded test test variance homogeneity test test considering dependence variables studied physical chemical soil characteristics test post hoc test applied determine statistical difference among three treatments harvested harvested harvested results indicate significant variations parameters shear penetration resistance though soil bulk density total porosity significantly altered short period since operations occurred physical changes induced qualitative presence absence number species quantitative abundance spatial species variations nitrogen microbial communities
deep convolutional neural networks widely used obtain high level representation various computer vision tasks however field remote sensing sufficient images train useful deep cnn instead tend transfer successful pre trained deep remote sensing tasks transferring process generalization power features pre trained deep plays key role paper propose two promising architectures extract general features pre trained deep remote scene classification two architectures suggest two directions improvement first pre trained deep design linear pca network synthesize spatial information remote sensing images spectral channel design spatial distance target source datasets pre trained deep second introduce algebra spectral distance remote sensing images images used pre train deep five known pre trained deep experimental results three independent remote sensing datasets demonstrate proposed framework obtains state art results without fine tuning feature paper also provides baseline transferring fresh pre trained deep remote sensing tasks
introduction etiology irritable bowel syndrome ibs unknown several factors appear play role pathophysiology including abnormalities gastrointestinal endocrine cells present review possible role gastrointestinal hormones pathophysiology ibs possibility utilizing current knowledge treating covered research intestinal endocrine cells possible role pathophysiology ibs discussed furthermore mechanisms underlying abnormalities gastrointestinal endocrine cells ibs patients commentary abnormalities observed gastrointestinal endocrine cells ibs patients explains visceral hypersensitivity gastrointestinal abnormal intestinal secretion symptoms time role intestinal stem cells pathophysiology ibs lead new treatment methods ibs
signaling pathways sustain disease process chronic nasal remain poorly understood sought determine expression levels wnt signaling genes study role wnt pathway inflammation epithelial remodeling nasal mucosa microarrays real time quantitative polymerase chain reaction comparing gene expression matched nps inferior revealed regulated regulated nps showed robust expression wnt ligands nuclear catenin tissue suggesting wnt beta catenin signaling activated nps used primary human nasal epithelial cell cultures test functional consequences wnt pathway activation monolayer treated recombinant human wnt altered epithelial morphology decreased adhesion without loss viability found neither treatment induced proliferation expression release inflammatory cytokines macrophage colony stimulating factor increased exposure differentiated air liquid interface wnt agonist treated abnormal epithelial architecture failed undergo defective wnt planar cell polarity signaling basis results propose model wnt beta catenin signaling mucosal inflammation leads spectrum changes consistent seen epithelial remodeling nps
frequent items high speed streaming data important many applications like network monitoring anomaly detecting deal high arrival rate streaming data desirable systems capable supporting high processing throughput tight guarantees errors paper address problem finding frequent top items present parallel version space saving algorithm context open source distributed computing system based theoretical analysis errors bounded algorithm parallel design achieve high throughput taking advantage distributed computing resources evaluation reveals design delivers linear speedup remarkable scalability
modern information network society data security important daily lives data encryption system help protect security personal information paper mainly introduces hardware software design lower computer data encryption system involving communication interface design design circuit design algorithm selection algorithm design system testing high success rates encryption decryption improves programming speed
piezoelectric single pole single switch developed since satisfying commercial low resistance high current contact switch available high magnetic field least piezoelectric switch shows low insertion loss less within bandwidth mhz operated switch also used mechanically connect electrodes electrical circuits one another elsevier rights reserved
procedure reuse finite element method fem programs heat transfer structure analysis solve advanced thermo mechanical problems presented powerful algorithm applicable coupling physical fields magnetic fluid flow etc case nonlinear block partitioned algorithm strongly couples heat transfer structural fem programs component based software engineering component template library provides possibility exchange data components solve corresponding structural component evaluates energy induced strain heat transfer component computes temperature change due dissipation convergence guaranteed global convergence criterion previously locally coupled variables enables reuse software allows numerical simulation thermo sensitive problems
low birth weight neonates commonly experience acute kidney injury neonatal intensive care unit hypothesize neonates exposed higher risk renal dysfunction childhood cohort study children aged years completed kidney health evaluation stratified according status primary outcome renal dysfunction defined following estimated glomerular filtration rate egfr blood pressure percentile thirty four subjects completed study twenty subjects history neonatal stage stage stage median age years group higher risk renal dysfunction compared group without relative risk overall total cohort egfr min using serum subjects subjects evidence renal dysfunction neonates born found early childhood work necessary determine reduce renal disease vulnerable population
heparin induced thrombocytopenia hit serious drug reaction leads decrease platelet count high risk thrombosis hit patients produce pathogenic immunoglobulin igg antibodies bind complexes platelet factor heparin hit immune complexes receptors resulting platelet monocyte activation events lead release chemokines tissue factor together create state hit represents atypical immune response features cell dependent cell independent mechanisms disorder characterized newly formed anti heparin igg antibodies characteristic cell dependent mechanism however exposure heparin months hit lead memory response consistent cell independent mechanism review discuss events explain features including role cell dependent cell independent mechanisms hit antibody generation immunogenic characteristics heparin antigen concept temporary loss immune regulation contributing onset hit also present novel model explain atypical immune response characteristic hit
tumor normal cell interplay defines course neoplastic malignancy outcome dual relation ultimate prevailing one cells death paper study mathematical principles one important scenario slow progressing cancers develop within stochastic framework mathematical model account tumor normal cell interaction clinically relevant situation derive number deterministic approximations stochastic model consider detail existence uniqueness solutions deterministic model study stability analysis focus model specific case low grade introduce optimal control problem different objective administration chemotherapy derive conditions singular control exist calculate optimal control states elsevier rights reserved
assess value cardiac magnetic resonance imaging evaluating cardiac tumours tertiary cardiology centre patients total received examination institution referred suspicion cardiac tumours dedicated protocol used included standard tissue characterization using black blood respectively without fat suppression perfusion structure late enhancement patients files retrospectively analysed data related clinical status results examinations echocardiography therapeutic approach histology results performed collected diagnosis cardiac tumour reached biopsy examination concordant histology results superior showed echocardiography forty two benign tumour malignant process frequent benign tumour cardiac metastases frequent form malignancies cell non hodgkin lymphoma frequent one benign tumours mostly located left versus whereas malignant tumours right left ventricle benign cardiac tumours single show signs infiltration conversely malignant cardiac tumours larger significant proportion showing myocardial infiltration malignant cardiac tumours higher proportion exhibited frequently signal images groups showed similar proportion perfusion signal intensity valuable tool evaluating cardiac tumours proving superior echocardiography establishing type cardiac tumour
social learning important process spread information especially changing environments inherited behaviors remain relevant many species decision trust reliable information depends relationship individuals many fish species including three preferentially associate familiar individuals previous studies three provided mixed evidence effect familiarity social learning species therefore study explores familiarity social learning specifically focused perspective found food patch discrimination task individuals unfamiliar performed significantly better familiar problem solving task found focal fish attended behavior detect effect familiarity performance indeed proportion individuals solve task observing low results suggest preference unfamiliar use social information varies depending context
extracellular matrix ecm protein implicated connective tissue development elastic fiber formation however little known underlying function cartilage development aim study investigate role probable mechanism stimulation ecm production differentiation observed abnormally elevated matrix level highly expressed human osteoarthritis chondrocytes cell line stimulation profoundly inhibited expression ecm gene type collagen type collagen expression attenuated expression master transcription factors effect expression additionally stimulation activated canonical wnt pathway reducing expression inhibitor moreover augmented expression wnt beta catenin signaling target genes like beta catenin wnt diminished beta activation abolished effect differentiation suggesting important regulator ecm production differentiation mediated wnt beta catenin signaling study provides evidence previously unknown link canonical wnt beta catenin pathway contribute understanding molecular mechanisms elsevier rights reserved
incompressible fluids current interest considering dimensional variable coefficient model incompressible fluid perform symbolic computation work variable coefficient dependent auto backlund transformation along two variable coefficient dependent classes shock wave type solutions auto backlund transformation different recently reported bilinear one
medical image provide valuable information preclinical research clinical diagnosis treatment widespread use digital medical imaging many researchers currently developing medical image processing algorithms systems order accommodate better result clinical community including accurate clinical parameters processed images original images paper propose web based platform present process medical images using internet novel database technologies users easily access medical images facilitate workflows processing server side powerful computing performance without installation implement series algorithms image processing visualization initial version integration system allows much flexibility convenience research clinical communities
field science medicine today remains big data psychiatry exception proteomics big data technology next generation biomarker supporting novel system diagnostics therapeutics psychiatry proteomics technology fact much older genomics dates launch international human genome project genome long framed master elite executive molecule cell biology proteome contrast yet proteome critical life ensures daily functioning cells whole organisms short proteins blue workers biology earth molecules live without since proteomics found renewed meaning international attention launch human proteome project growing interest big data technologies proteomics article presents interdisciplinary technology analysis terms social proteome define entire complement elements external human host microbiome ambient temperature weather conditions government innovation policies stock market dynamics human values political power social norms collectively shape human host spatially temporally social proteome subset influences transition proteomics technology innovative applications society social proteome encompasses example new reimbursement schemes business innovation models proteomics diagnostics life time genotypic tests anticipated context time sensitive proteomics tests building principle governance complex systems discussed propose organizational architecture big data science proteomics proposed nested governance structure comprised scientists scholars field ethics ethics aims robust social proteome personalized medicine often noted nested governance designs offer assurance political power embedded innovation processes distributed concentrated disproportionately single stakeholder person agree assessment conclude synergistic value social biological realize full potentials proteomics science personalized medicine psychiatry present era big data
immunity represents important defense mechanism pathogens linked fitness previous studies found significant variation immune responses wild populations emphasized importance ecological factors explaining variability deterioration environmental conditions agricultural modify resource availability result alter immune functions aim study investigate effect agricultural innate immune functions breeding adult tree investigated relationship agricultural bacteria killing ability strain coli also assessed presence number bacteria surface changed agricultural contrary expectations found positive relationship agricultural individuals higher intensive compared trend observed study also found tendency reduction time found relationships presence number different types bacteria agricultural association females bacteria results suggest differences immune function observed intensive reflect genetic differences among individuals trade offs traits expressed among habitats within study system
objectives diagnosis treatment thyroid diseases pregnant women remains challenge various medical associations recommend establishing reference intervals thyroid hormones local laboratory considering differences within socioeconomic conditions iodine prophylaxis various populations assess reference intervals thyroid hormones specific region residence objective assess trimester specific reference intervals tsh pregnant women polish population methods results conducted prospective study centers representing different regions poland study included consecutive healthy pregnant women patients age range years women negative history thyroid diseases normal thyroid peroxidase antibody levels proper iodine prophylaxis newborns tsh levels appropriate reference range serum tsh thyroid peroxidase antibodies measured trimester reference intervals calculated using percentile method recommended international federation clinical chemistry reference values calculated tsh consecutive pregnancy reference intervals pregnant women compared general population showed lower concentration tsh every trimester pregnancy lower conclusions using appropriate trimester specific reference intervals improve care pregnant women preventing inadequate treatment european thyroid association published karger basel
eukaryotes rna silencing encompasses range biochemical processes mediated similar small rnas chapter describes northern blot hybridization techniques optimized detection whether extracted plant animal tissues basic protocol described control illustrate detection specificity sensitivity method using dna oligonucleotide probes known endogenous analyzed samples prepared several model plant species including arabidopsis thaliana sativa animals drosophila miss finally usefulness northern blotting biogenesis shown particular case dna virus infection
article introduces new dataset historical family characteristics based ethnographic literature novelty dataset lies fact constructed level ethnic group test possibilities dataset construct measure family constraints womens agency explore correlation number geographical factors
objectiveto compare counts crack users non users materials methodsa cross sectional study conducted involving seventy four crack cocaine users eighty one non users matched age gender tobacco use demographic clinical variables analysed bacterial samples collected four sites greatest probing depths analysed using real time polymerase chain reaction significant difference found prevalence total counts bacterial species analysed groups however crack users greater probability higher counts percentile respectively crack users higher percentile bacterial counts total counts differ crack users non users leading hypothesis higher occurrence periodontitis crack users related non bacterial factors
alzheimers disease common cause dementia currently effective disease modifying treatments available hallmark symptoms include impaired hippocampus dependent episodic memory disrupted sleep circadian rhythms pathways connecting symptoms particular interest established sleep circadian disruption impair hippocampus dependent learning memory rodents procedures also markedly suppress adult hippocampal form brain plasticity believed play important role pattern separation thus episodic memory causal role sleep disruptions pathophysiology suggested evidence sleep dependent clearance metabolic waste products brain review explores complementary hypothesis sleep circadian disruptions contribute cognitive decline activating neuroendocrine signaling pathways suppress hippocampal evidence hypothesis underscores promise sleep circadian rhythms therapeutic targets remediation memory impairment published elsevier inc
objectiveto review place therapy active metabolite sulfate via review available literature drug chemistry spectrum activity pharmacokinetic pharmacodynamic profile trials assessing clinical efficacy safety data original research articles reviews gathered primarily use pubmed database search search conducted without date restrictions order collect historical recent data regarding key currently approved use invasive also activity candida species common fungal pathogens drug features make clinically appealing compared similar indications specific require vehicle due water solubility present require therapeutic drug monitoring moreover displayed improved safety tolerability compared available data phase iii clinical trials shows possible therapeutic option currently available therapies approved however clinical conclusions reserved results published data clinical use reported new broad spectrum antifungal activity including invasive
experimental identification dynamic models heat transfer walls needed optimal control characterization building energy performance models use heat equation time domain put matrix form state space representation transformed transfer function infinite order however model acts low pass filter needs respond frequency spectrum present measured inputs order transfer function determined using frequency spectrum measured inputs accuracy sensors main idea two models different orders one lower order used building parameter identification difference outputs negligible lower output measurement error homogeneous light wall used example detailed study examples homogeneous building elements high low time constants given first order model compared high order model hundreds states considered almost continuous space elsevier ltd rights reserved
help symbolic computation system maple equation mapping approach linear variable separation approach new family complex solutions dimensional system derived based derived solitary wave solution novel complex wave localized excitations obtained
course last decade fast qualitative computing power developments undoubtedly permitted better realistic modeling complex physiological processes due favorable environment fast generic reliable model high density surface signal generation cylindrical description volume conductor presented study main lies generation high resolution potential map skin related active motor units indeed analytical calculus fully performed frequency domain signals obtained numerical integration generated high resolution potential map following variety electrode shapes suggested model implemented using parallel computing techniques using object oriented approach comprehensive enough fairly quickly understood used potentially illustrate model abilities several simulation analyses put forward results section simulations performed muscle anatomy varying number processes order show significant speed improvement accuracy numerical integration method illustrating electrode shape diversity also investigated comparison analytical transfer functions definition additional section provides insight volume detection circular electrode according radius furthermore large scale simulation introduced muscle electrode grid composed electrodes three constant contractions finally advantages limitations proposed model discussed focus perspective works elsevier ltd rights reserved
present work parallel lattice boltzmann multiphase model developed investigate effects surface structures flow dynamics theory transition firstly discussed three types including triangular hierarchical shaped microstructures constructed surface examine effects drag reduction found flow behaviour strongly affected surface morphology channel results indicated hierarchical structures surface improve significantly rectangular structures improve increase height distance ratio structures improvement reach optimal value certain value moreover accelerate computational speed open employed parallelization model maximum speedup times obtained threads multi core cpu platform elsevier ltd rights reserved
research infiltration equipped extensive pretreatment filter bed consisting sand gravel utilized low impact development technique manage stormwater runoff highly road particular emphasis heavy metal removal findings revealed major factors influencing removal heavy metals concentration particulate matters heavy metals runoff runoff volume flow rates reduction heavy metals enhanced sedimentation pretreatment fine particles significant amount heavy metals thus enhanced adsorption filtration using various filter media important design considerations sediment highly attached surface area filter media like sand gravel geotextile suggested maintenance performed end winter season wherein high sediment rate observed maintain efficiency treatment system
growing complexity cyber physical systems together increasingly available parallelism provided multi core chips parallelization simulation simulation speed ups expected simulation parallelization based model splitting weakly coupled framework functional interface however synchronization associated solvers running parallel introduces integration errors kept inside acceptable bounds forecasting framework enhancing performance complex system simulation first consider framework computationally online prediction system allows improve tradeoff integration speed ups needing large communication steps simulation precision needing frequent updates model inputs second adaptive forward prediction improves simulation accuracy obtained past weighted extrapolation based causal polynomials third signal behavior segmented handle signals segmentation performed contextual hierarchical ontology patterns implementation strategies simulation results demonstrate framework ability adaptively data communication constraints beyond synchronization points accelerate simulation framework extends range applications standard polynomial extrapolation often deemed unstable embedding predictions lag dependent smoothing handling demonstrates practical efficiency
objective little parenting group program effective intervention preventing anxiety disorders young children risk inhibited temperament program six group sessions delivered trained psychologists parents year old children online adaptation little online developed overcome barriers wide dissemination community study tested efficacy little online randomized controlled trial method total parents child aged years inhibited temperament randomized online parenting program week online program interactive modules providing strategies parents implement child manage childs avoidant coping reduce parental encourage child independence parents provided telephone consultation support requested parents completed self report questionnaires baseline weeks baseline results intervention group showed significantly greater improvement time child anxiety symptoms compared control group intervention group also showed greater reductions anxiety life interference lower rates anxiety disorders control group versus minimal effects broader internalizing symptoms parenting conclusion results provide empirical support efficacy online delivery little program online dissemination improve access evidence based prevention program child anxiety disorders
base stations equipped resources harvest renewable energy environment friendly also reduce grid energy consumed thus bringing cost savings cellular network operators intelligent management harvested energy increase cost savings management energy savings carefully coupled managing quality service ensure customer satisfaction process trade energy drawn grid quality service unlike prior studies mainly focus network energy minimization paper proposes framework jointly managing grid energy savings quality service terms network latency achieved power control user association reconfiguration use real deployment scenario london show performance proposed framework compare existing benchmarks show proposed framework lead around grid energy savings better network latency performance traditionally used scheme
background study explored details immune response autologous hematopoietic stem cell transplantation treatment type diabetes mellitus methods peripheral blood mononuclear cells pbmcs patients type diabetes mellitus taken baseline months insulin therapy lymphocyte proliferation mrna expression secretion pro inflammatory anti inflammatory cytokines belonging helper type helper type regulatory treg cells culture supernatants assessed results compared patients receiving insulin treatment patients receiving treatment showed better residual peptide secretion lower anti titers less exogenous insulin dosages months follow treatment associated significantly reduced cell proportions decreased ifn gamma levels culture supernatants although significant treg cell expansion treatment observed increased tgf beta mrna expression increased tgf beta levels however found significant changes cell subpopulations insulin treatment except higher mrna expression lower proportion treg cells conclusions treatment associated decreased expansion function cells explain better therapeutic effect compared traditional intensive insulin therapy
efficient facile hydrothermal route synthesis flower like photocatalyst developed scanning transmission electron microscopy characterization show detailed morphologies ray diffraction photoelectron spectroscopy analysis confirm obtained product hexagonal phase photocatalytic properties flower like evaluated degradation methylene blue natural sunlight irradiation synthetic value performance exhibited best response amongst samples published elsevier
fuzzy sets intersection procedure select optimum sizes analog circuits composed metal field effect transistors presented cases study voltage current feedback operational amplifier width length selected space feasible solutions computed swarm evolutionary algorithms evaluation three objectives namely gain bandwidth power consumption performed using standard integrated circuit technology therefore intersection procedure among three fuzzy sets representing gain close unity high bandwidth minimum power consumption presented main advantage relies usefulness select feasible sizes automatically considering deviation percentages desired target specifications basically assigning threshold fuzzy set result proposed approach best feasible sizes solutions guarantee enhance performances ics analog signal processing applications
development efficient visible light driven photocatalysts water splitting drawn much attention herein demonstrated novel producing photocatalytic system employed nitrogen doped graphene quantum dots hydrogen evolving catalysts prepared favorable light harvesting charge separation showed highly efficient photocatalytic performance water splitting hydrogen results showed ratio amount displayed important influence production moreover optimum synthesis conditions ratio amount obtained corresponding sample performed much higher hydrogen evolution rate mol studies enhanced photocatalytic activity ascribed crucial roles photocatalytic system resulted efficient charge separation largely enhanced photocatalytic activity meanwhile possible photocatalytic mechanism also proposed work creates new opportunities constructing designing efficient visible light driven photocatalysts hydrogen evolution reaction published elsevier
aging population worldwide osteoporosis osteoporotic fractures becoming serious health care issue western world although less frequent women osteoporosis men relatively common problem hip vertebral fractures particularly relevant associated significant mortality disability since bone loss fragility fractures men recognized serious medical conditions several randomized controlled trials rcts undertaken males osteoporosis investigate anti fracture efficacy pharmacological agents commonly used treat postmenopausal osteoporosis overall treatments osteoporosis men less defined women mainly due fact fewer rcts performed male populations relatively smaller sample sizes lack long term extension studies however key question whether men expected respond differently osteoporosis therapies women pharmacological properties make differentiation unlikely available clinical data support efficacy men primary osteoporosis women series designed rcts acid demonstrated reduce risk new vertebral fractures men presenting primary osteoporosis including osteoporosis associated low testosterone levels improve bone mineral density bmd preliminary studies also showed beneficial effects surrogate outcomes bmd markers bone turnover men osteoporosis although direct evidence non vertebral anti fracture efficacy lacking effects surrogate outcomes bmd markers bone turnover similar reported pivotal rcts undertaken postmenopausal women vertebral non vertebral anti fracture efficacy clearly demonstrated conclusion sufficient data exist support use pharmacological agents men primary osteoporosis rcts warranted establish long term efficacy safety
significant advancements field additive manufacturing past decades current technologies field allow complex physical prototypes also functional electronic components now possible fabricate simple circuits embedded several kinds passive components example resistors capacitors fundamental building blocks electrical circuits order aid future developments printing electronics wider range applications review attempts provide overview recent developments fully additive printing techniques used circuits electronic components including comparisons advantages disadvantages individual fully additive printing technique presented discussed detail potentials challenges additive manufacturing electronics also discussed
adolescence developmental period marked considerable biological social psychological changes rates self reported stress rise adults mindfulness interventions increasingly implemented high schools improve students stress management psychosocial outcomes despite researched role primary secondary control strategies management adolescent stress impact mindfulness attributions examined current study addressed gap extant literature mindfulness based arts program delivered high school students risk self regulation challenges measures primary secondary control cognitive errors completed pre post treatment compared control findings suggested students mindfulness program showed significant improvements secondary control reductions cognitive errors pre post treatment compared control significant group time changes found primary control findings discussed relation changes control related attributions associated cognitive behavioral therapy specific consideration possible mechanisms mindfulness improve secondary control decrease cognitive errors directions future research discussed
examined weeks cap supplementation affected appetite body composition metabolic health markers seventy seven healthy male female volunteers randomly assigned either low dose cap cap high dose cap cap placebo corn starch weeks baseline weeks weeks waist hip ratio body composition via dual energy ray absorptiometry self reported intakes appetite levels via council nutrition appetite questionnaire serum metabolic health markers analyzed moreover oral glucose tolerance test administered serum glucose insulin responses examined min post test drink consumption waist hip ratio significantly decreased cap although supplementation significantly affect body composition cap consumed less compared difference cap participants difference twenty three percent originally enrolled cap participants reported distress although participants cap group reported adverse events interestingly cap participants presented significant increases serum insulin significant decreases serum hdl cholesterol levels however supplementation affect insulin response administered indices insulin sensitivity data suggest cap supplementation reduces self reported energy intake weeks supplementation cap supplementation also reduces waist hip ratio longer term effects supplementation basal insulin cholesterol levels warrant investigation authors published elsevier ltd
association transportation occurrence bovine respiratory disease complex long recognised many hypotheses regarding association past decades agreed upon researchers multiple stressors experience transportation result overall immunosuppression allows respiratory tract numerous opportunistic pathogens furthermore innate immune cells neutrophils trapped paradox whereby crucial defence pathogen killing activities excessive inflammation tissue damage exacerbate disease including response glucocorticoids attributed influx immature neutrophils newly released bone marrow decrease neutrophil along endothelial walls decrease neutrophil apoptosis several explanations confirmed altered expression genes proteins important neutrophil apoptosis
present study investigated activity complex phenol present large quantities olive tree products opportunistic fungal pathogen candida albicans found vitro antifungal activity minimal inhibitory concentration value morphological changes nuclei staining fluorescent dna binding dyes revealed apoptosis primary mode cell death analyzed samples treated concentrations results suggest antifungal agent targets virulence factors essential establishment fungal infection noticed modulates conversion inhibits albicans assay showed sub values significantly decreased aerobic anaerobic conditions cellular surface albicans factor associated adhesion epithelial cells also demonstrated tested compound inhibits activity cellular enzymes secreted albicans reported related pathogenicity fungi additionally detected causes reduction total content membrane albicans cells involved mechanism antifungal activity
low cost mini tubular microbial fuel cell mfc developed treating groundwater contained monitoring wells experimental results indicate increasing length density reducing size particles anode effectively reduced internal resistance additionally thinner alcohol hydrogel higher molecular weight improved electricity generation optimal parameters mfc anode density anode length mol thickness results continuous flow experiments reveal increasing sets connecting parallel markedly improved degradation removed electricity generated mfc continuously days without maintenance elsevier ltd rights reserved
paper study resource allocation algorithm design distributed antenna networks full radio base stations enable simultaneous communications considered resource allocation algorithm design formulated optimization problem taking account antenna circuit power consumption quality service qos requirements users minimize total network power consumption jointly optimizing transmit power antenna selection overcome resulting problem optimization problem decoupled binary selection variables constraints problem facilitates design iterative resource allocation algorithm obtains optimal solution based generalized decomposition algorithm also propose simple technique improve speed convergence furthermore balance computational complexity system performance suboptimal resource allocation algorithm polynomial time complexity proposed simulation results illustrate proposed based iterative algorithm globally optimal solution suboptimal algorithm achieves close optimal performance results also demonstrate tradeoff power efficiency number active transmit antennas circuit power consumption taken account particular activating large number antennas efficient approach reducing total system power consumption addition results reveal systems facilitate significant power savings compared traditional half systems despite self interference
objectives increased cerebrospinal fluid csf flow recently reversed csf flow suggested hallmarks idiopathic normal pressure however findings adequately confirmed objective investigate flow blood csf compared healthy elderly order clarify flow parameters related pathophysiology materials methods sixteen patients years healthy subjects years underwent phase contrast magnetic resonance imaging mri measurements included cervical csf flow total arterial inflow carotid vertebral arteries internal vein flow flow net flow flow delays compared multiple linear regression correcting sex age results stroke volume higher healthy net csf flow similar magnitude direction cervical csf stroke volume lower internal carotid artery net flow lower although differences found internal vein flow flow delays conclusions typical flow blood csf mainly characterized increased csf reduced cervical csf direction mean net csf flow third fourth ventricle findings reflect altered distribution intracranial csf volume although causality relationships unclear
system generating tunable orbital angular momentum radio beams method measuring states proposed experimentally investigated beams generated uniform circular array dynamically configured controlling digital signals near field scanning platform built measure states system platform provide multiple feed ports transmitting array iteration used calibrate amplitude phase feed port experimental results demonstrate feasibility proposed methods generating measuring tunable beams
article explores reacted persistence state underlying ideology predicted paper adopts law context approach critically analysing legal instruments expert social scientists legal scholars period argues state attempted suppress criminal law many state experts ultimately fell back extra legal normative system gender women sexually behaviour women failing gender roles good women mothers whereas official policy thus morality experts traditional morality clear promises state ideology regards equality sexes heightened responsibility women given prevent unique state thus yet another case study regime controls vulnerable side transaction gendered way instead demonstrates become vehicle promoting traditional gender norms towards women women society
serious health problem especially immunocompromised individuals new bearing compound containing functionality synthesized characterized different spectroscopic techniques used preparation new antifungal agents double bond determined via single crystal ray technique title compound space group circle circle circle beta circle molecules packed crystal structure eight hydrogen bond interactions comprehensive spectral analysis title molecule performed based scaled quantum mechanical force field obtained density functional theory dft calculations molecular docking study illustrated binding mode title compound target protein preliminary antifungal activity title compound determined using assay
crucial element group conflict group members manage stigma imposed groups across three experiments propose group identification cause consequence self labeling group labels practice known reduce stigma experiment found group identification increased self labeling group label experiment individuals self labeled group label felt identified group reduced labels perceived negativity also persisted longer group helping task effect partially mediated group identification experiment observers perceived self identified group viewing label less negatively perceived group identification mediated relationship group identification critical component labels provides insight highly identified members group conflict groups identity
methodology developing manufacturing engineering presented often planning similar noted limited duration normal way overcome limitation prepare educational documents students disposal date point ict tools used virtual teaching like learning become significant advancement however paper considered elaboration materials students also whole educational strategy developing manufacturing engineering stated
order achieve rapid development process reduce time market new approaches investigated automotive body assembly design research presents prospective study using plant digital mock support process design reviews concept digital lot introduced design object validate layout assembly processes alternative collaborative way result better synchronization manufacturing engineers quick identification key issues related future assembly process configuration
objectives migraine diseases characterized severe headaches neurological systemic findings purpose study investigate prevalence migraine examine whether relationship atopic disorders parental history migraine asthma patients material methods total asthma outpatients diagnosis early late test showing reversible airway obstruction according hospital database included presence headache atopic symptoms parental history asthma atopic disorders migraine asked patients headache neurology department investigated presence migraine diagnosis migraine headache made patients fulfilled international headache society criteria results patients described headache patients headaches meeting criteria migraine patients migraine aura atopic symptoms patients according parental history asthma atopic symptoms migraine parents patients atopic symptoms found significantly high rate headaches prevalence migraine significantly high patients parental atopic symptoms multiple logistic regression analysis identified gender parental history asthma migraine smoking independent risk factors presence migraine conclusion high prevalence migraine headaches patients asthma coexistence asthma headaches related similar pathophysiological mechanism parental history common genetic compounds smoking play role mechanism headaches asthma patients atopic symptoms family history questioned clinicians careful presence migraine
proved two independent experimental studies group young given food supplement metabolism one two carbon units given one dose daily one month induced reciprocal changes muscle mass body fat changes characteristic four groups divided basis increased decreased level urine increased decreased levels vitamin blood comparison results short long term showed individual deviations found within rank group characteristic person study changes level acid urine proved good markers deviations homeostasis
people often talk others personal past discussions inherently selective selective retrieval memories course conversation induce related memories speakers cue defined part within individual retrieval induced part socially shared retrieval induced however associated taken seriously mechanism shapes individual shared memories mechanism demonstrated meaningful material ecologically valid groups first experiments extended material emotional memories experiment intimate couples experiment merely selectively practice memories extended results context free flowing conversation experiments experiments found regardless emotional valence individual ownership memories discuss findings terms role shaping personal shared
paper puts forward novel design method permanent magnet synchronous generator significant advantage method output power improved without increasing material costs main difference traditional design scheme volume permanent magnet remains unchanged entire design procedure maximum output power scheme found just optimizing shapes change mechanical pole arc coefficient words method aims obtain maximum utilization design scheme produce effective magnet field generate larger output power dimension parameters different shapes calculated equivalent analytic geometry method verify availability novel method performed four common types different rotor structures satisfactory performance results obtained comparison traditional machine design scheme also presented illustrate innovation priority finite element analysis method based maxwell applied electromagnetic models building simulation
paper presents controller design implementation high precision six degree freedom dof high precision positioning system consists novel concentrated field magnet matrix triangular single moving part carries three three phase permanent magnet planar motor since single moving part namely generates required fine coarse motions positioning system reliable potentially low cost three planar motors based lorentz force law produce vertical force triangular also control position orientation horizontal plane main contribution paper dof motions solely controlled magnetic forces without means support weight gravity suitable controller magnetic system designed implemented regarded pure mass spring damping effects neglected except vertical directions single input single output digital lead lag controllers designed implemented digital signal processor dof fully total mass exhibits maximum travel range position resolution position noise root mean square demonstrated sub angular resolution axes maximum velocity achieved single moving part structure highly suitable semiconductor manufacturing applications several experimental motion profiles presented demonstrate stages capability accurately tracking planar three dimensional paths
sea surface temperature plays fundamental role exchange heat momentum water vapor atmosphere ocean therefore measurement done offshore platforms satellites past decades satellites increasingly used datasets wide areas obtained paper moderate resolution imaging modis board products examined validated coastal waters yellow sea using situ data strict match method adopted view complexity variability coastal area resulting match ups respectively modis agreed situ squared correlation coefficients relative situ satellite derived bias degrees degrees standard deviation degrees degrees root mean square error degrees degrees differences modis situ exhibited apparent seasonal variations accuracy modis products spring summer lower autumn caused frequent sea along southern coast bias approximately depended wind velocity low wind velocity enhance diurnal amplitude bulk skin temperature difference however significant dependence bias air sea temperature difference surface flow velocity
evaluated capacity gene diagnostic marker quantitative real time pcr gene encodes enzyme phosphate dehydrogenase plays important role metabolism related survival intracellular environment macrophage assay includes internal amplification control order avoid false negative results specific analytical sensitivity genome equivalent reactions quantification highly linear efficient pcr efficiency log dynamic range finally applicability assay evaluated artificially contaminated biological matrices implicated transmission bacterium sheep raw milk pig blood real time pcr assay allowed detection ten cells per sheep raw milk per pig blood conclusion present alternative detection genus therefore facilitate establishment preventive prophylactic measures food farm environments
paper discusses empirical results study influence gender role identity representations violence young female students age attitudes towards violence use violence interpersonal relations appear long realization interpersonal interaction authors assumption traditional ideas gender features violent behaviour inadequate gender system modern society study sample consisted respondents authors used following research methods writing essay semantic differential sex role inventory obtained empirical data indicated girls undifferentiated neutral gender role identity wider range representations violence compare respondents guided models gender behaviour masculine feminine patterns girls undifferentiated polarized gender role identity able recognize large variety forms violence flexibly use combine various forms violence achieving goals corresponding circumstances sample girls typically feminine gender role identity less able forms violence especially interpersonal relations violence usually polar forms representations either physical psychological moreover girls typically feminine gender role identity perceived violence behavioural patterns assessed violent given context findings study useful improving practices prevention correction rehabilitation female violent reducing manifestations extreme forms female violence society
paper index based approach proposed locate stations water distribution network common practice secondary essential protection microbiological contaminant intrusion however higher levels free residual lead unwanted products taste complaints used maintain minimum levels requires proper selection locations approach proposed uses generic hydraulic water quality modeling software programmers toolkit predict total converted thereafter water quality index heuristic algorithm maximum covering location problem used optimization maximizes converted species using quadratic optimization cancer risk potentials finally required number stations recommended based trade analysis risk potentials life cycle cost proof concept case studies conducted hypothetical municipal american society civil engineers
paper study cooperative cognitive radio networks consisting primary user multiple secondary users transmit sensed silent interfere primary transmission due sensing primary activity sensed correctly assisting failed packets analyze packet throughput three variations proposed cooperation method signal flow graph based approach employed obtain closed form expressions packet throughput analysis done two cases individual sensing cooperative sensing furthermore characterize optimal transmission probability maximizes individual secondary packet throughput keeping system stable results present comparison throughput performance proposed cooperation methods different scenarios show benefits throughput
supporting learners carrying stressful educational activities open research issue requires appropriate infrastructure recognizing emotional states accordingly runtime paper describe open platform implemented named detect changes physiological signals associated stressful situations happens recommends learner delivering modulated support terms light sound vibration relaxation breath rate way taking advantage ambient intelligence learner perceive recommended action without learning activity case practicing oral exam second language signal acquisition system combines sensors health platform others integrated hoc compared commercial system engineering obtaining similar outcomes identifying significant changes physiological signals learner experiments emotional reaction however cost much lower time open hardware flexible thus advantage providing runtime data processing user studies served evaluate participants perception support calibrate delivery rule evaluate effectiveness support provided
robust efficient object tracking algorithm required variety computer vision applications although various modern impressive performance challenges occlusion target scale variation still intractable especially complex scenarios paper proposes robust scale adaptive tracking algorithm predict target scale sequential monte carlo method determine target location correlation filter simultaneously analyzing response map target region completeness target measured peak rate lower likely target strict template update strategy designed accommodate appearance change avoid template occlusion occurs retained scheme allowed tracker away additionally feature integration incorporated guarantee robustness proposed approach experimental results show method outperforms state art terms distance precision overlap precision publicly available dataset
objective explore australian rural food policy acts influence local food environment focusing specifically composition functions processes food related strategies policy outputs design qualitative case study approach undertaken three sources used data eleven semi structured depth interviews members analysis thirty seven documents relating observation one meeting data analysed using thematic constant comparison approach community action theory provided theoretical framework interpret findings setting two rural local government areas south eastern coast australia subjects eleven members food policy results five themes emerged data analysis themes described leadership processes membership structure function pool resources food system advocacy focus collaborative cross strategies ability influence policy change conclusions australian case study demonstrates strong leadership small sized core membership focus collaborative strategies food policy mechanism positively influence local food environments
background paucity data heart failure incidence among low income minority populations objective investigate incidence post survival race sex among low income adults southeastern united states methods results participants white black men women enrolled southern community cohort study history receiving centers medicare medicaid services incident diagnoses december ascertained using international classification diseases revision codes via linkage centers medicare medicaid services research files participants black women mean age years risk factors common hypertension diabetes mellitus myocardial infarction obesity median follow years participants diagnosed age standardized incidence rates person years white women white men black men black women respectively remarkably higher previously reported among cases deaths occurred median follow years men lower survival hazard ratios confidence intervals white men black men black women compared white women conclusions low income population incidence higher race sex groups previously reported cohorts unique resource investigate determinants risk segment population existing cohorts
disease rare infectious disease fatal left untreated disease caused infection bacterium common initially assumed patients present nonspecific symptoms routine cultivation bacterium feasible difficult diagnose infection hand due generic symptoms infection bacterium actually quite often differential diagnosis gold standard diagnosis used periodic acid staining biopsy specimens staining poor specificity sensitivity development molecular techniques resulted convenient methods detecting infections greatly improved diagnosis often missed infection addition molecular detection resulted increase knowledge pathogenicity review gives overview new insights epidemiology pathogenesis clinical manifestations diagnosis treatment infections
influence content piezoelectric performance mol doped ceramics investigated results show ceramic achieves optimized piezoelectric properties bright red emission enhanced piezoelectric response achieved ceramics room temperature furthermore results show performance ceramics enhanced greatly present study opens way enhance rare earth doped elsevier rights reserved
key points exercise training effectively improves vascular skeletal muscle function however effects training blunted postmenopausal women result loss accordingly capacity deliver oxygen active muscles also impaired postmenopausal women premenopausal recent postmenopausal women exercise training shown improve leg vascular skeletal muscle mitochondrial function interestingly effects pronounced postmenopausal women skeletal muscle oxygen supply utilization similar two groups women findings suggest early postmenopausal phase associated enhanced capacity leg vasculature skeletal muscle mitochondria adapt exercise training ability deliver oxygen match demand active muscles preserved early phase following menopausal transition exercise training leads favourable adaptations within skeletal muscle however effect exercise training blunted postmenopausal women result loss furthermore postmenopausal women impaired vascular response acute exercise examined response acute exercise matched pre postmenopausal women aerobic high intensity exercise training twenty premenopausal early postmenopausal final menstrual period women separated age included training leg blood flow delivery uptake lactate release knee exercise similar pre postmenopausal women exercise training reduced leg blood flow delivery uptake lactate release blood pressure heart rate absolute workloads postmenopausal women effects detected premenopausal women muscle protein contents mitochondrial complex iii endothelial nitric oxide synthase cyclooxygenase cox cox related receptor increased training postmenopausal women whereas levels mitochondrial complex cox increased premenopausal women findings demonstrate vascular skeletal muscle mitochondrial adaptations aerobic high intensity exercise training pronounced recent post compared premenopausal women possibly effect enhanced signalling also response acute exercise appears preserved early postmenopausal phase key points exercise training effectively improves vascular skeletal muscle function however effects training blunted postmenopausal women result loss accordingly capacity deliver oxygen active muscles also impaired postmenopausal women premenopausal recent postmenopausal women exercise training shown improve leg vascular skeletal muscle mitochondrial function interestingly effects pronounced postmenopausal women skeletal muscle oxygen supply utilization similar two groups women findings suggest early postmenopausal phase associated enhanced capacity leg vasculature skeletal muscle mitochondria adapt exercise training ability deliver oxygen match demand active muscles preserved early phase following menopausal transition
objective determine prevalence repeat pregnancy interval first recent repeat pregnancies evaluate sexual reproductive health characteristics teenagers repeat pregnancies methods prospective observational study undertaken hospital south africa september teenagers aged years pregnant recently delivered terminated pregnancy enrolled questionnaire used obtain data results among participants seen first pregnancy repeat pregnancy interval first recent repeat pregnancies months lower repeat pregnancy participants participants previously used contraception stopped within months used emergency contraception participants repeat pregnancy first pregnancy positive hiv status one sexual partner past months partner least years older conclusion high repeat pregnancy rates low contraception use high hiv prevalence among teenagers south africa focused interventions targeting teenagers following first pregnancy need urgently implemented international federation gynecology obstetrics published elsevier ireland ltd rights reserved
theory research suggests individuals greater social capital resources benefits gained relationships experiences social interactions likely active prosocial bullying situations therefore goal current study examine association social capital social support social skills prosocial behavior role internalizing problems potential barrier relation among students girls white sixth grades results indicate positive relation social capital prosocial behavior addition internalizing problems significant risk factor hinder youth particularly girls engaging behavior prosocial essential component prevent reduce bullying research needed better understand foster prosocial behavior bullying situations perhaps utilizing social capital related school bullying
field affective clinical science expanded dramatically past several decades gross important part research understanding emotion regulation dysregulation particular individuals differ ability identify accept manage emotional experiences one common widely cited measures emotion dysregulation difficulties emotion regulation scale extensively used facilitate understanding emotion dysregulation associated psychiatric symptoms emotion related constructs treatment progress scale contributed greatly understanding emotion regulation problems length makes inclusion brief study protocols difficult limiting utility increasing participant burden order address issue developed short form version composed strongest items measures six subscales original publication validated measure five datasets vary age sample type results demonstrate item short form exhibits similar structure original item demonstrates excellent reliability validity performs similarly original despite comprising half items potential improve expand emotion regulation assessment reducing demands research participants
light falling retina converted electrical signal stimulates serotonin synthesis previous studies described increase plasma cns serotonin levels bright light exposure leptin peptide hormones involved regulation related serotonin immunological markers also linked serotonin biosynthesis study healthy male volunteers exposed bright light conditions min cross manner subjective various serotonin associated plasma factors assessed light exposure subjective showed small increase bright light small decrease light resulting significant interaction light condition time concentrations increased significantly light conditions interaction light time correspondingly leptin decreased significantly light conditions increased significantly light time interaction also found significant decrease tryptophan tyrosine levels interaction light time conclusion ambient light affecting subjective rather serotonin associated biological factors published elsevier ireland ltd
study aims investigate influence different neck structures implant stress distribution computer aided design cad mandibular model based adult mandibular computed tomography information first established used create mandibular model related mandibular implant model using implant fitted mandibular first molar four neck type implants uniform implant wide neck implant implant single neck implant double neck received axial horizontal loads using ansys software von equivalent stress maximum principal stress different implant groups compared axial load maximum cortical bone area mpa respectively superior edge cortical bone mpa four groups respectively horizontal load respectively four groups respectively load respectively four groups respectively smallest
cytotoxic chemotherapy cornerstone medical therapy gastrointestinal cancers better understanding molecular biology cancer cell led therapeutic revolution targeted therapies monoclonal antibodies small molecule inhibitors directed proteins specifically overexpressed cancer cells agents specific cancer cells expected less toxic cytotoxic agents targeted agents provided clinical benefit many cancer types example anti egfr therapies significantly improved survival patients affected metastatic colorectal cancer deeply changed therapeutic strategy disease however effects sometimes due intrinsic acquired resistance mechanisms ras mutation anti egfr therapies activity restricted tumour settings lack activity cancer types microscopic residual disease adjuvant setting many studies negative overall population positive specific patient subgroups positive gastric cancer illustrating importance patient selection early identification predictive biomarkers response therapies propose comprehensive two part review providing approach successes failures targeted agents cancers unravel pharmacologic opportunities future directions agents oncology first part focus squamous cell carcinomas targeted therapies mostly used combination chemotherapy elsevier inc rights reserved
introduction sinus often neglected difficult access deep position sinus hinders early diagnosis pathologies location delayed diagnosis cause serious complications due proximity many important structures objectives aim study demonstrate different pathologies affect sinus elucidate findings methods cases isolated sinus lesions encountered setting rare pathologies discussed pathologies cell solitary pituitary fungal infection appeared primarily sinus discussed along imaging features pathological findings conclusion multitude different pathologies occur sinus detailed preoperative imaging helpful biopsy histological study required often definitive diagnosis possible advantages early diagnosis spread pathology prognosis
treatment risk developing anti factor antibodies inhibitors dominant concern among healthcare providers immune tolerance induction remains effective method inhibitors approximately patients accompanied significant emotional economical burden certain risk factors type mutation offer insight remains strategy predict development inhibitor moreover even predictive tool existed currently proven protocol tolerance induction previously untreated patient recent years growing body knowledge concerning fundamental immunology inhibitors light potential therapeutic interventions review highlight new findings influences translational medicine
schema therapy behavior therapy shown effective treatment methods especially borderline personality disorder roots cognitive behavioral therapy aim helping patient deal emotional dysregulation however major differences terminology explanatory models techniques used methods article gives overview major therapeutic techniques used respect emotion regulation systematically puts context gross process model emotion regulation similarities differences two methods highlighted illustrated case example core difference two approaches directly acquisition emotion regulation skills whereas seldom address emotion regulation directly modules mindfulness distress tolerance emotion regulation interpersonal effectiveness intended improve emotion regulation skills patients encouraged train skills regular basis assumes improved skills skills use result better emotion regulation problems emotion regulation seen consequence adverse early experiences lack safe attachment childhood abuse emotional neglect negative experiences led psychological fear emotions result attempts avoid emotions dysfunctional meta cognitive schemas meaning emotions assumes underlying problems addressed emotion regulation improves major techniques trauma processing emotional avoidance dysregulation limited empathic experiential techniques like imagery
present study method coating process used fabricate functionally graded thermal barrier coating application automatic film used coating attempt minimize production cost ceramic thermal barrier coatings stabilized ceramic nickel metal mixed appropriate proportion produced functionally graded material mixture based coating method used fabrication coating compositions stabilized nickel stabilized nickel stabilized nickel used first second third layers functionally graded thermal barrier coating substrate respectively field emission scanning electron microscopy scanning electron microscope ray diffraction used study evaluate integrity reliability coating produced results indicated sustainability suitability method adopted study regards production good quality functionally graded thermal barrier coating problem good adherence substrate elsevier ltd rights reserved
review examines vast catalytic therapeutic potential offered type oxygen insensitive enzymes partnership particular focus gene directed enzyme therapy form cancer gene therapy important first indications potential demonstrated years ago enzyme pairing escherichia coli however become apparent enzyme prototypical pairing limitations clinical progression recently substantial advances made engineering superior variants particular development high throughput screening capabilities enable optimization desirable activities via directed evolution advances enzymology advances medicinal chemistry leading development second third generation offer substantial advantages including greater dose potency enhanced ability activated metabolite exhibit local effect addition substantial progress towards future clinical trials research supporting fields notably development improvement targeted cellular ablation capabilities small animal models zebrafish enable cell specific physiology regeneration studies
discriminant analysis method used differentiate classify water quality three major rivers south florida study used assess water quality evaluate spatial temporal variations surface water quality south florida important data reduction method used assess water pollution status analysis spatiotemporal variation found stepwise five variables dissolved oxygen total nitrogen total phosphorus water temperature important discriminating water quality parameters responsible temporal variations spatial variation water quality also evaluated identified five variables ammonia magnesium sodium seven variables ammonia magnesium chloride significant discriminating variables wet dry season respectively three selected rivers south florida believed results useful local authorities control management pollution better protection important water quality
ecological impacts invasive plants increase dramatically time since invasion targeting young populations treatment therefore economically ecologically effective management approach especially linked post treatment monitoring evaluate efficacy management however collecting detailed field based post treatment data expensive typically resulting inadequate documentation ecological effects invasive plant management alternative approaches remote detection unmanned aerial vehicles uav provide opportunity advance science practice restoration ecology study sought determine plant community response different mechanical removal treatments dominant invasive wetland spp along age gradient within great lakes coastal wetland assessed post treatment responses intensive field vegetation uav data prior treatment oldest stands lowest plant diversity lowest native spp cover greatest cover following treatment plots mechanically harvested surface water differed control water harvested plots several plant community measures including lower dominance lower native plant cover greater floating submerged aquatic species cover repeated measures analysis revealed water cutting increased plant diversity aquatic species cover across ages maintained native spp cover portions stands uav data revealed significant post treatment differences normalized difference vegetation index scores blue band reflectance vegetation height remotely collected measures corresponded field observations findings suggest mechanically harvesting water biomass young stands harvesting older stands water promote overall native community resilience increase abundance floating submerged aquatic plant vulnerable large provided fast spatially data compared field monitoring effectively measured plant community structural responses different treatments study results suggest pairing uav targeted field data collection maximize quality post restoration vegetation monitoring
ecological assessment group research methods collect data frequently many contexts real world settings fairly neglected current article provides overview including definitions data collection considerations different sampling strategies next benefits reduced recall bias accurate tracking fluctuating variables testing assumptions theories use interventions participant safety considerations examples published research investigate self directed violence variables using discussed article concludes summary suggested directions research particular aim increased use methodology among
work studied parameters affecting localization hydrophobic particles impact morphology development polyethylene poly methyl ternary blends originally preferred core type morphology means combination electron microscopy attempt also made compare experimental results thermodynamic predictions ternary blend samples blend ratio varying loadings prepared melt using laboratory internal demonstrated localization controlled sequence feeding play significant role determining morphology development ternary blend samples shown contrary thermodynamic prediction core morphology samples highly enhanced melt elasticity filled phase allow phase form complete
evaluate associations diagnostic statistical manual mental disorders edition dsm alternative model personality disorder traits domains diagnosed personality disorder borderline personality disorder bpd respectively inpatient outpatient participants consecutively admitted clinical psychology psychotherapy unit san hospital italy administered personality inventory dsm pid structured clinical interview dsm axis personality disorders scid based scid participants assigned following groups bpd emotional separation insecurity impulsivity risk taking hostility significantly associated bpd diagnosis attention seeking significantly discriminated participants received scid categorical diagnosis separation insecurity impulsivity perceptual dysregulation dsm traits significantly discriminated bpd participants domain level analyses confirmed extended trait level findings
selecting relevant factors particular domain utmost interest machine learning community paper concerns feature selection process twin support vector machine powerful classification method constructs two order define classification rule besides euclidean norm proposal includes second aims eliminating variables twin synchronized fashion baseline classifier twin svm implementation based second order cone programming confers robustness approach leads potentially better predictive performance compared standard formulation proposal studied empirically compared known feature selection methods using microarray datasets finding low dimensional solutions highest average performance among methods studied work
objectives universal health insurance system medicare generates large amounts data pocket expenditure highly aggregated statistics routinely published primary purpose develop indices medicare administrative data quantify changes level distribution hospital medical services time methods data obtained australian hypertension absolute risk study involved patients aged years socio economic clinical information collected linked medicare records five year period march fisher price quantity indices used evaluate year year changes relative concentration index used evaluate distribution across socio economic results price index indicates overall rising faster considerable variation across different types services professional rose five year period items fell around concentration indices adjusted demographic factors clinical need indicate tends higher among higher conclusions major challenge utilizing large administrative data sets develop reliable easily statistics policy makers price quantity concentration indices represent statistics move beyond average author published elsevier ireland ltd
establishment environments associated changes physiology behaviour problem solving compared speed learning urban rural female common using standard visual discrimination task followed reversal learning phase also examined quickly progressed different stages learning including sampling acquisition within initial reversal learning persistence following reversal based reliance different food resources expected urban learn reversal learn quickly sample new longer learning quantified first presentation criterion achievement urban took trial blocks learn initial discrimination reversed contingency rural detailed analyses level stage revealed urban explored novel cue outcome longer despite faster subsequent acquisition remained overall slower rural females findings draw attention fine adjustments learning strategies response urbanization caution interpreting speed learn task reflection cognitive ability
isolated male hypogonadism congenital acquired mean platelet volume determinant platelet function independent risk factor cardiovascular disease cvd aim study evaluate values male relationships low testosterone levels metabolic syndrome impaired fasting glucose cardiovascular risk thirty one patients untreated isolated male mean age years age bmi matched healthy individuals mean years included study hormonal analyses done assay study participants evaluated biochemical platelet parameters significantly higher controls respectively positive correlation metabolic syndrome insulin homeostasis model assessment bmi negative correlation total testosterone free testosterone luteinizing hormone fsh although control patients metabolic syndrome patients metabolic syndrome significantly often respectively age metabolic syndrome bmi fasting glucose insulin crp independent predictive factors multiple regression analysis results suggest men susceptible increased platelet activation increased values contribute increased risk cardiovascular complications study observed low testosterone feature metabolic syndrome increased levels cardiovascular risk young adult males copyright wolters kluwer health inc rights reserved
ideal gas equation log rho entropy pressure rho mass density define interconnection entropy temperature density plasma therefore different phenomena relating plasma entropy need investigated employing transport equations electron ion two new parameters entropy distribution function entropy gradient drift defined new dispersion relation obtained dependence anomalous transport entropy also proved results like entropy principle second law thermodynamics proved new definition entropy work open new fusion processes controlling entropy particularly regions mode space also engineering sciences
building railway passenger stations often large space extremely comfortable resulted high energy consumption taking south railway station case paper introduced green energy saving design adaptable climate natural ventilation structure natural lighting ventilation heating meanwhile design effects verified simulation experimental test
study examined associations teacher aggressive students students characteristics sample youth grade classrooms assumption certain student characteristics either prime hinder teachers aggressive students teacher measured agreement teacher peer students start teachers rated students following characteristics academic competence affiliation popularity internalizing behavior qualities higher affiliation popularity internalizing behavior associated decreased odds teacher aggressive youth higher qualities associated increased odds teacher aggressive youth implications interventions discussed wiley periodicals inc
background diet high fat low carbohydrates mimics metabolic state used therapeutically epilepsy known generation triiodothyronine thyroxine decreases fasting periods aim study evaluate thyroid function children receiving least year due drug resistant epilepsy methods total patients males mean age years median interquartile range iqr years treated least year enrolled seizure control side effects compliance diet recorded free free thyroid stimulating hormone tsh levels measured baseline post treatment months mann whitney test repeated measures analysis variance anova post hoc bonferroni correction logistic regression analysis used data analysis results hypothyroidism diagnosed thyroxine medication initiated eight seven five patients patients total months therapy respectively logistic regression analysis showed baseline tsh elevation odds ratio confidence interval female gender independent risk factors development hypothyroidism treatment children conclusions causes thyroid thyroxine treatment required first report documenting effect treatment thyroid function thyroid function monitored regularly patients treated
common practice modern construction industry performance construction projects adversely affected relationships main contractors properly managed therefore relationships main contractors becoming important success construction projects based comprehensive questionnaire survey hong kong construction industry relationship main contractors studied main contractors local industry classified four clusters according nature relationship namely collaborative furthermore impact relationships main contractor competitiveness critical factors affecting collaborative relationships main contractor competitiveness also explored findings research reveal good relationships positively associated main contractor competitiveness long term relationship based principles likely benefit parties construction practice american society civil engineers
background aged long term residents suffer wide range skin problems dry skin associated severe pruritus inflammation prevalent exact figures lacking maintaining skin tissue health enhancing quality life major goals institutional long term care using mild skin care products considered improve skin barrier reduce adverse events however available evidence supporting particular skin care approaches limited objective study aims answering two general questions prevalence skin conditions skin diseases aged nursing home residents associated general person health related characteristics structured skin care regimen improve skin health aged nursing home residents design methods using random sample nursing homes state residents seven institutions undergo nursing medical dermatological assessments biophysical skin parameters like water loss skin surface measured residents dry skin included three arm randomized pragmatic trial investigating effectiveness two standardized skin care regimens compared usual care primary outcome overall dry skin score follow period two months settings institutional long term care facilities germany participants long term care residents years gave informed consent sample size statistical methods due nature study formal sample size analysis possible expected sample size first part study considered sufficiently large obtain precise point estimates planned allocate eligible nursing home residents ratio per group intervention part detectable mean difference using group sizes groups depending level measurement variables described using absolute relative frequencies means associated spread estimates possible multivariable associations analyzed primary outcome dry skin described mean differences one way anova analysis post hoc pairwise two sample tests results study started september results expected july trial registration study registered https show elsevier ltd rights reserved
virus one four viruses geographically diverse five distinct genotypes emerging strains lineages increasingly reported availability genomic data strains provides opportunity study population structure complete genome sequences available strains four genotypes iii isolated worldwide analyzed using population genetics evolutionary approaches map landscape genomic diversity population observed stratified five major subpopulations genotype formed independent subpopulations genotype iii subdivided three subpopulations therefore heterogeneous genotypes subpopulations comprise asian strains whereas comprises american strains subpopulation includes mainly american strains along strains genetic predominantly observed strains genotype iii strains genotype inter genotype recombination observed occur non structural region several asian strains whereas extent recombination limited american strains significant positive selection found operational genes observed main driving force genetic diversity positive selection strongly operational branches leading asian genotypes helped delineate genetic differences asian american lineages thus inter genotype recombination migration adaptive evolution major determinants evolution elsevier rights reserved
background thyroid carcinomas represent two distinct entities quite frequently occur simultaneously aim provide genetic analysis occurring patient elucidate origin methods sequencing analysis ras hot spots mutations normal tissues patients results two patients affected familial harboring germline mutations tissues eight sporadic cases show somatic mutation three tissue components considering component patients show somatic mutation somatic mutation presented mutations ras gene additional case ras mutations simultaneously present considering component patients mutation ras mutation ras mutation remaining cases show somatic mutation one case mutation mutation none mutations found present tumors conclusion knowledge first study analyzing possible involvement ras oncogene mutations data clearly suggest classical activating mutations commonly involved pathogenesis responsible simultaneous occurrence
robust multi objective optimization method optimum design presented robust design materials loads assumed affected uncertainties lack knowledge uncertainty quantification using evidence theory optimum design subject uncertainty undertaken addition functional objective evidence based measure failure constraint satisfaction minimized formulate robust design multi objective optimization problem order alleviate computational difficulties evidence theory based uncertainty quantification analysis combined strategy differential evolution based interval optimization method parallel computing technique proposed population based multi objective differential evolution optimization algorithm designed searching robust pareto front two structures shape sizing optimum design problems presented demonstrate effectiveness applicability proposed method
previously shown high exchange activity bovine adrenal cells study monitoring change single cells population cells reverse mode exchanger activity initiated shown activity enhanced enhanced activity accounted significant proportion dependent uptake activity cells results support hypothesis exchanger present cells expression cells confirmed using pcr northern blotting addition plasma membrane exchanger activity measured dependent uptake also present membrane isolated granules enriched fraction mitochondria enriched fraction results support present bovine cells regulation probably efficient participation
main goal paper propose probability model computing probabilities class action cases united states federal district mean prejudice response motion eventual discovery process proposed probability model hybrid two widely used methods logistic regression naive bayes using dataset class action cases show proposed hybrid model potential computing better probabilities either models better mean lower root mean square errors probabilities proposed hybrid model uses following features generally accepted accounting principles violations lack internal control class period section violations act short term drop stock price model useful insurance companies policy elsevier rights reserved
jet machine associated facilities require significant maintenance enhancement installation activities support experimental exploitation programme proportion activities within radiological respiratory hazardous environments breathing air fed one piece provide workers protection inhalation airborne dust design essentially developed empirically practical necessity improve design optimise worker performance protection thermal comfort paper details complexity modeling three dimensional domain inner surface suit includes mass heat transfer geometry human metabolism respiration effects limb movements methods used include computational fluid dynamics cfd theoretical adaptations mixed phase turbulent now profile scanning suit life size data processing images experimental validation trials achievements current programme collaborations presented paper future discussed elsevier rights reserved
paper studies historical approaches followed theory elasticity authors chosen pearson love perhaps important english language since second half century shown historical purpose changed one next ranging history known evolution elasticity path progress investigated significant differences although overall sense towards form truth relation history theory identified recurrent theme author although explicitly stated seen change following main trends times possible avenues research mentioned towards end
current study examines prison programming availability participation gender national level authors build upon previous literature using national level data something done limited cases previously main concern study gender effects programming availability participation corrections field undergone major changes regard population trends constraints policies research last decades without large scale examination effects changes programming across united states study multiple types programming areas examined results indicated often female housing females likely offer programs mental health options women likely participate many programming options compared male men respectively discuss possible reasons implications future research
measurement widely used estimate systolic blood pressure diastolic blood pressure paper propose deep belief network deep neural network learn complex nonlinear relationship artificial feature vectors obtained wave reference nurse blood pressures using based regression model powerful generative network feature extraction address local special phase therefore model provides alternative way replacing popular shallow model based apply based regression model estimate however small amount data samples enough train without problem reason use parametric bootstrap based artificial features used training samples efficiently learn complex nonlinear functions feature vectors obtained reference nurse blood pressures far know one first studies using based regression model estimation small training sample available based regression model provides lower standard deviation error mean error mean absolute error compared conventional methods
waste ponds used worldwide wastewater treatment throughout operation require periodic sludge surveys sludge accumulation impact performance reducing effective volume pond altering pond hydraulics wastewater treatment efficiency traditionally sludge heights thus sludge volume measured using low resolution labour intensive methods sludge judge white test device readily available technology fitted remotely operated vehicle shown improve spatial resolution accuracy sludge height measurements reduce labour safety requirements coupled dedicated software package profiling several shown autonomous device capable providing sludge greatly increased spatial resolution greatly reduced profiling time leading better understanding role played sludge accumulation hydraulic performance high resolution collected used support much detailed hydrodynamic assessment systems low medium high sludge results modelling show hydraulic performance influenced sludge accumulation also spatial distribution sludge plays critical role reducing treatment capacity systems range ponds modelled reduction residence time ranged pond uniform sludge distribution reduction pond highly flow combination high resolution measurement sludge accumulation hydrodynamic modelling help development frameworks wastewater sludge management including development reliable computer models potentially wider application monitoring small medium water bodies channels recreational water bodies commercial ports elsevier ltd rights reserved
emergence hardware architectures increased performance applications however traditional architectures suitable real time operating systems performance oriented scheduling algorithm conflict software scheduling letter presents portable architecture provides unified hardware software scheduling bringing benefits domain show tightly coupled real time compliant hardware integration achieves throughput benefits maintaining scheduling policy intact increasing solution shows average speed ups times native versions low area usage performance overhead ratio due minimal cost extra slices per hardware supported thread work related work providing complete hardware solution independent specific
background purpose study examine contribution cognitive functioning arithmetic problem solving explore cognitive profiles children attention deficit hyperactivity disorder adhd mathematical learning disabilities methods sample made total students grade organized three adhd typically achieving control group assessment conducted two sessions pass processes arithmetic problem solving evaluated results adhd groups performance planning attention worse control group children obtained poorer results control group planning simultaneous successive processing executive processes predicted arithmetic problem solving adhd group whereas simultaneous processing unique predictor sample conclusions children adhd showed characteristic cognitive profiles groups problem solving performance predicted cognitive functioning elsevier ltd rights reserved
background purpose study identify risk factors outcome implications day hospital lung transplant recipients methods conducted retrospective cohort study lung transplant cases single high volume lung transplant program january march demographic health data reviewed patients risk factors day defined within days discharge index lung transplant hospitalization modeled using logistic regression selection parameters backward elimination results sample comprised patients excluding scheduled hospital deaths overall day rate rates similar across different diagnosis categories procedure types univariate analysis post operative complications day included pneumonia infection atrial fibrillation kaplan meier analysis multi regression modeling assess predictor long term outcomes showed day significant predictor worse survival lung recipients conclusions occurrence least post transplant complication increases risk day lung transplant recipients patient population day predispose adverse long term survival quality indicators day needed assess hospitals perform lung transplantation international society heart lung transplantation rights reserved
article family polynomial estimators estimation linear system response weakly non linear systems examined regarding estimation errors applicability estimator introduced extension measurement input output noise shown results obtained polynomial estimators related parameters models bias variance tradeoff estimation error derived methods obtaining minimum error presented
paper discusses discrete time loop shaping algorithm servo enhancement multiple wide frequency bands design considerations motivated large class practical control problems vibration rejection active noise control reference tracking recent novel challenges demand new design servo technologies pseudo parameterization scheme proposed using inverse system model bring enhanced control selected local frequency regions design methodologies created control come fundamental limitations feedback control finally simulation experimental verification conducted precision control semiconductor manufacturing elsevier ltd rights reserved
paper explains software architecture planned designed implemented help support activities within virtual laboratory inside second life virtual world problems related kind systems architectures detects possible benefits provide processes paper shows software engineering principles procedures applied order solve problems data gathering virtual worlds data analytics information related interaction user environment applied enhance students learning process teachers assessment learning process paper also shows software product resulting engineering process outcomes application solution real context two academic years involving students subjects pharmacy quality assurance end paper explain considerations knowledge retrieved experience focusing utility learning point view innovation possible future work done improve solution implemented
doubly salient mechanical structure switching characteristics switched reluctance motor led torque ripple low dynamic performance problems using conventional control algorithm speed control method view fractional pid control algorithm strong robustness advantage fuzzy control depend precise mathematical model paper proposed control algorithm based fuzzy fractional order pid torque control algorithm basis fuzzy rules using control algorithm adaptive torque control using speed deviation deviation changing rate input turn torque ripple smaller changing proportional coefficient integral order differential order fuzzy inference adaptive fractional order pid controller simulation results indicate control algorithm feasible torque ripple switched reluctance motor smaller dynamic response better
background purpose study determine total serum immunoglobulin ige predict compared patients allergic rhinitis methods retrospective study cohort patients underwent allergy testing differences total ige level subjects calculated pearson correlation coefficient calculated determine whether relationship total ige level number positive allergen addition allergen sensitization class calculated allergen sensitization patient pearson correlation coefficient calculated determine relationship total ige level weighted allergen sensitization class results patients compared patients patients almost sensitized one dust total ige higher patients compared compared controls pearson correlation coefficient total ige number positive allergen pearson correlation coefficient total ige allergen class weighted conclusion ige level used predict moderate correlation total ige sensitization number positive allergen allergen class weighted llc
paper provides depth understanding social dynamics form societies gender roles relationships community level understand social structures created pattern relations enhance hinder coping initiatives lake lake socio ecological system using qualitative quantitative methods including depth interviews focus group discussions household questionnaires paper provides insights people lake social ecological system prepare cope lake water social networks findings shown lake poor households lake socio ecological system households lineage networks strong tradition generic term tradition group norms via series rules based system women strong rights land allocation use female group stable great deal food redistribution among households self organization provides deeper meaning people dynamics affecting social natural environments specifically findings provide evidence households communities africa reconstructed natural resources elsevier ltd rights reserved
available data support contribution neurodevelopmental neurodegenerative factors etiology schizophrenia bipolar disorder note one important issue current psychiatric research identify specific factors contribute impaired brain development neurodegeneration especially factors alter normal brain development physiological aging process hypothesis specific damages taking place precise brain development stages associated future onset neurodegeneration consists acceleration brain aging onset support hypothesis results present narrative mini review shows neurodevelopmental damages generally contribute neuropsychiatric syndromes hypothyroidism specifically associated adult substance abuse particularly happen specific stages brain development hand cognitive impairment brain changes associated long duration look like happens aging memory executive domains prefrontal cortex implicated aging progression future research explore possible validity etiological model
opportunities challenges related internet use continue grow social concern around problematic internet use online risky behaviors intensive use internet mainly among adolescents aim study conduct general screening large sample school based adolescents spain providing updated prevalence data different online risky practices rates internet social network use differences problematic users explored terms demographics parental control motivations using association involvement online risky behaviors also analyzed role intensive use findings show global prevalence among spanish adolescents percent although higher among females late intensive users without parental control logistic regression confirmed intensive use risk factors involved online risky behavior explanation common deficit personal social skills underlying intensive use online risky practices perspective value based education life skills training best way reach responsible use internet among adolescents parents schools institutions adolescents called upon actively engage facing problem
european union working strategies order increase energy efficiency buildings useful solution identify energy performance buildings energy performance provides information comparison buildings different architectural typology shape design technology geographic location however tool assess real energy consumption building always take account impact environment work two different types analysis carried one based energy efficiency one based environmental impact analyses applied standard building set three different italian locations purpose obtaining cross related information evaluation results interventions parameters walls insulation windows frame gas identified order improve energy behavior building acceptable environmental impact aim paper propose methodology integrates green building rating systems leading conscious choice interventions compromise energy performances environmental impact
article aims various benefits modular green roof technology nowadays smart solutions green roofs popular ecological technical economic benefits qualities green roofs used residential commercial public buildings innovative energy efficient construction technologies bring great benefit ecology help relief heat island effect purpose research provide effective apparatus method green roof system principal results research focused adjusting optimal physical parameters green roof modules friendly environmental green roof technology oriented policy sustainable development protection urban ecology authors published elsevier ltd
cpg cpg reported protect airway hyper responsiveness also known potent vaccine adjuvant anti tumor therapy little known effect cpg mice radiation induced lung fibrosis common late stage form tissue damage occurs radiotherapy evaluated immunomodulatory effects cpg development mice divided four groups single dose whole cpg intraperitoneal injection cpg total weeks cpg irradiation plus cpg treatment irradiation total weeks control cpg treatment study found cpg treatment attenuated lung fibrosis collagen deposition increasing number levels type cytokines tgf cpg administration regulated expression phosphorylation reversed expression type immune response key transcription factor activation jak signaling pathway enhanced macrophage differentiation type cytokine production study reveals mitigating effect early exposure cpg lung injury caused irradiation mice potential mechanism action related enhancement type immunity conclusion cpg potential therapeutic target treat elsevier ltd rights reserved
associated placental sharing traditionally analysed using conventional chromosome staining polymerase chain reaction however former technique requires presence proliferating cells whereas latter associated possible blood cell contamination therefore aimed develop single cell analysis technique cells applied fluorescent situ fish cell nuclei using differentially labelled chromosome specific probes herein present validation method cells cell line application method evaluation cross sex blood lymphocytes bone marrow cells mixed sex results show cells bone marrow blood cross sex chimeric mixed sex addition single samples liver spleen cell suspensions one individual tested cross sex observed spleen liver cells conclude fish method choice identify cross sex especially combined morphological identification nuclei different cell types allow targeted tissue specific analysis
strongest best documented risk factor drug hypersensitivity history previous reaction accidental exposures drugs lead severe even fatal reactions sensitized patients preventable prescription errors common often due inadequate medical history poor risk assessment recurrence drug reaction proper documentation essential information doctor make sound therapeutic decision european network drug allergy drug allergy interest group european academy allergy clinical immunology formed task force developed drug allergy general guidelines drug allergy documentation drug allergy drug allergy alert card discharge letter medical evaluation adequate means document patient patient advised carry documentation times especially away home drug allergy least contain information drug including international name clinical manifestations including severity diagnostic measures potential cross reactivity alternative drugs prescribe detailed information obtained given patients full allergy future electronic prescription systems alert functions become common include information paper based documentation
solar enhanced natural draft dry cooling tower efficient natural draft dry cooling tower utilizing solar radiation arid region three dimensional numerical model considering solar radiation effect developed investigate influence radiation intensity ambient pressure efficiency thermal characteristics numerical simulation outcomes reveal model consideration radiation results less air mass indicates previous simulations overestimated solar energy obtained solar collector underestimated heat loss cooling performance improved higher solar radiation intensity ambient pressure air temperature velocity increase solar radiation intensity ambient pressure solar radiation intensity inverse effects changes air temperature velocity condition solar load increases ambient pressure decreases increased rate heat transferred heat exchanger obvious elsevier ltd rights reserved
paper application commercial shelf thermoelectric generator type power supply autonomous sensors investigated architecture system established expected electrical power provision simulated tested agreement better one order magnitude simulation test mission heat flow reverse therefore taken account design corresponding electrical circuits sensitivity low temperatures degrees found addressed via selection different types tested without problems degrees concept central provision electrical power discussed shortly showed need new high temperature operate temperatures degrees elsevier ltd rights reserved
gene related peptide neuropeptide system important still evolving target migraine fundamental consideration current drugs clinical trials ongoing development area identity expression pattern function receptors knowledge safety efficacy considerations recent years receptor like receptor receptor activity modifying protein complex known receptor generally considered relevant however capable activating multiple receptors one endogenous receptor recent identification responsive receptor complex receptor subtype receptor system warrants deeper consideration molecular identity receptor involved pathophysiology thus potential treatment migraine perspective considers issues implications
mechanical properties nonwoven geotextile materials depend structural solutions technological conditions production thereby structural physical mechanical properties fibers surface mass geotextiles process parameters important function paper presents results analysis mechanical characteristics nonwoven geotextile material made fibers recycled fibers surface masses also elastic limits deformation geotextile materials determined define permitted loads geotextile materials subjected without structure force intensities work forces determined elastic limits geotextiles relationship appropriate breaking parameters presented proposed method results used predict permitted loads non woven geotextile material subjected exploitation
water pollution known major problem lake basin china compared industries domestic sewage non point pollution agriculture difficult detect measure control therefore range policies formulated among adjustment structure however policy implementation used simply convert fields dry land food crops crops surprisingly date research provided evidence agricultural land use change contributes reduction agricultural nutrient pollution based extensive farm survey research finds conversion rice dry land farming generated positive effect nutrient pollution control estimated nitrogen runoff agricultural land increased phosphorus runoff increased two times since land use patterns changed farmers inclined apply fertilizer dry land fields however agricultural land use change economically effective land use conversion increases net farming significant way demonstrated compared environmental concerns economic considerations seen greater benefits adjustment structure findings important implications policy making local authorities efforts improve environmental management pollution control
background pluripotent small embryonic like stem cells induced pluripotent stem cells reported technology whereas even today existence accepted underlying reason exist low numbers remain homeostatic conditions small size maintain life long tissue homeostasis serve pool adult stem cells stress conditions imbalance function uncontrolled proliferation result cancer search methods electronic database medline pubmed systematically searched subject term small embryonic like stem cells objective rationale primitive stem cells undergo asymmetric cell self give rise progenitors still remain elusive hematopoietic system testes presence stem cells ovary still debated propose review available literature methods isolation characterization compare embryonic stem cells germ cells cells role maintaining tissue homeostasis review includes look ahead result paradigm shifts basic reproductive biology outcomes adult tissue specific stem cells including hematopoietic ovarian mesenchymal stem cells good proliferation potential indeed committed progenitors cytoplasmic oct arise asymmetric cell pluripotent nuclear oct primitive stem cells postulated overlapping population rather migrate survive various adult body organs throughout life express pluripotent specific markers developmentally mature compared cells obtained inner cell mass stage embryo result readily differentiate three embryonic germ layers spontaneously give rise sperm vitro like divide readily culture produce integrate developing embryo property relatively quiescent allows endogenous survive various kinds toxic survive targeted induce endogenous regeneration non functional healthy niche mesenchymal cells resulted improved gonadal function live births wider implications quiescent possibly accumulate genomic nuclear mitochondrial mutations thus ideal endogenous pluripotent stem cell candidates regenerative reproductive medicine presence adult fact survive need bank gonadal tissue fertility preservation prior ability undergo neo presence healthy niche help identify newer strategies toward fertility restoration cancer survivors delaying menopause also enabling aged mothers better quality eggs
background limited data regarding associated factors return sports activities years anterior cruciate ligament acl reconstruction purpose test patient characteristics concomitant articular lesions graft maintenance sports activities years acl reconstruction hypothesized years operation young adult men maintenance greater activity level better knee function associated greater activity level younger age reconstruction absence concomitant articular lesions minimal graft follow study design case series level evidence methods one hundred six men autologous acl reconstruction ages years reviewed years surgery excluded patients contralateral acl tear revision reconstruction another injury function fifty five patients eligible available follow independent variables included score time interval injury surgery smoking status age articular lesions side side difference shift grade main outcome measures activity level international knee documentation committee subjective score knee injury osteoarthritis outcome scale score years surgery results greater activity level follow associated regression model greater activity level correlation coefficient lower difference correlation coefficient negative shift correlation coefficient younger age operation predicted return greater activity level univariate analysis correlation coefficient regression model significant lesions surgery predicted lower subjective scores scores affect maintenance sports activities conclusion years autologous acl reconstruction young men predictors greater sports activity level primarily high activity level knee younger age operation moderate lesions lower impact respect
research violence television directed main efforts mostly quantitative statistical analysis media violence detailed experimental studies effects specific scenes violence present work deals interpretation media violence based analysis focus groups tries light mediating factors dimensions violence possible effects particular conditions recognition classification violence scenes functions violent images emotions feelings processes identification main characters analysed
channel width length ratio important transistor parameter integrated circuit design contact diffusion channel fabrication operation alters channel width important parameter novel methodology combining atomic force microscopy scanning probe microscopy self consistent modeling developed detection contact diffusion active devices scans surface potential modeled using physically based technology computer aided design simulations transistor terminals grounded biased conditions simulations also incorporate tip geometry investigate effect measurements due electrostatic tip sample interactions method particularly useful semiconductor metal semiconductor interfaces potential contrast resulting diffusion usually detectable scanning probe microscopy
objective unusual clinical course background acute coronary syndrome present atypical chest pain symptoms attributed heart disease benign self limited condition become persistent intractable overlooked underlying etiology various causes including metabolic abnormalities disorders malignancy central nervous system pathology medications pulmonary disorders gastrointestinal etiologies rarely attributed cardiac disease case report report case intractable year old male cocaine related myocardial infarction placement coronary showed thrombosis initial intervention following patient recovered without additional episodes although known present particular cause myocardial ischemia case additionally explained effects cocaine lead coronary arteries conclusions associated cardiac enzyme elevation segment elevation percutaneous coronary intervention manifestation acute without fact patient cocaine user contributed unique presentation
objectives provide overview presentation pathology diagnosis update current diagnostic criteria methods review recent literature performed results migraine process significant impact quality life disease attacks spontaneous migraine symptoms lasting several minutes inner ear disease exist migraine symptoms occurring migraine mimic inner ear disorders providing challenge clinicians establishing diagnosis recent diagnostic criteria migraine proposed joint committee society international headache society provide important standard clinical diagnosis research conclusion migraine challenging disease process diagnose treat proper diagnosis treatment requires thorough understanding current literature elsevier rights reserved
study integrates emotion social influence literatures examine emotion recognition ability era relates annual income sample employee peer broad range jobs organizations find peoples level era indirectly relates much per year relationship era annual income mediated sequentially political skill interpersonal facilitation results imply emotional abilities allow people process affect information effectively also use information successfully social world organizations pursuit copyright john wiley sons ltd
introduction common practice adolescent population often para improve appearance potent allergen frequent cause allergic contact dermatitis material method study conducted results consecutive children patch tested university general hospital consortium results almost half cases children one positive patch test findings allergic mean age patients allergic years male cases atopic dermatitis positive reactions considered current clinically relevant origin cases conclusion relatively common child adolescent population frequent origin performing adolescents higher risk developing due strongly children published elsevier espana slu rights reserved
rice false caused destructive disease many rice growing areas described many fungal species little information regarding study double stranded rna patterns assessed wild type isolates obtained different geographical regions china presence viral infections common isolates contained elements viral characteristics presence mixed infections two related unrelated commonly detected isolate contained four rna virus belonging rna virus belonging family includes thermal tolerance virus last two probably belonging biological comparisons virus free infected fungal isolates revealed strain likely since infected strains show apparent symptoms northern blotting experiments revealed strain frequently found irrespective place origin similarly sized bands always similar sequence thus findings suggest infecting china widespread highly diverse elsevier rights reserved
introduction presence polymorphism thought several effects influence enzymatic function associated increased expression genes involved oxidative stress brain tissue predict favorable response combination levothyroxine plus triiodothyronine therapy hypothesized homozygous carriers allele different thyroid hormone parameters reduced health related quality life hrqol cognitive functioning methods participants cohort study genome wide genetic data available effects polymorphism evaluated general population people treated thyroid hormone replacement therapy latter mainly primary hypothyroidism addition evaluating anthropometric data medication use existence metabolic syndrome hrqol assessed item health survey fluency test used sensitive test executive functioning data thyrotropin free thyroxine free levels available subset participants results mean age standard deviation years body mass index users compared years participants general population genotype polymorphism present users general population total subjects thyroid hormone data available normal tsh users females users higher lower lower ratio female patients lower scores hrqol domains physical functioning vitality mental health social functioning bodily pain general health compared using executive functioning scores part cognitive functioning comparable female users general population groups polymorphism associated differences tsh ratio presence metabolic syndrome comorbidities use medication hrqol cognitive functioning conclusion polymorphism associated thyroid parameters hrqol cognitive functioning general population participants thyroid hormone replacement therapy
maximum energy release rate criterion max criterion commonly used crack propagation analysis fracture criterion based elastic macroscopic strength materials present investigation however max criterion modified order accommodate consideration plastic strain energy modified criterion extended study fatigue crack growth characteristics mixed mode cracks predict crack propagation due fatigue loads new plastic energy model presented new model includes effects material properties strain exponent yield strength sigma fracture toughness stress intensity factor ranges results obtained compared obtained using commonly employed crack growth law experimental data
output routine enables error message processing strategies design numerical mathematical software supports separate output different processes parallel computing environment
large scale data intensive web services evolving faster ever accelerating global growth data usage traffic rapid rate rapid growth demanding expansion high cost data infrastructures also underscores need cost effective high performance distributed key value stores designing key value stores often involves trade performance memory usage example many previous studies focusing minimizing memory usage developed disk indexing schemes leading lower performance alternative design based memory indexing allows better performance expense greater memory usage paper proposes novel key value store called packed hash based advanced design index data structures ensures high performance small memory usage advantages make proposed scheme better fit processing demanding workloads large scale data intensive applications compared best performing proposed scheme significantly reduces memory consumption per key value improves get throughput put throughput decreases particular get performance proposed scheme reaches optimal performance raw solid state drive elsevier inc rights reserved
zero dimensional thermodynamic model simulation developed simulate combustion characteristics performance four stroke homogeneous compression combustion ignition engine gasoline model applies first law thermodynamics closed system inclusive empirical model predicting important parameters engine cycles combustion timing mass fraction combustion process hypothesis increasing intake temperature reduce combustion duration fuel consumption wide range equivalence ratio intake temperature increased increment engine operated range equivalence ratios constant engine speed rpm intake pressure simulations performed using simulink different engine operating conditions increasing intake temperature allows reducing combustion duration degrees degrees equivalence ratios respectively brake specific fuel consumption decreases equivalence ratios thus fuel consumption reduced increasing intake temperature
new diffusion sign adaptive filtering algorithm individual weighting factor proposed distributed estimation impulsive noise environment since inherent property adaptive filtering fully used proposed algorithm obtains better performance terms convergence rate tracking capability compared diffusion sign adaptive filtering algorithm addition stability analysis algorithm performed based prices theorem order obtain faster convergence rate sparse distributed system identification improved algorithm proposed gain distribution matrix incorporated algorithm finally simulations carried distributed system identification context results simulations demonstrate proposed algorithms achieve better convergence performance counterparts
women still management men hold majority higher positions nonetheless one often heard claim popular media female people centered leadership skills empathy communication etc better match business world especially future furthermore related idea women use advantage take mens dominant position leadership four studies show claims paradoxically maintain gender inequality support action reduce female leadership earlier research shows positive stereotypes women suggesting leadership current findings show even positive stereotypes claim women particularly qualified leadership women chances gaining leadership positions although good highlight advantages female leadership claims contribute gender inequality
structural health monitoring shm gained popularity recent years since assess performance condition instrumented structures real time provide valuable information assets manager owner operational modal analysis plays important role shm involves determination natural frequencies damping ratios mode shapes constructed structure based measured dynamic data paper presents operational modal analysis seismic response characterization suspension bridge long subjected different earthquake events three kinds events short distance middle distance long distance taken account fast bayesian modal identification method used carry operational modal analysis modal properties bridge identified compared use field monitoring data acquired earthquake type events research emphasis given identifying predominant modes seismic responses deck short distance middle distance long distance respectively characterizing response pattern various structural portions deck towers main cables etc different types since bridge long seismic wave tower two side spans different time behaviors structural dynamic responses side span side span type earthquake events compared results obtained study beneficial seismic design future long span bridges built around hong kong hong kong bridge
across broad range design extensive research design practices considerable progress creating new computer based systems support design work research focused educational instructional design students learning sub field progress limited particular neither research systems development paid much attention fact design becoming collaborative paper reports latest research outcomes educational design eds facility developed iteratively four years support understand collaborative real time present design work eds serves enhance scientific understanding design processes design cognition provide insights designers work improved appropriate technological support study presented introduced complex multi user digital design tool existing ecology tools resources available eds analysed activity four pairs teacher designers design task identified different behaviors task working methods usage data provide new insights different digital analogue design surfaces used elsevier ltd rights reserved
understanding development skull deformity requires understanding normal morphogenesis premature pathologic ossification one cranial leading skull review english medical literature using standard search engines performed gather information prenatal development growth cranial process sequencing begins prenatal development growth continues contributes basis differential manner growth cranial bones improved knowledge facilitate comprehension pathophysiology
building projects consume large amount energy resources solid waste harmful eco environment order study eco environmental impact green building development policies green building eco environment model constructed method system dynamics implemented using software model used simulate evaluate current state future trend variation eco environmental impact green building development years current green building development policies policy factors adjusted simulation determine optimal green building development policies quality regional ecological environment improved economically elsevier ltd rights reserved
study examined role microrna mir bladder cancer related mechanisms real time polymerase chain reaction pcr performed determine expression level mir western blot used determine expression mainly factors akt jak stat pathways cell counting kit assay assay wound healing assay transwell flow cytometry used explore respectively cell proliferation survival migration invasion apoptosis bladder cancer cell line expressions mir bladder cancer cells including significantly increased compared human bladder epithelium cells proliferation rate fraction migration invasion cells mir transfected group significantly increased significantly decreased mir inhibitor transfection moreover mir suppression increase apoptotic rate cells addition drug resistance cells increased mir treated group decreased mir inhibitor compared empty control overexpression mir expression cells activate akt jak stat pathways found mir expression positively related proliferation motility cells moreover mir suppression promote sensitivity cells also found mir activate akt jak stat pathways cells
study improved structure address generation method fast fourier transform fft presented proposed method uses reduced logic generate addresses avoiding parity check commonly used fft implementations general methodology point transforms derived signal flow graph point fft presented furthermore case study point fft bit complex numbers synthesized using cmos technology circuit gate count analysis indicates significant logic reduction achieved improved throughput compared conventional implementations
potential recovery high value products yeast waste confers value industrial residue aqueous two phase systems demonstrated attractive alternative primary recovery biological products therefore suitable recovery residue sixteen different polyethylene glycol peg potassium phosphate tested evaluate effects peg molecular weight tie line length upon partition behavior concentrations crude extract yeast waste varied systems presented best behaviors potential recovery enzyme results show use peg mol system resulted bottom phase recovery purification factor recovery yield scaling system total weight represents per processed bottom phase results single stage process recovery proposed international union biochemistry molecular biology inc volume number pages
tasks processors known hard problem distributed computing systems due lack exact solutions attracted researchers working heuristic based suboptimal search algorithms recent inclusion multiple objectives minimizing cost maximizing throughput maximizing reliability problem gets even complex efficient approximate method becomes valuable work propose new solution multi objective task allocation problem solution consists designing problem specific neighboring function existing metaheuristic algorithm proven successful quadratic assignment problems neighboring function namely greedy maximum release provides dynamic mechanism switch preference search exploration exploitation experiments validate quality solutions close optimal proposed method performs significantly better comparing three metaheuristic algorithms neighboring functions common components metaheuristic algorithms also utilized metaheuristic based solutions future elsevier ltd rights reserved
fixed geo satellite communications impaired long especially geo possible presence packet losses satellite radio channels moreover satellite receiver mobile short long disruptions due line sight associated presence cause performance deterioration paper evaluate impact disruptive channel tcp splitting previously developed authors results obtained satellite link caused real railway line highlight advantages tcp splitting architecture enabling adoption optimized version tcp satellite connection satellite specific tuning tcp parameters offer significant resilience kind satellite impairments
biologic therapies cause called paradoxical side effects onset exacerbation new symptoms diseases biological treatment effective among psoriatic skin lesions described report case series ten patients either new onset seven cases worsening three cases psoriasis occurring biologic therapy six patients receiving biologic monotherapy four patients combination treatment methotrexate psoriasis remission observed two patients discontinued biologic therapy six patients biologic therapy discontinued complete partial improvement skin lesions achieved following topic steroid therapy two patients three patients respectively remaining patient psoriasis developed adalimumab monotherapy completely disappeared infliximab combination started potential pathogenetic mechanisms shortly reviewed
cardiovascular disease leading cause death women advanced age affected decade later compared men cardiovascular risk factors women properly investigated treated events frequently lethal menopause type diabetes substantially increase cardiovascular risk female sex promoting modifications lipid metabolism circulating lipoprotein suffer shift menopause towards lipid profile consisted lower levels total high density lipoprotein hdl also higher levels small low density lipoprotein particles review discusses impact diabetes menopause lipid profile challenges lipoprotein determination potential contribution cardiovascular risk assessment women still unclear whether lipoprotein changes major driver cardiometabolic risk modifications predominant prospective trials larger samples methodological pharmacological approaches needed clarify role lipoprotein determination cardiovascular risk prediction intervention planning postmenopausal women without
objectives examined extent different aspects parenting able moderate association spending time unstructured urban areas high disorder adolescent methods used detailed data time use disorder neighborhoods parenting among adolescents aged study peers activities neighborhoods two wave longitudinal study interval two years measurements longitudinal multilevel analyses used examine interactions effects parenting aspects mean differences individual changes time spent unstructured areas high disorder results find person level interaction effects parenting time spent settings cross level analyses however indicated levels parental monitoring quality parent adolescent relationship mitigated effects changes time spent settings conclusions whether increases time spent settings related increases seems conditional level parental monitoring quality parent adolescent relationship aspects parenting sufficient changes time spent settings necessarily detrimental
lymphocyte differentiation set produce myriad immune effector cells ability respond foreign substances uniqueness developmental system lies great diversity cellular functions generate also ability differentiation intermediates mature effector cells expand upon demand thereby providing lifelong immunity surprisingly goals developmental system met relatively small group dna binding transcription factors work control timing magnitude gene expression fulfill demands cellular specialization expansion maintenance cellular molecular mechanisms lineage promoting transcription factors operate focus basic research immunology mechanisms development effort guiding clinical research disorders immune cell base focus one earliest regulators lymphoid lineage identity lymphocyte homeostasis
paper deals charging stations electric cars containing accumulation electrical energy support usually charging stations called active charging stations parts modern electrical grid known smart grids micro grids paper also contains brief summary current knowledge structures service electricity distribution networks analysis electric car industry growth potential impact electrical network
introduction investigated child outcomes mothers perspectives following technology based intervention sessions aimed improving childrens social play skills method participants multiple case study included five children attention deficit hyperactivity disorder mothers five typically developing completed parent delivered play based intervention months previously initial intervention included use technology based interactive home clinic based sessions involving video modelling study children received two additional technology based clinic sessions involving video modelling childrens social play skills measured pre post intervention using test trends scores analysed case mothers perspectives explored semi structured interviews data analysed group case results two children attention deficit hyperactivity disorder showed increase social play skills three decrease skills three showed consistent social play skills one increase one decrease qualitative findings suggest parents felt better able support child parents also suggested next steps intervention necessary child continued develop conclusion additional intervention support using technology initial intervention need adapted different developmental stages use across different contexts
errors metabolism play role pathology autism spectrum disorders increased vulnerability oxidative stress report case supplementation improved symptoms aggression disruptive behavior child autism tested positive allele reductase enzyme gene knowledge first report administration situation controlled studies population warranted copyright wolters kluwer health inc rights reserved
theme free availability genetic information nature heart attention areas investigation biology medicine philosophy law biotechnology area science said interested subject recent years tried
osteoporosis periodontal disease linked altered receptor activator nuclear factor ligand ratio rankl medical treatment help control molecules effect clinical findings fluid values rankl using enzyme linked immunosorbent assays evaluated postmenopausal women patients chronic periodontitis osteoporosis group systemically healthy patients chronic periodontitis group healthy patients osteoporosis group systemically healthy individuals group recordings repeated end months groups baseline groups exhibited lowest values use effective preventing periodontal breakdown controlling levels markers osteoporosis adjunct periodontal treatment
report first application graphics processing units gpus accelerated computing technology improve performance numerical methods used optical characterization single various liquids different volatility molecular weight water etc mixtures liquids diverse suspensions inside trap chosen temperature composition atmosphere series scattering patterns recorded processed fitting complete theory predictions table method showed computations gpus effectively applied inverse scattering problems particular technique accelerated calculations scattering theory single core processor matlab environment times almost times comparing corresponding code language additionally problems time consuming data post processing parameters particularly index investigated liquid uncertain program allows track parameters characterizing droplet nearly simultaneously progress evaporation
purpose review currently available computer based silico models relating molecular structure low molecular weight compounds respiratory sensitization hazard present review places focus two main applications structure activity relationship sar models hypotheses disease mechanisms toxicological prediction recent findings analyses chemical structures low molecular weight organic compounds known caused occupational asthma led development mechanistic usually based reaction chemistry protein cross linking potential protein cross linking potential also found consistent feature chemicals caused human cases hypersensitivity stepwise iteration quantitative sar modelling shown improvements occupational asthma hazard useful prospects practical application good case also made potential use structural alert based mechanistic predictive toxicology summary understanding molecular interactions chemical respiratory components human proteins obtained vitro silico techniques developments qualitative mechanistic offer potential use predictive algorithm toxicological screening industrial chemicals respiratory sensitization potential
research suggests fetuses open close mouth relation directed movements unclear whether mouth opening touch reaction touch analysis far facial area touch sequential ordering touch mouth movements prenatal development anticipation touch expect frequency fetal mouth opening immediately preceding hand mouth area increase fetal age fifteen healthy fetuses eight girls seven boys underwent four additional scans weeks gestation changes frequency touch different facial regions indicated significant decline touch upper side parts face significant increase lower regions face increasing gestational age results supporting hypothesis showed significant increase proportion mouth movements touch increasing around week gestational age additionally decrease proportion reactive mouth movements decreasing around week gestational age wiley periodicals inc
attributable fraction commonly used measure quantifies public health impact exposure outcome originally defined binary outcomes extension recently proposed right survival time outcomes called attributable fraction function maximum likelihood estimator attributable fraction function developed requires model outcome paper derive doubly robust estimator attributable fraction function estimator requires one model outcome one joint model exposure estimator consistent either model correct necessarily
angiotensin converting enzyme inhibitor induced angioedema angioedema upper airway bradykinin receptor antagonist effective drug approved indication administered emergency situation label corticosteroids seem work condition effectiveness esterase inhibitor verified double blind study
broadly neutralizing antibodies elicited response hiv infection mutated one goal hiv vaccine development induce antibodies similar potent broad isolated infected subjects effective high mutation frequencies indicative long periods activation necessary acquire phenotype affinity maturation understanding mutational patterns define maturation pathways development critical vaccine design efforts vaccination successful routes breadth potency occurred natural infection studying mutational changes occur affinity maturation however requires accurate partitioning sequence data cell clones identification starting point cell clonal lineage initial rearrangement describe statistical framework used perform tasks recent advancement similar computational methods many hiv antibodies inferred synthesized structures determined allowed first time investigation structural mechanisms underlying affinity maturation process hiv antibody development review learned atomic level structural characterization affinity maturation hiv antibodies implications vaccine design
unit extraction considered minimally invasive procedure injury donor area caused sharp result dermal fibrosis clinically observed objectiveto evaluate advanced image processing efficacy using normal saline minimizing injury donor area donor harvesting patients methodsthe term acute extraction used describe donor harvesting technique whereby follicular unit removed aligned parallel exit angle hair follicle term vertical extraction describes technique removed like manner normal saline injected prior harvesting perpendicular skin thirty five patients selected study apply harvesting techniques compare differences wound surface size skin mass removed resultsa significant reduction mean values wound surface skin mass recorded vertical extraction compared acute extraction conclusionthe injection normal saline prior harvesting proved efficient minimizing skin injury harvesting
patients uterine typically present vaginal bleeding pain pelvic mass atypical presentations also reported radiographic evaluation combined positron emission tomography computed tomography assist diagnosis surveillance women uterine commonly used stage tumour grade prognostic indicators recently developed risk assessment index predict disease specific survival recent studies shown addition adjuvant therapy surgical management seem improve survival ovarian preservation appear negatively impact outcome experimentally noteworthy proteasome subunit beta beta deficient mice exhibit spontaneous development uterine disease prevalence similar months age furthermore recent report showed loss ability induce beta expression regulated interferon gamma ifn gamma human uterine tissues reviewed human uterine genetic mutations ifn gamma signal cascade found serious mutations three genes janus activated kinase signal transducer activator transcription beta promoter regions moreover molecular experiments demonstrated differential expression cyclin regulate cell cycle arrest via beta expression discovery mutational activation key cell signalling pathway provide new targets diagnostic approaches therapeutic intervention
industrial deployment internet things iot provides development ideal platform decentralized management paper propose iot infrastructure collaborative order based ambient intelligence multi agent system consists physical devices layer middleware ambient platform multi agent system enterprise resource planning integrates bottom approach decision support mechanisms self organization negotiation protocols agents based competition cooperation concept approach selected improve reaction capabilities decentralized management dynamic environment collaborative example conducted demonstrate implementation proposed infrastructure elsevier rights reserved
catalyze cleavage fatty acids previously reported use analogs determine acidic activity work investigated activity compounds bacterial human purified neutral expressed mouse neutral different selectivity depending acyl chain length hand microsomes alkaline knockdown cells less competent controls microsomes overexpressing cells showed activity toward substrates conversely acid overexpressing cells acidic overall lesser extent compounds although selectivity substrates toward modulated length acyl chain none specific particular enzyme despite lack specificity substrates prove useful library screening programs aimed identifying potent selective inhibitors
central nervous system comorbidities identified patients epilepsy several comorbidities correlated poor surgery outcomes patient cohorts authors sought determine prevalence comorbidities pediatric epilepsy surgery patients families correlate long term seizure outcome cross sectional analysis three generation elicited compare family history epilepsy adhd anxiety autism bipolar disorder cognitive disability depression migraine motor disability surgery outcomes patients proportions affected patients relatives compared general population comorbidity rates patients recent seizure outcome classification patients families significantly higher rates comorbidities general population poorer long term seizure outcomes following surgery associated autism cognitive disability patients together data support evidence common pathophysiological mechanism epilepsy central nervous system comorbidities
year old male presented emergency room symptoms chest following conversion atrial fibrillation sinus rhythm deep symmetrical wave changes symptoms resolved almost immediately initial negative underwent cardiac angiography utilizing emergency room protocol resulted diagnosis coronary artery disease apical hypertrophic cardiomyopathy following hospital stay less discharged outpatient follow medical management remained asymptomatic case presentation illustrates example diversity pathology presents emergency rooms symptoms consistent acute coronary syndrome
malaria one important public health problems ethiopia objective study identify prevalence associated factors malaria among children presented investigation cross sectional health facility based study conducted october november east zone regional ethiopia blood samples finger collected microscopic diagnosis malaria children age years symptoms suggestive malaria attending five health centers interview conducted parents children using pre tested structured questionnaire bivariate multivariate logistic regression employed study associations malaria infection associated factors children provided blood samples confirmed malaria parasites predominant species whilst mixed infections species identified patients relative proportion respectively households ownership treated nets significantly associated decreased odds malaria infection adjusted odds ratio aor confidence interval however increased odds malaria infection observed among children years old aor compared children age years strong association reported households ownership malaria infection among children part ethiopia call continued efforts net distribution use control malaria turn improve childrens health development elsevier rights reserved
objective endoscopic surgery revolutionized surgery ventral skull base yet widely adopted use angle given relatively normal anatomy angle patients trigeminal authors hypothesized fully endoscopic microvascular provide pain outcomes equivalent microscopic fewer complications methods authors conducted single institution single surgeon retrospective study patients treated period surgery patients completed questionnaire included validated multidimensional pain outcome tool facial pain scale known brief pain inventory facial point scale measures pain intensity interference general activities daily living facial specific using standardized independent research conducted follow telephone interviews results total patients available follow ups female patients underwent underwent preoperative characteristics classification components medication use similar surgical groups except variables patients group slightly higher incidence pain groups differed date surgery hence length follow years group years group trend toward finding conflict time surgery frequently group internal often performed group groups significantly differ length procedure approximately hours self reported headaches month postoperatively present patients group versus group pain outcomes recent equivalent patients reporting point improvement pain intensity point improvement pain interference point improvement interference facial specific freedom pain recurrence equivalent groups pain control years conclusions fully endoscopic conventional appear provide patients equivalent pain outcomes complication rates also similar groups exception rate headaches significantly lower group month postoperatively
purpose purpose paper illustrate application six sigma define measure analyze improve control problem solving methodology portuguese industrial enterprise aimed reducing rejection rate specific manufactured product due defects generated aluminum gravity die casting operation design methodology approach along five stage set analytical conceptual tools systematically employed better characterize problem define products critical quality characteristics estimate process baseline determine relevant cause effect relationships identify root causes leading high rejection rate implement improvement plan determine effectiveness improvement actions put place control plan findings project team discovered high rejection rate caused factors inherent gravity die casting operation mixing rejected parts made different types alloys locations within plant another key finding successful execution project possible due belief support top management active involvement team members practical implications case study illustrates successful practical application six sigma project small medium enterprise portugal operational financial benefits derived thus providing good example others follow originality value cases improvement initiatives including six sigma projects developed portuguese company available literature paper void describing successful application demonstrates advantages companies learn terms adopting structured methodologies improve quality products efficiency processes moreover analysis conclusions herein presented great importance companies using gravity die casting technology
highly conserved degradation process cytosolic materials including proteins lipids damaged organelles broken basic components role autophagy elimination materials also serves dynamic recycling system produces new components energy cellular homeostasis association autophagy organ physiology pathogenesis various disorders neurodegenerative diseases cancer infection inflammatory bowel disease revealed recent years autophagy also plays essential role cellular homeostasis kidney age related stress kidney diseases critically review current evidence regarding autophagy kidney particular assessed tissue cell lineage specific autophagy deficient mice better insight mechanisms underlying roles autophagy way toward novel therapies kidney diseases
direct oral anticoagulants drugs used clinical practice since prevention stroke systemic embolism non atrial fibrillation treatment secondary prevention venous thromboembolism four including three factor inhibitors one direct inhibitor provide oral anticoagulation therapy alternatives vitamin antagonists despite clear advantages require part thorough knowledge pharmacokinetic pharmacodynamic characteristics ensure correct use laboratory monitoring appropriate management adverse events document represents consensus paper use representatives three italian scientific societies italian society internal medicine federation associations hospital managers society study thrombosis document expert opinion guidance pragmatic managing monitoring reversing anticoagulant effect chronic emergency settings practical guidance help create adequate protocols patients hospitalized ion internal medicine patients often elderly subjects affected poly morbidities renal insufficiency thus require particular attention drug drug interactions peri procedural protocols
low grade account second common location pediatric low grade cerebellum pathological spectrum includes tumors diffuse among others clinically represent recognized cause intractable epilepsy children adolescents excellent long term outcome surgery remains cornerstone patients gross total resection typically need therapies recent literature reviewed provide date overview molecular cell biology tumors multiple alterations involving however clinical significance alterations still defined role ras mapk mutations alterations interest diagnostic prognostic therapeutic perspectives molecular testing tumors encouraged since findings important impact prognosis also therapeutic strategies
objective investigate validity test retest reliability sensitivity change feasibility dual task assessments patients dementia design validation study setting post ward rehabilitation participants geriatric patients dementia age mmse score main outcome measures psychometric quality performance different tests analyses performed motor cognitive performance relative costs results spearmans rank correlations examined tests moderate high motor tasks small high cognitive tasks small high relative motor cognitive combined correlations external assessment moderate high motor tasks small moderate cognitive tasks small moderate relative motor cognitive combined test retest reliability excellent motor tasks icc fair excellent cognitive tasks icc poor good relative motor icc cognitive icc combined icc sensitivity change acceptable excellent trained tests effect sizes small large gait parameters large cognitive tasks small large relative motor cognitive combined completion time ranged min conclusions tests showed acceptable excellent psychometric properties patients dementia highest quality gait based tests walking counting walking abc elsevier rights reserved
paper proposes method model constraints different models run optimization models different machine learning proposed method proven able accurately map constraints minimize number call model handles continuous discrete variables design rules statistic approach create surrogate model
report case discordant phenotypic sex twins mosaic twins twins presented cognitive comprehension delay behavioural language disorders symptoms frequently reported syndrome molecular analysis several markers confirmed twins effect array comparative genomic hybridization found evidence implication copy number variation phenotypes ultrasound scans reproductive organs revealed abnormalities endocrine tests showed low testosterone level twin male phenotype low level twin female phenotype combined results ultrasound examination provided useful information potentially predicting future fertility potential twins blood revealed presence normal cell line cell line patients examination chromosome various tissues blood urinary sediment surprisingly proportions cell lines likely explains discordant phenotypic sex mild features plausible underlying biological mechanism post loss chromosome initially result embryo cells lines subsequently divide two embryos process two cell lines distributed differently tissues result phenotypic twins observations emphasize importance regular paediatric evaluations determine optimal timing fertility preservation measures detect new features appear throughout childhood two subjects
background two old drugs choice little known secondary effects acute stage oral transmitted disease chd methods cross sectional analytical surveillance study conducted cohort patients seen largest acute chd registered far individuals treated common terminology criteria adverse events assessed categorize side effects according treatments applied one adverse effects adults compared children risk side effects significantly higher four adults child treated severe side effects pulmonary infarction facial neutropenia vision bone marrow hospitalization drug suspension adverse effects frequently reported abdominal pain weight loss headache nausea whereas skin rash effects fatigue abdominal pain observed frequency severity side effects treatment acute oral infection demand direct supervision close follow even asymptomatic prevent life threatening situations
scene change detection image scenes used interpret variation regional land use significant potential application urban development monitoring semantic level traditional methods directly comparing independent semantic classes neglect temporal correlation thus suffer accumulated classification errors paper propose novel scene change detection method via kernel slow feature analysis fusion integrates independent scene classification scene change detection accurately determine scene changes identify transition type representation bag visual words model proposed extract nonlinear temporally invariant features better measure change probability corresponding image scenes two fusion methods based bayesian theory predefined rules respectively employed identify optimal coupled class combinations scene pairs furthermore addition identifying semantic changes proposed method also improve performance scene classification since unchanged scenes likely belong class two experiments high resolution remote sensing image scene data sets confirm proposed method increase accuracy scene change detection scene transition identification scene classification
childhood risky behaviors always result adverse health outcomes behaviors greatly affected social environment individual factors however studies explored social determinants health behaviors cross sectional study social determinants health behaviors examined among resident students beijing china data children six urban primary schools analyzed using multiple linear regression analysis results showed less children performed healthy behaviors although health knowledge generally good childrens health behavior scores greatly determined school characteristics health knowledge demographic characteristics family context therefore improving health education conditions primary schools priority promote childrens healthy behaviors especially disadvantaged children
emergency contraception available two products status ulipristal acetate prescription medicine considering pharmacists health care professionals impact use yet little known beliefs practices regarding medicines surveyed october october community pharmacists january april results showed significant differences two groups suggesting provision users inconsistent pharmacists reduce abortion rate versus however concerned pharmacists easy access cause less regular contraceptive use versus risky sexual behaviors including initiating sexual activity younger age versus sexual partners versus additionally pharmacists versus said provide even victims sexual assault results indicated need establishing official guidelines practices
objective assess benefit intra articular injection toxin chronic refractory joint pain regardless joint pathology data sources search performed medline process non indexed citations medline embase web science scopus inception week trial selection clinical randomized controlled trials evaluated intra articular injection patients refractory joint pain included data extraction two independent reviewers conducted data extraction results total records included analysis indicated statistically significant decreased pain score found therapy group control group week injection respectively score also significant decreased therapy group control group week injection respectively difference adverse event therapy group control group conclusion compared conventional therapy intra articular injection beneficial effects improved pain score score adult patients refractory joint pain
paper presents system modeling method multi stage operational amplifier circuit based step response experiment taking step voltage signal input measure data collected estimating system parameters defining minimizing output error criterion function newton iterative estimation algorithm derived order show accuracy estimated circuit model use proportional integral controller construct closed loop operational amplifier circuit terms estimated circuit model moreover take step experiment test tracking performance operational amplifier circuit simulation results indicate proposed method generate parameter estimates multi stage operational amplifier circuit system
controlling images central reproduction racial class gender inequality yet dearth knowledge pertaining drawing sixty two depth life history interviews latino men ask controlling images members sports athletes impose constraints channel emotions respond images document institutions people deploying controlling images blockade access education upward mobility find life course stage shapes responses imagery youth latino respondents used emotional strategies resist racial adults respondents controlling images leadership activities professional since adults possess social power youth adults better equipped engage leadership resistance compared youth constrained age utilized emotional resistance strategies
amyloid beta beta plays pivotal role pathogenesis alzheimers disease clearance beta promising therapeutic strategy previously demonstrated peripheral organs play important roles clearance brain derived beta present study recruited patients liver cirrhosis normal controls found plasma beta beta levels significantly higher cirrhosis patients normal controls notably cirrhosis patients hepatitis virus hbv infection higher plasma beta beta levels hbv negative cirrhosis patients besides cirrhosis patients significantly higher plasma levels interleukin beta beta plasma tumor necrosis factor alpha tnf alpha interferon gamma ifn gamma levels significantly different groups moreover found significant correlations hepatic functions plasma beta beta levels plasma levels also significantly correlated plasma beta levels however linear regression model found significant correlation plasma beta levels hepatic functions plasma levels results indicate hepatic dysfunctions result decreased peripheral beta clearance liver protecting hepatic functions helpful clearance brain derived beta blood
new results corrosion resistance alloy exposed solution different days estimated means electrochemical impedance spectroscopy technique coating developed surface alloy using powder pack process exposure corrosion resistance cobalt alloy evaluated fitting suitable equivalent electrical circuits using plots obtain electrochemical parameters results compared non alloy samples non characterized scanning electron microscopy energy dispersive ray spectrometry techniques determine elemental chemical composition developed surface materials addition reaction products formed surface alloy exposed solution day immersion analyzed ray photoelectron spectroscopy xps technique results showed corrosion resistance cobalt alloy affected reduced presence clusters formed materials surface finally electrochemical reactions developed immersion cobalt alloy day exposure proposed according xps results
traditionally considered neuronal synchronization epilepsy caused chain reaction synaptic excitation however shown synchronous activity also arise without synaptic transmission order investigate respective roles synaptic interactions mechanisms seizure transitions developed computational model hippocampal cells involving extracellular space realistic dynamics ions glial uptake extracellular diffusion mechanisms show network behavior fixed ionic concentrations quite different neurons behavior detailed modeling ionic dynamics included particular show extended model strong discharge inhibitory result long lasting accumulation extracellular depolarization principal cells causes pathological discharges effect present reduced purely synaptic network results point importance mechanisms transition seizure
currently primary myelofibrosis pmf relies international prognostic scoring system dynamic plus incorporate age blood counts constitutional symptoms circulating red cell transfusion need although mutation discovered decade ago mpl mutations shortly thereafter recent discovery calr mutations vast majority mpl patients recognition powerful impact calr mutations triple negative mpl calr negative status outcome set stage revision traditional prognostic models include molecular information additionally advent next generation sequencing identified host previously somatic mutations across hematologic malignancies syndromes majority common informative mutations pmf affect epigenetic regulation mrna splicing thus need incorporate mutational information genes risk stratification systems mutations yet genes appear important players transformation new insights disease pathogenesis emerging finally number detrimental mutations affect survival response ruxolitinib significant implications clinical decision making review briefly summarize prognostic models use today discuss detail somatic mutations commonly encountered patients pmf along prognostic implications role transformation emerging prognostic models incorporate new molecular information existing systems exclude clinical variables also presented elsevier inc rights reserved
electric trend almost automotive industry trend followed transportation industry result conventional mechanical transmission based propulsion systems gradually electric power transmission based propulsion systems driven electric motor common configuration found modern electric propulsion systems due tight speed control propulsion systems load transients easily get link motor drive subsequently upstream power bus transients cause disturbances loads connected power system worst case stability power system gets affected transients paper proposes use capacitor inverter based motor drive absorb transients thereby prevent propagation power bus efficacy proposed concept verified computer simulations simulation results show capacitor inverter capable absorbing load transients without passing upstream power bus
disseminated rare disease data scant pediatric patients registry identified children disseminated analysis largest pediatric case series reported date adds pediatric specific experience management opportunistic infection children
games one popular global media events however ways opening games london reported varied significantly one country another order compare different countries represented event conducted qualitative discourse analysis three days television news coverage channels five countries united states china japan germany united kingdom explored whether different locations political systems television systems affect event reported found european public service serious critical political commercial counterparts japanese commercial coverage event critical public service throughout china market oriented evaluative reporting state run broadcast rights united states emphasized universal values avoided light results future attention directed toward role commercial contemporary world ideological changing
model predict motor temperature electrical pump variable conditions flow rate loading developed model takes account coupled behavior motor pump production system thus given defined frequency variable speed drive motor temperature determined result equilibrium heat generation calculated power pump demands motor heat extraction resistance calculated production flow rate around motor furthermore real field operations measurement motor temperature made lower end stator winding exactly maximum temperature point order predict maximum motor temperature value model developed work determines motor temperature distribution convective heat transfer study also made comparing models based fully developed temperature profile models consider development thermal boundary layer case study made several oil water cut results showed fact commonly observed field operations motor temperature rises motor speed continuously increased also shown effect thermal boundary layer development result motor prediction actually motor maximum temperature much lower upper limit thus observed fully developed temperature profile models suffer used viscous oil applications great thermal entry length elsevier rights reserved
advent native mobile technologies particularly advances mobile operating systems among android windows mobile ios acceptance alternative existing based access enabled remote access equipment instruments world wide web remote control solutions implemented industry via local area networks wide area networks web online remote accessible laboratory oral simulation tool learning scientific methods results observations real time rather ideal facilitate conduct experiments specific instrumentation location aim paper introduce easy accessible remote laboratory measuring system provide students perform laboratory experiments actual measurement instrumentation smart mobile device tablets pcs proposed architecture real laboratory setup provides solutions remote access opens ways future developments system realized using labview graphical programming environment confers advantages
objective noninvasive diagnostics early stages coronary artery disease discrimination various vascular lesions patients important clinical problem especially considering wide spread use cholesterol lowering drugs affect lipid lipoprotein profiling main goal study evaluate applicability new combinations noninvasive biomarkers leptin insulin adiponectin ratios detection early stages coronary atherosclerosis versus later stages methods number previously validated serum biomarkers tested group patients coronary artery disease examined association severity coronary lesion according score determined coronary lowest extent coronary lesions associated significant increase levels significantly increased ratios adiponectin leptin insulin male female patients adiponectin ratio associated score representing early high coronary lesions female male patients leptin insulin ratio associated score representing early high coronary lesions conclusion leptin insulin adiponectin ratios novel derived biomarkers useful noninvasive diagnostics initial stages coronary lesions patients coronary artery disease
radical right political parties usually heavily male dominated accordingly previous research concentrated perspective men present study aims enhance understanding women within radical right parties taking critical psychological approach study looks female radical right politicians sweden finland negotiate tension societal norm gender equality one hand ideology radical right parties analysis suggests female radical right politicians discourse indeed highly ambivalent tension gender equality politics heavily two tensions first societal norm prejudice versus politics based second culture versus political pressure political cultural study compares discourse female radical right politicians two country contexts moreover discusses differences similarities discourse one hand male radical right politicians finally analyses gendered accomplished patterns societal implications
aim explore exact interaction notch transforming growth factor tgf beta signaling liver fibrosis methods established rat model liver fibrosis induced peripheral blood mononuclear cells pbmcs isolated modeled rats cultured inhibitor tgf beta inhibitor mrna levels notch tgf beta signaling detected quantitative real time polymerase chain reaction expression notch tgf beta proteins analyzed western blotting results compared control rats notch tgf beta signaling activated pbmcs model rats administration tgf beta inhibitor suppressed notch tgf beta signal transducer pbmcs model rats reduced mrna protein expression tgf beta signaling tgf beta tgf beta inhibitor also downregulated mrna protein expression notch signaling pathway conclusion notch tgf beta signaling play role liver fibrosis tgf beta signaling notch signaling promotes tgf beta signaling
algorithm successfully utilized adaptively learning sparse seismic high computational cost many singular value algorithm applicable practical situations especially problems paper extend learning based approach address computational efficiency problem propose fast learning approach based sequential generalized means algorithm multidimensional seismic data algorithm updates atom taking arithmetic average several training signals instead calculating used algorithm summarize sparse learning algorithm using introduce algorithm together detailed mathematical implications synthetic field data examples used demonstrate performance algorithms shown algorithm significantly increase computational efficiency slightly degrading performance
bipolar disorder fundamentally disorder emotion regulation associated explicit processing biases socially relevant emotional information human faces less known however whether implicit processing type emotional information directly influences social perception thus investigated group related differences influence emotional processing conscious person perception judgments using continuous flash suppression task among individuals bipolar disorder age age female compared healthy adults age age female across groups participants rated neutral faces trustworthy warm competent paired happy faces compared angry neutral faces participants rated neutral faces less trustworthy warm competent paired angry compared neutral faces findings suggest emotion related disturbances explained early automatic processing stages activity dorsal visual stream underlying implicit emotion processing intact bipolar disorder implications understanding etiology emotion disturbance discussed elsevier rights reserved
impairment physical performance identify older people higher risk dementia time present study evaluated strength independent predictor cognitive decline observational prospective follow duration months geriatric outpatients center consecutive stroke dementia free older adults men ages years clinical dementia rating scale clock drawing test administered strength assessed using hand brain magnetic resonance imaging studies performed white matter damage expressed severity white matter longitudinal changes cognitive function expressed year decline performance robust association observed baseline strength year cognitive decline multiple adjustment note strength association minimally attenuated adjusting deep extent beta coefficient strength strength predicted accelerated year decline cognitive function assessed sample older adults future studies needed elucidate causal mechanisms linking limitations physical function dementia risk
aim experimental research flat objects recognition linear discriminant analysis using dimensionless signs binary images determining possibility applying method computer vision systems published elsevier
since cost rare earth permanent magnets increasing great interest designing machines without adopting rare earth replacing cheaper magnets referring interior machines expected performance reduction limited owing anisotropic structure reluctance torque component use low energy paper investigates convenience adopting magnets machine sometimes also referred assisted synchronous machine instead rare earth surface mounted machine shown even though stack length required anisotropic machine adopts magnets represent valid surface machine rare earth
paper proposed various methods extract parasitic capacitance components using technology computer aided design simulation first parasitic capacitance components extracted ideal method using structure without extracted results calculated values almost identical next non ideal methods varying length dielectric constant used extract parasitic capacitance components method using length structural change relatively large error occurred extracting outer however method varying dielectric constant structural change method showed much smaller error method varying length also found show almost results extracted ideal method
last decades function method used solving fractional differential equations paper obtain exact solutions fractional generalized reaction model nonlinear fractional diffusion reaction equation fractional derivatives described modified riemann sense fractional complex transform suggested convert fractional order differential equations modified riemann derivatives integer order differential equations reduced equations solved symbolic computation
objective study assess effect silica nano particle diameters computer aided design manufacturing cad cam composite resin block physical properties multi scale silico cad cam blocks modeled consisting silica nano particles matrix bis volume contents calculation youngs ratios block macro scale analyzed macro scale cad cam blocks modeled compressive strengths defined fracture loads exceeded values nano scale models compared localization analysis size decreased youngs compressive strength increased ratios decreased parameters significantly correlated diameters particles pearsons correlation test silico multi scale model established study demonstrates youngs ratios compressive strengths cad cam blocks enhanced loading silica particles smaller diameter cad cam blocks using smaller silica nano particles potential increase fracture resistance
objectives describe national patterns chronic care across academic community practices determine prevalence comorbid disorders patients including nasal allergic rhinitis asthma cystic fibrosis identify demographic clinical practice type factors associated endoscopic sinus surgery study design cross sectional study setting national research network creating healthcare excellence education research subjects methods total adult patients identified seen community practices sites academic practices sites multivariate logistic regression used evaluate association demographic practice type clinical factors odds patient undergoing results average age years patients female caucasian prevalence comorbid diseases follows allergic rhinitis nasal asthma cystic fibrosis addition patients academic centers underwent compared community sites multivariate analyses nasal odds ratio cystic fibrosis academic site type associated adjusting factors conclusions describe practice patterns care demographic clinical factors associated first study practice patterns utilizing network used guide future research
deployment ami technologies large facilities sets new challenges due difficulty perform experiments physical large settings high number users propose framework domain using simulations combine social simulation techniques specialized assessing large population behaviors along experience ami systems simulations specialized considering sensor actuator networks embedded physical environment framework allow configuration simulation features options according user device models defined domain experts interaction proposed simulator context generated external sources simulators ami infrastructures paper also proposes first steps towards implementation architecture contributions known simulators
hepatitis virus hbv infection one major risk factors leading development hepatocellular carcinoma hcc hepatitis surface antigen plays pivotal role hbv related hcc pathogenesis toll like receptor also considered mediate tumor progression however interaction hcc progression remains unclear thus aim study explore effect pathway growth invasion hbv related hcc cells examine potential mechanisms involved expression measured two different hcc cell lines without recombinant real time reverse polymerase chain reaction western blot cellular proliferation invasion cytokine downstream signaling pathways also measured silencing cells response stimulation mrna protein levels significantly elevated cells cells simulation increased proinflammatory cytokine production invasion cells process inhibited however sirna transfection alone affect tumor cells moreover increased expression phosphorylation kappa downregulation inhibited induced kappa cells conclusion stimulation promotes invasion hbv related hcc cells kappa signaling pathway involved upregulation cytokine production interaction contribute poor prognosis hbv related hcc
multivariate spatial inference max stable processes observed large collection points challenging problem current approaches typically rely less expensive composite constructed small subsets data work explore limits modern state art computational facilities perform full likelihood inference efficiently evaluate high order composite extensive simulations assess loss information composite likelihood estimators respect full likelihood approach widely used multivariate spatial extreme models discuss choose composite likelihood improve efficiency also provide recommendations practitioners article supplementary material online
hydrogen measured solid solution low content alloys content ranges available approximate mpa delta ash determined phase region function content alloys thermodynamic parameters determined formation decomposition reactions temperature dependence plateau pressures hysteresis determined alloys alloy form phase alloys internally oxidized form composites determined indicate trapping interfaces trapping determined reaction calorimetry internally oxidized alloy relative partial absorption quite negative compared solution phase pure results probe properties metal oxide interfaces important number technological applications elsevier rights reserved
objectives exposure violence associated chronic physical conditions adults although violence exposure common among youths unknown whether violence associated chronic physical conditions childhood adolescence examined associations violence exposure chronic physical conditions population representative sample adolescents determined whether associations explained occurring mental disorders methods data drawn national comorbidity survey replication adolescent supplement national cross sectional survey adolescents ages lifetime exposure violence diagnostic statistical manual mental disorders fourth edition mood anxiety substance disorders self reported arthritis frequent headaches back neck problems chronic pain asthma allergies assessed results one adolescents reported exposure violence violence exposure associated elevated odds back neck pain headaches chronic pain allergies asthma odds ratio confidence interval adjustment socioeconomic status lifetime mental disorders regarding new sets violence exposure associated greater hazard subsequent first onset back neck pain hazard ratio headaches hazard ratio associations explained mental disorders conclusions childhood violence exposure associated chronic physical conditions emerge early life course although associations stronger prevalent incident conditions violence exposure predicts incident pain conditions associations explained mental disorders begin violence exposure interventions policies aimed preventing violence detecting treating early onset mental disorders potential reduce morbidity mortality health disparities beginning early development
aims deletion syndrome condition associated increased risk developing schizophrenia previous studies shown negative symptoms represent specific clinical characteristic psychosis strongly associated outcome however psychological mechanisms associated symptoms population poorly understood accordance recent field schizophrenia present study aims investigating whether negative symptoms associated presence negative performance beliefs cognitive deficits methods thirty five participants typically developing individuals aged years included study self reported symptoms cognitive perceptual negative symptoms dysfunctional beliefs negative performance beliefs need approval assessed measures processing speed verbal memory working memory executive functioning face recognition also extracted broad cognitive evaluation protocol results adolescents reported significantly higher score negative dimension personality questionnaire controls even controlling influence anxiety depression intellectual functioning negative symptoms associated severity negative performance beliefs lower face recognition abilities mediation analyses revealed negative performance beliefs significantly mediated association face recognition negative symptoms conclusions findings suggest negative performance beliefs basic social cognitive mechanisms associated negative symptoms individuals implications intervention discussed article
hybrid systems class dynamical systems whose behaviors based interaction discrete continuous dynamical behaviors since general method analysis hybrid systems available researchers focused specific types hybrid systems piecewise affine systems one subsets hybrid systems identification systems includes estimation parameters affine subsystems coefficients defining partition state input domain paper proposed identification approach based modified clustering technique using fuzzy pca guided robust means clustering algorithm along neighborhood detection two main drawbacks known clustering algorithms poor initialization presence outliers eliminated furthermore modified clustering technique enables determine number subsystems without prior knowledge system addition applying structure state input domain considering time sequence input output pairs provides efficient clustering algorithm novelty work finally proposed algorithm evaluated parameter identification servo actuator simulation together experiment analysis proved effectiveness proposed method
acute inflammation gestational membranes commonly caused microbial infection associated adverse neonatal outcomes including preterm birth neonatal sepsis cerebral palsy layer gestational membranes likely important initial site contact microbes infection however little known stromal cells respond microbial threat defining contributions individual cell types complex inflammatory signals lead improved interventions aimed disease review available published data supporting role responding microbial infection special focus expression pattern recognition receptors evidence responsiveness pathogen sensing likely play important role sensing responding infection pathogenesis important knowledge gaps areas future research highlighted
low diet new dietary therapy management irritable bowel syndrome gaining popularity around world developing low diet required extensive food composition data also establishment cutoff values classify foods low cutoff values relate particular present food including sugar excess glucose cutoff values derived considering levels typical serving sizes foods commonly trigger symptoms individuals irritable bowel syndrome foods generally tolerated reliability cutoff values tested number dietary studies development techniques quantify content foods greatly advanced understanding food composition composition affected food processing techniques ingredient selection usa use high corn contribute higher levels detected via excess processed foods food processing techniques ingredients vary countries comprehensive food composition data needed diet easily implemented internationally
chinese fusion engineering testing reactor first fusion energy generation device china based structure like superconducting fusion power designed first phase duty cycle designed order optimize steady state electrical network type transformer model used analyze influence short circuit impedance voltage regulation factor reactive power loss short circuit current like lower short circuit impedance implemented main step transformers accordance comparisons annual operating cost year comprehensive loss efficiency silicon steel transformers amorphous transformers amorphous core adopted distribution step transformers realize high efficiency energy saving
stress one key factor impacts quality daily life productivity efficiency production processes ability military individuals making rational decisions also stress propagate one individual working close proximity toward common goal military operation workforce real time assessment stress individuals alone however sufficient understanding source direction group people equally important continuous near real time situ personal stress monitoring system quantify level stress individuals direction propagation team however stress monitoring individual via mobile device always possible extended periods time due limited battery capacity devices overcome challenge novel distributed mobile computing framework proposed organize resources vicinity form mobile device cloud enables computation tasks stress detection algorithm resource constrained devices low residual battery limited cpu cycles resource rich devices framework also supports computing parallelization workflows defining data tasks divided assigned among entities framework designed direction propagation magnitude influence stress group individuals studied applying real time situ analysis causality tangible benefits terms energy expenditure execution time proposed framework comparison centralized framework presented via thorough simulations real experiments
youth autism spectrum disorder asd experience significant difficulties assuming adult responsibilities achieving independence little known desire ability manage study explored financial circumstances money management skills financial independence among youth asd youth took part min semi structured interviews independence strategies theme analysis identified three critical themes emerging adulthood youth asd youth defined independence able manage lack money management skills cited poor financial skills barrier independence results suggest youth asd understand importance financial capability financial independence lack skills support needed achieve financial goals study provides preliminary information clinicians educators researchers develop financial capability modules youth asd
sustainability become priority throughout united global sustainability seen innovative efforts commitment leadership sustainable principles numerous alternatives exist green building design advance support commitment includes leed sustainable sites sites approaches green building regulations system specific considerations vary approach focus design order promote ensure long term energy sustainability green buildings also constructed using green construction techniques subsequently efforts underway foundation explore approaches evaluating sustainability construction site operations available sustainable design options examined evaluate construction specific parameters adequacy collective information examined recommendations made regarding construction implementation authors published elsevier ltd
recent approaches network functions virtualization shown commodity network drivers struggle keep increasing hardware speed despite popular cloud networking services still rely commodity operating systems device drivers taking account hardware underlying commodity servers built tracks movement packets across systems memory hierarchy collecting key hardware level performance leveraging data service chain scc run time user space service chains based commodity drivers scc combines system calls scheduling strategies taking time priority processing load account longer time network functions combined scc reduces unnecessary scheduling resulting three fold latency reduction due cache main memory utilization improvements importantly scc reduces latency variance service chains compared standard chains making average case chain perform best case improvements possible accuracy author published elsevier inc open access article license http creativecommonsorg licenses
design paper proposes improvements existing electrical network aircraft system also suggests improvement circuitry introducing super capacitors reduce number batteries board ensure improved safety reliability proposes higher frequency power distribution owing several benefits several advantages high frequency power distribution conventional distribution low frequency power distribution paper explores idea employing switched capacitor switched inductor converters design multi level inverters high frequency power supplies power distribution
development computer graphics technology machine vision virtual reality technology recent years reconstruction method sequence images outdoor scenes become key research direction computer vision graphics acquisition process image due measurement equipment environment single shot sequence photos able extract enough surface information lead unable complete reconstruction objects solve problem fusion method point clouds multi group images adopted thesis firstly color histogram matching used complete supplement image sequence next point cloud supplement image sequence solely calculated transform parameters overlap area different point clouds computed using improved iterative closest point algorithm finally registration fusion among point cloud data different photos conducted experiments show method effectively supplement point cloud data reconstruction
paper analyze algorithm detail decompose components implement multiple gpu architecture operations vector updates dot products sparse matrix vector multiplication implemented parallel addition specific communication mechanism designed established host cpu solved devices gpus validated series numerical experiments gpu based solver effective favorable parallel performance achieved elsevier ltd rights reserved
continued effort reducing resource consumption technologies rainwater harvesting useful dependence treated water associated energy requirements paper applies exergy analysis efficiency evaluate performance eight different scenarios urban rainwater harvesting systems mediterranean climate metropolitan area water scarce resource life cycle approach taken production use end life stages rainwater harvesting systems quantified terms energy material requirements order produce rainwater per year purposes results show highest exergy input associated energy uses namely transport materials construct rainwater harvesting systems scenario highest efficiency considers household building rainwater storage tank installed roof exergy requirements minimized material substitution minimizing weight distance elsevier rights reserved
three dimension fast low angle shot magnetic resonance imaging flash sequence widely adopted medical diagnostic imaging availability simplicity high spatial resolution improve quality structural brain images acquired flash sequence developed parameter optimization scheme image correction methods optimal imaging parameters determined maximizing gray matter white matter efficiency compared protocols based published parameters applying proposed optimal imaging parameters increased efficiency image including signal corrected choice optimal angle estimated transmit function estimated receive sensitivity result optimization image homogeneity correction greatly improved quality images acquired flash sequence published elsevier inc
physiology cells cultured vitro depends obviously external conditions including nutrients present culture medium order test influence parameter macrophages grown either compared combination targeted analyses proteomic approach two media differ glucose amino acids vitamins concentrations significant differences cell cycle percentage cells media although capacity number particles higher conversely found cells grown produced nitric oxide response lipopolysaccharide proteomic study highlighted differences affecting central metabolism nucleotide metabolism cytoskeleton protein degradation cell signaling furthermore proteomics showed cells grown exposed copper oxide nanoparticles respond rather differently proteins similarly modulated cells grown media taken together results show basal state cells grown two different media different affect way respond external stimulus stress
mutation results hyper activation kinase pathway molecular marker myeloproliferative neoplasms using allele specific real time pcr detected mutation blood normal donors mutant allele burden however low polycythemia vera much higher differentiated blood cells peripheral blood undifferentiated cells stimulated differentiation normal cells liquid culture increased mutation frequency fold progenitors normal donors grown stimulated semi solid cultures mutation found colonies alleles positive colony suggesting mutation occurred cells per colony mouse cells carrying human dna wild type frequencies mutations wild type vice versa increased following erythroid differentiation results suggest mutation occurs differentiation hypothesize genetic stability relies dna repair efficient normal hematopoietic stem cells differentiating cells rendering susceptible mutations including elsevier inc rights reserved
objectives quantify impact image optimization absorbed radiation dose associated risk children undergoing cardiac background various imaging system technical parameters including camera source image distance grids beam quality pulse rates affect radiation dose studied younger children methods used ages newborn years old measure surface radiation exposure various imaging approaches estimated absorbed organ doses effective doses using monte carlo simulations models developed national biological effects radiation report used compare imaging protocol optimized dose reduction versus suboptimal imaging source image distance setting lifetime attributable risk cancer results newborn year old respectively changes follows increase camera increase source image distance addition periphery removal grid compared optimized protocol suboptimal imaging increased fold newborn years old estimated cancer min using optimized versus suboptimal imaging respectively versus newborn female versus newborn male versus year old female versus year old male conclusions radiation related risks children undergoing cardiac substantial markedly reduced optimized imaging approach wiley periodicals inc
paper report differentiating properties platelet rich plasma human chondrocytes within citrate porous scaffold human derived cellular content total collagen determined scaffold enriched cells immunostaining real time pcr applied evaluate expression levels extracellular gene markers chondrocytes scaffold enriched showed significant increase total collagen production compared chondrocytes grown within control scaffold without cells mrna levels collagen increased significantly upregulation cartilage matrix protein expression statistically insignificant also report reduction expression levels collagen iii chondrocytes consequence proximity cells within scaffold interestingly pre loading caused increase expression levels following extracellular matrix ecm proteins integrin beta period days overall results introduce scaffold new system cartilage tissue engineering method cells loading prior culture considered potential environment cartilage tissue engineering differentiation ecm formation enhanced significantly
laparoscopic surgery complex minimum invasive operation requires long learning curve new adequate experience become qualified surgeon development virtual reality technology virtual reality based surgery simulation playing increasingly important role surgery training simulation laparoscopic surgery challenging involves large non linear soft tissue deformation frequent surgical tool interaction complex anatomical environment current researches mostly focus specific topics deformation collision detection rather consistent efficient framework direct use existing methods achieve high visual quality satisfactory rate time especially complex surgery simulation paper proposed set tailored key technologies laparoscopic surgery simulation ranging simulation soft tissues different properties interactions surgical tools soft tissues rendering complex anatomical environment compared current methods tailored algorithms aimed improving performance accuracy stability efficiency perspectives also abstract design set intuitive parameters provide developers high flexibility develop simulators copyright john wiley sons ltd
monocytes patients ankylosing spondylitis toll like receptor overexpression monocytes myeloid related protein protein complexes calcium binding proteins act endogenous ligands thus studied levels adult patients levels assessed adult patients satisfying assessments ankylosing spondylitis international society criteria healthy controls elisa patient disease parameters like patient physician global assessment bath ankylosing spondylitis disease activity index basdai joint count count enthesitis index erythrocyte sedimentation rate esr reactive protein crp also recorded levels patients months treatment nsaids values median iqr serum levels patients significantly higher healthy controls iqr patients peripheral arthritis higher levels pure axial disease iqr levels correlated disease activity score crp crp correlation better early disease years disease duration respectively baseline levels higher treatment responders non responders change levels correlated change basdai crp respectively levels used biomarker activity peripheral arthritis response therapy
locus control one widely studied concepts history personality psychology spite popularity associations numerous relevant outcomes ability locus control predict future behaviors involving parenting effectiveness researched parent locus control childrens outcome studies characterized cross sectional methodologies focus mothers present study uses prospective methodology compare data mothers fathers locus control childs behavior outcomes large scale research project longitudinal study parents children based social learning theory published past empirical research predicted found parent associated positive child outcomes parent specifically parents internal children positive outcomes sleeping eating behavior compared parent locus control combination however external parents less restrictive attitude appeared beneficial effect eating results confirmed important parent locus control lives children based findings researchers develop interventions change advice parents promote internal locus control among parents
applications computer graphics bidirectional texture function used realistic predictive rendering goal current research get surface representation indistinguishable real world developed built tested portable instrument acquisition based imaging discuss color issues experienced initial tests show color balance applied whole image spectral response instrument varies depending position within image optical elements contributions spectral behavior instrument software simulator mathematical model device implemented found way implement contributions image processing pipeline way correct white balance individual pixel image found applied allowing color representation also proposed optimized dielectric protective layer causing least possible color society photo optical instrumentation engineers spie
interleukin axis strongly implicated pathogenesis psoriasis previous studies showed elevated early active progressive plaque type psoriatic lesions serum plasma levels correlated psoriasis area severity index however mechanism whereby affects disease severity remains unknown study investigated effects psoriasis like skin inflammation model induced recombinant mouse found induced prominent inflammation enhanced psoriasis like epidermal hyperplasia skin mice treated plus expression interferon gamma significantly upregulated chemokine motif ligand synergistically increased histologically strong positive signals observed around infiltrating inflammatory cells current results suggest induce helper immune reaction without inhibiting axis thus psoriatic inflammation
radio frequency spectrometer two channel digital receiver spectrometer make remote sensing observations radio waves situ measurements electrostatic electromagnetic fluctuations solar wind part fields suite solar probe plus spp optimized measurements inner solar radio intense plasma frequency higher compared previous measurements distances greater inputs receiver four electric antennas mounted near front spp single axis spp search coil channel antenna input input via primary data products cross spectra selected inputs spectra calculated using filter bank enables measurement low amplitude signals interest presence high amplitude noise generated systems discuss science signals interest driving measurement objectives describe analog design digital signal processing show examples current performance plain language summary solar probe plus spp mission travel much closer sun previous fields experiment spp composed sensors antennas receivers measure electric magnetic fields unexplored region paper describes radio frequency spectrometer receiver measure radio waves mhz describe types radio signal sources present space close sun show design makes possible measure sources demonstrate current performance receiver
rolling stock examination performed identify defects train movements speeds study process automated using computer vision models parts moving train segmented using four types active contour level set models based morphological differential gradient shape shape invariance level sets shape invariance model enables adjustment contour according scale rotation location shape prior object rolling stock frame train rolling stock video data captured high speed using sports action camera degrees wide angle level sets yielded optimal segmentation results compared traditional segmentation methods performance indicators segmented parts proposed four algorithms structural similarity index measure peak signal noise ratio total parts extracted using proposed models compared ground truth models test performance methods train passenger cars furthermore models tested various lighting conditions five trains shape invariance model yielded efficient qualitatively quantitatively
paper proposes forecast indicators transport system taking account relations indicators increased forecast accuracy priori information uncertainty attained optimization technique starting vector var model observed multiple time series state space representation subsequent adaptive filtering adaptive filter earlier proposed authors minimizes forecasting errors optimization criterion information divergence probability distributions real values estimations established main advantage proposed technique connected opportunity estimate future values multiple time series even presence structural breaks describing changes status crisis crisis observations available analysis performed period sample forecasting multiple time series volumes transferred different transport modes two macro indicators compared forecast based var model sample forecast realized last three months
objective study assess overall health including sexual reproductive health knowledge needs sexual behaviors testicular health practices among young minority males anonymous questionnaires administered year old males receiving services health clinics large city survey completed males mean age years young males identified african american hispanic results suggest study participants lack knowledge related pregnancy condom effectiveness engage risky sexual behavior including using birth control last sexual encounter although participants sexually transmitted infection past year approximately perceived hiv risk low low respondents low engagement lack knowledge testicular health practices majority respondents reported physical fight one times reported victims intimate partner violence data support need comprehensive health services minority young males
case young male patient diagnosed ankylosing spondylitis assessed literature year old male patient previously diagnosed ankylosing spondylitis admitted clinic beginning disease pain first bone low back magnetic resonance images interpreted diagnosed referred many hospitals received several therapies benefit treatment complaints worsened human leukocyte antigen hla test negative alkaline phosphatase level high old femur fractures reported whole body bone addition patient diagnosed patient receiving vitamin oral phosphate anti tumor necrosis factor therapy added patients diagnosis final diagnosis instead ankylosing spondylitis
aim study identify systemic local risk indicators associated peri material hundred eighty three patients treated titanium implants function least included present study implants installed foundation scientific technological development university factors related patients systemic conditions heart disorders hypertension smoking habits liver disorders hepatitis gastrointestinal disease diabetes mellitus hyperthyroidism hypothyroidism radiation therapy chemotherapy menopause osteoporosis active periodontal disease history periodontal disease implants characteristics location diameter length connection shape antagonist clinical parameters wear facets periodontal status adjacent tooth plaque accumulation adjacent tooth modified plaque index bleeding index probing depth bleeding probing width tissue marginal increased risk times history periodontal disease times compared screw retained times wear facets displayed prosthetic crown times total compared single found logistic regression analysis show association implants characteristics peri history periodontal disease wear facets prosthetic crown full mouth identified risk indicators peri implants characteristics related presence peri
water extract brown algae evaluated potential natural sources antioxidant compounds skin care assess efficacy inhibiting lipid oxidation caused photo stored room temperature control conditions compared samples stored accelerated conditions light room temperature degrees presence extracts skin care induced remarkable colour changes exposed light extensively high temperature high temperature also caused greater droplet size analysis content peroxide value volatile compounds storage revealed whereas water extracts showed emulsion protective effect water extract showed antioxidant activity practical applications research basis developing natural antioxidants derived limit lipid oxidation skin care products
coal mining accident key success coal mining emergency rescue trapped still rescue passage made new life saving equipment life saving foods used maintain viability self saving ability front line trapped coal mining accident life saving food effectively extend self save time trapped essentially improve rescued possibility trapped amount human metabolism measured hot humid environment determines salt targets nutrition indexes life saving food according underground environment passage explores method store life saving food reasonably select storage locations reviewing application mine life saving food conclude self saving food better future economic social aspects still needs demonstrated whether necessary carry food human body life saving food exposed hot humid environment deterioration cure still unclear
integrated optical signal processors many applications photonic processing microwave signals provides wideband stable signal processing operations miniaturized chips ultimate control precision creating general purpose processors introducing key enable system function flexibility offer great potential wide range applications review recent progress area highlights number key programmable chips promising applications
batteries power tank solar power systems play role power supply sun paper provides review battery charging control techniques photovoltaic systems addition presents new battery charge controller keeps good features drawbacks limitations traditional controllers new controller based newly developed maximum power point tracking technique enabling fast maximum power point capture moreover utilizes constant current constant voltage charging scheme reduce battery charging time addition enables accessing system parameters remotely monitoring administration purposes order determine performance parameters proposed controller prototype implemented together microcontroller based converter experimental results show new controller tracks faster conventional controllers moreover charging period significantly reduced moreover proposed controller high accuracy minimizes steady state oscillation errors around target elsevier ltd rights reserved
immune system possesses vast number potential targets therapeutic intervention although therapies many pathways pursued yielded significant success altering biologic pathways include potential unwanted downstream effects owing biological redundancy recognition therapeutic molecule foreign innate immune system risks subsequent malignancy autoimmunity article covers currently available agent classes potential direction future therapy
ghz state new type state potential application future quantum information paper propose protocol constructing arbitrary ghz state different previous protocols logic encoded coherent state protocol based linear optics feasible experimental technology protocol useful quantum information based ghz state
fractional calculus three hundred year old concept way back time focusing derivative non integer orders almost four decades ago engineers scientists began field fractional calculus applications fractional differential equation models valid found fractional calculus indeed becoming ubiquitous seeing applications many fields sciences engineering fractional diffusion equations various biomedical applications signal processing control engineering applications conclusion later proposed fractional calculus actually generalization integer order calculus powerful overcome advantages integer order counterparts paper offers comprehensive discussion applications fractional calculus design implementation fractional order systems form electronic circuits used signal processing control engineering applications article starts introduction fractional calculus including history mathematical definitions second part article focuses fractional order differential equations systems example circuit designs implementation discussed includes elaboration papers related area final part article presents possible research topics area
work focused estimation power requirements electric vehicle platform intra campus transport using high fidelity computational fluid dynamics cfd model based incompressible navier stokes equations starting point ordinary auto battery powered electric motor engine work aims benchmark aerodynamic drag standard auto designing assess power requirements
introduction mucosa associated lymphoid tissue lymphoma rare lymphoma good prognosis diagnosed correctly treated time presentation case year old woman referred department asymptomatic swelling left hard computed tomography magnetic resonance imaging revealed mass left hard performed pre surgery biopsy however difficult differentiate lymphoma reactive disorders via gross microscopic examination although lesion completely histological findings allow definitive diagnosis due absence visible performed polymerase chain reaction pcr using dna extracted fixed paraffin embedded surgical samples capillary electrophoresis showed monoclonal peaks immunoglobulin heavy chain gene rearrangement thus facilitating definitive diagnosis lymphoma discussion pcr technique rapid accurate enables definitive diagnosis without relying traditional histological molecular diagnostic techniques southern blotting conclusion suggest histological examination ambiguous fresh material insufficient pcr performed using paraffin embedded materials diagnose low grade lymphomas lymphoma authors published elsevier ltd behalf surgical associates ltd
interactive evolutionary computation iec solution evaluated human users means small number solutions evaluated execution iec algorithm application fields iec hearing aid design music composition single solution evaluated time moreover accurate precise fitness evaluation easy human users based discussions formulated iec model minimum requirements human users fitness evaluation ability evaluate single solution time single previous solution evaluation result current solution whether better previous solution paper propose meta level approach design interactive algorithms iec model novelty approach use different operator generate solution iec algorithm coded string operators generate solutions random creation mutation crossover string length number solutions generated string iec algorithm evaluated simulations iec model population strings evolved meta level evolutionary algorithm perform experimental studies using known test function surrogate human user simple test function obtain style algorithms next solution generated mutation best solution among examined ones complicated test function obtain style algorithms crossover mutation random creation
objective examine mediating role maladaptive schemas permissive parenting fathers personality disorders including antisocial depressive attitudes among adults methods cross sectional study conducted university pakistan comprised university students data collected administering parental authority questionnaire young schema questionnaire personality diagnostic questionnaire spss used data analysis study completed one year started june ended june results participants questionnaires returned fully filled women men scales greater alpha reliability coefficients values scales ranged permissive parenting style positive correlation antisocial personality disorders parenting positive correlation early maladaptive schemas depressive personality disorder conclusion permissive parenting styles led personality disorders among offspring adult phase lives
risk factors non skin cancer novo malignancy lung transplantation yet identified united network organ sharing database adult lung transplant patients standardized incidence ratios computed comparing data surveillance epidemiology end results program data excluding skin squamous basal cell carcinomas identified adult lung transplant patients median follow time days interquartile range occurred patients incidences years respectively overall cancer incidence elevated compared general population confidence interval common cancer types lung cancer malignancies disease predictors following lung transplantation age hazard ratio male gender disease etiology cystic fibrosis idiopathic pulmonary fibrosis interstitial lung disease single lung transplantation significant interactions donor recipient smoking single lung transplantation noted multivariable survival analysis associated increased risk mortality authors find novo malignancies occur often lung transplant recipients compared general adult population associated increased hazard mortality multivariable analysis
silicon compatible mature complementary metal oxide semiconductor cmos fabrication process extensively demonstrated monolithic integration photonic electrical circuits show integrated silicon modulator used advanced modulation formats despite nonlinear dependence index change applied voltage free carrier depletion modulator experimentally demonstrated use silicon direct detection optical orthogonal frequency division modulation advanced data formats phase shift phase shift amplitude modulation measured bit error rate performance back back single mode fiber transmission format forward error correction limit
keeping special issue theme remembering future article provides selective review research memory social information social category representation influences future processing behavior specifically authors focus categorization affect perceive others first part article reviews research individuals perceive others authors review research determinants outcomes social categorization stereotype activation influence ingroup outgroup categorization face processing second part article reviews research individuals perceive authors argue stereotype threat concerns judged ways confirm negative group stereotypes leading poor performance result self categorization stereotype activation overall article highlights complex relationship memory social category information future social perception behavior elsevier inc rights reserved
article reviews evolution diagnosis treatment hodgkin lymphoma since discovery morphological phenotypic molecular characteristics lymphocyte predominant classical revised light recent molecular information possible impact identification risk groups use targeted therapies contribution developing new treatment strategies advanced early stage highlighted
proportion workers larger ever current work force trends indicate global increases ages many individuals working later ages decades past older people applying jobs later ages research date age discrimination selection focused primarily disparate treatment intentional discrimination however based accumulated knowledge age related changes cognitive physical abilities changes personality work motivation across life course suggest attention paid possibility age based subgroup differences selection procedures manifested adverse impact differential prediction provide recommendations guide future human resource management research practice elsevier inc rights reserved
ambient intelligence ami deals new world ubiquitous computing devices physical environments interact people ami environments diverse homes offices meeting rooms schools hospitals control centers vehicles stores sports facilities music devices paper present design implementation testbed ami using mounted analyze performance optimized link state routing equivalent privacy protocol indoor scenario evaluation considered throughput delay metrics experimental results show nodes testbed communicating
lorentz force classical applied magnetic materials gives rise hidden energy hidden momentum removing contributions hidden entities vector electromagnetic momentum density lorentz force torque densities simplifies equations classical theory particular reduced expression force density becomes similar identical expression force exerted electric magnetic fields distribution charge current polarization magnetization examples reveal similarities differences among various equations describe force torque exerted fields material media important example afforded formula provided magnetic moving static electric field exhibiting effect
human mesenchymal stromal cells possess ability differentiate osteoblasts utilized source bone regenerative therapy pretreatment induces differentiation vitro widely used bone tissue engineering prior cell transplantation however molecular basis differentiation induced medium still unknown therefore used next generation investigate changes gene expression differentiation used study possessed self renewal ability whole transcriptome analysis revealed expression zinc finger domain containing significantly increased mrna protein expression enhanced small interfering rna sirna mediated gene silencing decreased activity alkaline phosphatase alp expression osteogenic genes osteocalcin bone formation induced sirna mediated gene silencing known essential regulator differentiation markedly downregulated expression addition chromatin immunoprecipitation chip assays showed associated promoter region containing rich canonical sequence specific binding site findings suggest acts downstream transcriptional regulator useful late marker differentiation cell wiley periodicals inc
dermatitis lies gray zone psychiatry dermatology condition mimic number lesions therefore source much confusion clinical practice describe case dermatitis years old girl self behavior borderline personality disorder discuss two differentiated becomes imperative dealing cases
background respiratory illnesses leading cause morbidity medical discharge military study aimed investigate effects baseline aerobic fitness salivary mood variables simultaneously novel approach identify factors illness attrition rate military training methods thirty five healthy male training weeks training prospectively investigated run time used surrogate baseline aerobic fitness saliva venous blood samples analysed secretory iga full blood counts cell cytokine production interleukin respectively recruit completed questionnaires mood profile gastrointestinal upper respiratory tract symptoms results significant salivary perturbations observed increased duration week mood disturbance military training period start end count decreased neutrophil percentage decreased lymphocyte increased neutrophil lymphocyte ratio decreased increased start mid end monocyte increased mid end increased mid end significantly associated duration addition min increase increased risk fold developing lasting average days week ranked high duration slower low attrition rate reached conclusions least fit found training physically demanding reflected higher duration led high attrition rate worth considering baseline aerobic fitness important factor illness development attrition rate type military training
paper devoted investigation existence compact random random dynamical system generated coupled suspension bridge equations white noises elsevier inc rights reserved
participating undergraduate research pivotal experience students life science disciplines development critical thinking skills addition scientific ideas oral written formats essential ensuring students develop greater understanding basic scientific knowledge research process current life sciences research environment accommodate growing demand students experiential learning needed developing implementing structured theory based approach undergraduate research life sciences specifically biochemistry successfully shown students provided high quality high impact research experience structure approach allowed students develop novel independent projects computational molecular modeling lab students engaged experience career goals problem solving skills time management skills independence research lab developed experiencing approach undergraduate research students reported feeling challenged think critically prepared future career paths approach allowed progressive learning environment undergraduate students participate research future areas development include implementation bench top lab extension disciplines beyond biochemistry study shown utilizing structured approach undergraduate research allow students experience undergraduate research develop confident independent life scientists prepared graduate schools professional research environments international union biochemistry molecular biology
idea taking nature particular living systems design technological systems fairly widespread originated much research work however field materials approach allowed construction systems high complexity time inexpensive able mass produced idea wider context natural systems necessarily optimized seems justified optimization evolution understand evolutionary processes mechanism producing design living organisms result optimal designs fulfil given task cause continuous adaptation environment similarly seems idea machines devices necessarily better obtained using traditional design approach designed taking nature trial error approach supported principles represents respect application scientific principles technology much contributed technological advancement modern world
across six studies examine magnitude expressed happiness influences social perception interpersonal behavior find happiness different judgments expressed high levels expressed moderate levels judgments influence opportunistic behavior specifically people perceive happy individuals naive moderately happy individuals perceptions reflect belief happy individuals negative information world result inferences happy people relative moderately happy people likely receive biased advice conflict interest likely chosen negotiation partners opportunity exploitation salient findings challenge existing assumptions organizational behavior psychology identifying significant disadvantage expressing happiness underscore importance examining emotional expressions different magnitudes call future work explore emotion experienced expressed different levels influences judgment behavior published elsevier inc
better understand sleep wake dysregulation affects alzheimers disease compared cerebrospinal fluid csf histamine levels patients probable high level evidence mild cognitive impairment mci due neurologic disorders controls determined relationships biomarkers csf biomarkers concentrations clinical sleep profile csf levels higher mci controls csf correlated csf amyloid beta mci independently age gender mmse total tau phosphorylated tau sleep parameters sleep duration longer mci patients controls mci sleep duration negatively correlated csf amyloid beta mmse conclude csf upregulated correlated amyloid beta level data suggested change sleep wake pattern early stage disease needs investigation deeply explain mechanistic interplay sleep alzheimer elsevier inc rights reserved
reporter mice widely used observe localization expression targeted genes protocol focuses strategy establish new transgenic reporter mouse model chose visualize interleukin gene expression cytokine important activities intestine contributes repair tissues damaged inflammation reporter systems offer considerable advantages methods identifying products vivo case studies first isolated cells tissues stimulated cells vitro normally secreted trapped inside cells using drug intracellular staining used visualize method identifies cells capable producing determine whether vivo reporter design includes gene fluorescent protein gene way fluorescent protein secreted therefore remains trapped inside producing cells vivo fluorescent producers visualized tissue sections vivo analysis flow cytometry actual construction process reporter included bacterial artificial chromosome contained gene engineered chromosome introduced mouse genome homeostatic reporter expression observed different mouse tissues including spleen thymus lymph nodes patch intestine flow cytometry analysis colitis induced cell transfer reporter expression visualized positive cells first present lymph nodes accumulated inside lamina distal small intestine colon tissues strategy using gave good fidelity reporter expression compared expression simpler knock procedures
background studying sleep alcohol dependent patients beginning course abstinence earlier studies interest current study focused direct effect doses alcohol blood alcohol level healthy sleep first study testing impact doses alcohol ingestion thus reflecting normal social drinking alcohol abuse single blind randomized design healthy volunteers study evaluated short term acute drinking period days withdrawal alcohol variables also subjective estimates sleep quality crossover design week interval healthy subjects received alcohol raise blood alcohol either consecutive alcohol free baseline night objective subjective sleep questionnaires recorded night following days alcohol discontinued simultaneous measurements sleep gauge withdrawal effects results dose alcohol leading clear effects detected following evening like effect shortened sleep latency reduced number wake periods decreased stage sleep occurred primarily first half night signs effects already present second half night increased stage sleep dose alcohol significantly increased slow wave sleep first half night reduced density beginning night discontinuation higher alcohol dose sleep amount increased significant withdrawal effects observed parameters sleep continuity discontinuation alcohol conclusions owing small sample size results study need interpreted caution short term moderate alcohol consumption significantly alter objective subjective parameters sleep higher doses alcohol resulting level immediately going bed mainly influenced sleep first half night resembling effects short acting drug including suppression aspects sleep density interestingly analysis latter part indicated immediate presence withdrawal effects increased light sleep statistically significant effects sleep parameters observable withdrawal alcohol higher interpreted carefully data indicate negative effects sleep occur already short term use alcohol doses despite like effects first hours sleep especially latter part night
surfaces common tool geometric modelling especially computer graphics computer animation nowadays concept become established engineering focus control grids generalized spline surfaces type classical theory surface defined limit repetitive application rules control grid based idea labour intensive process avoided using natural parameterization limit surface however simplification free defects classically defined limit surface lost paper describes rescue parameterization using basis function consistent classical definition expensive compute based introduce characteristic finite element use surfaces show integral representation complicated parameterization reduces decisive factor compare natural characteristic finite element approach solving surfaces model problem consider mean curvature flow whereby computation done step step changing geometry elsevier ltd rights reserved
breast cancer associated estrogen progestin therapy favorable characteristics cancer never users results conflicting known either whether body mass index bmi modifies association investigated breast cancer characteristics users lean bmi overweight women bmi cancer detection clinic cohort information breast cancer risk factors women linked population based cancer registry total women invasive breast cancer diagnosed years older matched controls cohort conditional logistic regression used estimating adjusted odds ratios confidence intervals according tumor characteristics stratified bmi logistic regression applied case analysis testing whether risk associated use differed according tumor characteristics ever users twofold higher risk breast cancer compared never users lean women use significantly less likely associated grade tumors grade tumors contrary overweight women risk increased irrespective grade use overweight women associated higher risk cancer among lean users tumor characteristics favorable among never users effect observed overweight women
fifty years end war independence french colonization still controversial topic brought public sphere one way better understand current intergroup relationships french french origin french origins investigate past influences present study explores french students emotional reactions historical period ideological underpinnings relationship willingness compensate past prejudice results show french students french endorse norm thinking past colonization express low levels collective guilt moral related emotions especially students right wing political orientation national identification form country group based emotions significantly related pro social behavioral intentions willingness compensate prejudice toward outgroup
article explores difference time series property economic output great china economic area china hong kong taiwan using powerful unit root test real period study sample results indicate presence break corresponds asian financial crisis additionally allowing break leads rejection unit root hypothesis taiwan important implications provided first considering presence break testing important false conclusions drawn second given found taiwan look beyond local economic focus world economy development taiwan contrast china hong kong pay attention shock likely persistent third relevant authorities recognize government policy intended promote long run economic growth ineffective taiwan whereas effective china hong kong
important intestinal homeostasis involves regulation immune function digestive health cholesterol absorption intestinal tumor growth amongst others previous investigations suggested oral intake heat lactobacillus suppresses dermatitis modulating immune function atopic dermatitis mouse model aim present study investigate effect heat intake skin hydration conditions humans randomized double blind placebo controlled study conducted volunteers slightly higher levels water loss subjects people aged years randomly allocated three groups level age distributed equally among groups subjects took placebo heat daily dose weeks following exclusion eight subjects plausible reasons two study two study violations one meeting exclusion criteria three due physical condition subjects subjected analysis results present study revealed following analysis whole populations marginal differences observed example suppression skin water loss neck day group week lower eye region day group week respectively compared placebo group analyzed test significant increase corneal hydration also observed neck day group week compared placebo group analyzed test analysis subpopulations whose habitual frequency taking lactic fermentation products less per week levels corneal hydration neck day group lower eye region day group significantly increased week conclusion results present investigation suggest oral intake heat effective improving skin hydration conditions populations low habitual frequency taking lactic fermentation products
educational attainment important often overlooked contributor health outcomes patients kidney disease lower levels education increased risk complications peritoneal dialysis worse transplant outcomes mortality mediators associations poorly understood involve complex interplay health knowledge behaviors socioeconomic psychosocial factors interventions targeting aspects care potential reduce disparities related educational attainment however programs described specifically address issue future research efforts systematically assess level educational attainment also report differential impact interventions across educational addition routine measurement health literacy useful identify high risk patients independent years better understanding influence educational attainment kidney health provides opportunity improve care outcomes vulnerable patients kidney disease national kidney foundation inc rights reserved
paper performs generalized analysis various developed series cascade boost converters based switching signal flow graph sfg method unified switching model constructed applied circuits effects caused diodes considered applications example proposed generalized analytical method shows advantages high convenience experimental results provided support theoretical analysis
rapid development internet especially development mobile internet network size network infrastructure changes especially random access node detect network attacks challenges traditional detection algorithm using neural networks calculated volume increased dramatically detection accuracy high problem use stochastic process theory hidden markov chain transformation neural network convergence substantial decline improving network attack detection accuracy degree
paper potential risk undesirable events occurring tunneling application tunnel machine method discussed along risk analysis systematically assess overall risk levels potential risks typical scenarios pertaining investigated based previous case histories correspondence experts relevant risks undesirable events categorized four groups related machine hold problems hinder materials segment defects fault tree set constructed grouping risk factors causes geological design construction management factors risk analysis performed adopting fault tree analysis analytic hierarchy process ahp consideration probability impact risks addition proposed method reliably validated comparison field observation thus indicates applicability risk management tunneling elsevier ltd rights reserved
hypothyroidism common adverse event head neck radiotherapy human medicine reported canine patients records dogs histologically confirmed thyroid carcinoma receiving definitive radiotherapy reviewed nine cases received fractions received fractions received fractions seventeen cases radiotherapy post operative setting ten cases developed hypothyroidism radiotherapy development hypothyroidism associated radiotherapy protocol used median time diagnosis hypothyroidism months range months hypothyroidism common side effect following radiotherapy thyroid carcinomas monitoring thyroid function following radiotherapy recommended specific risk factors identified
transgenic pigs failed milk yield curve lactate vitamin dependent protein even fed enriched times higher nutritional requirement higher supplementation required homozygous transgenic nursing divided control treatment groups respectively received enriched soluble supplemented diet enriched diet days next lactation control received treatment previous treated fed control diet results revealed treatment increased milk bioactivity day day gradually decreased day lactation control feeding bioactivity remained relatively unchanged however milk concentration ratio activated responded little treatment induced bioactivity curve known lactation pattern means secretion still requires high intake show spend common dependent expression system effectively overcome high supplementation folds improvement quality
aim evaluate association using short long acting durations migraine occurrence methods migraine group comprised subjects older years newly diagnosed migraine comparison group comprised subjects without migraine used subjects defined short acting half life long acting substances logistic regression model used calculate odds ratio migraine associated exposure diseases results adjusted migraine associated exposure confidence interval either exposure short acting alone using combining long acting significant higher risks migraine adjusted adjusted respectively whereas long acting use associated increase migraine meanwhile sleep disorders anxiety stroke strongly associated migraine adjusted respectively conclusions observed significant increase migraine occurrence subjects using short acting either alone combination long acting ones
procedures around interviewing police recently come increased argue allowed view available video body cameras wait two three days stress interviewed viewing video first increase accuracy details present also cause distortion parts situation captured camera including perception situation additionally memory likely decay delay waiting period little support claim long period improve accuracy compared immediate report though complex policy matter many considerations procedures harm good comes preserving accurate helpful memory police
latest variants denial service attack like low rate denial service attack require packets attack result reducing number packets required gained considerable importance packet schemes mark packets therefore large number packets required victim reconstruct complete attack path paper introduce efficient data structure known around counting filter minimize required number packets maintains set cyclic decide particular mark needs sent victim faster prove efficacy technique performing detailed theoretical analysis confirm using extensive experimental results case probabilistic packet proposed scheme reduces number packets times likewise case deterministic packet number packets required reduced times also show incorporated different variants probabilistic packet deterministic packet obtain effective results finally highlight benefits schemes like hybrid copyright john wiley sons ltd
microwave recently emerged novel suitable technology monitor vibrations displacements various engineering structures paper presents method evaluate possibility microwave long term periodic measurement dynamic deflection long span railway bridge dynamic loads train passing bridge without auxiliary equipment order eliminate influences transmitted electromagnetic waves different monitoring atmospheric environment empirical formula adopted calculate atmospheric index make atmospheric parameters correction improve measurement accuracy first experiment carried two corner fixed flat continuous stationary monitoring carried image survey validate method resulting rms errors reduce highlight reliability accuracy application microwave second long span beijing railway monitored twice interval months proposed methods results show monitored long span railway bridge stable condition microwave alternative technique long term periodic measurement dynamic deflection railway bridges
tcr ligation critical selection activation integrin expression lymphocytes explored role tcr protein cell biology compared controls ace ace mice carrying missense mutation within domain showed increase cells thymus lymph nodes decrease cells livers along reduced expression cytokine response comparable reduction cells observed livers deficient mice like cells ace ace cells characterized enhanced expression correlating impaired induction tcr immediate early gene decreased adhesion furthermore intrinsic effects inhibited cytokine release mediated inflammation cell accumulation liver unlike mice expression transcription factors reduced whereas expression enhanced ace ace mice blockade decreased recovery cells peripheral lymph nodes identifying cell specific adhesion factor thus contributes regulation tissue distribution cytokine expression cells via dependent independent mechanisms
identify different types models used economic evaluations smoking cessation analyse quality included models examining attributes ascertain new context methodsa systematic review literature economic evaluation smoking cessation interventions published april identified via medline embase national health service economic evaluation database health technology assessment checklist based quality included studies scores based european network health economic evaluation databases criteria studies smoking cessation original research model based economic evaluation consider adult population high income country excluded economic evaluations included review state transition markov model frequently used method quality adjusted life years frequently used outcome measure life time horizon small number included studies eligible checklist overall scores ranged average score average score per section range relative studies established due limitation present method existing economic evaluations smoking cessation lack one key study attributes necessary fully new context
paper presents new modeling method based signal flow graph correlation matrix firstly according signal flow graph signal tree selected based signal tree signal branch node added finding independent loop loop incidence matrix correlation matrix determine relevance loop help seek loop gain moreover mathematical model using formula theoretical analysis experimental results show nodes increase method simpler meaning formula comparison existing methods method obvious advantages calculation expression method makes model system accurate modeling process becomes faster convenient
background evidence linking maternal psychosocial stress pregnancy subsequent child atopic dermatitis growing definition diverse results inconsistent aimed analyze relationship stress using alternative measurements stress methods health study chronic stress symptoms anxiety depression assessed standardized self reported questionnaires mothers following delivery germany maternal hair cortisol concentrations cumulative incidences parent reported child symptoms parent reported diagnoses assessed age years overall examinations performed children showing symptoms crude adjusted risk ratios confidence intervals estimated results maternal stress anxiety associated child symptoms trend highest lowest quarter chronic stress possible anxiety symptoms symptoms relationship found stress related constructs diagnoses show consistent associations maternal hcc child however higher child evident families yet affected siblings given maternal depressive symptoms examined crude model conclusions stress measurements related constructs linked symptoms association diagnoses limited reason divergence still needs research
blood cell production bone homeostasis physically systems exhibit active cross talk examined bone health affected patients hematopoietic disorders due abnormal proliferation bone marrow cells electronic databases medline embase pubmed web science cochrane searched studies presenting numerical values trabecular bone volume bone mineral density control patients hematopoietic disorders identified studies beta cell anemia polycythemia vera essential thrombocythemia chronic leukemia myelofibrosis multiple studies systemic lymphocytic leukemia effect disease state bone density significant negative beta confidence interval cell anemia chronic leukemia lymphoblastic leukemia multiple changes negative significant polycythemia vera essential thrombocythemia myelofibrosis disease state associated increased bone density bone density change significantly negatively correlated level bone marrow hemoglobin thus independent hematopoietic lineage abnormal proliferation bone marrow cells appears associated bone loss iron metabolism independently contribute bone homeostasis american society bone mineral research
paper stochastic optimal strategy unknown linear discrete time system quadratic zero sum games input output form communication network induced delays packet losses otherwise referred networked control system zero sum games relating optimal control problem solved forward time manner first linear discrete time zero sum state space representation transformed linear state space form incorporating random delays packet losses input output form subsequently stochastic optimal approach referred adaptive dynamic programming adp introduced estimates cost value function solve infinite horizon optimal regulation unknown linear quadratic zero sum games presence communication optimal control worst case disturbance inputs derived based estimated value function absence state measurements update law tuning unknown parameters value function estimator derived lyapunov theory used show signals asymptotically stable estimated control disturbance signals converge optimal control worst case disturbances respectively simulation results included verify theoretical claims
one main complications caused diabetes mellitus development diabetic foot turn lead risks linked increase temperatures recent approaches analyze thermal changes approaches try identify spatial patterns temperature characteristic diabetic group however difficult task since thermal patterns wide variations resulting complex classification moreover measurement contralateral temperatures important determine whether abnormal difference provides information thermal changes asymmetric absence therefore work proposed quantitative index measuring thermal change region participants diagnosed diabetes mellitus regards reliable reference control regards contralateral foot usual also classification thermal changes based quantitative index proposed classification demonstrate wide diversity spatial distributions diabetic foot also demonstrate possible identify common characteristics automatic process based analysis image processing presented quantify thermal changes provide valuable information medical expert elsevier rights reserved
historically played relatively peripheral role language evolution research profound describe pragmatic perspective inform language evolution fundamental way making clear natural objects study hence aims field
todays power systems become prone cyber attacks due high integration information technologies paper demonstrate lines false data set measurements success topology attack guaranteed making injected false data current law voltage law avoid detected bad data detection program state estimation residual line detection increased line detected measurement unit data optimization problem set determine optimal attack vector maximize residual line ieee bus bus systems used demonstrate scheme
paper presents precision full wave rectifier low level signal operational conveyor current operational conveyor circuit topology based current steering output stage also described analyzed current mode full wave rectifier realized four unity gain current three current sources pspice program used verify proposed design operational conveyor precision full wave rectifier results simulation presented compared simulation results realization published
experiments younger older adults witnessed simulated received misleading information event interviewed cognitive interview memory experiments older adults disproportionately confident younger adults accuracy incorrect information recalled accuracy correct information critically age related increase high confidence errors occurred even comparison younger adults matched older adults overall amount accuracy information remembered addition experiment showed retrieval misinformation just effective older adults compared younger adults reducing reporting misleading information finally experiments showed across multiple retrieval stages cognitive interview final retrieval stage roughly half effective older adults relative younger adults eliciting previously information results indicate investigators much less gain older adults younger adults repeated session witnessed event
background present study aims assess physical responses multi component stress management program use cam approaches among teaching professionals hong kong method random controlled trial rct used compare group cam group interventions administered week eight consecutive weeks self administered questionnaire including perceived stress scale pss frequency symptoms measured baseline immediate program weeks program physical parameters measured results reduction pss observed group cam group yielded reductions pss significant interactions observed frequency symptoms physical parameters however significant downward time trend observed larger percentage changes physical responses shown cam group group conclusion clinical evidence cam program demonstrated current study approaches easy self implemented cam technique serve alternative choice self administered stress management replace additional time needed professional follow contacts improve physical responses strength resting heart rate associated better health better occupational stress management elsevier ltd rights reserved
solar occurred october accompanied multi wavelength emissions high flux particles observed present analytic results trace ace goes hard ray integral satellite radio radio neutron monitor data found inferred magnetic electric field correlates hard ray gamma ray neutron emission sun thus magnetic probably makes crucial contribution prompt particles detected since emitted minutes injection electrons propose magnetic field evolution configuration explain delay exclude effect driven shock probably plays important role delayed gradual phase solar energetic particles
objective paper formulate validate accurate approach numerical simulation large displacement membranes containing soil proposed approach membrane surface mesh allows accurate simulation membrane stresses membrane free move three dimensional grid continuum consisting elements approach applied model released split taking account frictional contact geotextile slip contact assumed geotextile soil inside effect interaction investigated second container copyright john wiley sons ltd
background general obesity abdominal obesity established risk factor gastroesophageal reflux disease however influence weight waist change improvement unclear aim investigate weight loss waist reduction improves symptoms methods retrospective longitudinal study subjects underwent health reported symptoms repeated conducted improvement symptoms according weight loss body mass index bmi waist reduction baseline bmi waist circumference categories assessed using logistic regression key results weight loss waist reduction associated improvement symptoms subjects general abdominal obesity among subjects general obesity bmi decreased bmi adjusted odds ratio improvement symptoms confidence interval among subjects abdominal obesity decreased corresponding association weight loss waist reduction improvement conclusions inferences weight loss waist reduction associated improvement symptoms subjects general abdominal obesity weight loss waist reduction important treatment option obese patients
migration osteoclasts circulation bone marrow bone surface plays critical role pathogenesis bone diseases rheumatoid arthritis osteoporosis date migration remains unclear investigated gene expression profiling differentiation bone marrow derived macrophages microarray analysis identified genes overexpressed differentiation among chemokine showed robust regulation signal high expression validated primary precursor cell line differentiation decreased rankl induced precursor cell migration invasion coated transwell membranes assay vitro wound healing assay however inhibition affect differentiation differentiation associated gene expression inhibition promoted phosphorylation rankl stimulation study indicated chemokine important regulator migration via pathway providing novel therapy target bone diseases
field pace although biologics tested approved one indications side effects label use contributed significantly understanding basic immune mechanisms involvement cytokines several apparently diseases importance immune responses review attempt give birds eye view major biologics highlight insights implications derived secondary effects adverse reactions
background several new rehabilitation modalities proposed anterior cruciate ligament acl reconstruction among trigger point dry useful treatment pain syndrome associated acl reconstruction reduce pain intensity increase knee flexion range modify mechanical properties muscle late stage rehabilitation date first randomized clinical trial support use early rehabilitation process acl reconstruction aim study determine pain intensity range motion stability functionality improvements adding rehabilitation protocol provided acl reconstructed patients methods randomized single blinded clinical trial included patients surgical reconstruction complete acl rupture patients randomized intervention groups pain intensity stability functionality measured baseline immediately hours week weeks first treatment results comparing statistically significant differences conclusion conjunction rehabilitation protocol patients surgical reconstruction complete acl rupture increases short term functionality short mid term although increase pain intensity addition detected beyond immediately first treatment furthermore stability seem modified
childhood adolescence rapid structural functional maturation brain networks implicated theory mind tom however impact paediatric traumatic brain injury tbi development higher order skills understood tom partitioned tom defined ability understand indirect speech acts involving empathy used influence mental affective state affective tom concerned understanding facial expressions often used social purposes convey emotions want people think feel sample children mild severe tbi typically developing controls study examined effect paediatric tbi affective tom evaluated respective contributions injury related factors injury severity lesion location non injury related environmental variables socio economic status ses family functioning long term tom outcomes results showed tom outcomes documented association mild complicated moderate tbi rather severe tbi lesion location ses significantly contribute affective tom post injury family affective responsiveness strongest significant predictor tom results suggest clinicians exercise caution based early clinical indicators group individual level outcome prediction incorporate assessment range injury non injury related factors moreover affective quality post injury family interactions represents potentially modifiable risk factor useful target family centred interventions designed optimise social cognitive outcomes paediatric tbi
aim aim article evaluate clinical cost implications failed endoscopic patients bleeding methods retrospective claims analysis medicare provider analysis review file conducted identify hospitalizations bleeding year main outcome measures compare cause mortality total length hospital stay los hospital costs payment patients managed one upper gastrointestinal endoscopy versus one endoscopy requiring interventional radiology guided surgery failed endoscopic attempt results claims data evaluated hospitalizations reported one endoscopy reported endoscopy reported failed endoscopy reported surgeries failed endoscopy cause mortality significantly lower patients underwent one endoscopy compared patients requiring endoscopy surgery endoscopy eight days nine days surgery days endoscopy surgery conclusions failure achieve index endoscopy significant clinical cost implications feasible repeat endoscopy attempted followed surgery reserved last patients fail treatment measures
although half century since first noted author problematic women little critical work closely examining aspect works essay examines construction women characters corpus whether textual grounds reading body work despite tendency development relation several social issues including gender roles conclude patterns male female relations always traditional based conventional notions womens
post transplant infrequent complication reported allogeneic hematopoietic stem cell transplantation anemia acute myeloid leukemia chronic myeloid leukemia pre factors treatment clearly defined present post transplant cases studies conducted distinguish pathogenesis follow rare complication
inadequate regulation spatial development origin current global crisis increases years crisis unequal distribution wealth importance related risks draw attention systems spatial governance planning states regulate spatial development europe countries affected unequal effects crisis spatial planning systems traditionally based preventive rights land use development plan systems countries established new rights land use spatial development rather assigned public control development projects effects despite evidence models operate better others ensuring public government spatial development improvement spatial planning systems however limited complex nature institutional technologies especially context crisis planners responsible increase public awareness concerning role spatial governance economic social life
one primary goals applied proteomics development new computational methods modeling properties proteins primary structure work used concept semi supervised learning relatively new machine learning philosophy combines labeled instances simultaneously perform classification protein mutants according physical properties unlike traditional methods demand specification class labels every sample particularly useful many available actual class membership available marginal subset spite desirable properties semi supervised learning seldom applied molecular biology recent years novel algorithm capable performing semi supervised learning proposed algorithm namely tree based neural network inspired known self organizing maps paper use predict stability human mutants since plays central role immunologic system prediction structural stability primary importance molecular biology experimental results show possible predict stability accuracy two known classifiers prediction based historical data without necessity expensive chemical substances human resources
purpose prevalent childhood brain cancer children typically receive combination surgery radiation chemotherapy survival rate high survivors often sequelae radiotherapy entire developing brain spinal cord ongoing genetic studies suggested decreasing dose radiation possible among children favorable molecular variants however result increased disease recurrence need investigate nature trade offs individuals willing make regarding treatment method used best worst scaling estimate importance attributes affecting general decision making around treatment conducting focus groups selected three relevant attributes accuracy genetic test probability serious adverse effects treatment survival rate using paired method applied conditional model estimate preferences results total respondents female average age years answered questionnaires coefficients statistically significantly different zero attribute levels adverse effects survival rate impact individuals stated decision making conclusion overall respondents showed high sensitivity children experiencing disability particularly setting good prognosis however among children poor prognostic molecular variants participants showed tolerance child mild partial disability compared low rate survival
vitamin ascorbic acid essential component collagen biosynthesis also proper functioning cardiovascular system humans unlike animals humans lack ability synthesize ascorbic acid due mutation gene encoding last enzyme biosynthesis result vitamin obtained dietary sources like plants study developed transgenic potato plants valley expressing gene control promoter increased ascorbic acid levels integration gene plant genome confirmed pcr southern blotting ascorbic acid levels transgenic determined high performance liquid chromatography hplc expression resulted fold increase transgenic potato levels positively correlated increased activity transgenic lines enhanced vitamin content showed enhanced tolerance abiotic stresses induced methyl nacl compared control plants leaf disc senescence assay showed better tolerance transgenic lines retaining higher chlorophyll compared control plants present study demonstrated expression gene enhanced level potato performed better different abiotic stresses compared control elsevier ireland ltd rights reserved
full length cdna encoding novel like protein identified first time gut cdna library comprised open reading frame orf amino acids predicted molecular mass approximately kda situ hybridization revealed tissue specific expression pattern high levels ovary lower level gut testis hepatic absent muscle neural tube chinese ovary cells transfected expression plasmid fusion protein targeted cytoplasm cells suggesting cytosolic protein work provide framework understanding physiological function
building information modelling bim trend future increased use documented construction industry last years sustain momentum bim effective workforce development aims balance supply demand equation labor market essential many experience bim begins academia challenges reside classic gap academic focus disciplinary principles industry needs specific application result architecture civil engineering education needs opportunities provided bim overcome challenges presented bim remain current relevant growing number architecture engineering construction programs begun offer courses include bim related content programs strategies place fully integrate paper presents modular approach adopted department civil architectural environmental engineering institute technology promote bim enabled learning experiences creating adapting collaboration coordination learning modules bim education respectively construction management engineering graphics programs presented discussed content created implement facilitate learning understanding bim evaluated objective educate engineers architects future actively using bim routinely strategy relative bim learning modules expected help architecture engineering construction professionals prepared needs industry future
monte carlo techniques widely applied check design robustness estimating production yield integrated circuits using standard random sample yield estimation large number samples required accurate verification especially high yield desired make extremely time consuming data follows normal gaussian distribution much faster yield prediction possible using known method extended specification distance based scheme far difficult general non normal case three different means new generalized process capability index named first apply parametric modeling specification sided distribution part way difficulties distribution parts actually little yield impact degrade model fit second improve parametric model introduce new tail parameter third allow modeling difficult multimodal flat distributions also introduce new reference location parameter instead using mean advantage improving way opposite many enhancements like importance sampling performance negatively impacted design complexity described formulation derived confidence intervals using advanced bootstrap scheme verified performance sample yield representative set distributions including real production data data design cmos operational amplifier circuits
mammals isoforms fatty acid binding protein expressed various tissues understand role multiple isoforms quantitatively examined transcript levels individual isoforms various tissues northern blotting using synthesized rnas corresponding mrna isoform external standards result absolute transcript levels individual isoforms expressed tissue successfully determined isoforms classified three categories isoforms markedly expressed tissue examined isoforms showing certain transcript levels multiple tissues isoforms expressed certain levels one particular tissue based expression profiles isoforms individual tissues also classified three groups tissues high level expression isoforms observed tissues multiple isoforms expressed certain levels tissues single isoform expressed certain level results give better understanding meaning presence multiple isoforms mammals
background ovarian reserve testing serum anti hormone provide information womans fertility potential aim study assess interest knowledge testing investigate utility measuring women reproductive age pregnancy methods women ages years currently delaying childbearing invited take survey regarding attitudes knowledge testing measurement explanation results results women took pre test survey believed testing beneficial median women underwent testing iqr nineteen percent women percentile age undetectable although women using hormonal contraception none known risk factors diminished ovarian reserve seventy eight percent women low levels age planned seek fertility preservation pregnancy levels within established age post test survey reported benefit knowing level follow testing months initial measurement showed stable levels participants conclusions women interested testing women knowing level whereas lower fertility preservation options attempt pregnancy earlier
new pathological elements voltage mirror current mirror shown advantages analog behavioral modeling circuit synthesis recently floating mirror elements used derive pathological sections ideally represent various popular analog signal processing properties involve differential multiple single ended signals order take advantage symbolic nodal analysis mirror networks present equivalents differential voltage cell differential voltage cell current replication cell paper proposed equivalents used represent many popular active devices performing symbolic two representative filter circuits containing differential characteristics active devices given verify feasibility expect used within analog design automation environment enhance circuit analysis modeling
world population corresponding million individuals infected hepatitis virus hcv small single stranded rna virus prevalence hcv infection among dialysis patients japan europe north america period found study hcv spread facilities still occurs increased hepatic tissue iron shown play deleterious role course hepatitis favor development fibrosis cirrhosis possibly increase risk liver cancer general population regular loss blood circuit routine blood sampling laboratory tests monitoring gut due results iron deficiency patients commonly treated intravenous iron preparations data effects iron patients hepatitis limited studies strongly suggest iron contribute hepatocellular injury iron overload extremely prevalent among population worldwide iron overload toxicity emerged one controversial topic management anemia dialysis patients given known impact iron promoting growth virulence hcv associated liver disease necessary use iron therapy closely monitor plasma markers iron metabolism liver iron stores non means mri avoid iron overload vulnerable population
environmental noise control offered undergraduate students whose major environmental engineering let students know basic knowledge control technologies noise pollution solve related problems one main special courses requires constructed keep date currents noise control technologies paper analyzed current conditions course addition described construction process effects including adjustment content improvement methods revision mode databases performance experiments noise control
objectivesto determine whether racial ethnicity group differences resources enhancing alzheimers caregiver health reach intervention delivery controlled trial based intervention delivered five sites across united states caregivers persons dementia randomized active intervention condition home sessions minutes three telephone sessions minutes intended delivered designed reduce caregiver burden depression improve caregiver self care social support help caregivers manage behavior problems persons dementia recorded type intervention home telephone start stop times whether specific intervention content modules stress management social support administered session reach intervention delivery high randomized caregivers completing least five home sessions receiving eight hours intervention contact black caregivers completed fewer home sessions mean mean whites mean received less total intervention contact time mean minutes mean minutes whites mean minutes significant differences exposure content according race ethnicity found controlling demographic covariates reach received significantly less intervention contact similar interventions examine whether systematic differences intervention delivery across specific demographic subgroups explore implications treatment outcomes
receiver front end supporting non intra band carrier aggregation scenarios fully integrated spectrum sensor detect gap band blockers implemented cmos technology achieved using noise linearized used achieve improvement band filter band edge spectrum sensor detect blocker levels steps system consumes supply
acute valve thrombosis occur surgery sometimes cause hemodynamic instability shock risk factors valve thrombosis atrial fibrillation atrial low cardiac function lack anticoagulation therapy authors present case severe stenosis due valve patient diagnosed phase hypertrophic cardiomyopathy underwent valve replacement required membrane due extremely low cardiac output scheduled left ventricular assist device implantation examination implantation revealed severe stenosis due valve detected echocardiography intensive care unit contributed low cardiac function removed left implantation possibility valve thrombosis considered patient dependent support early examination valve helpful contribute surgical decision making
analysis protein protein interactions protein cross linking coupled mass spectrometry become essential tool recent years variety cross linking reagents used covalently link interacting amino acids identify protein binding partners spatial proximity cross linked amino add residues used elucidate structural models protein complexes main challenges mapping protein protein interaction low low frequency cross linked peptides relative linear peptides accurate efficient matches corresponding peptide sequences low false discovery rates identifying site cross link evaluate current state chemical cross linking mass spectrometry applications special emphasis recent development informatics data processing analysis tools help complexity interpreting data article part special issue entitled physiological enzymology protein functions elsevier rights reserved
paper design build high performance machine presented machine comprises special six phase winding exhibits low harmonic content winding properties discussed detail design process machine shown fem used accurately compute eddy current effects permanent magnets building process shown respect special challenges finally computed results provided
china become world largest paper however pulp paper industry involved high resource consumption severe pollution especially water research assessed eco efficiency chinas pulp paper industry national level level overview regarding production chinas pulp paper industry presented reveal measures reducing environmental impact last two decades based measure used analyze efficiency levels provinces pulp paper industries uncover underlying causes eco efficiency performance index calculated discover drivers productivity growth pulp paper industries results showed pollution treatment chinas pulp paper industry made progress terms water consumption water pollution although absolute amount pollution discharge still large chemical oxygen demand emissions still first critical influencing factor pulp paper furthermore efficiency progress contribution productivity growth policies adjusting industrial structure pulp paper industry resulted scale effects eliminating backward production capacity accelerating moreover productivity pulp paper industry underestimated undesirable outputs ignored indicates environmental regulations positive effects paper companies environmental pressures production activities environmental management future pulp paper companies cost pollution treatment scale effects technology improvement elsevier ltd rights reserved
develop prediction model first recurrence child maltreatment within first year initial report carried historical cohort study using administrative data incident cases child maltreatment physical abuse psychological abuse neglect receiving support services reported april march central child guidance center japan total items related characteristics child maltreatment household related factors selected predictive variables analyzed multivariate logistic regression model association first recurrence maltreatment according stepwise selection procedure six factors identified include year age child aor year age aor offenders history maltreatment childhood aor household financial instability poverty aor absence someone community child aor organization referral source aor using six predictors generated linear prediction model sensitivity specificity respectively model useful assess risk maltreatment help child family welfare develop preventive strategies recurrence author published elsevier ltd
generalized additive mixed models introduced extension generalized linear mixed model makes possible deal temporal structure experimental data structure likely consequence learning fatigue flow attention within experiment human factor unlike molecules plots subjects experiments intelligent beings depend survival constant adaptation environment including environment experiment three data sets illustrate human factor interact predictors interest factorial metric also show especially within framework generalized additive model nonlinear world fitting maximally complex models take every possible contingency account modeling strategy alternative modeling strategies discussed confirmatory exploratory data analysis elsevier inc rights reserved
studies cooperative field research broad range applications including evolutionary biology genetics scientists using ancient molecules source material historical questions colleagues observing interest concern research affecting academic identities concepts history research developed way described cycle technological triggers sanger sequencing polymerase chain reaction multitude experiments ancient dna many molecule promoted time machine media attention enormous experiments implementations began fail contamination discovered tremendous problem media interest many labs lost interest turned systematic research methodology established lab routines problem first addressed control oriented measures later approached cognitive theoretical perspective pitfalls limits became end field reached current plateau productivity cross disciplinary debates conflicts collaborations increasing critical reflection among participants consider joining field kind critical friendship make possibilities give input perspective
background aims recent opioid epidemic prompted renewed interest opioid use disorder treatment little evidence regarding health related quality life hrqol outcomes treatment programs measuring hrqol represents opportunity consider outcomes opioid use disorder treatment patient centered relevant overall health abstinence alone conducted systematic literature review explore extent collection hrqol opioid treatment programs documented treatment program literature materials methods searched pubmed embase psycinfo web science papers published reported hrqol outcome measures substance abuse treatment programs results articles initially identified screening articles met criteria review articles unavailable english therefore articles reviewed articles included quality life measure included validated hrqol measures supported derivation quality adjusted life year utility weights frequently used validated measure addiction severity index non recent studies likely include measure hrqol conclusions hrqol measures rarely used outcomes opioid treatment programs field incorporate hrqol measures standard practice especially measures used derive utility weights instruments provide policy makers evidence impact programs patients lives data quantify value opioid use disorder treatments elsevier inc rights reserved
objective use modern high resolution inner ear imaging modalities evaluate patient migraine associated fluctuating hearing loss without dizziness background described patients disease human temporal bone studies modern high resolution imaging however study date knowledge examines presence patient migraine bilateral hearing loss present mri findings using sequence detecting unique case patient experiencing migraine headaches accompanied fluctuating hearing loss without methods magnetic resonance imaging sequences included three dimensional delayed intravenous enhanced three dimensional fluid attenuation inversion recovery sequences performed bright bright inversion times bright images bright images create composite image bright dark intermediate bone signals results year old female presented left sided hearing loss severe migraine headaches began age past year experienced severe right sided fluctuating hearing loss confirmed drop right sided hearing times increased symptom severity testing within normal limits mri demonstrated presence severe bilateral conclusions present patients without disease relationship migraine disease complex demonstrated patient migraine associated bilateral hearing loss mri documentation severe bilateral fact migraine associated important demonstrates potential relationship pathophysiology migraine given patients previous association migraine hearing loss age appears attacks occur simultaneously hearing loss potentially causative fluctuating hearing loss mediated possibly development new imaging modalities allow studies field inner ear pathology significant implications future research
present study application solar thermal system automatic generation control unequal two area thermal system thermal systems equipped single turbine generation rate constraint dead band system dynamics without tested integral proportional integral proportional integral derivative three degree freedom proportional integral derivative pid secondary controllers simultaneous optimisation controller parameters controller done based optimisation technique pid controllers system outperform controllers terms magnitude oscillation peak deviation settling time system dynamic responses validated random load perturbation sensitivity analysis proves optimised pid controller parameters obtained nominal conditions healthy enough optimised pid controller parameters necessarily needed optimise wide changes system loading inertia constant step load perturbation areas higher integration thermal system safely attributed
paper presents analog building blocks find potential applications display panels buffer source follower high gain amplifier employing type enhancement amorphous zinc oxide thin film transistors designed simulated fabricated characterized circuit simulations carried using neural model developed house measured characteristics transistors circuit presents power consumption amplifier presents gain power consumption load omega authors knowledge highest gain reported far single stage amplifier technology
necessity schools implement human resources management increasingly acknowledged specifically holds potential increasing student outcomes increased involvement empowerment motivation teachers educational literature however little empirical attention paid ways different practices comprehensive system content best implemented attain positive teacher student outcomes process regarding content following theory performance argued systems comprise ability motivation opportunity enhancing practices regarding process based system strength literature argued teachers perceive distinctive consistent perceive consensus enhance teachers schools performance combining insights educational studies single practices theories paper builds conceptual framework used design systems understand way operate
wireless communication systems conventional secret key exchange based public key cryptography requires complex computations retain level key bits proposed physical layer based algorithms shown promising performance extract secret keys shared randomness relying reciprocal channel state communicated nodes study authors propose physical layer key exchange method key bits encoding within phase sequences indexed specific channel criterion sequences data phases thus efficiency reduction incurred fact choosing pool sequences certain statistical properties also used condition signal meet physical layer transmission requirements bandwidth envelope quantify potential proposed method demonstrating within context multiple input multiple output orthogonal frequency division system results reveal relative existing techniques proposed method offers superior key error rate performance lower computational complexity better level
whole human body kidney undergoes age related changes translate progressive decline renal function renal aging multifactorial process gender race genetic background several key mediators chronic inflammation oxidative stress angiotensin system impairment kidney repair capacities background cardiovascular disease play significant role features aging kidney include macroscopic microscopic changes important functional adaptations none aging assessment renal function framework aging problematic question whether renal aging considered physiological pathological process remains much debated issue although promising dietary pharmacological approaches tested aging processes renal function decline elderly proper lifestyle modifications applicable general population currently represent plausible approach maintain kidney health elsevier rights reserved
background decreased endothelial function prognostic marker stroke measuring pharmacological effects interest development personalized medicine stroke prevention study assessed reliability repeated measurements using pulse amplitude technology acute stroke patients similarly reliability tested healthy subjects devoid vascular disease estimate reactivity reliability younger non stroke population materials methods assessed using healthy volunteers men mean age years stroke patients men mean age years mean standardized conditions measured reactive index measurements separated assess day day day reliability respectively results fair moderate correlations measurements correlation coefficient icc day day detected healthy subjects stroke patients found moderate substantial correlation day day day repeated measurements day day compared showed best reliability conclusion repeated measurements stroke patients show moderate reliability day substantial day day measurements likewise healthy subjects substantial reliability day day measurement moderate day measurements general day day correlation repeated measurements far better day measurements ranged poor moderate depending specific outcome measure possible effect considered day repeated testing drug effects applied future studies
mast cells long lived resident cells known substantial role antigen induced anaphylaxis immunoglobulin mediated allergic reactions tumor promotion activation results release pro inflammatory factors histamine tumor necrosis factor stored secretory granules ige dependent hypersensitivity thought major pathway mediating mast cells nucleotide receptor activated glucose also enhance process study identified molecule inhibiting induced rat mast cell line additionally diminished evoked intracellular calcium mobilization stable cell line overexpressing receptor therefore demonstrate use novel anti inflammatory approach based preventing mast cell activation
propose many core gpu implementation robotic motion planning formulated semi infinite optimization program approach computes constraints gradients parallel result nonlinear optimization solver running cpu ensure continuous satisfaction constraints use polynomial approximations time intervals constraint gradient evaluated independently time interval end highly problem take advantage many core architectures classic robotic computations geometry kinematics dynamics also benefit parallel processors carefully study implementation context results full constraint running gpu present several optimization examples robot reveal substantial improvements terms computation performance compared parallel cpu version
paper propose multi cue object representation image classification using standard bag words model ever since success bag words model image classification several modifications proposed literature variants target improve key aspects efficient compact learning advanced image encoding techniques methods efficient kernels final classification step particular soft encoding methods sparse coding locality constrained linear coding fisher vector encoding received great attention literature improve upon hard assignment obtained vector quantization nevertheless methods come higher computational cost little attention paid extracted local features contrast propose novel multi cue object representation image classification using simple vector quantization show highly competitive classification performance compared state art methods popular datasets like apart object representation also propose novel detection scheme helps achieve classification rate comparable popular dense sampling strategy much lower computational cost elsevier ltd rights reserved
like many developing countries taiwan experienced social process constructing controlling population relied fertility studies essential governing tools article investigates population politics knowledge production taiwan synthesizing three bodies literature just begun one another histories population control analyses turn cold war history production social scientific knowledge via science study approaches along complexities asian three main social elements affecting production knowledge time discussed historical cold war civil war met acting group taiwanese agencies individuals took part process three types fertility studies data ultimately expanded focus process population control population general reproductive behavior women complexities asia also discussed
gain better understanding dimensions characteristics phenomenon child maltreatment policy responses article provides systematic review peer reviewed literature review provides summary analysis core child maltreatment issues examines child protection policy responses takes systematic approach identifying peer reviewed articles diverse range scholarship met criteria subjected quality appraisal tool findings provide important details child maltreatment child protection arrangements recommends research policy approaches child maltreatment greater focus social cultural structural influences child maltreatment investigation child maltreatment particularly child sexual abuse contexts outside home institutions
genome wide association studies gwas generalization replication genotype phenotype association population different population first identified current practices rely testing associations controlling family wise error rate discovery study separately controlling error measures follow study approach guarantee control false discovery rate generalization null hypotheses also fails leverage two stage design increase power detecting generalized associations provide formal statistical framework quantifying evidence generalization accounts consistency directions associations discovery follow studies develop directional generalization controlling values used associations generalized framework extends generalization testing applied published list single nucleotide polymorphism snp trait associations methods control various snp selection rules based values discovery study find often beneficial use value threshold genome wide significance threshold gwas total cholesterol hispanic community health study study testing snps values genomic regions generalization large gwas whites generalized snps regions testing snps values regions generalized snps regions
study prevalence erectile dysfunction serum sexual hormone levels evaluated men obstructive sleep apnea patients efficacy continuous positive airway pressure determined men mean age years enrolled study stratified within four groups based apnea index score simple mild moderate severe international index erectile dysfunction score obtained patient blood samples analysis sexual hormones prolactin follicle stimulating hormone estradiol progestin testosterone drawn morning test serum sexual hormone measurements repeated months treatment men severe prevalence patients overall severe compared simple group patients severe significantly lower testosterone levels lower scores differences sexual hormones groups significant months treatment significant changes sexual hormone levels score improved significantly severe patients low testosterone concentration high prevalence scores increased significantly treatment effect serum testosterone levels
four conjugated iii iii based metal complexes synthesized screen inhibitor activity prostate cancer cells complexes show high stability solubility biological system study iii complex kappa inhibit translocation transcriptional activities moreover complex shows potential activity cells suppresses tumor growth prostate cancer xenograft mouse without observable adverse effects complex provide basis developing new therapeutic strategy vivo vitro treatment advanced prostate cancer elsevier rights reserved
environmental impact major oil marine microorganisms yet thoroughly investigated using molecular biology techniques horizon drilling rig explosion affected approximately surface area mexico estimated million oil prospect environment complex two surface species marine brown critically important habitat ecosystem prospect oil released event using rrna pcr effect oil bacterial population associated waters examined comparing sequence data generated samples collected non locations northern sequence data showed similar microbial composition regardless exposure oil primarily dominated five bacteria microbial composition water samples significantly less diverse consisted primarily due distributed abundance microbial species non study findings indicate oil minimal effect composition diversity microbial community associated waters however higher one species found water samples compared non water samples indicating effect oil microbial composition seawater though number marine studies using molecular biology approaches first molecular examination impact oil bacterial communities associated waters
background double blind placebo controlled food challenge considered definitive diagnostic test food allergy nevertheless validated foods scarce standardized differ centers sensory evaluation techniques triangle test necessary validate used methods developed use milk egg white used triangle test validate phase study volunteers participated phase participants tried samples active placebo placebo active identify odd one phase samples given simultaneously whereas phase samples foods failed validation phase given sequentially visual analog scale vas ranging used evaluate much participants results phase egg white validated volunteers found odd sample milk validated phase foods participants found odd sample median vas scores ranged conclusions used sensory testing validate milk egg white use validated easy prepare clinical setting provide equivalent serving dose participants
introduction patients philadelphia negative chronic myeloproliferative neoplasms mpn vera essential primary myelofibrosis pmf prone develop thrombotic events aimed investigate coagulation status plasma using generation assay tga functional global assay alpha materials methods samples collected consecutive negative mpn patients controls tubes blood cell counts tga coagulation screening tests generation analysed platelet poor plasma using tga assay kit results found significantly increased peak generation velocity index patients comparison controls especially patients significantly higher values peak patients receiving comparison treated hydroxyurea also noticed inverse correlation length therapy tga parameters peak auc conclusion results suggest mpn patients especially thrombotic events due higher peak values risk decreases treatment longer patients treated hydroxyurea generate less less prone develop thrombotic events comparison treated
part paper proposed analyzed novel algorithmic framework minimization objective function subject constraints based inner convex approximations part devoted application framework following relevant large scale problems ranging communications machine learning rate profile maximization mimo interference broadcast networks max min fair problem environment general constrained criteria formulation sparse variable selection statistical learning two criteria loss objective function measuring fitness model data latter sparsity inducing constraint general form difference functions allows unified fashion convex function proposed algorithms outperform current state art schemes theoretically numerically instance first distributed schemes class problems also lead closed form solutions
background reward punishment sensitivities identified potential contributors binge eating compensatory behaviors though studies examined gender differences behaviors method college aged sample completed eating disorders diagnostic scale sensitivity punishment sensitivity reward questionnaire results rates binge eating similar males females among reporting compensatory behaviors women reported engaging compensatory behaviors frequently men sensitivity reward sensitivity punishment positively associated binge eating frequency genders contrast women high reward sensitivity reported engaging compensatory behaviors frequently conclusions rates binge eating compensatory weight control behaviors similar college aged males females though females engaged compensatory behaviors frequently males sensitivity punishment greater females whereas sensitivity reward greater males reward punishment sensitivity positively associated binge eating males females reward sensitivity positively associated compensatory behaviors females
main plant source precursor production steroid hormones used pharmaceutical industry extraction process generate high acid high strength wastewater large scale threaten environment microorganisms produce effective way avoid pollution however little known genes involved biosynthesis obtained average length bases transcriptome rna seq large number annotated assigned secondary metabolite pathways database encoding key enzymes found present biosynthesis pathways addition found encoding proteins encoding proteins involved modifications downstream pathway expression patterns key biosynthesis genes studied identify important members enzyme family results add available genetic data lay foundation production using genetic engineering
purpose headache common presenting feature patients pituitary tumors region however present still unclear whether headache actually caused tumor explore whether relation examined detail headache types relationship underlying pathology headache responded prospective study design methods one hundred twelve patients tumors region scheduled single center analyzed presence quality headache surgery least months surgery patients received headache depression self rating presented computer clinical variables thought impact headache analyzed conjunction results fifty nine patients reported headache months prior headache time filling questionnaires four patients pituitary described headache patients diverse headache types encountered frequently migraine untreated deficiency significantly associated absence headache none clinical morphological variables related headache presence headache disability due headache significantly reduced surgery conclusion apart pituitary detected specific headache type patient group significant improvement headache headache alone constitutes neither valid diagnostic marker presence tumors region sufficient indication tumor removal
health care changing rapidly change times develop efficient practical cost effective importantly high quality methods care patients teach medical students optimal patient care requires face face interaction collect information patients history perform physical examination however management many patients especially chronic diseases always require physical examination offers opportunity take advantage technology leveraging progressive push toward efficiency value also requires belief excellent patient care always provided person include variety aspects patient care adapted performed remotely education evaluated practice demonstrated feasibility patient preference produced mixed results regarding patient outcomes combining tools new care models chronic disease management include fewer person visits patients yet increase access patients need seen change lead higher value care improving experience care decreasing costs improving health population barriers include reimbursement licensing fear however hope meet needs patients within changing health care system incorporated strategy
lack appropriate animal models affective disorders major factor better understanding underlying pathologies development efficacious treatments circadian rhythms play important role affective disorders recently suggested diurnal rodents advantageous model animals found diurnal rodents short photoperiod induces depression anxiety like behaviors similarities human seasonal affective disorder pilot study also found behaviors ameliorated morning bright light administration present study evaluated effects morning evening bright light administration short photoperiod induced depression anxiety like behaviors diurnal fat sand rats animals maintained short neutral photoperiod treated morning evening bright light red light control morning bright light ameliorated behavioral deficits elevated plus maze social interaction tests whereas evening bright light effective social interaction test first detailed presentation effects bright light treatment animal model clear demonstration advantages utilizing diurnal rodents study interactions circadian rhythms affect
background partners cancer patients report psychological distress reduced quality life however partners mental health status quality life child rearing years influence social support yet studied objective aim study describe psychological distress quality life social support partners facing cancer child rearing years investigate whether social support moderated relationship psychological distress quality life methods cross sectional data collected norway december july part cancer study results five questionnaires administered females males participants reported psychological distress lower quality life scores healthy norwegian populations psychological distress seemed associated control received social support moderated effect psychological distress quality life conclusions facing cancer child rearing years seemed substantial impact partners mental health adverse impact quality life accordingly partners self care abilities reduced received social support reduce multiple burdens consequently allow enhancement self care implications practice interventions aim improve social support provided child rearing partners improve quality life providing adequate information partners cancer illness treatment enhance feelings control beneficial mental health status
applications artificial intelligence considerably expanded recent years new class industrial systems beginning evolve incorporates using high volume data advanced analytics better optimize product quality reducing energy consumption artificial neural networks ann combined advanced modeling control begins form platform enhanced future paper provides demonstration initial work developed future systems generic way considering polymer processing plastic injection cavity temperature profile directly relates part quality part reject rates therefore desirable optimize cooling process using real time control directly affect part quality however affected number interacting nonlinear dynamic parameters often neglected due challenge quantifying parameters advanced model based control algorithms often used providing improved control complex systems however depend good model formulations analytically insufficient online intelligent system identification approach cooling process developed tested ann designed adjust online sub space parameters govern cooling model results demonstrate online ann approach used accurately predict dynamic behavior cavity surface temperature key many industrial systems states directly observable uncertainties unknown methodology readily adapted different operating conditions case polymer processing good potential integration advanced model based control schemes cloud computing approaches next generation machines elsevier ltd rights reserved
partial label learning aims learn training examples associated set candidate labels among one label valid training example basic strategy learn partial label examples trying recover ground truth labeling information candidate label set one popular machine learning paradigms maximum margin techniques employed solve partial label learning problem existing attempts perform optimizing margin maximum modeling output candidate labels non candidate ones nonetheless formulation considering margin ground truth label candidate labels paper new maximum margin formulation partial label learning proposed directly optimizes margin ground truth label labels specifically predictive model learned via alternating optimization procedure coordinates task ground truth label identification margin maximization iteratively extensive experiments artificial real world datasets show proposed approach highly competitive established partial label learning approaches
sinus augmentation procedure demonstrated highly predictable treatment posterior atrophy surgical interventions region require deep knowledge anatomy possible anatomical variations article pre operative post operative assessments sinus cavity novel approaches knowledge behavior bone substitute materials described awareness patients conditions enables exact planning invasive surgery aids avoid complications pre operative evaluation region sinus lift planning sinus augmentation selection alignment optimum placement implants possible measure vertical dimension graft volume changes cone beam computed tomography become gold standard plan comprehensive implant treatment achieve post operative assessment computer aided design computer aided manufacturing cad cam technique proposed produce custom made block sinus lift procedure customized cutting guide accurately place lateral wall ease membrane elevation procedure allows reduce intervention time precisely adapt scaffold reduce risk complications improve operation quality recently novel approach used knowledge behavior means micro tomography analyzing method suitable examine dynamic spatial arrangement regenerative phenomena complex anatomical structures bone tissues several morphologies alveolar process extracellular matrix regenerated vessels etc compete achieve final goal bone regeneration
mechanical properties soft materials critically important wide range applications ranging packaging biomedical purposes constructed simple mechanical testing apparatus using shelf materials open source software total cost less device consists frame supporting central loading apparatus attached via perform mechanical test sample within two custom made printed base frame load cell extension force applied user moving central loading apparatus thereby stretching sample recording force measured load cell displacement measured ultrasonic sensor load cell ultrasonic sensor linked arduino microcontroller connected port data acquisition analysis instrument easy assemble enabled students better grasp meaning tensile testing promoting experimentation electronics computer programming mechanical design low cost ease use arduino based tensile ideal device introduce concepts mechanical properties among concepts students numerous fields
dual energy ray imaging vast range application security inspection essential process court house security securing mass events image content package help figure dangerous object inside avoid possibly threatening situation raw ray images always easy analyze interpret image processing methods like object detection frequency resolution increase used since color powerful tool improve usefulness information display propose improvement modifying material based approach edge detection fill color layers image making easier read analyze demonstrate effectiveness methods using real data acquired professional dual energy ray scanner
dielectric electro active polymer suitable actuator material finds wide applications field robotics medical areas material highly controllable flexible capable developing large strain influence geometrical behavior becomes critical material used miniaturized actuation devices robotic applications present work focuses effect surface topography performance flat single sheet stacked actuators non active areas form spots affect performance actuator identified using scanning electron microscope sem energy ray experiments performance actuation critically evaluated compared presented analytical experimental results
paper presents estimation power output produced electro active paper energy harvesting transducer base vibration thin cellulose piezoelectric film exhibits direct piezoelectric effect subjected stress patch bonded aluminum cantilever structure energy harvesting tests performed energy harvesting transducer without proof mass near tip cantilever beam voltage current power frequency response functions respect base acceleration identified presented voltage show monotonic trend increasing load resistor omega omega current also demonstrate monotonic dynamic behavior trend opposite voltage contrast voltage current output power show monotonic trend exhibiting maximum value without proof mass output power increases proof mass attached preliminary study indicates promising energy harvesting transducers vibration environment
growing leaves expand constant rate exhibit pronounced growth rhythms however mechanisms giving rise distinct growth dynamics different species still largely unknown first step towards identifying genes controlling rate timing leaf growth analysed rapidly expanding fully expanded leaves points high low expansion night tissues defined temporal growth rates harvested using online growth monitoring system based digital image sequence processing method developed quantitative mapping leaf growth unlike plants studied previously leaf growth characterised lack base tip gradient across lamina maximal minimal growth respectively microarray analysis revealed nocturnal decline growth regulation ribosomal protein genes indicating cytoplasmic growth subsequent time course experiment northern blotting real time pcr confirmed ribosomal protein gene cell cycle gene regulated following decrease cellular carbohydrate concentrations thus propose spatio temporal growth pattern leaves primarily arises cytoplasmic growth whose activity increases thereafter decreases species
considered one major environmental hazards poses threat plant animal health selenium however recognized essential plants understand role oxidative stress management regulation defence mechanism heavy metal stress seedlings raised plates containing nutrient media supplemented combination observed causes increase reactive oxygen species ros seedlings leading oxidative stress histological studies using confocal visible microscopy confirmed biochemical results supplementation media containing reduced contents ros increased enzymatic non enzymatic antioxidants seedlings concentration however toxic results suggested appropriate concentrations exogenous application enabled seedlings counteract effects thereby increasing resistance plants
theories morality emphasize reasoning plays important role moral judgments prosocial behavior theory mind reasoning ability mental domain considered moral development present study examined whether theory mind consistently positively associated morality middle childhood late adulthood two hundred four participants including elementary school children adolescents younger adults older adults completed theory mind moral judgment prosocial behavior tasks theory mind measured stories understanding lies white lies double moral judgments measured variants dilemma prosocial behavior measured participants performance interactive situation helping request made results indicated specific rather similar developmental trajectories theory mind moral judgments prosocial behavior quadratic trend theory mind combination quadratic cubic trends moral judgments linear decline helping behavior thus suggested theory mind associated morality way development results indicated theory mind moral judgments negatively correlated children adolescents older adults positively correlated younger adults theory mind helping behavior positively correlated children negatively correlated adolescents however relationships disappeared adulthood sum present study reveals theory mind tool facilitation moral judgments prosocial behavior also tool blocking moral judgments prosocial behavior moreover theory mind permanent tool moral judgment development temporary tool prosocial behavior development thus present study theories morality developmental perspective different relationships theory mind morality middle childhood late adulthood discussed
article means intervention two departments centre secondary prevention addiction treatment military hospital department psychiatric hospital first department runs detoxification short term one month intervention programme medium term long half year programme implemented second part text presents results focused tracing differences connections clients perception benefits overall concept intervention said departments implementation questionnaire method reveal differences evaluations clients departments
rheumatoid arthritis immune mediated disease primarily affects joints susceptibility severity disease influenced factors environmental stress suggesting important role epigenetic changes review summarize epigenetic changes dna methylation histone modification mirna expression fibroblast like joint mesenchymal cells play important role joint inflammation damage also review effects epigenetic changes rheumatoid arthritis pathogenesis discuss therapeutic potential
objectives characterization strains regard gene role binding proteins heterogeneous resistance methods eighty four randomly selected highly resistant isolates included agar dilution methods used determination pcr experiments nucleotide sequencing used detect gene molecular features binding experiments determine affinity assays also applied southern blotting used determine copy number genes results sixteen strains random collection proved positive distribution negative positive strains display clear separation majority positive strains collection common region end region encoded open reading frame exhibited homology infection proteins genes low frequencies conjugation experiments affinity studies species largely insensitive whereas species affected low concentrations seven resistant strains positive mutations regulatory regions conclusions major minor roles respectively inferred role newly recognized control copy number
context currently many service operations performed service oriented software engineering service composition discovery depend heavily quality service qos due factors varying loads real value dynamic qos attributes response time availability changes time however existing qos based studies approaches consider changes instead assumed rely static qos information provided service providers seriously impair outcomes objective predict dynamic qos values objective devise approach generate predictor perform qos forecasting based past qos observations method use genetic programming type evolutionary computing used search based software engineering forecast qos attributes web services proposed approach used search evolve expression based one step ahead qos predictors evaluate performance accuracy based approach also implement current time series forecasting methods comparison approach methods discussed context real world qos data results compared common time series forecasting methods approach found suitable stable solution defined qos forecasting problem addition numerical results experiments also analyze provide detailed descriptions advantages benefits using perform qos forecasting additionally possible validity threats using approach validity discussed evaluated conclusions paper thoroughly completely demonstrates realistic situation real world qos data proposed based qos forecasting approach provides effective efficient accurate forecasting considered instance elsevier rights reserved
study examines time report following close maltreatment investigation cases involving food neglect data families children involved child protective services investigations cohort national survey child adolescent national child abuse neglect data system used half families history involvement third received services one ten families child place home care following investigation controlling types maltreatment multiple covariates families investigated food neglect greater chance reported subsequent investigations shorter length time families without food neglect small percentage families food neglect problems adequately feeding child whether due severe poverty abusive placed family higher risk future investigation elsevier ltd rights reserved
background aged residents institutional long term care facilities high risk developing skin tissue diseases besides various common skin problems dry skin one frequent skin conditions setting objectives investigate effectiveness two structured skin care regimens comparison routine skin care nursing home residents design multi center pragmatic randomized controlled blinded study three parallel groups settings study conducted random sample ten institutional long term care facilities federal state germany participants long term care residents years affected dry skin included methods residents allocated one three study groups two interventional groups used standardized skin care regimens consisting body twice daily applications leave products eight weeks third control group performed skin care usual participating residents examined baseline weeks measured overall dry skin score instrumental skin barrier measurements performed baseline weeks diaries used document washing skin care frequencies results total residents included allocated one three groups mean age years female residents care levels according german social code book mean score mean score leg skin areas compared arms trunk areas end study overall dry skin scores intervention groups lower compared control group statistically significant improvements skin intervention groups compared control group time conclusions results pragmatic trial indicate structured skin care regimens effective reducing skin aged nursing home residents within eight weeks elsevier ltd rights reserved
gram negative bacterium isolated spa waters described beneficial effects skin characterized detailed structure lipopolysaccharide lps lipid moiety active component bacterium contributes observed skin activation properties two different differing cell recovery tested chemical analyses mass spectra obtained mild treatments revealed lipids share common beta linked acid linkage short chain fas acid found ratio two lipid structures differed relative amount acyl molecular species substitution phosphate groups two lps induced variable interleukin tnf secretion stimulated cells without difference reactive oxygen species production activation caspase different known highly purified lps samples characterized structurally used standards structural data obtained work explain low inflammatory response observed lps previously demonstrated beneficial effects skin
paper propose novel domain decomposition method large scale simulations continuum mechanics merging concepts particle dynamics introduced achieve high level partitioning algorithm decreases energy number computational elements neighboring partitioning scales communication effort parallel simulations optimized implicitly generated partitioning convex simply connected small aspect ratios moreover particle dynamics employing physical analogy tailored equation state developed particle system towards target partition good load balance since equilibrium computed iterative approach partitioning exhibit locality incremental property numerical experiments reveal proposed particle based algorithm produces high quality partitioning high efficiency independently computational element types thus used wide range applications computational science engineering elsevier inc rights reserved
introduction detailed comparative analysis effects direct current point stimulation autonomic nervous system applied protocol patients histories pain methods evaluations standard baseline visual analogue scale vas pain saliva cortisol baseline status autonomic nervous system functions total markers repeated prior following cohort patients results response point electrical nerve stimulation reflected statistically significant pre post improvement markers collected pain vas scale reduced points confidence interval heart rate variability improved points high frequency tone improved points exercise tolerance increased points parasympathetic activity improved points stress reduced points index cardiac marker endothelial function arterial blood flow regulation improved points cardiac marker low frequency index regulation marker endothelial function indicator cell activity statistically significant reduction points salivary cortisol decreased points conclusions positive impressive results study showed significant improvement several parameters function reduction pain cortisol levels replicated study way use applied protocol pathologies known affected sympathetic nervous system activation
testosterone suggested risk factor disease correlate disease severity low common men sexual dysfunction role pathogenesis remains unclear aim study compare prevalence low men low compared men levels correlate plaque size degree curvature group sexual dysfunction characterized either similarly low levels low correlate severity surgical correction rate comparable prevalence low men suggests high rate low men related common process among men abnormal erectile physiology specifically causative plaque formation low testosterone similar prevalence among men sexual dysfunction due either disease erectile dysfunction correlate disease severity sex med
many couples want together even differ age drawing theories leisure gender roles social status article uses comprehensive swedish register data explore association age differences socio demographic factors rates dual couples per cent year per cent following year contrary theoretical expectations common women older couples men older couples although largely consequence skewed distribution age differences moreover education assets employment health differently associated age men older women older couples total population average age differed little couples couples yet women earlier age women whereas men later men partly effect predominance men older couples men men older couples also likely women women older couples delay order
excessive force lead damage tissue minimally invasive surgery study focuses mechanism laparoscopic surgery tool order control force first dynamics mechanism conventional laparoscopic investigated using analytical experimental methods smart laparoscopic surgery tool designed using shape memory alloy wire bias spring force controlled actuator different type controllers performance controllers compared closed loop dynamics mechanism achieved overshoot zero steady state error elsevier ltd rights reserved
novel replacement traditional used mount boards cold plates presented project began part design competition develop field reversible thermal repeatedly assembled without use tools providing constant thermal resistance team designing new device meet constraints design meets goals significantly reduces thermal resistance electrical board heat sink device consists opposing aluminum driven thermally actuated springs one another provide force hold board place decrease contact resistance interfaces smart material springs push towards outside device upper surface board place cold plate design increases contact area components decreases thermal resistance relative current devices experimental results shown team addressed chief design problems posed program shown effective material use thermally actuated spring capable repeatedly engaging without use tools force increases rising temperature enhancing thermal performance design shown perform similar sized current state art designs terms thermal resistance reductions thermal resistance demonstrated shown prototype design increases interfacial contact area dramatic impact performance means higher power density electronics utilized real made available current computer boards order maintain current performance use thermally actuated leaf springs removes need mechanical force installation allowing less installation time
objectives examine relationships location demographics lifestyle beliefs experience hot night amongst women living two cities thailand methods cross sectional study peri postmenopausal women aged years participants completed questionnaires demographics health prevalence frequency problem rating beliefs menopause sub sample women location interviewed results total women aged standard deviation years took part prevalence average frequency per week problem rating women significantly problematic prevalence frequency similar sites poor general health predicted prevalence frequency location frequency age diet beliefs menopause associated problematic location remained significant controlling education occupation age location partially explained beliefs qualitative interview responses illustrated differences beliefs menopause locations conclusion reports prevalent moderate frequency problem ratings urban centers thailand results included broader international menopause society study climate altitude temperature cat impact climate
background incidence inflammatory bowel disease ibd increases thus common pregnant women ibd risk factor venous thromboembolism clear whether ibd women excess risk pregnancy postpartum period methods nationwide population based cohort study denmark using data two nationwide health registries danish national patient registry medical birth registry computed incidence rates per person years crude adjusted relative risks confidence intervals cis pregnancy first postpartum weeks women without ibd results included women identified events pregnancy events postpartum pregnancy ibd patients women without ibd corresponding adjustment maternal age smoking pregnancies yielded adjusted ibd associated pregnancy postpartum among ibd patients women without ibd corresponding adjusted conclusions ibd risk factor pregnancy postpartum
purpose study evaluate transfer learning deep convolutional neural networks classification abdominal ultrasound images images consecutive clinical abdominal ultrasound studies categorized categories based text annotation specified image images resolution randomized images studies training set images studies test set fully connected layers two convolutional neural networks based previously trained large scale visual recognition challenge data set training set weights convolutional layers network frozen serve fixed feature accuracy test set evaluated network experienced abdominal ultrasound also independently classified images test set categories network classified test set images accurately images top accuracy images larger network classified test set accurately images top accuracy images classified test set images correctly images differences classification accuracies neural networks statistically significant results demonstrate transfer learning convolutional neural networks used construct effective classifiers abdominal ultrasound images
among occurring conditions autism spectrum disorders asd sleep disorders exacerbate associated behavioral disorders lead existing autistic symptoms several studies investigating use melatonin treatment sleep disorders asd shown comparative efficiency sleep little side effects report case asd non hour rhythm effect melatonin circadian parameters actigraphy visual analysis first days recorded suggest patient showed non hour rhythm asd subject showed melatonin administration activity rest rhythm lower hours results show melatonin increased approximately times regularity circadian activity rhythm resting average showed positive effects improving quality sleep behavior actigraphy showed asd subject non hour activity rest rhythm changed rhythm hour rhythm melatonin administration result prospect therapy melatonin synchronization increased regularity endogenous rhythms improve sleep quality hence behavior indicates actigraphy choice tool characterize several parameters activity rest rhythm asd individuals
previously shown combination metabolic glucose results oxidative stress mediated malignant cells via mitochondrial dysfunction non coordinated expression antioxidant defense besides inhibition repair recovery present study objective study panel human malignant cells various origins lung carcinoma squamous carcinoma oral carcinoma inhibitory activity combination tumor growth considered general phenomenon determine effect cell cycle results revealed combination treatment result significant cell growth inhibition induced ros generation cancer cells studied anti proliferative effect related ability combination provoke growth inhibition arrest apoptosis furthermore combination induced arrest closely correlated decreased cyclin cyclin levels
glycerol skin improve barrier function short period studied effects glycerol physiological properties morphology skin longer term application twelve volunteers dry skin examined three areas arms determined area served untreated control vehicle applied area area treated twice daily formulation containing glycerol days water loss hydration biomechanical properties skin monitored biopsies taken routine histology immunohistochemistry matrix metalloproteinase mmp increased skin hydration protein quantity elevated index decreased improved biomechanical properties skin change protein expression mmp combination glycerol useful additional therapy dry skin
fully digital nonlinear wide bandwidth current controller voltage source converters presented paper exploiting sampling controller mimics analog hysteresis current controller employ analog digital analog converters analog signal pre circuitry indeed fully hysteresis controllers operation based nonlinear efficient current error processing algorithm drives power converter almost constant switching frequency overall offers excellent dynamic performance analog hysteresis controller time solves related problems current error sample processing algorithm inherently parallel structure controller suited synthesis field programmable gate array implementation guarantees flexibility low cost together minimum computation signal conversion delays intended application areas include active filters power supplies microgrid distributed energy resource controllers laboratory battery welding machines
acetylcholinesterase inhibitors one drugs families validated clinical use treatment alzheimers disease reason finding new potent selective always interest since inhibitory activity evaluated method herein reported based evaluation potential new determination inhibitory activity compared method uses substrate analog ionization ion trap mass spectrometry consists monitoring conversion ratio low concentration natural substrate acetylcholine present inhibition activity six bearing different functional groups position towards recombinant human acetylcholinesterase mechanisms action selected inhibitors evaluated means plot analysis constants inhibitory constants examined allow classifying series derivatives inhibition potency comparison reference results demonstrate drugs potent inhibitors especially inhibitory activity recombinant human range study reveals interest compounds treatment published elsevier
emerging cloud applications growing rapidly need identifying managing service requirements also highly important critical present software engineering information systems established techniques methods technology two decades help achieve cloud service requirements design development testing however due lack understanding software security vulnerabilities identified managed requirements engineering phase successful applying software engineering information management requirements management principles established past least years developing secure software systems therefore software security just added system built delivered customers seen todays software applications paper provides concise methods techniques best practice requirements engineering management emerging cloud service also provides guidelines software security service paper also discusses integrated secure model benefit practitioners researchers learners educators paper illustrates approach large cloud system amazon service elsevier ltd rights reserved
order improve quality human beings living working environment different types wood structure building ecological architecture green building advocated due lots advantages study compared three types houses different weather conditions peoples psychological physiological indexes results showed temperature heart rate respiratory rate people different types housing environment different physiological indexes structural wood structure environment better steel concrete structure environment physiological indexes structural environment better structure environment means subjects test easy comfortable relaxed feeling structure environment provided theoretical support use product scientific efficient ways guidance design application construction structure environment future
context states obesity women associated insulin resistance androgens reduce glucose uptake adipose cells increase tnf alpha production peripheral monocytes inflammatory cytokines known detrimental effect insulin resistance aim present study explore role testosterone local cytokine production visceral adipose tissue women reproductive age design twenty four women years old undergoing elective abdominal surgery benign non inflammatory conditions recruited study women clinical diabetes hepatic renal dysfunction hypothyroidism bmi drugs known interfere hormonal levels fat metabolism excluded women classified two groups according bmi non obese bmi obese bmi basal blood sample drawn time surgery measurement glucose insulin total testosterone lipid profile circulating total adiponectin fat tissue obtained women samples adipose tissue incubated vehicle testosterone androgen receptor mrna levels measured real time quantitative polymerase chain reaction qpcr normalized expression secretion measured conditioned media elisa results expression significantly higher obese group compared non obese group fold fold differences groups markers total group without stimulation significant correlations expression bmi levels total cholesterol expression expression correlated bmi levels stimulation produced increase expression significantly larger obese group compared non obese group obese non obese moreover whole group positive correlation expression treated tissues bmi cytokine followed pattern mrna without significant differences conclusions testosterone increases expression visceral adipose tissue obese women reproductive age response associated bmi results show new possible mechanisms connecting androgens insulin resistance chronic inflammation elsevier rights reserved
authors describe case patient appears suicide case identified result routine internally collected suicide data government collected mortality data authors discuss evolution concept clinical literature consider issues related behaviors suicide surveillance measurement
chronic hepatitis virus hcv infection characterized high variability response interferon ribavirin genetic polymorphism chromosome upstream interferon associated twofold change sustained response rate treatment interferon ribavirin hcv genotype treatment naive patients conducted epigenetic analysis promoter investigate whether dna methylation associated response hcv therapy dna samples hcv infected subjects receiving interferon free containing combination regimen hcv uninfected healthy controls analysed methylation levels methylation strongly associated allele status whether adjusting hcv status hcv infected subjects genotypes significantly lower methylation levels relative genotypes allele resulting nine unit increase mean methylation level methylation levels correlate response subjects treated weeks however non subjects higher methylation levels likely relapse treatment duration analysis suggests methylation status promoter region useful parameter identifies patients likely relapse following hcv therapy however continuing therapy sufficient duration overcome difference findings provide mechanistic insight role genetic variants hcv treatment response
fully mature vast number available virtualization solutions uptake creating opportunity remote virtual laboratories either supplement fully replace physical networking laboratories approach focuses nodes rather environments hosting nodes paper addresses setting virtual laboratories made widely available general purpose operating systems based linux act network operating system discuss several software defined networking solutions lay configuration setup virtual laboratories evaluate opportunity provide context learning potential experience conclude observation increasing number linux based network operating systems management network devices becomes management servers leads cloud fabric
adaptive deep brain stimulation uses feedback state neural circuits control stimulation rather delivering fixed stimulation time currently performed patients parkinsons disease elevations beta activity nucleus demonstrated correlate clinical impairment provided basis feedback control trials adaptive deep brain stimulation pilot studies suggested adaptive deep brain stimulation potentially effective efficient selective conventional deep brain stimulation implying mechanistic differences two approaches test hypothesis differences arise differential effects temporal dynamics beta activity latter constantly increased parkinsons disease comes different durations amplitudes demonstrate amplitude beta activity nucleus increases proportion burst duration consistent progressively increasing synchronization effective adaptive deep brain stimulation truncated long beta shifting distribution burst duration away long duration large amplitude towards short duration lower amplitude critically shorter duration negatively longer duration positively correlated motor impairment stimulation conventional deep brain stimulation change distribution burst durations although adaptive conventional deep brain stimulation suppressed mean beta activity amplitude compared state achieved selective effect burst duration adaptive deep brain stimulation whereas conventional deep brain stimulation globally suppressed beta activity relatively selective effect adaptive deep brain stimulation provides rationale approach efficacious conventional continuous deep brain stimulation treatment parkinsons disease helps inform adaptive deep brain stimulation best delivered
article presents personal account socially just inclusive education means academic university identify critical elements recognition right claim duty protect value members society inclusion social justice belonging world poverty illness prejudice dependent upon interdependence community collaborative enterprise call upon students education take stand work together end exclusion poor control together free
abnormal redox homeostasis oxidative stress proposed play role etiology several neuropsychiatric spectrum disorders emerging interest recently focused markers oxidative stress neuroinflammation spectrum disorders least particular subgroups patients altered expression genes related oxidative stress oxidative damage dna protein lipids reduced glutathione levels central peripheral tissues act synergistically contribute course disease herein discuss cellular mechanisms operative neuroinflammation schizophrenia address modulation endogenous cellular defense mechanisms potentially innovative approach therapeutics schizophrenia neuropsychiatric conditions associated neuroinflammation specifically discuss emerging role heme prominent member neuroprotective network redox stress responsive mechanisms importance glutathione relevant schizophrenia pathophysiology finally introduce dose response concept relevant important review mechanisms possible approaches manipulation targets viable treating schizophrenia spectrum disorders wiley periodicals inc
trust common factor network security cloud trust major factor trust develops relation user resource service provider develop strong trust strong trust path two entities model proposed builds strong trust path two important entities cloud namely user resources service provider trust path thus built security resources authentication user implementation proved trust model developed efficient terms computation time
teach problem solving students develop problem solving skills process pass problem solving known identifying steps students difficulty process provide data assist study aimed investigate students problem solving process related force motion unit scope need purpose supported problem solving instrument consists problems enables students reach need problem solving process developed participants study consist students receive education grade province students solved problems using five course hours one course hour per week data collected system records provided semi structured interviews conducted students field notes conclusions reached students difficulty steps understanding problem making solution plan need problem solving differ according students problems students need problem solving decrease regularly students helped certain degree solving problems suggestions made teachers provide students using problem solving strategies organizing researchers study condition using similar software students different levels
aims growing burden cardiovascular disease requires growth research innovation examine worldwide participation citation impact across cardiovascular research landscape investigate cross fertilization countries examine whether cross border collaboration affects impact methods results state art methods indicators used identify cardiovascular publications web science map trends time output citation impact collaboration publication output cardiovascular research grown steadily increased participation worldwide china highest growth relative share usa share initially yet reduced steadily time national region increased participation usa though average greater citation impact usa however number european countries australia canada improved absolute relative citation impact usa europe hub cross fertilization strengthening collaborations strong citation links germany france remain central network usa highest number strong citation links countries countries especially smaller highly collaborative countries higher citation impact internationally collaborative research compared domestic publications conclusion participation cardiovascular research growing growth impact show wide variability countries cross border collaboration increasing particular within associated greater citation impact
clustering unsupervised learning algorithm means algorithm one known promising clustering algorithms converge local optimum iterative work means algorithm genetic algorithms look solution global search space order converge global problem clustering number clusters increases number total records dataset leads scenario cluster contains single record thus cluster purity maximized maximum value however since common among records seen therefore choosing best number clusters trivial instead choosing inappropriate number clusters main purpose clustering process genetic algorithm based means ensemble proposed order find consensus result several runs clustering task using different number clusters
analyze new results body block including magnet whose bottom pole set way upper pole magnetic base excited non ideal energy source unbalanced electric motor limited power supply new results related jump phenomena increase power required sources near resonance manifestations non ideal system referred effect energy sink work also discuss control strategies applied system resonance conditions order decrease vibration amplitude avoiding apparent energy sink
objectives syndrome rheumatoid arthritis ankylosing spondylitis spa autoimmune diseases unknown etiology share clinical manifestations common previous family based investigations support genetic contributions susceptibility diseases current study evaluated whether three previously reported associated single nucleotide polymorphisms snps near near genetic overlap across multiple autoimmune diseases including syndrome spa materials methods genomic dna obtained spa han chinese patients healthy controls snps genotyped matrix assisted laser desorption ionization time flight mass spectrometry genotype allele frequencies analyzed using chi square test results significantly different cases healthy controls odds ratios confidence intervals snps associated risk developing spa analysis genotype distributions showed similar results significant difference found genotype frequency cases significant differences detected among patients spa conclusions results suggest associated risk developing han chinese populations people carry risk allele prone developing syndrome
fast nearest neighbor search becoming crucial given advent large scale data many computer vision applications approaches provide fast search mechanisms compact index structures address critical need image retrieval problems labeled training data available supervised methods unsupervised methods state art supervised approaches employ batch learners unfortunately batch learning strategies inefficient confronted large datasets moreover batch learners unclear adapt hash functions dataset continues grow new variations appear time handle issues propose online supervised technique based error correcting output codes consider stochastic setting data sequentially method functions discriminative manner method makes assumption number possible class labels new classes presented incoming data stream experiments three image retrieval benchmarks method yields state art retrieval performance measured mean average precision also orders magnitude faster competing batch methods supervised also method significantly outperforms recently introduced online solutions elsevier inc rights reserved
background individuals knee osteoarthritis fatty infiltration muscle associated poor physical performance strength however known whether also occurs impacts physical function aims investigated relationships volumes fat fat subcutaneous fat lean muscle muscle adiposity compared women knee methods mri scans acquired women years knee discovery healthcare axial ideal iterative decomposition water fat echo asymmetry least squares estimation fat separated images segmented quantify lean muscle volumes correlation linear regression analyses run results found positive relationship muscle adiposity volume controlling waist hip ratio relationships lean muscle combined volume significant discussion although correlation exists muscle adiposity hold true lean muscle greater amount infiltration occurs compared women knee conclusion involved pathologic changes muscle composition knee
water pollution large scale small scale plastic area growing concern macro plastic known threat aquatic however effects micro sized nano sized plastic particles health organisms understood small scale plastic particles easily ingested various aquatic organisms potentially interfere immune system therefore authors used freshwater fish species model organism exposure characterization particles respectively plasma performed effects innate immune system investigated vitro effects neutrophil function determined using battery neutrophil function assays exposure neutrophils caused significant increases primary granules neutrophil extracellular trap release compared control whereas oxidative burst less affected present study outlines stress response cellular component fish innate immune system nanoparticles aggregates indicates potential interfere disease resistance fish populations
visualizing large graphs edge promising method yet subject several challenges speed level detail parameter control present framework addresses problems integrated way fully gpu based graphs million edges interactive times faster comparable state art methods simple intuitive control parameters extends existing techniques offering ways control bundle shapes separate edge direction create level detail visualization shows graph core structure details demonstrate several large graphs extracted real life application domains
purpose childhood cancer stressful entire family anxiety surrounding childs illness result parents children cancer less emotionally responsive toward children parenting response negative life event like childhood cancer cause survivors attached healthy peers downstream effects survivors romantic relationships later life therefore examined survivors perspectives parent behaviors adult attachment marital status among adult survivors childhood cancer relative controls methods one hundred forty nine young adult survivors matched controls age range indicated relationship status single completed standardized questionnaires assessing memories warmth rejection adult attachment avoidance anxiety results adult survivors childhood cancer remembered mothers fathers emotionally mothers less controls adult attachment overall similar survivors controls survivors reported particularly low attachment related anxiety childhood cancer related higher mother father warmth associated lower attachment related avoidance turn greater likelihood relationship conclusion adult childhood cancer survivors remember parents reported positive parenting relative controls similar adult attachment relationship status results unexpected offer novel insights future prospective studies necessary better understand psychosocial late effects childhood cancer
newly proposed source inverter proven literature exhibit steady state voltage buck boost capabilities using unique impedance network coupled power source converter circuit paper now presents transient modeling analysis voltage type source inverter aspects found challenging need carefully investigated attempting design advanced control algorithms controlling source inverter detailed analysis paper identifies several phenomena sides inverter result inverter inferior non minimum phase transient response side phenomenon associated source impedance network shown small signal signal flow graph analyses right half plane zero control output transfer function also side phenomenon shown space vector analysis depend time intervals inverter states used desired inverter output voltage based analysis method improving inverter transient response also presented lastly simulation results obtained using switching functional model experimental results obtained using laboratory prototype presented validating described theoretical concepts
prior research child general sex offenders produced inconsistent contradictory results theoretical practical policy reasons however assume psychopathy exist sex offenders study light issue mean cut maximum covariance latent mode factor analysis mode procedures employed three overlapping samples sex offenders non relative child victims sex offenders non relative child adolescent victims child victims mixed sample sex offenders analyses revealed evidence continuous latent structure three samples results suggest psychopathy sex offenders child particular quantitatively continuous rather qualitatively categorical
consider linear state dynamic game played event tree determine analytically price given ratio players outcome cooperative game outcome game next illustrate findings context pollution control problem conduct sensitivity analysis assess impact lower upper bounds varying different parameter values elsevier rights reserved
inflammatory bowel diseases associated various disorders reported crohns disease ulcerative colitis occur moment natural course disease prevalence liver dysfunction rises accordingly definitions used different studies fatty liver considered common complication inflammatory bowel diseases primary specific one less frequently inflammatory bowel diseases associated disorders include autoimmune hepatitis primary overlap syndrome associated primary hepatic hepatitis portal vein thrombosis liver spectrum manifestations varies according type inflammatory bowel diseases treatments inflammatory bowel diseases cause liver toxicity although incidence serious complications remains low however early diagnosis drug induced liver injury major importance affects future clinical management facing abnormal liver tests clinicians undertake full diagnostic work order determine whether hepatic abnormalities related inflammatory bowel diseases management hepatic manifestations inflammatory bowel diseases usually involves complexity situations
research carried appraisal toxic anti action extracts grain research training storage management cell department protein molecular biology laboratory department biochemistry year various dilution levels viz plants extracts assessed test insects toxic effect plant extracts observed exposure period days inhibition different enzymes acetylcholinesterase alpha beta beta acid alkaline alp calculated survivors toxicity assay results evidenced plant extracts lethal effects three stored grain insect species comparison means mortality proved extract effective causing maximum mortality respectively resulted maximum mortality respectively results also revealed significant inhibition alpha beta alp upon exposure various concentrations tested plants plant extract proved efficient inhibition test enzymes three stored grain insect results suggest ability using plants extracts wheat grains protection safe alternative
online photo sharing increasingly popular activity internet users users now constantly sharing images various social media social networking sites online communities content sharing sites article present extensive study exploring privacy sharing needs users images develop learning models estimate adequate privacy settings newly images based carefully selected image specific features study investigates visual textual features images privacy classification consider basic image specific features commonly used image processing sophisticated abstract visual features additionally include visual representation evoked images knowledge never used context image classification privacy purposes identify smallest set features combined together others perform properly predicting degree sensitivity users images consider case binary privacy settings public private case complex privacy options characterized multiple sharing options results show carefully selected features one achieve high accuracy especially high quality tags available
elliptic curves finite field invariant ordinary whose embedding degree low studied ordinary case give conditions characterizing elliptic curves fixed embedding degree respect subgroup prime order conditions give terms two show several examples families many curves similar need fixed root unity underlying field moreover elliptic curve distortion maps example provided
cloud computing become area high performance distributed computing provides demand access shared resources internet self service dynamically scalable manner full benefits much research required across broad array topics one important research issues need focused efficient performance scheduling goal scheduling map job resources optimize one objectives scheduling cloud computing belongs category problems known hard problem due large solution space thus takes long time find optimal solution cloud environment best find suboptimal solution short period time metaheuristic based techniques proved achieve near optimal solutions within reasonable time problems paper provide extensive survey optimization algorithms cloud environments based three popular metaheuristic techniques ant colony optimization particle swarm optimization pso genetic algorithm novel technique league algorithm lca
generated network functions analog integrated circuit complicated general reason variety simplification methods proposed literature work novel topology based symbolic simplification method proposed capable generating simplified symbolic network function together simplified small signal circuit technique developed applying recently proposed graph pair decision diagram algorithm generates symbolic network function stored binary decision diagram two types element elimination directly operated data structure performance variation eliminating symbol original circuit assessed means two monitored response metrics gain phase margin sorting performance loss circuit elements less performance loss eliminated resulting reduced automatically simplified network function simplified small signal circuit available simultaneously reduction applications two operational amplifier examples confirm effectiveness proposed methodology
water reactors inherently nonlinear physical system physical system reactivity feedback caused moderator density temperature allows several effects reflecting nonlinear behavior system stability analyses done simplified reduced order model couples point reactor kinetics thermal hydraulics reactor core linear stability analysis steady states shows critical value bifurcation parameter feedback gain bifurcation occurs stable unstable domains parametric spaces predicted linear stability analysis stability system include stability steady states stability dynamics system limit cycles included study stability nonlinear stability analysis bifurcation analysis becomes indispensable component stability analysis scenario bifurcation occur one free parameter studied birth limit cycles excitation limit cycles makes system case bifurcation whereas stable limit cycles continues unstable region supercritical bifurcation distinction supercritical done two parameter analysis bifurcation scenario generalized bifurcation takes place sub supercritical bifurcation various types bifurcation limit point bifurcation limit cycle period bifurcation limit cycles bifurcation limit cycles identified manifests region whereas chaotic region exist region chaotic solutions drawn various parametric bifurcation diagrams elsevier rights reserved
large variety molecular pathways melanoma progression suggests individual molecular alteration crucial aim define molecular alterations underlying metastasis formation gene expression profiling performed using microarray qrt pcr define alterations matched primary metastatic melanoma cell lines data integrated publicly available tissue data cell lines determined invasion assays invasive clones primary melanoma derived cell lines also selected two metastatic cell line models created regional lymph node distant lung metastatic models majority metastasis genes downregulated enriched adhesion pathways upregulation immune pathways characteristic distant metastases whereas increased signaling specific regional sub cutaneous metastases qrt pcr analysis selected highlighted possible importance metastatic process distinguishing regional distant metastases identified functionally relevant gene clusters influenced metastasis formation data provide evidence integrin expression patterns important distant metastasis formation copyright wolters kluwer health inc rights reserved
micrornas mirnas family non protein coding endogenous small rnas group gene regulators function mainly binding untranslated regions specific target messenger rna mrna leading gene inactivation repression mrna transcription induction mrna mature mirnas short molecules approximately nucleotides length regulate wide range biological functions cell proliferation death cancer progression cellular mirna expression levels used biomarkers onset disease states gene therapy genetic disorders methods detection mirna mainly include northern blotting microarray polymerase chain reaction pcr review focuses use electrochemical biosensors detection microrna elsevier rights reserved
based ieee standard frame aggregation considered one major factors improve system performance wireless local area networks medium access control mac perspective order fulfill requirements high throughput performance feasible design automatic repeat request mechanisms becomes important providing reliable data transmission paper two mac defined schemes proposed consider effect frame aggregation enhancement network throughput aggregated selective repeat algorithm proposed incorporates conventional selective repeat scheme consideration frame aggregation hand aggregated hybrid protocol proposed enhance throughput performance adopting block code forward error correction scheme novel analytical models based signal flow graph established order realize behaviors schemes simulations conducted validate compare proposed mechanisms existing schemes based service time distribution numerical results show proposed protocol outperforms schemes owing effective utilization mechanism
model description crystal proposed incorporating classical theory concepts spatial heterogeneity glass forming liquids assumed processes proceed detectable rates liquid like soft regions suppressed solid like rigid parts determining appropriately fraction liquid like solid like regions dependence temperature approach allows one achieve satisfactory agreement classical theory experiment relatively high temperatures also temperatures lower rate maximum model tested successfully several revealing homogeneous volume phenomena interplay glass transition also discussed giving independent verification validity basic assumption elsevier rights reserved
objective investigate effects prostate patients treated aging male syndrome methods cross sectional study conducted june september metabolism department university van turkey comprised patients symptoms aging male syndrome low testosterone given day per oral two months aging male symptoms international prostate symptom score prostate related quality life scores completed prostate ultrasonography performed treatment total testosterone free testosterone estradiol prolactin sex hormone binding globulin total free prostate specific antigen also studied results patients study prostate volume increased decreased change however statistically significant significantly improved aging male symptoms international prostate symptom prostate related quality life scores improvements though significant independent changes prostate volume total testosterone sex hormone binding globulin decreased free testosterone showed change fraction free testosterone increased total free prostate specific antigen change conclusion proved safe alternative treatment aging male syndrome also improved lower urinary tract symptoms prostate related quality life
epidemiological data linked birth control formulations increased risk infant acute leukemia involving rearrangements reverse transcription polymerase chain reaction pcr studies showed estradiol enhanced transcription addition common translocation partners concentration estradiol triggered localization without affecting interaction genes located chromosomes estradiol also stimulated generation fusion transcripts seen pcr rnai knockdown activation induced suppressed induction fusion transcript formation observed estradiol additionally chromatin immunoprecipitation chip analysis showed estradiol dependent localization intron upstream dna cleavage rearrangement downstream within intron combined studies show levels estradiol consistent observed pregnancy potential initiate mediated mechanism
advent nanotechnology medical arena led unique ways biomaterials engineering device modifications disease detection treatment end two principal focus areas cancer cardiovascular pathologies current chapter aimed presenting comprehensive review nanotechnology based strategies cardiovascular diseases emphasis targeted delivery therapeutic selectively disease site rationale strategies stem need resolving issues rapid drug clearance plasma induced drug suboptimal drug availability disease site drugs leading harmful systemic side effects arise drugs administered directly systemic circulation significant application nanotechnology resolving issues packaging drugs within plasma stable preferentially accumulate vascular disease site via passive uptake bind actively site via antigen specific ligands vehicle surface past three decades significant advancements understanding vascular disease associated genomics proteomics cellular molecular mechanisms nanoscale strategies biomaterials engineering led several exciting approaches vascular disease treatment chapter describe approaches terms materials engineering payload release mechanisms biochemical biophysical design parameters delivery platforms integration multiple design parameters functionalities single vehicle platform along discussing promises limitations vascular approaches
autism spectrum disorders asd highly heterogeneous developmental conditions characterized deficits social interaction verbal nonverbal communication obsessive patterns behavior repetitive movements social interaction impairments characteristic deficits asd also evidence language empathy profound inability use standard nonverbal behaviors eye contact affective expression regulate social interactions others difficulties showing empathy failure share enjoyment interests achievements others lack social emotional developed countries now reported children asd reports approximately one children suffer asd despite intense research focus asd last decade underlying etiology remains unknown genetic research involving twins family studies strongly supports significant contribution environmental factors addition genetic factors asd etiology comprehensive literature search implicated several environmental factors associated development asd include pesticides solvents air pollutants heavy metals especially aluminum used vaccines adjuvant importantly majority common ingredients cosmetics almost regularly exposed form face air food review describe various scientific data show role environmental factors asd elsevier ltd rights reserved
present work introduces like directional filter discusses application edge detection general images fracture detection data filter essentially adjustable anisotropy orientation tuned given target retaining properties bound scaling rules frame individually local trait data hence used single multi directional modes manner simple computationally inexpensive efficient data generally contains straight curved edge like objects comprising reflections planar interfaces susceptible broadband noise fractures important class interfaces determine health state man made structures primary targets surveys geotechnical engineering environmental applications demonstrated examples efficiently recover information specific scale geometry straight curved edges general images data distinguish reflections small large fractures discriminate groups fractures resolve fracture density aid assessment damage structures elsevier rights reserved
aim article present findings analytical framework designed monitor political discourse immigration understanding relevant studies three disciplines political science social psychology framed racism try infer racism manifest discourse particular tendencies combination tendencies contributed designing proposed analytical framework aims means standards systematically political discourse quantify much discourse assess discrimination justified implementing framework within context pilot study offers global picture political discourse immigration constructed standards appears appear discourse viability framework proven conclude basis comparative research contexts
osteoporosis characterized increasing fragility fracture resulting low mass deteriorated bone tissue hormone replacement therapy frequently used treat osteoporosis primary therapeutic strategy adverse effects severely limited extensive clinical application therefore urgent develop alternative complementary therapeutic agents anti osteoporosis interestingly people focusing complementary alternative medicine traditional chinese formulas gradually recognized safe effective agents treatment osteoporosis particular notable trend increasing studies making efforts clarify anti osteoporotic effects mechanism kidney formulas category agents identified effective therapy therefore purpose study comprehensively review kidney formulas reported treatment osteoporosis agents play roles detail current study advance understanding actions kidney formulas also provide new evidence clinic use kidney formulas treatment osteoporosis
article address increasingly important yet understudied phenomenon decision making three experimental studies investigated whether messages company delivered american speech influenced choice study found individuals likely choose company product message read standard american english message delivered chinese french study found expectations regarding company messages speakers turn expectation violations mediated relationship choice study replicated findings effect choice using indian british also hypothesized found support conditional indirect effects model implicit pro american bias moderated indirect relationship choice mediated expectation violations theoretical practical implications topic study discussed
overall performance electric machine closely linked thermal design machine trend include thermal analysis machine design procedure academic literature thus also motivation prototype experimental machines accurate thermal analysis one challenges measure rotor temperatures online machine operation paper presents experience designing online temperature monitoring system experimental total sensors successfully placed inside volume small temperature data transmitted rotor end shaft using infrared light found online temperature monitoring system reliable used analog digital sensors exhibit equal results immunity placed inside noisy environment inside machine
objective children lateral sinus thrombosis following minor head injury occasionally reported neuroimaging techniques however condition rare pathophysiology remains unknown aimed identify factors associated etiology severity provide information guide diagnosis management prognosis methods retrospectively reviewed patients aged years trauma presenting emergency department total patients following identified also performed comprehensive literature review identify relevant cases studies published yielded studies patients analyzed data patients cases results mean age cases years male female ratio nausea vomiting headache common symptoms signs symptoms increased intracranial pressure present patients sinus commonly affected total patients treated remaining patients received anticoagulation patients good outcomes major complications radiological follow showed complete patients partial patients conclusions although following still rare children findings indicate much common previously thought though patients appear excellent prognosis high degree suspicion maintained assessing patients non specific symptoms make diagnosis difficult neuroimaging magnetic resonance computed tomography crucial diagnosis follow disorders excluded anticoagulation therapy given patients disorders persistent progressive conservative therapy recommended although anti edema drugs intermittent lumbar beneficial authors published elsevier open access article license http creativecommonsorg licenses
intestinal barrier integrity prerequisite homeostasis mucosal function balanced capacity maintaining efficient defensive reactions chemical microbial challenges evidence mounting disruption epithelial barrier integrity one major factors associated several gastrointestinal diseases including infection pathogens obesity diabetes irritable bowel syndrome inflammatory bowel disease notion specific probiotic bacterial strains affect barrier integrity research vitro cell lines animal models clinical trials used assess whether probiotics diseased state back homeostasis health review lines evidence available literature role probiotics epithelial integrity consequently beneficial effect reduction gastrointestinal disease symptoms
across six studies people used bad black heuristic social judgment assumed acts committed people skin regardless racial background actors studies news articles written black white popular culture study american politicians study critical rather stories skin tone photographs printed article remaining four studies participants associated acts people examining surveillance studies matching good bad actions studies additionally found race based studies based studies associations determine whether people demonstrate bad black effect discuss implications social perception identification
paper investigates applicability reliability economic benefit rainwater harvesting rwh systems partially offset daily water demand residential buildings combination town water supply systems city comprehensive computer software developed view assessing reliability feasibility rwh systems urban setup software developed using daily water balance modelling concept uses input data like daily rainfall roof catchment area runoff losses tank volume three distinct climatic scenarios wet average dry years chosen analysing historical years daily rainfall data typical residential buildings plot size considered study results indicated reliability achieved wet climatic condition catchment sizes varying rainwater harvested year several reliability curves presented two roof catchment sizes three climatic scenarios insignificant increase reliability rwh system beyond tank volume observed current underground tank sizes residential buildings sufficient prevent potential monetary saving around achieved catchment size tank size average year climate condition monetary saving increases increase catchment size elsevier rights reserved
progenitors shown survive give rise different classes dopamine neurons integrate host brain alleviating symptoms following transplantation patients animal models disease dopamine neuron subpopulations namely identified based cell morphology axonal projections protein gated potassium channel calcium binding protein two best available markers currently used label overlap like dopamine neuron subtypes respectively tyrosine hydroxylase expressing neurons classes dopamine neurons survive striatum extend axonal projections normal dorsal ventral striatal targets depending phenotype nevertheless transplanted dorsal striatum input nucleus enriched dopamine neurons express remains elucidated whether different transplantation sites favour differential survival development concordant dopamine neuron subtypes within used rat progenitors two developmental stages corresponding peak either examined commitment respective dopaminergic phenotypes grafting cells different regions contain targets either dopamine dorsal striatum ventral area dopamine nucleus prefrontal cortex sparse dopamine rich hippocampus demonstrate young embryonic day older tissue transplant environment influence survival functional integration specific subtypes dopamine neurons host brain also show irrespective donor age like expressing neurons responsive environmental cues adopting dopaminergic phenotype differentiation post grafting novel findings suggest dopamine progenitors use targets transplantation site complete maturation efficacy cell replacement therapy patients improved deriving tissue earlier developmental stages current practice authors published elsevier inc
passive house first presented university sweden germany nowadays passive house widely used kind low energy consumption high comfort energy saving building around world passive low energy consumption green building understanding made housing urban rural development first projects classified projects paper analyze building load energy consumption science order conform consumption index suit province
currently within framework graduate education student make strong self learning work technical field task complicated difficulty contents covered make better use sessions necessary student reaches previous knowledge independently addressing truly relevant contents difficulties meetings work consists design didactic unit combining learning activities sessions order improve academic productivity new context higher education unit designed engineering field specifically subject strength materials mechanical engineering degree combining activities student acquire basic skills needed carry practical activity consisting analysis using technique students attain knowledge skills necessary practice laboratory fulfill evaluation results responding questions asked teacher
coal top fuel power generation china united states replacement one critical method mitigate serious environmental impacts natural gas associated much less air pollution one important alternative fuels united state gas one key type natural gas become disruptive energy resource past years china worlds largest resource gas develop alleviate air pollution ensure energy security however one big obstacle standing reality potentially serious environmental impacts caused gas development construct analytical framework focusing coverage monitoring reporting verification systems qualitatively evaluate probability detecting enhancing compliance china united states three prominent environmental impacts including water contamination water consumption methane leakage china improve significantly dimension pay urgent attention currently weak systems water contamination united states needs extend coverage ground water consumption environmental impacts gas development effectively controlled fuel switching replace coal bring significant environmental gains elsevier rights reserved
report detailed investigation effect carbon black morphology network formation evolution high density polyethylene composites three types networks study electrical network solid state electrical rheological networks melt state evolution network polymer melt simultaneous electrical dynamic testing oscillation strain used investigate network stability large strain found high structure morphology easier form polymer network low structure spherical morphology composite melt high structure network stable large strain compared low structure one meanwhile low structure aggregates stronger capability movement aggregation polymer melt wiley periodicals inc appl sci
electrical machines design studies found literature lie concept design investigation optimization focuses mainly geometrical aspects machine thus takes account certain ferromagnetic material iron parts studies give little information influence material alternatives optimized design manufacturers point view though information crucial especially nowadays lot commercially available materials market context paper presents results research project design stage energy efficient three phase cage induction motor investigating effects several soft magnetic materials adopted stator rotor parts multiple quantities primary concern efficiency power factor output torque losses weight cost brief proposed design procedure total twenty two different materials recent manufacturers data examined also main electromagnetic analysis performed commercial analysis software simple ranking methods also proposed different application areas results obtained thoroughly discussed
paper investigates distribution forces within mine using discrete element method compares existing analytical method virtual modeled via simulate underground mining granular materials normal shear forces particle contacts within model tracked analyzed particular attention effect friction evaluates normal force chains reveals concentration high forces within model shows profiles forces different obtained analytical solutions quantitative analyses spatial distribution forces number contact points changes orientation forces presented demonstrates capacity good tool looking closely particle scale highlights potential force distribution concentration within shows limitations analytical solutions helps engineers mining industry better understand possible mechanisms within american society civil engineers
study presents first attempt link multi algorithm genetically adaptive search method groundwater model define pumping rates within distributed set pareto solutions pumping rates along three minimization objectives minimizing shortage affected failure supply modified shortage index minimization extent within regions chosen define optimal solution groundwater hydraulic conductivity specific yield parameters modular finite difference groundwater model first optimized using optimization algorithm coa minimizing sum absolute deviation observed simulated water table depths parameters applied optimize pumping rate variables arid groundwater system iran pareto parameter sets yielded satisfactory results maximum minimum aquifer defined range year overall modelling optimization simulation procedure capable compute set optimal solutions displayed pareto front proposed optimal solution provides sustainable groundwater management alternatives decision makers arid region
study proposes algorithm calculating outputs tunable four chip led according black body radiation curve proposed algorithm based generalized reduced gradient method lumen outputs four chip calculated real time color temperatures ranging without using table enabling achieving high quality lighting designs finally algorithms method average color shift proposed algorithm much smaller memory size requirements microcontroller unit current method
polyacrylamide based become essential component geotextile tube processes act binding fine sediments charge particle bridging resulting faster rates greater retention fine sediments recently however momentum begun shift towards use sustainable materials natural starch chitosan increasingly tested attractive alternative synthetic polymers researchers identified number natural derivatives particular candidates applications study performance four soils sand natural organic soil evaluated synthetic starch based performance five cationic starch based polymers charge densities ranging molecular weights ranging mol mol compared five cationic based polymers charge densities ranged molecular weights ranged mol cationic cationic selected wide range charge densities molecular weights order study effect properties performance used soils optimum dose determined using test additionally pressure filtration tests performed determine rates filter properties test results showed properties especially charge density significant effect optimum dose optimum doses cationic starch two four times higher cationic polyacrylamide polymers additionally found cationic effective turbidity natural organic soils cationic finally cationic allowed increase rate comparison soil samples tested without
online social networks become popular attracted great many users recommendation one important services help users discover interested friends alleviate problem information overload however existing recommendation methods consider either user link content information hence effective enough provide high quality recommendations paper propose topic community based method via matrix factorization method first applies joint model mine topic communities existing link content information computes user pairwise similarities makes friends recommendation based topic communities furthermore method implemented using mapreduce distributed computing framework extensive experiments show proposed method better recommendation performance state art methods also good scalability deal problem recommendation large moreover application case demonstrates significantly improve recommendation service real world copyright john wiley sons ltd
background end west african virus disease outbreaks total cases probable confirmed deaths reported guinea clearly surveillance activities aiming stopping human human transmission breakthrough outbreak management application times easier said done article presents five confirmed probable cases arose towards end guinea epidemic demonstrate flaws surveillance follow case presentation case safe requirements followed cases negative polymerase chain reaction pcr results interpreted infection first case sample taken properly second disease possibly early stage case stopped border health checkpoint despite high temperature allowed continue bus case oral sample taken death found retrospective testing despite characteristic symptomatology case identified case long weeks conclusion epidemic contexts health systems able track samples cases deaths regardless laboratory results social mobilization communities training health care facilities strengthened tail outbreak avoid natural disease surveillance particular long lasting
study aimed assess relationship emotional social support emotional among immigrants breast cancer test whether two culturally relevant coping strategies acceptance mediate relationship hundred fifty spanish speaking within breast cancer diagnosis participating randomized trial stress management intervention assessed person baseline via telephone later survey measures included baseline emotional support acceptance emotional later generalized linear models estimated direct effects emotional support emotional indirect effects acceptance age years women low education levels emotional support negatively associated positively associated acceptance emotional support acceptance positively associated emotional whereas negatively associated emotional multivariable models emotional support associated emotional direct effect remained significant additionally controlling acceptance separate models significant indirect effect emotional support emotional marginally significant effect acceptance support increase among spanish speaking cancer survivors reducing cancer john wiley sons ltd
energy storage unique provide multiple services feature raises cost recovery issues storage due combination competitive markets cost recovery used many power systems today hybrid regulatory paradigm relies classifying assets providing prices services handling cost recovery based classification recent regulatory suggest storage developers choose classifying assets providing services former case storage costs recovered market asset classified providing services costs recovered regulatory design cost recovery storage lead inefficient storage investment use propose alternate solution whereby storage capacity rights third parties use rights services storage capacity rights storage cost recovery regulatory treatment end use formulate storage capacity model demonstrate efficiently price storage capacity rights show storage owner marginal value storage capacity revealed market
project develop accelerator driven system ads nuclear waste launched chinese academy sciences since three stages china lead based reactor clear selected reference reactor project means lead lead used primary coolant reactor institute nuclear energy safety technology one leading teams involved ads project taking charge design activities clear series reactors according research development clear lead cooled pool type research reactor named clear coupled proton accelerator constructed first stage second stage china lead based engineering demonstration reactor clear constructed third stage china lead based commercial prototype reactor clear iii constructed order verify key components investigate thermal hydraulics phenomena clear even pool type lead based reactor integrated multifunctional non nuclear test facility named clear built end note clear used test prototype components clear primary pump heat exchanger control rod driven system vessel system verify design safety analysis codes paper design description latest progress presented clear authors international journal energy research published john wiley sons ltd
evaluated ruxolitinib patients myelofibrosis according age sex time diagnosis grade fibrosis prognostic score risk janus kinase jak status primary secondary myelofibrosis previous treatment dosage outcome measures response rate time response duration response event free survival survival kaplan meier curves show significant difference event free survival according prognostic score favor patients low cox stepwise model confirmed result high risk score powerful negative independent parameter followed jak parameters diagnosis years earlier grade iii fibrosis ruxolitinib dose negligible impact time response shorter primary myelofibrosis conclusion ruxolitinib effective better outcome patients low risk score suggest considering earlier administration disease course
multi material arbitrary lagrangian method effective way simulate multi material flow severe surface deformation comparing traditional arbitrary lagrangian method method allows multiple materials single cell overcomes difficulties grid refinement process recent decades many researches conducted lagrangian surface reconstruction phases less attention paid multi material phase especially three dimensional problems due two complex geometric problems intersection paper propose algorithm intersection whose basic idea comes commonly used method new algorithm solves geometric problem incremental modification topology based segment plane comparison shows new method improves efficiency calculating moreover instability caused geometric thoroughly avoided geometry integrity preserved new algorithm also focus process describe algorithm automatically precisely tackle various situations including convex non convex multiple numerical studies indicate using intersection algorithm volume conversation phase exactly preserved simulation elsevier inc rights reserved
many simulation models expensive physically obtain complete set experimental data calibrate model parameters cases one alternatively employ validated higher fidelity codes generate simulated data used calibrate lower fidelity code paper employ information theoretic framework determine reduction parameter uncertainty obtained evaluating high fidelity code specific set design conditions conditions chosen sequentially based amount information contribute low fidelity model parameters goal employ bayesian experimental design techniques minimize number high fidelity code evaluations required accurately calibrate low fidelity model illustrate performance framework using heat diffusion examples kinetic neutron diffusion equation particle transport model include initial results integration high fidelity thermal hydraulics code low fidelity exponential model friction correlation factor elsevier inc rights reserved
bulk viscosity zeta medium estimated within resonance gas model including density states thermodynamics within canonical ensemble provides mean number fluctuation fluctuation chemical composition medium canonical ensemble result non zero divergence fluid flow velocity allowing estimate zeta matter relaxation time study influence spectrum zeta find correlation conformal symmetry breaking measure element estimate zeta along constant total entropy net number plane temperature chemical potential also assess value zeta chemical curve various centers mass energy root find bulk viscosity entropy density ratio zeta larger energy range beam energy scan program low energy run fair energies
monte carlo method used quantitative structure activity relationship modeling bis bis compounds acetylcholine esterase inhibitors series compounds quantitative structure activity relationship models calculated representation molecular structure simplified molecular input line entry system one split training test set examined statistical quality developed model good best calculated quantitative structure activity relationship model following statistical parameters training set test set structural indicators defined molecular fragments responsible increases decreases inhibition activity calculated computer aided design new compounds potential acetylcholine esterase inhibitors application defined structural presented
fiber forced composite materials outstanding mechanical electrical properties applications expanded commercial products military components using composite materials researchers studied radar absorbing stealth technology research develop radar absorbing structure ras hybrid composite materials fabricated three dimensional shape series experiments analysis conducted characterize ras hybrid composite consists absorbing layers made three phase composite glass fiber epoxy black reflection layers made carbon fiber reinforced epoxy manufacture spring back free composite aluminum additional bending angles used cure process composite finally evaluate radar absorbing efficiency ras radar cross section measured compact range method hybrid ras shows average radar absorption efficiency
electric vehicles evs become popular abundance valuable engineering resources dedicated creating full scale test beds validate modify vehicle hardware software paper presents systematic approach scaling full size electric vehicles parameters environmental conditions level handled small scale hardware loop simulation test bed paper also presents method scaling simulation results back full size vehicle level test bed realized using two electric machine system one machine represents vehicles traction motor vehicle parameters operating environment
cognitive bias questionnaire psychosis valid instrument assessing cognitive biases psychosis validate japanese version investigate relationships various schizophrenia symptoms positive symptoms negative symptoms autistic patients schizophrenia patients depression healthy controls recruited using samples psychometric properties japanese version tested total scores good reliability two subscales moderate reliability furthermore scales adequate concurrent validity given significant correlations positive symptoms accurately distinguish schizophrenia patients healthy controls novel findings total scores positively correlated autistic furthermore study using japanese sample showed marginally significant correlations cognitive biases event severity relationship seen previous study used western sample difference shame culture explained characteristic japanese japanese version reliable valid original
printing one promising technologies high volume production printed electronics films devices characteristics printed pattern volume resolution pattern placement registration directly related fluid mechanics liquid transfer process cell substrate around rotating roll liquid transfer mainly controlled free surfaces dynamic contact lines available analyses restricted flows relative motion cavity substrate greatly simplified recent results shown use complete description relative motion roll roll process critical obtain accurate results amount liquid transferred substrate work present extension model describing liquid transfer substrate process order consider liquid transfer small individual cell end solve full free surface flow moving contact lines results show liquid transfer dynamics governed two different characteristic time scales one associated contact line motion liquid dependent capillary number predictions show volume registration shape printed dot varies operating conditions liquid properties predictions helpful designing high precision printing operations elsevier ltd rights reserved
collapse drinking water management systems one serious consequences natural disasters article aims analyze vulnerability drinking water management natural disaster rural coastal areas considered extreme event coastal district study area collection drinking water normal situations difficult mainly spatially varied availability drinking water sources tube wells ponds rainwater harvesting units addition decreasing trend pre rainfall intensity increased salinity play significant role regard due destruction coastal locality heavily damaged drinking water sources analyze associated vulnerability factors drinking water sector conducted household based structured questionnaire survey three revenue collection unit district using principal component analysis identified six factors influencing drinking water vulnerability factors related warning dissemination damage water sources damage households water collection time family composition frequency water collection used factors prepare index comparative analysis vulnerability among three considering vulnerability issues article concludes presenting scope robust drinking water management plan coastal areas elsevier ltd rights reserved
metabolic pathophysiology underlying ischemic stroke remains poorly understood gain insight mechanisms performed comparative metabolic transcriptional analysis effects cerebral ischemia metabolism cerebral cortex using middle cerebral artery occlusion rat model metabolic profiling gas chromatography mass spectrometry analysis showed clear separation ischemia control group decreases phosphate phosphate suggested enhancement phosphate pathway cerebral ischemia min without transcriptional profiling microarray hybridization indicated toll like receptor mitogen activated protein kinase mapk signaling pathways upregulated cerebral ischemia without relation upregulation heat shock protein observed mapk signaling pathway confirmed real time polymerase chain reaction immunoblotting showed slight increase protein expression marked increase phosphorylation serine min min without corresponding upregulation glucose phosphate dehydrogenase activity increase nadph nad ratio also observed min furthermore injection mutated kinase inhibitor significantly reduced phosphorylation upregulation protein kinase inhibitor affect phosphorylation consequently activation via ischemia induced phosphorylation kinase part endogenous antioxidant defense mechanism earliest stages ischemia findings important therapeutic implications treatment stroke ibro published elsevier ltd rights reserved
purpose study conducted evaluate changes liver stiffness volume function occlusion spontaneous shunt materials methods twenty four patients men women mean age years age range years underwent percutaneous occlusion spontaneous shunt gastric hepatic march june liver fibrosis index indicating liver stiffness calculated using ultrasound shunt occlusion liver volume liver profile also evaluated results spontaneous shunt occlusion performed patients mean liver fibrosis index significantly decreased shunt occlusion month months months afterwards significant increase liver volume observed shunt occlusion month months afterwards significant improvement child score also found month months months shunt occlusion compared conclusion liver stiffness decreases along increase liver volume improvement liver function spontaneous shunt occlusion published elsevier masson sas rights reserved
background fatty acids classified short chain medium chain long chain hold promise adjunctive agents treatment colorectal cancer potential remains accordingly compared acid terms capacity induce apoptosis modify glutathione gsh levels generate reactive oxygen species ros modify phases cell cycle iec intestinal cell lines methods iec cells treated acid vehicle controls apoptosis ros cell cycle analysis determined flow cytometry gsh availability assessed enzymology results acid induced apoptosis iec cells compared cells acid reduced gsh availability generated ros compared acid reduced iec cells cells phases acid induced apoptosis iec cells compared protected iec cells ros induced damage whereas acid induced high levels ros compared conclusion compared acid displayed preferential properties including induction apoptosis crc cell line karger basel
todays data reconstruction digital communication systems requires designs highest throughput rate low power algorithm key element digital signal processing applications nonlinear recursive nature makes high speed implementation challenging several promising approaches achieve either high throughput low power proposed past combination developed paper additional new concepts allow building signal flow graph suitable design high speed low power using flexible generator facilitates essential quantitative optimization architectural physical level fully exploit low power high speed potential given technology design entry generator establishes basis scalable platform based design library altogether allows coverage range todays industrial interest high throughput rates using conventional cmos logic features two implementations prove benefit physically oriented design methodology terms speed low power compared leading edge implementations
design simulate type multiple ring resonator filters achieve wider free spectral range different ring expanded determined least common multiple individual ring dependence transmission characteristics coupling coefficients directional studied improvement suppression interstitial using high order filters also investigated graphical approach signal flow graph found useful quickly deriving optical transfer functions filters domain society photo optical instrumentation engineers
ionic liquids heat transfer fluids limited lack strong ability absorption sunlight hence nanoparticles added pure improve thermal optical properties study highly stable ionic liquid first prepared sic nanoparticles optical properties thoroughly investigated application direct absorption solar collectors enhancement thermal properties observed sic increase specific heat pure degrees respectively increase temperature thermal properties increase viscosity density decreased indicated sic suitable medium high temperature application additionally results optical properties showed sic superior solar absorption material extinction coefficient sic increase summary advantageous performance ensured potential sic advanced solar energy system believed information guide meaning practical design dac system
recently growing evidence atrial fibrillation common cardiac arrhythmia independently associated risk dementia represents recent high social impact number individuals involved expected increase incidence next years although number potential processes altered cerebral blood flow arise connecting links two pathologies causal mechanisms far clear silico approach proposed combines sequence two lumped parameter schemes cardiovascular system cerebral circulation systemic arterial pressure obtained cardiovascular system used input cerebral circulation aim studying role cerebral respect normal sinus rhythm beat recording particular alteration pressure patterns analysed means different statistical tools correlation coefficients functions crossing times extreme values analysis multivariate linear regression models remarkable signal alteration reduction signal correlation less increased probability three four times higher extreme value events emerges peripheral brain circulation described scenario offers number plausible cause effect mechanisms explain occurrence critical events links relating dementia
migratory animals sustainable management african populations within around protected areas major challenge conservation policy many african countries captured seven female representative members family groups different parts national park used gps satellite radio tracking november june monitor space habitat use seasonal throughout wet dry seasons patterns home range overlap revealed existence two large occupied north central southern parts respectively end dry season southern southeast park boundary northern remained mostly inside park used periodically wet season core areas nearby game controlled areas natural mortality occurred study two outside park human disturbance also affected activity patterns less active day outside inside park home range size varied northern southern migration routes characterised higher cover open closed forest core areas results indicate management considered across park boundaries migration protected human disturbance land cultivation society problems linked conservation solved creating alternative sustainable use natural resources enhance local communities published elsevier gmbh rights reserved
rapid development space technology operational amplifier widely used basic liner circuit satellite system many charged particles trapped particles electrons damage caused electrons causes bulk recombination surface recombination increase subsequently current gain decrease transistor gain degradation primary cause parametric shifts functional failures linear bipolar circuits severity electron radiation response correlates electrons energy flux therefore important understand electron radiation response different conditions paper tested devices used study input bipolar operational amplifiers commercial shelf manufactured texas instruments input bipolar operational amplifiers irradiated different energy different beam current electrons respectively different bias conditions study electron radiation damage effect experiment using gamma ray radiation conducted compare different radiation damages gamma ray electron radiation total radiation experiments carried gamma ray source technical institute physics chemistry radiation dose rates test samples total accumulated dose subsequently room temperature high temperature conducted analyze parametric failure mechanism caused total dose radiation different biases result shows beam current electrons induce damage caused electrons energy electrons induce damages electrons electron beam current former produces displacement damage latter comparison zero forward biased devices shows different biased devices different radiation radiation produces damages zero biased devices forward biased devices electron energy beam current forward biased suppress edge electric field thus leading decrease oxide trapped charge interface trapped charge high temperature annealing degradation devices obviously recovered almost return initial value finally result indicates electron radiation mainly induces ionization damage bipolar operational amplifier
using data american community survey found million people either eligible medicaid childrens health program chip appeared likely qualified health plan lacked residential high speed internet specifically million people eligible medicaid chip million people appeared likely high speed internet home medicaid chip eligible likely proportion people living households without internet varied substantially race socio demographic characteristics
although potent androgen receptor pathway inhibitors improve overall survival metastatic prostate cancer patients treatment induced neuroendocrine prostate cancer consequence selection pressures becoming common clinical issue improved understanding molecular biology essential development new effective management approaches study identify splice variant associated factor gene highly expressed tumor biopsies neuroendocrine cell lines prostate lung cancers show splicing stimulated neuronal rna splicing factor rather inducing neuroendocrine trans differentiation cells prostate adenocarcinoma upregulation stimulates cell proliferation independent cell growth invasion xenograft tumor growth gene microarray identifies actions part mediated genes findings suggest variant induce neuroendocrine differentiation prostate cancer cells rather facilitates progression increasing proliferation rate cells acquired neuroendocrine phenotypes
objective schizophrenia devastating mental disorder accompanied aberrant structural brain connectivity question whether schizophrenia progressive brain disorder yet resolved thus clear structural alterations occur develop time methods selective review summarized recent findings longitudinal magnetic resonance imaging studies investigating structural brain alterations impact clinical outcome different stages illness subjects ultra high risk developing psychosis patients first episode psychosis chronically patients moreover reviewed studies examining longitudinal effects medication brain structure patients schizophrenia results studies pre clinical stages conversion showed pronounced cortical gray matter loss superior temporal inferior frontal regions individuals later made transition psychosis studies investigating patients first episode psychosis revealed decline multiple gray matter regions frontal regions thalamus time progressive cortical thinning superior inferior frontal cortex studies focusing patients chronic schizophrenia showed gray matter decreased greater extent frontal temporal areas thalamus cingulate cortices especially poor outcome patients studies reported effects white matter microstructure longitudinal course illness conclusion adequate evidence suggest schizophrenia associated progressive gray matter abnormalities particularly initial stages illness however causal relationships structural changes illness chronically interpreted caution findings longer periods treatment higher doses antipsychotics related illness
understanding genetics influences inter individual variation antibody titers response vaccination vital understanding possible sources vaccine failure improved vaccine development although recognized human leukocyte antigen hla genes immunoglobulin genes play significant roles immune response significant variation antibody titers explained genes obtain complete estimate role entire genome used large panel single nucleotide polymorphisms estimate heritability antibody response vaccine based subjects european estimated heritability standard error also estimated heritability attributable chromosome found large range chromosome specific notably chromosome largest estimate chromosome hla estimated heritability compared prior study twins community resulted heritability estimate study suggests either many rare genetic variants many common genetic variants small effect sizes contribute variations antibody titers response vaccine elsevier ltd rights reserved
single phase inverters widely used connect small scale distributed renewable energy sources grid however unlike three phase system designing vector control single phase inverter challenging paper presents neural network based vector control technique single phase inverter develop design embedded digital control system implement neural network vector controller using texas instruments chip paper addresses circuit design effective interface high power inverter system embedded microcontroller utilize built achieve efficient digital control implementation user specified sampling time generation high quality pulse width modulated driving pulses moreover embedded software design developed implement neural network vector control single phase inverter laboratory scale single phase inverter system built test evaluate embedded neural network microcontroller hardware experiment assessment shows microcontroller works using novel neural network vector control mechanism challenging variable distorted hardware experiment conditions
integration coordination make order supply chains critical successful execution construction projects study aims investigate potential language action perspective analyze way bound fulfilled supply chain members affect integration coordination construction supply chains two case studies carried including agents building cut supply chains multiple sources evidence exploratory structured interviews site visits document analysis provided data support analysis evidence reveals information flow problems chains way among people firms managed along chains also shows kinds failure managing associated poor connectivity among study suggests adoption provide novel alternative approach understanding information communication problems affect integration coordination supply chains construction identifying possible ways avoid problems
objective study aimed investigate face scan paths face perception abilities children type relate emotion recognition abilities population method authors investigated facial emotion recognition face scan paths face perception children compared age matched typically developing controls correlations facial emotion recognition face scan paths face perception children examined results children displayed significantly poorer recognition expressions compared controls nonsignificant trend toward poorer recognition anger significant difference groups time spent viewing individual core facial features eyes nose mouth regions children spent significantly less time controls viewing face whole children also displayed significantly poorer face perception abilities typically developing controls facial emotion recognition deficits significantly associated aberrant face scan paths face perception abilities group conclusions results suggest impairments perception identification interpretation information faces important aspects social cognitive phenotype
background development new anti migraine treatments limited difficulty migraine pain laboratory animals depression activity one diagnostic criteria rats goal present study test hypothesis home cage wheel running reliable clinically relevant method assess migraine rats methods adult female rats implanted onto induce migraine pain shown rats recovered implantation surgery days containing running wheel home cage wheel running recorded day migraine medication administered hour prior onset dark phase results administration caused concentration dependent decrease wheel running lasted duration magnitude induced depression wheel running consistent following three repeated injections apart administration attenuated induced wheel running large dose administered immediately following administration wheel running patterns change given naive rats conclusions data indicate home cage wheel running sensitive reliable clinically relevant method assess migraine pain rat
long non coding rnas associated various biological roles stem cell biology cellular development present specific tissue expression profiles aberrant expression thought play critical role progression development various cancer types including common malignant primary brain tumours brain cancer stem cells isolated low high grade tumours adults children cell fraction express neuronal stem cell surface marker purpose study investigate expression profiles brain tumour cells determine potential biological function purpose stem cell series used human parental brain cancer cells included control group expressions disease related human profiles studied real time pcr expression profiles genes analyzed significant dysregulation compared control cells among genes regulated genes regulated showed low expression compared human parental brain cancer stem cells indicating role tumour suppressor genes result significant changes anti cancer gene expressions detected disease related human array plates identification novel target genes lead promising developments human brain cancer treatment elsevier rights reserved
moderate exposure alcohol development leads subtle neurobiological behavioral effects classified term fetal alcohol spectrum disorders alterations social behaviors frequently observed consequence maternal drinking children display inappropriate aggressive behaviors altered responses social cues rodent models mimic behavioral alterations seen humans rats exposed ethanol development displaying increased aggressive behaviors decreased social investigation altered play behavior work laboratory observed increased behavior adult male rats following prenatal alcohol exposure increased expression containing nmda receptors cortex study undertaken determine negative modulator significant effect social behaviors rats using voluntary ethanol exposure paradigm rat dams allowed drink solution either ethanol throughout gestation offspring months age implanted animals isolated vehicle min recorded social interaction chamber treatment altered aspects social behaviors ultrasonic rats exposed ethanol development observed control animals data indicate containing nmda receptors play role social behaviors underlie alterations behavior observed animals elsevier rights reserved
cultural psychology built powerful theoretical yet consolidated methodology analysis thus cultural psychologists adopt models empirical investigation social science domains taking latter consistent theoretical framework result mountain powerful theory ends giving birth mouse empirical analyses runs risk just translation language psychology already stated normative common sense paper divided two parts first provide arguments support focusing problematic role played interpreting empirical investigation terms inductive generalization second part paper propose generalization alternative ground empirical investigation psychological phenomena providing arguments highlighting sustain valid methodology cultural psychology particular attention paid form generalization generalization leads search boundary variability basic strategy investigation
optimization process parameters important aspect manufacturing engineering multi objective optimization process parameters complex process pareto optimal solution methodologies widely used now days present investigation focuses three objective multiple performance optimization drilling parameters drilling composite drilling process objective research optimize drilling parameters drilling spindle speed feed speed diameter maximizing material removal rate minimizing thrust force surface roughness drilling composites experiments conducted computer numeric control drilling machine bit second order regressions developed responses based equations non dominated sorting genetic algorithm used optimize drilling conditions non dominated solution set obtained presented study
new hepatitis virus hbv therapies expected breakthrough benefit patients hbv functional cure sustained hepatitis surface antigen loss anti gain normalization serum therapy complete cure additionally includes loss hbv covalently closed circular dna currently available endpoints therapy inadequate evaluate efficacy many new therapeutics therefore either new ways using existing endpoints laboratory values entirely new biomarkers needed review discuss currently used endpoints potential new endpoints new markers needed assess ability hbv therapeutics achieve functional cure various phases hbv infection addition discuss patient selection differing phases hbv impacts choice hbv drug needed achieve cure
delay captures elements self denial characterize real life problems money problem behaviors unhealthy risk taking according fuzzy trace theory decision makers mentally represent social values delay coarse meaningful form memory called applying theory developed measure delay involve quantitative trade offs delay hypothesize construct explains unique variance beyond sensation seeking inhibition accounting problem behaviors across four studies examine delay scale using principal components analyses evaluating convergent divergent validity potentially related scales future orientation propensity plan time perspectives inventory sensation seeking cognitive reflection monetary choice questionnaire delay new item measure captured single dimension delay correlated predicted scales accounted unique variance predicting outcomes bank accounts substance abuse overall subjective results support theoretical distinction reward related approach motivation including sensation seeking inhibitory including cognitive reflection however individuals agreement qualitative delay expressed many cultural reduced quantitative conceptions delay shedding light mechanisms self control risk taking copyright john wiley sons ltd
study aimed observe incidence rates strain injuries across different competition levels ages year period injuries treated medical staff recorded type injury anatomic location event injury occurred competition level demographic data documented absolute relative per participants determined odds ratios ors calculated sexes competition levels events throughout study period athletes registered participate treated medical team high school girls displayed lesser risk high school boys athletes likely high school college level athletes suffer relay displayed greater likelihood compared relay high school boys level athletes likely suffer higher risk events compared events
paper present way insert reliability models expansion planning electrical network real data coming database geographic information system gis company software friendly interface developed real network used example computational results presented elsevier ltd rights reserved
aims carcinoma variant differentiated squamous cell carcinoma anal region regarded giant tumour aetiology diagnostic criteria clinical behaviour lesions controversial recent studies suggest sites associated human hpv hypothesized anal also related hpv hpv induced lesion methods results ten cases four cases included several techniques used hpv detection situ hybridization six different polymerase chain reaction pcr protocols detection least hpv types alpha beta gamma genera situ hybridization high risk hpv mrna immunohistochemistry morphometric analysis also performed alpha gamma found case detected cases overexpression present lesions among microscopic features absence enlarged cells seem useful distinguish conclusions results suggest anal similarly sites associated hpv infection distinguished associated low risk hpv set diagnostic criteria possible ascertain clinical behaviour optimal treatment lesions
non adherence remains issue hiv treatment decades research supporting efficacy antiretroviral therapy non adherence medication remains important issue patients non anti therapy art appears mismatch model illness necessity art treatment propose active technique utilised improve understanding treatment subsequently adherence individuals living hiv risk infection discuss theoretical background highlight initial evidence suggesting utility active discuss active utilised live demonstration improve adherence art pre exposure prophylaxis medications
despite clear need progress toward vaccine congenital cytomegalovirus slow however recent events provided new interest several vaccine candidates either clinical trials trials close starting issue clinical vaccine immunology colleagues show lymphocytic virus vaccine expressing glycoprotein induces cells improves survival guinea pig model congenital infection vaccine https combination vaccine appeared effective
since proposal many variants proposed researcher using different different algebraic structure article try explore existing variants comparative study copyright john wiley sons ltd
introduction wide range preclinical studies testing cellular therapies repair injured spinal cord yet remain challenge translate inconsistencies efficacy limited number patients acute sci high costs clinical covered paper therapeutic potential neural precursor cells provide cellular components capable promoting repair enhancing functional improvement following spinal cord injury sci authors discuss challenges transplantation respect different populations glial neuronal lineages timing treatment relative acute chronic injury progress ongoing clinical commentary preclinical research continue elucidate mechanisms recovery associated including increasing partnership related fields spinal multiple sclerosis clinical trials landscape grow include acute chronic sci increased partnership strengthened communication biotechnology government academia also growing effort develop better biomarkers imaging outcome measures detailed assessment neurological function measures quality life
flow around circular cylinder classic scenario draws attention fluid mechanics circle relevant studies theoretical practical however experiments conducted reynolds number regime due limitations wind tunnel modeling technique makes obtained results full scale conditions end field measurements wind induced pressures meter high large cooling tower conducted enrich experimental results flow past circular cylinder regime besides wind effects low also obtained tests rigid cooling tower model wind tunnel considering types wind speeds types surface roughness flow fields employing data obtained field measurements wind tunnel model tests variations static dynamic flow characteristics increasing studied found increase drag coefficient smooth walled tower uniform flow field decreases dramatically critical regime increases slowly supercritical regime results smooth walled tower base pressure coefficient pressure coefficient increase significantly increase critical supercritical regimes qualitatively results finding number supportive result shedding rough cylinder persists throughout range tested importantly special attention paid independence phenomenon fluid flow typical phenomenon occurring regime results indicate independence exists range circular cylinder relative roughness greater increased free stream turbulence also induce independence probably exists narrow low range considering flow mechanism reasonable explanation found independence phenomenon critical supercritical regimes narrow move lower range increase surface roughness increase free stream turbulence independence occur low red
renal cell carcinoma one common kidney malignancies comprehension molecular biology implicated development cancer stimulated increase research development innovative antitumor therapies aim study analyze medical literature hypertension renal toxicities adverse events vascular endothelial growth factor vegf signaling pathway inhibitor anti vegf therapy relevant studies identified pubmed databases eligible studies phase iii prospective clinical trials meta analyses retrospective studies described events hypertension patients received anti vegf therapy total studies included systematic review incidence grade hypertension ranged proteinuria increased creatinine levels ascertained patients respectively adverse events often mild severity sometimes lead treatment discontinuation hypertension related multiple mechanisms however one main disturbances patients vegf inhibition significant risk developing hypertension renal dysfunction among patients receiving anti vegf treatment however also evidence side effects used biomarkers response agents
background double stranded breaks serious form dna damage via homologous recombination repair non homologous end joining mammalian cells stages cell cycle viewed error prone although notion sufficiently challenged due shortcomings many current systems multi copy provide large pool genetic material repair studied plasmids back cloned bacteria characterized sequence alterations used ebv based carrying resistance marker genes repair studies single generated encoded rapidly high efficiency brief time post infection employed pcr southern blot follow kinetics repair formation processing intermediates screen plasmids altered joints resulting loss resistance employed system study role found humans primates key component pathway function fully characterized intact cells results found repair end joining highly accurate cells lack less rescued plasmids showed deletions instead cells express transfected revealed large number rescued plasmids altered joint typically form large deletions moreover quantitative pcr southern blotting revealed less accurately plasmids expressing cells conclusions careful examination fidelity repair mammalian cells carrying cohesive ends revealed repair efficient highly accurate predominant however background cells important establishing accuracy human cells perhaps surprisingly much prone generate deletions junctions abundantly expressed
data structures explored several domains computer applications order ensure efficiency data store retrieval however data structures present different behavior depending applications used three dimensional interactive environments offered techniques virtual reality require operations loading manipulating objects real time response time two important requirements efficient representation geometrical models plays important part simulation become real paper present implementation comparison two efficient data structures compact half edge face representation objects three dimensional interactive environments structures tested different conditions processors ram memories results show structures used efficient manner face structure shown efficient manipulation neighborhood relationships compact half edge efficient loading geometric models also evaluated data structures embedded applications biopsy simulation using virtual reality considering deformation simulation method applied virtual human organs results showed use allows building applications considering objects high resolutions number vertices without significant impact time spent simulation therefore use contributes construction realistic simulators elsevier inc rights reserved
pediatric practical beside great variety direct dental restoration materials take account several factors structural temporary teeth clinical situation physician performance behavioural features children last least quality chosen material thus investigated behavior glass stress determining mechanical properties study aims determine vertical compressive strength values one mechanical properties filling materials strength materials useful research forces exerted future used two glass resin modified glass cement tested obtain comparative data resistance vertical compression
study investigates contrasting community based tourism earthquake focuses potentials tourism transformations towards green tourism environment linked sustainable relationship potentials community based tourism directed transformations towards green qualitative research design used examine contrasting specific green elements community based tourism peoples village county province west china discuss tourism compatible human wellbeing demonstrating commitment sustainable development study argues potential economic social environmental costs tourism need considered evaluating loss community benefits toward sustainability green elements suggest potential community based tourism transformations towards green involving green agricultural green building green energy green governance green service green consumption study contribute debate relationship tourism environment sustainability green learned community development green tourism regions inevitable natural disasters
far systematic reviews suggested increased risk cardiovascular diseases cvd psoriatic patients though results conflicting aim study update current level evidence systematic search medline embase cochrane central register databases total high quality observational studies estimating incidence cvd included patients mild psoriasis increased risk stroke hazard ratio myocardial infarction cardiovascular death risks stroke cardiovascular death increased patients severe psoriasis conclusion updated meta analysis confirmed patients psoriasis increased risk cvd especially severe psoriasis
development novel medicines important responsibility researchers field pharmaceutical sciences however discovery new therapeutically effective without side effects easy job think limiting step drug discovery process evaluating therapeutic effects candidate drugs overcome problem like propose novel approach drug discovery
network introduce non singular symmetric matrix called path intersection matrix provide new method computing ratio tree number lab obtained new edge two distinct nodes quantities appear various networks effective conductance electrical network ingredient information centrality social network review several examples networks path intersection matrices applied elsevier inc rights reserved
aim study identify existing gender roles greenhouse vegetable production province turkey purpose conducted face face interviews owners vegetable producing understand dominant household structures activity profiles information sources training needs access resources control resources income stream activity profiles reflected hours per day men women spent specific greenhouse production household tasks observed access control production resources income streams two genders compared men women higher rates lower levels education also overall workloads despite similar workloads greenhouse productive activities difference resulting household reproductive activities carried mainly women women received agricultural information neighbors men obtained information chemical notably men received information agricultural extension service women women also less access control productive resources furthermore income streams selected households benefited men women study compared differences among three independent demographic variables age producers level education producers years experience farming womens ability prepare family budget spend money without asking purchase agricultural inputs select vegetables produce statistically significant links found womens age ability manage family budget education level ability make purchase decisions years production experience ability select vegetables purchase results study provide evidence unequal social structure show efforts made increase womens access control production resources including information extension service
determination acids recently gained interest potential role markers inflammatory disorders chronic diseases hydrolysis conjugated derivatives solid phase extraction steps constitute sample preparation prior insertion analytical sample liquid laser induced fluorescence detector present method determination two representative human metabolism ultrasound accelerated hydrolysis released free efficiently concentrated dynamic manner using lab valve module allows automation step line connected labeling shortened min required conventional heating method min ultrasound assistance individual separation target analytes achieved within min detection overall method high sensitivity provided method ranged expressed column amount respectively high efficiency removal enabled application method four different serum urine saliva breast milk determination target metabolites elsevier rights reserved
reduced physical function health related quality life common rheumatoid arthritis studies needed examine novel reduced physical function study examines whether state increased vulnerability stressors associated differences self reported physical function among adults adults longitudinal cohort participated study using established definition individuals three following physical deficits classified body mass index low strength adjusted sex body mass index bmi measured severe fatigue measured multidimensional assessment fatigue slow walking speed adjusted sex height low physical activity measured international physical activity questionnaire individuals one two deficits classified pre deficits robust self reported physical function assessed health assessment questionnaire valued life activities difficulty scale regression analyses modeled associations category valued life activities difficulty scores without controlling age sex disease duration reactive protein use oral steroids pain among adults compared robust associated worse score effects covariates held constant compared robust associated clinically meaningful differences self reported physical function among adults
posttraumatic stress disorder ptsd psychiatric disorder repetitive transcranial magnetic stimulation found effective treating ptsd whether different frequencies different effects remains controversial conducted systematic review meta analysis address question searched literature studies written english chinese electronic databases databases inception august additional articles identified reference lists identified studies personal reference collections eighteen articles included suitable meta analysis combined sample size active groups sham controlled groups low frequency resulted significant reduction ptsd total score depression score ptsd total score pooled depression pooled high frequency showed following results ptsd total score pooled experiencing pooled avoidance pooled pooled depression pooled anxiety pooled therefore alleviate ptsd symptoms although evidence extremely limited reduce overall ptsd depression symptoms improve main related symptoms ptsd however additional research needed findings elsevier ltd rights reserved
background parkinsons disease progressive neurodegenerative disorder results widespread loss select classes neurons throughout nervous system pathological hallmarks parkinsons disease lewy bodies alpha synuclein major component alpha synuclein aggregation reported gut parkinsons disease patients even decade motor symptoms similar observations made animal models disease however unlike central nervous system nature alpha synuclein species form aggregates classes neurons affected gut unclear previously reported selective expression alpha synuclein cholinergic neurons gut suggesting particularly vulnerable degeneration parkinsons disease methods study used immunohistochemistry detect alpha synuclein via conformation specific antibodies treatment prolonged exposure high vivo segments guinea pig maintained culture key results prolonged raising caused accumulation alpha synuclein cholinergic enteric neurons took place time case concentration dependent manner also caused selective necrosis indicated increased cellular cholinergic enteric neurons labeled immunoreactivity also concentration dependent manner conclusions inferences knowledge first report causing selective loss neurochemical class enteric nervous system cholinergic enteric neurons particularly susceptible lewy pathology degeneration parkinsons disease
study analyzes social correlates month olds instrumental helping reach objects alleviating distress reach helping basic type prosocial behavior associated social variables associated maternal responsible parenting day care attendance fear accounting total variance corresponding regression model data present study suggest simple instrumental helping seems robust developmental phenomenon associated specific social experiences child temperament constitute differences thereby help explain domain specific development elsevier inc rights reserved
authentication user online major issue recent days transactions carried using insecure internet channel modern communication medium much exposed various threats one time used prove ones identity wireless channel sent users registered mobile number commonly used technique user authentication sent normally plain text vulnerable various attacks along communication channel solve problem research aims provide technique transform using lightweight cryptography cipher text using text send text user mobile personal identification number pin supplied bank registration used user needs know pin read user proceed business transaction authentication process provides end end encryption
work excited state single double proton transfer mechanisms bis investigated using time dependent density functional theory method first time calculations showed hydrogen bond center dot center dot center dot strengthened excited state provides driving force effectively facilitate proton transfer process constructed potential energy surface excited state demonstrated double proton transfer reaction occurs readily dynamics thermodynamics aspects implemented simultaneous double proton transfer successive single transfers furthermore assignments multiple fluorescence bands experiment confirmed fluorescence spectral simulation calculated emission spectra indicated experimental fluorescence attributed normal stokes shifted emission large stokes shifted fluorescence peaks double proton transfer emission experimentally observed shoulder peak similar results excited state single proton transfer elsevier ltd rights reserved
powerful instrument modelling analysing simulating dynamic systems nets used many times past solve software engineering problems model different aspects information system however none research attempts modelling complete information systems behaviour formal way time field requirement specification modelling information systems usual find object oriented methodologies instead formal methods nets paper propose model based extension nets creating formal static dynamic models information systems proposed model designed replacement dynamic diagrams modelling static structure system still suggest using methods proposed nets extension provides complete integration static elements nets used dynamic model main contribution proposed nets extension get formal model unlike known formal models directly completely precisely created model net represents real information system functionalities moreover created case tool allows modelling execution system using proposed model
chemokines family small cytokines share typical key structure stabilized disulfide bonds cysteine residues terminal protein secreted great variety cells several different conditions function directly dependent interactions receptors chemokines involved cell maturation differentiation infection autoimmunity cancer general situation immune components involved however role inflammation fracture healing yet established article discuss response chemokines bone fracture potential roles inflammation healing based data studies previously published studies
viral vaccines remarkable positive impacts human health health domestic animal populations despite impressive vaccine successes however many infectious diseases yet efficiently controlled vaccination often impossible sufficient proportion population recent advances molecular biology suggest old method individual based vaccine delivery major revolution specifically genetic engineering brings life possibility live vaccine unfortunately releasing highly vaccine poses substantial evolutionary risks including high virulence documented oral vaccine alternative far safer approach rely genetically engineered weakly vaccines reduced scope evolutionary use mathematical models evaluate potential efficacy weakly vaccines results demonstrate vaccines even modest ability transmit significantly lower incidence infectious disease facilitate eradication efforts consequently weakly vaccines provide important tool controlling infectious disease wild domestic animal populations reducing risks emerging infectious disease humans
alcohol dependent patients ads known encounter severe interpersonal problems nonverbal communication skills important development healthy relationships present study aimed explore emotional facial expression recognition posed spontaneous male ads divided two groups according typology impact interpersonal relationship quality potential nonverbal deficits twenty type ads twenty one type ads twenty control participants took part recognition task task considered personal emotional events spontaneous response photo word cue posed coding based ratings participants emotional facial expressions participants additionally completed questionnaire interpersonal relationship quality difference three groups emerged recognition task type ads showed heightened deficits compared type ads perceived less accurate posed response cue word less intense positive spontaneous type ads compared control participants addition type ads reported relationship difficulties compared type ads control participants interpersonal relationship difficulties related deficits study important differences interpersonal functioning subtypes
objective previous studies indicated association type small posterior studies limited quantitative methods recent studies utilizing methodologies time intensive manual segmentation authors sought develop automated tool calculate posterior volume correlate changes surgical outcomes methods segmentation program developed used compare pre postoperative volumes posterior cranial csf spaces fourth ventricle cohort pediatric patients volume changes correlated postoperative symptomatic improvements headache descent overall surgical success results forty two pediatric patients included study mean percentage increase volume significantly greater patients showed clinical improvement versus improvement headache descent overall clinical success associated larger postoperative volume increase clinical improvements also significantly associated larger increase volume increase portion posterior volume also larger patients showed improvement conclusions greater increase postoperative volume specifically increase volume associated greater likelihood clinical improvements headache descent patients larger increases portion posterior volume also associated greater likelihood improvement
introduction aggression one leading clinical characteristics antisocial personality disorder studies aiming clarify control biological basis aggression ongoing thyroid hormones indicated play role development aggression aim study examine level aggression serum thyroid hormone sample make contributions field current findings methods sample consisted subjects diagnosis subjects control group structured clinical interview dsm axis scid used diagnosis aggression questionnaire administered based criminal patterns group divided two subgroups criminal groups day interview one night fasting blood collected subjects thyroid function tests biochemical analyses related confounding variables also administered study group control group compared terms aggression scores thyroid hormone levels results mean score free level criminal group found significantly higher group subjects higher free levels also higher aggression scores group serum free levels increased also increment aggression scores however criminal group significant correlation thyroid hormone levels aggression conclusion findings study indicated criminal groups actually show different properties
objectives define different characteristics treatment overactive bladder adults know barriers use drug establish proposals minimize barriers methods local sessions held country divided sessions moderated technique led external results experts believe tolerability clinical efficacy important attributes choose formulation lack scientific publications least valued opinions based clinical experience scientific publications without establishing comparison treatment options main barriers administrative obstacles difficulty use lack rejection administration patient actions proposed correct significant barriers better training specialists patients creating informative materials reinforce health education managing patches generating greater volume scientific evidence support use overactive bladder clearly identifying profile patients benefit therapeutic strategy conclusions although standard treatment overactive bladder recent years conclusion working group new formulation offers better tolerated alternative patients therefore necessary tools generate evidence implemented increase proper use among specialists patients
paper introduced autonomous robots benefit improvements intelligence overview systems real world want robots help perform tasks remote environment paper also synergy human operator robot various applications healthcare medicines entertainment education graphic arts industry space aim design construct robotic arm cooperation feedback processes conceptualization design assembly final coding required complete tasks ranging needs assessment static dynamic load analyses design manufacturing machining finally microcontroller coding name
paper presents methodology generate manufacturing routes operations using rules provide logical approach rules order prioritize knowledge various manufacturing processes taking account theories machining assembly heat treatments also utilizes theories accumulation tolerance process capability others proposed methodology requires development manufacturing data bases manufacturing process capabilities deviations machine tool cutting tool device work piece rules make viable generation manufacturing operations usage structured knowledge instead one approach allows structured development manufacturing routes deployed engineers working areas manufacturing engineering
systematic unified method using signal graph sfg technique presented analyzing modulated pwm switch mode power converters operating continuous conduction mode loop gains single systems reviewed sfg converter generated perturbed state space averaged equations characteristic polynomial system computed grouping terms associated gain error amplifier unique definition system loop gain introduced locations breaking loop discussed system loop gains voltage current programming converters either leading edge modulation derived shown loop gain measured analog injection method system loop gain determines stability converter
passive moderator cooling system advanced heavy water reactor designed remove heat moderator case extended station black condition hot heavy water moderator inside rises upward due cooled tube heat exchanger located within loop returns back completing natural circulation loop heat exchanger turn cooled water gravity driven water pool forming second loop coupled natural circulation loop system provides sufficient cooling prevent increase moderator temperature inside vessel beyond safe limits feasibility system assessed implemented reactor thus scaled test facility set simulate thermal hydraulic characteristics set time varying power experiments performed capture flow initiation rest phenomena multidimensional natural convection flow coupled natural circulation system next experimental geometry simulated using three dimensional computational fluid dynamics code predicted temperature flow distribution inside system cfd results agree experimental data within flow initiation phenomena shows initial flow generated within similar flow able come experiments show time lag starting primary secondary loop circulation work demonstrates experimental computational capability understand design effective passive moderator cooling system elsevier ltd rights reserved
aim study investigate association physical activity objective heart rate variability based stress recovery subjective stress longitudinal setting working age participants women men overweight body mass index points general health questionnaire objective stress recovery based recordings work days subjective stress assessed perceived stress scale level questionnaire data collected three time points baseline post intervention week follow adopted latent growth model investigate initial level change objective stress recovery subjective stress three measurement time points results showed initial levels objective stress recovery associated change subjective stress results persisted adjustment intervention group present results suggest high objectively assessed low stress good recovery positive effects changes subjective stress long term
water shortage water pollution climate changes highly interrelated global issues raised immense concerns possible serious adverse effects quality treatment reuse wastewater research aims investigate potential impact fungus aspergillus ability organism remove contaminated wastewater found toxic toward irreversible effects whereas inhibitory toward reversible effects concentration ranges vary initial concentrations contact time initial concentration remove respectively day increase respectively day another experiment showed initial concentration respectively day increases day adsorption mechanisms employed organism removal thus enhance biological treatment wastewater
possible construct age curve ages women biologically old reproduce constructed curve based distribution female age last birth natural fertility populations reflecting ages women become biologically old children median age last birth females similar years age across range natural fertility populations suggests fairly universal pattern age related fertility decline however little known distribution female present era modern birth control impossible assess age specific distribution reliable information lacking benefit couples delaying childbearing study review high quality historical data sets natural fertility populations distributions female age last birth analysed studies selected used retrospective cohort design women followed age reproductive years using common set eligibility criteria large data files natural fertility populations prepared analysis performed parallel across populations data confounding variables presented box plots percentile distribution age last birth population analysis includes estimation kaplan meier curves age last birth population hazard curve obtained hazard curve population taking lowest hazard within time period least years lowest hazard curve transformed cumulative distribution function representing composite curve end biological fertility curve based data three six populations lowest hazards end fertility selected six natural fertility populations comprising eligible women populations represent different historical time periods distribution ages last birth remarkably similar curve end fertility indicates women last birth age years meaning almost able least one child thereafter cumulative curve end fertility slowly increases age years age years age years age years thereafter rises rapidly age almost age years approaching age years argued historical fertility data apply present time however age dependent decline fertility similar current populations consistent pattern seen women treated donor furthermore reproductive ageing note unlikely conserved biological process high degree heritability changed significantly within century two argue age specific curve used couples children future findings challenge regarding possibility natural conception age years
brushless doubly fed machine brushless electrical generator allows variable speed operation power converter rated fraction machine rating paper details example implementation medium scale wind turbine details simplified design procedure based electrical magnetic loadings given along results tests manufactured machine show scale works expected chosen slower thus larger turbines original induction machine implementation turbine system discussed including vector based control scheme ensures operates speed maximum power point tracking scheme rotor speed extracts power incident wind conditions
application integration process creating designed application systems operate collectively whole integration easy task developers combine disparate structural designs include different data process object models developers also make solution operate across several operating systems middleware technologies databases integration essential new technology solution study discusses different approaches feasible solutions estimates disparate enterprise solution synchronization also discuss influential forces made enterprise summarize inspection areas selecting method individual enterprise requirements moreover provide important aspects considered planning creating integration solution
widespread distribution smart mobile devices offers promising perspectives timely collection huge amounts data realizing sophisticated mobile data collection applications numerous technical issues arise example many real world projects require support different mobile operating systems platform specific properly handled existing approaches often rely specifically tailored mobile applications drawback changes data collection procedure result costly code adaptations remedy drawback model driven approach proposed enabling end users domain experts create mobile data collection applications model relies complex questionnaires called instruments instrument contains information data collected additionally comprises information processed different mobile operating systems purpose developed advanced mobile kernel service capable processing sophisticated instruments various platforms paper discusses fundamental kernel requirements introduces developed architecture altogether mobile service allows effective use smart mobile devices data collection application scenarios clinical trials
long syndrome rare cardiac associated sudden death due ventricular fibrillation sudden death frequently associated physical emotional stress management patients consists life style modification beta blockers left cardiac sympathetic implantable icd implantation competitive exercise avoidance drugs important issues life style modification although beta blockers primary treatment modality patients drugs completely effective patients lifelong icd implantation young active patients associated significant complications relatively simple highly effective surgical procedure however rarely used
enormous amount information available cell biology created challenge selecting core concepts teaching undergraduates one way define set essential core ideas cell biology analyze specific cell biology community teaching students main objective analyze cell biology content currently taught brazilian universities collected cell biology courses public universities brazil analyzed frequency cell biology topics course also compared brazilian data contents major cell biology analysis showed cell biology topics plasma membrane cytoskeleton present similar brazilian curricula analyzed others cell signaling cell differentiation present similar average cell biology content taught brazilian universities quite different presented discuss several possible explanations observations also suggest list essential cell biology topics biological biomedical undergraduate course comparative discussion cell biology topics presented valuable educational contexts
atomic scale tomography defined place microscopy considered arguments made defined ultimate microscopy available pathways achieving examined conclude atom probe tomography viable basis conjunction transmission electron microscopy likely path possible configurations instrumentation achieving described concept introduced data multiple techniques create multidimensional data structure coupled integrated computational materials engineering structure properties microscopy implications science technology explored
technological advancements contemporary learning theories school environment ict technology many aspects learning process particular ict technology exploited monitor learners behaviour learning activities example identify whether learner paying attention lecture presents functional requirements visual tool smart classroom allows teachers view attention monitoring subsystem individual student classroom whole order improve educational process preliminary usability findings regarding design reported collected cognitive evaluation experts
since situ preservation material become widespread european union need stop active attack wood wood become urgent aim current study examine ability two plastic materials plastic membrane stop initial attack effects wood active degradation blocks submerged southern part denmark known settling attack confirmed blocks removed either polypropylene polyethylene plastic membrane polyethylene normally used protection denmark optical oxygen sensor packed together block measure amount available oxygen around wood one week oxygen level around test blocks plastic membrane dropped drastically lead death within test blocks one four weeks although new wood geotextile impede passage seawater living individuals found blocks weeks elsevier ltd rights reserved
senior author introduced modern concept migraine surgery since articles published eight centers across europe asia describing positive outcomes surgery cases surgeons patients increasingly interested new treatment method however majority publications topic found surgical literature articles presented neurology journals review introduction migraine surgery surgeons view discusses surgical treatment migraine headaches based discoveries made articles published senior author outlines current history migraine surgery presents evidence supporting effectiveness tries claims seeing placebo effect describes detection trigger sites outlines surgical techniques peripheral nerve hope review generate positive discussion surgeons lead interdisciplinary collaboration benefit patients future
fibrotic diseases understood represent number different diseases characterized development severe organ fibrosis without obvious cause devastating diseases idiopathic pulmonary fibrosis ipf diseases poor prognosis comparable cancer given phenotypic differences assumed different fibrotic diseases also different demonstrate many fibrotic diseases including ipf myelofibrosis kidney pancreas heart fibrosis converge activation transcription factor jun pathologic fibroblasts expression related transcription factor restricted pulmonary artery hypertension induction jun mice sufficient induce severe fibrosis multiple organs dependent sustained jun expression single cell mass cytometry revealed jun activates multiple signaling pathways mice including also induced human disease alpha antibody treatment vegf inhibition reversed various organ jun mediated vivo data suggest jun central molecular mediator fibrotic conditions
study describes first time distribution calcium binding protein anterior nuclei guinea pig development brains animals ranging embryonic day postnatal day used study immunoreactive present among thick fibers containing crossing nucleus first neurons appeared lateral part fibers disappeared whole area displayed closely packed stage also appeared neurons nucleus particularly lateral part along dorsal border moreover short thin fibers observed medial part newborns already showed adult like distribution pattern distributed number slightly decreased comparison nucleus devoid neurons studied stages conclusion results demonstrate appears first time neurons various anterior nuclei guinea pig day prenatal development elsevier rights reserved
study engineering experimentation plays great role understanding concepts teaching engineering always challenging theoretical study augmented experiments students get feel real life applications concepts study automation control laboratory area students verify diagrams develop various applications unless programmable logic controller lab new concept virtual lab enabled teach concepts diagrams development control systems using easily students develop diagrams design digital control systems using simulation environment given virtual lab platform implement developed study carried institute exit surveys shows students results test platform
objective determine bone characteristics seen magnetic resonance imaging associated patient reported outcomes prior following anterior cruciate ligament reconstruction combined presence bone articular cartilage pathology results inferior year outcomes design bone volume severity measured patients preoperative magnetic resonance imaging medial lateral femoral mfc medial lateral tibial plateau using classification modified version technique relationships bone volume severity knee injury osteoarthritis outcome score international knee documentation committee scores assessed pre postoperative scores compared bone either without combined local articular cartilage pathology results patients bone least region bone regions common followed mfc neither bone volume severity associated inferior postoperative outcomes subset patients bone combined articular cartilage pathology times likely symptomatic year follow without articular cartilage pathology conclusions volume severity preoperative bone alone associated year outcomes however bone combined local articular cartilage pathology appear symptomatic acl reconstruction
valve academic research consortium aortic valve replacement set standard selecting appropriate clinical endpoints reflecting safety effectiveness devices defining single composite clinical endpoints clinical trials standardization exists surgical valve leak closure document seeks provide core principles appropriate clinical endpoints endpoint definitions used clinical trials closure devices academic research consortium met review evidence make recommendations assessment disease severity data collection updated endpoint definitions class grading scheme evaluate developed concordance recommendations unresolved issues field outlined current academic research consortium provides recommendations assessment disease severity data collection endpoint definitions future research field warranted american college cardiology foundation european society cardiology
